The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
9 METERS BIOPHARMA INC COM 654405909 687 1,573 SH Call DFND 1 0 1,573 0
9 METERS BIOPHARMA INC COM 654405959 50 115 SH Put DFND 1 0 115 0
ACTINIUM PHARMACEUTICALS INC COM 00507W906 868 1,699 SH Call DFND 1 0 1,699 0
ACTINIUM PHARMACEUTICALS INC COM 00507W956 752 1,471 SH Put DFND 1 0 1,471 0
ACUTUS MEDICAL INC COM 005111109 1,416 1,018,950 SH   DFND 1 0 1,018,950 0
ADITXT INC COM 007025959 86 1,890 SH Put DFND 1 0 1,890 0
ADITXT INC COM 007025109 264 577,727 SH   DFND 1 0 577,727 0
AGM GROUP HOLDINGS INC COM G0132V105 2,450 1,178,012 SH   DFND 1 0 1,178,012 0
ALPINE 4 HOLDINGS INC COM 02083E955 77 735 SH Put DFND 1 0 735 0
AMPLITECH GROUP INC COM 03211Q200 411 122,400 SH   DFND 1 0 122,400 0
AMPLITECH GROUP INC *W 03211Q119 438 455,920 SH   DFND 1 0 455,920 0
APPLIED GENETIC TECHNOLOGIES COM 03820J900 15 140 SH Call DFND 1 0 140 0
APPLIED GENETIC TECHNOLOGIES COM 03820J950 293 2,737 SH Put DFND 1 0 2,737 0
APPLIED GENETIC TECHNOLOGIES COM 03820J100 1,038 970,057 SH   DFND 1 0 970,057 0
ARCADIA BIOSCIENCES INC COM 039014954 77 553 SH Put DFND 1 0 553 0
ASLAN PHARMACEUTICALS LIMITED ADS 04522R101 839 932,399 SH   DFND 1 0 932,399 0
ATHERSYS INC COM 04744L956 86 307 SH Put DFND 1 0 307 0
ATHERSYS INC COM 04744L106 816 291,444 SH   DFND 1 0 291,444 0
ATOSSA THERAPEUTICS INC COM 04962H906 120 958 SH Call DFND 1 0 958 0
ATOSSA THERAPEUTICS INC COM 04962H956 1,431 11,448 SH Put DFND 1 0 11,448 0
ATOSSA THERAPEUTICS INC COM 04962H506 453 362,072 SH   DFND 1 0 362,072 0
BARCLAYS BANK PLC IPTH 06747R907 10,781 4,195 SH Call DFND 1 0 4,195 0
BAUDAX BIO INC COM 07160F206 33 18,900 SH   DFND 1 0 18,900 0
BIOCEPT INC COM 09072V501 71 30,502 SH   DFND 1 0 30,502 0
BIO-KEY INTERNATIONAL INC COM 09060C958 253 1,056 SH Put DFND 1 0 1,056 0
BIO-KEY INTERNATIONAL INC COM 09060C408 105 43,652 SH   DFND 1 0 43,652 0
BIOPHYTIS SA ADS 09076G104 196 77,819 SH   DFND 1 0 77,819 0
BIOVIE INC CL A 09074F207 2,893 612,914 SH   DFND 1 0 612,914 0
BIT BROTHER LIMITED CL A G1144D109 170 500,000 SH   DFND 1 0 500,000 0
BIT DIGITAL INC SHS G1144A955 1,232 3,422 SH Put DFND 1 0 3,422 0
BIT MINING LIMITED ADR 055474950 321 1,152 SH Put DFND 1 0 1,152 0
BIT MINING LIMITED ADR 055474100 969 347,299 SH   DFND 1 0 347,299 0
BONE BIOLOGICS CORP *W 098070113 37 108,476 SH   DFND 1 0 108,476 0
BRIACELL THERAPEUTICS CORP COM 10778Y952 6,610 6,519 SH Put DFND 1 0 6,519 0
BRIACELL THERAPEUTICS CORP COM 10778Y302 304 29,962 SH   DFND 1 0 29,962 0
CALADRIUS BIOSCIENCES INC COM 128058203 1,483 2,371,525 SH   DFND 1 0 2,371,525 0
CANAAN INC ADS 134748102 266 49,058 SH   DFND 1 0 49,058 0
CANAAN INC ADS 134748952 2,400 4,420 SH Put DFND 1 0 4,420 0
CASTOR MARITIME INC SHS Y1146L955 152 824 SH Put DFND 1 0 824 0
CASTOR MARITIME INC SHS Y1146L125 126 68,419 SH   DFND 1 0 68,419 0
CATALYST BIOSCIENCES INC COM 14888D208 871 1,320,000 SH   DFND 1 0 1,320,000 0
CBAK ENERGY TECHNOLOGY INC COM 14986C952 319 2,492 SH Put DFND 1 0 2,492 0
CBAK ENERGY TECHNOLOGY INC COM 14986C102 256 200,025 SH   DFND 1 0 200,025 0
CEA INDUSTRIES INC COM 86887P200 334 133,081 SH   DFND 1 0 133,081 0
CHECK CAP LTD SHS M2361E203 340 875,057 SH   DFND 1 0 875,057 0
CINGULATE INC *W 17248W113 156 555,754 SH   DFND 1 0 555,754 0
CINGULATE INC COM 17248W105 1,486 754,130 SH   DFND 1 0 754,130 0
COCRYSTAL PHARMA INC COM 19188J300 3,087 5,612,037 SH   DFND 1 0 5,612,037 0
CONTEXT THERAPEUTICS INC COM 21077P108 2,528 1,165,100 SH   DFND 1 0 1,165,100 0
CONTRAFECT CORP COM 212326900 414 1,135 SH Call DFND 1 0 1,135 0
CONTRAFECT CORP COM 212326300 343 94,020 SH   DFND 1 0 94,020 0
CORE SCIENTIFIC INC COM 21873J908 1,067 1,296 SH Call DFND 1 0 1,296 0
CURIS INC COM 231269200 823 345,905 SH   DFND 1 0 345,905 0
CYREN LTD COM M26895132 290 57,493 SH   DFND 1 0 57,493 0
DIGITAL ALLY INC COM 25382P958 357 3,277 SH Put DFND 1 0 3,277 0
DIGITAL ALLY INC COM 25382P208 434 398,187 SH   DFND 1 0 398,187 0
DIGITAL WORLD ACQUISITION CO CL A 25400Q905 34,268 5,312 SH Call DFND 1 0 5,312 0
DIGITAL WORLD ACQUISITION CO CL A 25400Q955 66,516 10,311 SH Put DFND 1 0 10,311 0
EKSO BIONICS HOLDINGS INC COM 282644301 1,153 398,800 SH   DFND 1 0 398,800 0
EQONEX LTD SHS Y2074E959 28 125 SH Put DFND 1 0 125 0
EQONEX LTD SHS Y2074E109 76 33,887 SH   DFND 1 0 33,887 0
ESPERION THERAPEUTICS INC COM 29664W905 46 100 SH Call DFND 1 0 100 0
ESPORTS ENTERTAINMENT GROUP COM 29667K956 7 100 SH Put DFND 1 0 100 0
ESPORTS ENTERTAINMENT GROUP *W 29667K132 270 1,000,000 SH   DFND 1 0 1,000,000 0
EVOFEM BIOSCIENCES INC COM 30048L954 16 476 SH Put DFND 1 0 476 0
EXELA TECHNOLOGIES INC COM 30162V959 38 903 SH Put DFND 1 0 903 0
EXELA TECHNOLOGIES INC COM 30162V409 29 70,579 SH   DFND 1 0 70,579 0
FLUX POWER HOLDINGS INC COM 344057302 208 77,833 SH   DFND 1 0 77,833 0
GLOBUS MARITIME LIMITED COM Y27265956 189 819 SH Put DFND 1 0 819 0
GLOBUS MARITIME LIMITED COM Y27265126 1,650 714,163 SH   DFND 1 0 714,163 0
GROM SOCIAL ENTERPRISES INC *W 39878L118 3 12,737 SH   DFND 1 0 12,737 0
GUARDFORCE AI CO LTD *W G4236L120 443 1,163,566 SH   DFND 1 0 1,163,566 0
HARBOR CUSTOM DEV INC PFD SR A 41150T207 5 319 PRN   DFND 1 0 319 0
HARBOR CUSTOM DEV INC *W 41150T124 730 1,973,494 SH   DFND 1 0 1,973,494 0
HEARTBEAM INC COM 42238H108 762 413,089 SH   DFND 1 0 413,089 0
HEARTBEAM INC *W 42238H116 133 360,458 SH   DFND 1 0 360,458 0
HUMANCO ACQUISITION CORP *W 44487N117 64 200,314 SH   DFND 1 0 200,314 0
HUMANCO ACQUISITION CORP CL A 44487N109 2,403 244,684 SH   DFND 1 0 244,684 0
IMPERIAL PETE INC COM Y3894J954 604 4,168 SH Put DFND 1 0 4,168 0
IMPERIAL PETE INC COM Y3894J104 125 86,466 SH   DFND 1 0 86,466 0
INHIBIKASE THERAPEUTICS INC COM 45719W106 147 99,000 SH   DFND 1 0 99,000 0
ION GEOPHYSICAL COM 462044957 267 3,059 SH Put DFND 1 0 3,059 0
ION GEOPHYSICAL CORP NOTE 462044AJ7 172,009 3,150,000 PRN   DFND 1 0 3,150,000 0
ISHARES RUSSELL 2000 ETF 464287905 63,141 3,076 SH Call DFND 1 0 3,076 0
ISHARES RUSSELL 2000 ETF 464287955 56,244 2,740 SH Put DFND 1 0 2,740 0
KANDI TECHNOLGIES INC COM 483709951 1,128 3,524 SH Put DFND 1 0 3,524 0
KANDI TECHNOLGIES INC COM 483709101 858 268,052 SH   DFND 1 0 268,052 0
KEMPHARM INC COM 488445956 1,836 3,651 SH Put DFND 1 0 3,651 0
KEMPHARM INC COM 488445206 1,302 258,780 SH   DFND 1 0 258,780 0
KIROMIC BIOPHARMA INC COM 497634105 91 106,758 SH   DFND 1 0 106,758 0
LEXARIA BIOSCIENCE CORP *W 52886N117 383 425,883 SH   DFND 1 0 425,883 0
MMTEC INC COM G6181K106 114 184,633 SH   DFND 1 0 184,633 0
MODULAR MEDICAL INC COM 60785L207 133 30,285 SH   DFND 1 0 30,285 0
MOGO INC COM 60800C959 145 497 SH Put DFND 1 0 497 0
MOGO INC COM 60800C109 197 67,651 SH   DFND 1 0 67,651 0
NANOVIBRONIX INC COM 63008J108 12 10,000 SH   DFND 1 0 10,000 0
NEUROBO PHARMACEUTICALS INC COM 64132R107 337 373,111 SH   DFND 1 0 373,111 0
NEWAGE INC COM 650194103 2,299 3,956,726 SH   DFND 1 0 3,956,726 0
NISUN INTL ENT DVPMT GP CO LTD COM G6593L106 2,814 2,876,526 SH   DFND 1 0 2,876,526 0
NOVAN INC COM 66988N205 114 28,838 SH   DFND 1 0 28,838 0
NRX PHARMACEUTICALS INC COM 629444950 444 1,813 SH Put DFND 1 0 1,813 0
NRX PHARMACEUTICALS INC COM 629444100 1,917 782,473 SH   DFND 1 0 782,473 0
NUZEE INC COM 67073S958 42 193 SH Put DFND 1 0 193 0
OCEAN POWER TECHNOLOGIES INC COM 674870956 195 1,382 SH Put DFND 1 0 1,382 0
OLB GROUP INC COM 67086U307 498 284,600 SH   DFND 1 0 284,600 0
ONION GLOBAL LIMITED ADS 68277G107 2,140 1,320,750 SH   DFND 1 0 1,320,750 0
PERSHING SQUARE TONTINE HLDG COM 71531R909 3,992 2,007 SH Call DFND 1 0 2,007 0
PHARMACYTE BIOTECH INC COM 71715X953 158 687 SH Put DFND 1 0 687 0
PHARMACYTE BIOTECH INC COM 71715X203 2,934 1,275,468 SH   DFND 1 0 1,275,468 0
PROGENITY INC COM 74319F907 235 2,027 SH Call DFND 1 0 2,027 0
PROGENITY INC COM 74319F957 599 5,161 SH Put DFND 1 0 5,161 0
PROGENITY INC COM 74319F107 579 499,357 SH   DFND 1 0 499,357 0
PROSHARES TR ETF 74347G950 2,753 964 SH Put DFND 1 0 964 0
PULMATRIX INC COM 74584P301 1,625 237,958 SH   DFND 1 0 237,958 0
PURPLE BIOTECH LTD ADS 74638P959 138 352 SH Put DFND 1 0 352 0
PURPLE BIOTECH LTD ADS 74638P109 105 26,672 SH   DFND 1 0 26,672 0
RECON TECHNOLOGY LTD CL A G7415M124 1,816 1,681,766 SH   DFND 1 0 1,681,766 0
REWALK ROBOTICS LIMITED SHS M8216Q950 493 4,254 SH Put DFND 1 0 4,254 0
REWALK ROBOTICS LIMITED SHS M8216Q200 1,474 1,271,062 SH   DFND 1 0 1,271,062 0
SIYATA MOBILE INC COM 83013Q509 13 10,184 SH   DFND 1 0 10,184 0
SMART FOR LIFE INC COM 83204U103 369 329,537 SH   DFND 1 0 329,537 0
SPDR S&P 500 ETF TR ETF 78462F903 99,993 2,214 SH Call DFND 1 0 2,214 0
SPDR S&P 500 ETF TR ETF 78464F950 50,934 1,642 SH Put DFND 1 0 1,642 0
SPHERE 3D CORP COM 84841L908 37 178 SH Call DFND 1 0 178 0
SPHERE 3D CORP COM 84841L958 1,340 6,379 SH Put DFND 1 0 6,379 0
SPHERE 3D CORP COM 84841L308 909 432,840 SH   DFND 1 0 432,840 0
SPI ENERGY CO LTD SHS G8651P950 796 2,774 SH Put DFND 1 0 2,774 0
SPI ENERGY CO LTD SHS G8651P110 550 191,624 SH   DFND 1 0 191,624 0
SPLASH BEVERAGE GROUP INC COM 84862C953 733 2,581 SH Put DFND 1 0 2,581 0
SPLASH BEVERAGE GROUP INC COM 84862C203 348 122,698 SH   DFND 1 0 122,698 0
SPLASH BEVERAGE GROUP INC *W 84862C112 317 317,185 SH   DFND 1 0 317,185 0
STATERA BIOPHARMA INC COM 857561104 22 69,103 SH   DFND 1 0 69,103 0
SURGALIGN HOLDINGS INC COM 86882C955 4 120 SH Put DFND 1 0 120 0
TANTECH HOLDINGS LTD SHS G8675X123 734 1,541,060 SH   DFND 1 0 1,541,060 0
THE9 LIMITED ADS 88337K952 194 652 SH Put DFND 1 0 652 0
THE9 LIMITED ADS 88337K302 237 79,653 SH   DFND 1 0 79,653 0
TRICIDA INC COM 89610F901 226 4,738 SH Call DFND 1 0 4,738 0
TRICIDA INC COM 89610F951 59 1,229 SH Put DFND 1 0 1,229 0
TWIN VEE POWERCATS CO COM 90177C101 378 90,656 SH   DFND 1 0 90,656 0
US WELL SERVICES INC CL A 91274U200 1,072 974,275 SH   DFND 1 0 974,275 0
VINCERX PHARMA INC COM 92731L106 1,138 284,572 SH   DFND 1 0 284,572 0
VINCERX PHARMACEUTICALS INC COM 92731L106 171 42,664 SH   DFND 1 0 42,664 0
VIRPAX PHARMACEUTICALS INC COM 928251107 18,339 1,005,156 SH   DFND 1 0 1,005,156 0
VISTAGEN THERAPEUTICS INC COM 92840H952 389 3,135 SH Put DFND 1 0 3,135 0
WIMI HOLOGRAM CLOUD INC ADS 97264L950 89 334 SH Put DFND 1 0 334 0
WIMI HOLOGRAM CLOUD INC ADS 97264L100 89 33,400 SH   DFND 1 0 33,400 0
XPRESSPA GROUP INC COM 98420U953 557 4,928 SH Put DFND 1 0 4,928 0