The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
9 METERS BIOPHARMA INC COM 654405909 12 543 SH Call DFND 1 0 543 0
ACTINIUM PHARMACEUTICALS INC COM 00507W956 1,582 2,143 SH Put DFND 1 0 2,143 0
ADITXT INC COM 007025505 588 173,409 SH   DFND 1 0 173,409 0
AGILE THERAPEUTICS INC COM 00847L209 15 50,000 SH   DFND 1 0 50,000 0
AGM GROUP HOLDINGS INC CL A G0132V105 481 299,000 SH   DFND 1 0 299,000 0
AKARI THERAPEUTICS PLC ADR 00972G108 2,585 4,103,098 SH   DFND 1 0 4,103,098 0
AMPLITECH GROUP INC COM 03211Q200 251 136,382 SH   DFND 1 0 136,382 0
AMPLITECH GROUP INC *W 03211Q119 145 454,246 SH   DFND 1 0 454,246 0
APPLIED DNA SCIENCES INC COM 03815U300 150 132,694 SH   DFND 1 0 132,694 0
APPLIED DNA SCIENCES INC COM 03815U950 158 1,397 SH Put DFND 1 0 1,397 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 299 499,045 SH   DFND 1 0 499,045 0
ASPIRA WOMENS HEALTH INC COM 04537Y109 584 1,569,782 SH   DFND 1 0 1,569,782 0
ASSURE HOLDINGS CORP COM 04625J204 496 775,001 SH   DFND 1 0 775,001 0
ATOSSA THERAPEUTICS INC COM 04962H506 343 411,896 SH   DFND 1 0 411,896 0
ATOSSA THERAPEUTICS INC COM 04962H906 55 661 SH Call DFND 1 0 661 0
ATOSSA THERAPEUTICS INC COM 04962H956 391 4,696 SH Put DFND 1 0 4,696 0
AYTU BIOPHARMA INC COM 054754874 234 1,262,516 SH   DFND 1 0 1,262,516 0
BAUDAX BIO INC COM 07160F206 108 439,220 SH   DFND 1 0 439,220 0
BIOCEPT INC COM 09072V501 28 30,502 SH   DFND 1 0 30,502 0
BIOLINERX LTD ADS 09071M205 2,807 3,034,107 SH   DFND 1 0 3,034,107 0
BIORA THERAPEUTICS INC COM 74319F107 139 287,641 SH   DFND 1 0 287,641 0
BIORA THERAPEUTICS INC COM 74319F957 158 3,257 SH Put DFND 1 0 3,257 0
BIOVIE INC CL A 09074F207 244 98,048 SH   DFND 1 0 98,048 0
BIT DIGITAL INC COM G1144A955 309 2,571 SH Put DFND 1 0 2,571 0
BLUE WATER VACCINES INC COM 09610B108 944 552,249 SH   DFND 1 0 552,249 0
BLUEJAY DIAGNOSTICS INC COM 095633103 20 26,091 SH   DFND 1 0 26,091 0
BONE BIOLOGICS CORP *W 098070113 9 108,476 SH   DFND 1 0 108,476 0
BRIACELL THERAPEUTICS CORP COM 10778Y302 528 94,005 SH   DFND 1 0 94,005 0
BRIACELL THERAPEUTICS CORP COM 10778Y952 3,181 5,661 SH Put DFND 1 0 5,661 0
BRIGHT GREEN CORP COM 10920G100 5,143 4,761,905 SH   DFND 1 0 4,761,905 0
BRIGHT GREEN CORP COM 10920G950 43 398 SH Put DFND 1 0 398 0
BRUUSH ORAL CARE INC COM 11750K203 10 10,234 SH   DFND 1 0 10,234 0
BRUUSH ORAL CARE INC *W 11750K120 372 365,752 SH   DFND 1 0 365,752 0
CANAAN INC ADS 134748102 730 222,559 SH   DFND 1 0 222,559 0
CANAAN INC ADS 134748902 46 141 SH Call DFND 1 0 141 0
CANAAN INC ADS 134748952 730 2,225 SH Put DFND 1 0 2,225 0
CASTOR MARITIME INC SHS Y1146L125 62 55,511 SH   DFND 1 0 55,511 0
CASTOR MARITIME INC SHS Y1146L955 92 824 SH Put DFND 1 0 824 0
CBAK ENERGY TECHNOLOGY INC COM 14986C952 70 605 SH Put DFND 1 0 605 0
CEA INDUSTRIES INC COM 86887P200 121 115,000 SH   DFND 1 0 115,000 0
CINGULATE INC COM 17248W105 126 117,793 SH   DFND 1 0 117,793 0
CINGULATE INC *W 17248W113 122 611,295 SH   DFND 1 0 611,295 0
CLARUS THERAPEUTICS HLDNGS INC COM 18271L107 5 146,900 SH   DFND 1 0 146,900 0
COCRYSTAL PHARMA INC COM 19188J300 1,538 5,284,256 SH   DFND 1 0 5,284,256 0
CURIS INC COM 231269200 350 500,000 SH   DFND 1 0 500,000 0
CYNGN INC COM 23257B107 69 69,440 SH   DFND 1 0 69,440 0
DIGITAL ALLY INC COM 25382T101 509 1,114,646 SH   DFND 1 0 1,114,646 0
DIGITAL ALLY INC COM 25382T951 38 829 SH Put DFND 1 0 829 0
DOGNESS INTL CORP CL A G2788T103 2,844 2,430,345 SH   DFND 1 0 2,430,345 0
EKSO BIONICS HOLDINGS INC COM 282644301 160 102,400 SH   DFND 1 0 102,400 0
EQONEX LTD SHS Y2074E109 10 23,854 SH   DFND 1 0 23,854 0
ESPERION THERAPEUTICS INC COM 29664W955 121 180 SH Put DFND 1 0 180 0
ESPORTS ENTERTAINMENT GROUP COM 29667K306 142 1,154,302 SH   DFND 1 0 1,154,302 0
ESPORTS ENTERTAINMENT GROUP *W 29667K132 458 3,723,748 SH   DFND 1 0 3,723,748 0
ESPORTS ENTERTAINMENT GROUP COM 29667K956 2 200 SH Put DFND 1 0 200 0
GEVO INC COM 374396956 148 650 SH Put DFND 1 0 650 0
GLOBUS MARITIME LIMITED COM Y27265126 638 506,659 SH   DFND 1 0 506,659 0
GLOBUS MARITIME LIMITED COM Y27265956 106 842 SH Put DFND 1 0 842 0
GREENWAVE TECHNOLOGY SOLUTION COM 57630J304 544 314,674 SH   DFND 1 0 314,674 0
GROM SOCIAL ENTERPRISES INC *W 39878L118 1 12,737 SH   DFND 1 0 12,737 0
GUARDFORCE AI CO LTD *W G4236L120 47 388,000 SH   DFND 1 0 388,000 0
HARBOR CUSTOM DEVELOPMENT INC *W 41150T124 1,267 1,439,795 SH   DFND 1 0 1,439,795 0
HEARTBEAM INC *W 42238H116 235 399,150 SH   DFND 1 0 399,150 0
HUMANCO ACQUISITION CORP *W 44487N117 44 400,314 SH   DFND 1 0 400,314 0
IMPERIAL PETROLEUM INC COM Y3894J954 250 7,680 SH Put DFND 1 0 7,680 0
INMED PHARMACEUTICALS INC COM 457637601 101 15,284 SH   DFND 1 0 15,284 0
INNOVATIVE EYEWEAR INC COM 45791D109 208 149,528 SH   DFND 1 0 149,528 0
INNOVATIVE EYEWEAR INC *W 45791D117 530 381,640 SH   DFND 1 0 381,640 0
ISHARES TR ETF 464287955 6,415 389 SH Put DFND 1 0 389 0
IVEDA SOLUTIONS INC COM 46583A204 413 635,443 SH   DFND 1 0 635,443 0
JEFFS BRANDS LTD *W M61472110 13 77,282 SH   DFND 1 0 77,282 0
KEMPHARM INC COM 488445206 1,551 248,592 SH   DFND 1 0 248,592 0
KEMPHARM INC COM 488445956 2,583 4,140 SH Put DFND 1 0 4,140 0
LEXARIA BIOSCIENCE CORP *W 52886N117 699 285,360 SH   DFND 1 0 285,360 0
LISATA THERAPEUTICS INC COM 128058302 294 63,508 SH   DFND 1 0 63,508 0
LIXTE BIOTECHNOLOGY HOLDINGS COM 539319202 56 99,644 SH   DFND 1 0 99,644 0
META MATERIALS INC COM 59134N104 891 1,372,752 SH   DFND 1 0 1,372,752 0
META MATERIALS INC COM 59134N954 254 3,916 SH Put DFND 1 0 3,916 0
METEN HOLDING GROUP LTD COM G6055H148 119 330,504 SH   DFND 1 0 330,504 0
MOLECULAR DATA INC COM 60852L205 2 178,972 SH   DFND 1 0 178,972 0
NANOVIBRONIX INC COM 63008J108 5 10,000 SH   DFND 1 0 10,000 0
NEWAGE INC COM 650194103 13 1,266,800 SH   DFND 1 0 1,266,800 0
NISUN INTL ENT DVPMT GP CO LTD CL A G6593L106 1,132 2,177,039 SH   DFND 1 0 2,177,039 0
NOCERA INC COM 655186500 318 227,440 SH   DFND 1 0 227,440 0
NUVECTIS PHARMA INC COM 67080T108 4,488 632,979 SH   DFND 1 0 632,979 0
OCEAN POWER TECHNOLOGIES INC COM 674870506 66 80,163 SH   DFND 1 0 80,163 0
OCEAN POWER TECHNOLOGIES INC COM 674870956 49 596 SH Put DFND 1 0 596 0
ONFOLIO HOLDINGS INC COM 68277K207 108 93,500 SH   DFND 1 0 93,500 0
ONION GLOBAL LTD ADS 68277G107 578 1,713,689 SH   DFND 1 0 1,713,689 0
PALISADE BIO INC COM 696389105 44 445,899 SH   DFND 1 0 445,899 0
PHARMACYTE BIOTECH INC COM 71715X203 1,362 567,600 SH   DFND 1 0 567,600 0
PHARMACYTE BIOTECH INC COM 71715X953 414 1,723 SH Put DFND 1 0 1,723 0
PINEAPPLE ENERGY INC COM 72303P107 168 192,906 SH   DFND 1 0 192,906 0
PULMATRIX INC COM 74584P301 1,114 312,000 SH   DFND 1 0 312,000 0
RECON TECHNOLOGY LTD CL A G7415M124 1,123 1,973,609 SH   DFND 1 0 1,973,609 0
REVIVA PHARMACEUTICALS HOLDINGS COM 76152G100 48 30,000 SH   DFND 1 0 30,000 0
REVIVA PHARMACEUTICALS HOLDINGS COM 76152G950 48 300 SH Put DFND 1 0 300 0
REWALK ROBOTICS LIMITED SHS M8216Q200 782 880,446 SH   DFND 1 0 880,446 0
REWALK ROBOTICS LIMITED SHS M8216Q950 64 722 SH Put DFND 1 0 722 0
SPDR S&P 500 ETF 78462F953 199 1,518 SH Put DFND 1 0 1,518 0
SPDR SER TR ETF 78464A950 10,113 1,275 SH Put DFND 1 0 1,275 0
SPHERE 3D CORP COM 84841L908 25 565 SH Call DFND 1 0 565 0
SPI ENERGY CO LTD SHS G8651P110 13 10,226 SH   DFND 1 0 10,226 0
SPI ENERGY CO LTD SHS G8651P950 13 100 SH Put DFND 1 0 100 0
SPLASH BEVERAGE GROUP INC COM 84862C203 29 21,255 SH   DFND 1 0 21,255 0
SPLASH BEVERAGE GROUP INC *W 84862C112 370 270,163 SH   DFND 1 0 270,163 0
TANTECH HOLDINGS LTD COM G8675X123 212 1,200,000 SH   DFND 1 0 1,200,000 0
THE9 LTD ADS 88337K302 14 14,453 SH   DFND 1 0 14,453 0
TOUGHBUILT INDUSTRIES INC COM 89157G884 887 434,730 SH   DFND 1 0 434,730 0
TRICIDA INC COM 89610F901 3,000 2,863 SH Call DFND 1 0 2,863 0
TRICIDA INC COM 89610F951 796 760 SH Put DFND 1 0 760 0
VINCERX PHARMA INC COM 92731L106 698 505,559 SH   DFND 1 0 505,559 0
VIRPAX PHARMACEUTICALS INC COM 928251107 1,255 1,054,400 SH   DFND 1 0 1,054,400 0
WEARABLE DEVICES LTD SHS M97838102 654 743,641 SH   DFND 1 0 743,641 0
WEARABLE DEVICES LTD *W M97838110 515 2,464,241 SH   DFND 1 0 2,464,241 0
XPRESSPA GROUP INC COM 98420U953 377 4,928 SH Put DFND 1 0 4,928 0