The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1847 GOEDEKER INC COM 28252C109 738 307,518 SH   DFND 1 0 307,518 0
1847 GOEDEKER INC COM 28252C959 1,052 4,383 SH Put DFND 1 0 4,383 0
9 METERS BIOPHARMA INC COM 654405909 192 1,960 SH Call DFND 1 0 1,960 0
9 METERS BIOPHARMA INC COM 654405959 313 3,194 SH Put DFND 1 0 3,194 0
ACTINIUM PHARMACEUTICALS INC COM 00507W206 441 73,366 SH   DFND 1 0 73,366 0
ACTINIUM PHARMACEUTICALS INC COM 00507W906 840 1,398 SH Call DFND 1 0 1,398 0
ACTINIUM PHARMACEUTICALS INC COM 00507W956 2,405 4,001 SH Put DFND 1 0 4,001 0
ACUTUS MEDICAL INC COM 005111109 2,543 745,600 SH   DFND 1 0 745,600 0
ADAMIS PHARMACEUTICALS CORP COM 00547W908 19 320 SH Call DFND 1 0 320 0
ADITXT INC COM 007025109 658 1,227,320 SH   DFND 1 0 1,227,320 0
ADITXT INC COM 007025959 183 3,410 SH Put DFND 1 0 3,410 0
AGM GROUP HOLDINGS INC COM G0132V105 3,584 1,493,437 SH   DFND 1 0 1,493,437 0
ALPINE 4 HOLDINGS INC CL A 02083E105 39 20,209 SH   DFND 1 0 20,209 0
ALPINE 4 HOLDINGS INC CL A 02083E955 28 146 SH Put DFND 1 0 146 0
ALSET EHOME INTERNATIONAL INC COM 02116A104 1,836 3,290,318 SH   DFND 1 0 3,290,318 0
AMARIN CORPORATION PLC ADR 023111206 1,173 348,067 SH   DFND 1 0 348,067 0
AMARIN CORPORATION PLC ADR 023111956 1,537 4,562 SH Put DFND 1 0 4,562 0
AMARIN CORPORATION PLC ADR 023111906 2,982 8,848 SH Call DFND 1 0 8,848 0
AMPLITECH GROUP INC COM 03211Q200 511 129,600 SH   DFND 1 0 129,600 0
AMPLITECH GROUP INC *W 03211Q119 566 441,863 SH   DFND 1 0 441,863 0
APPLIED GENETIC TECHNOLOGIES COM 03820J950 23 120 SH Put DFND 1 0 120 0
ARCADIA BIOSCIENCES INC COM 039014954 56 539 SH Put DFND 1 0 539 0
ARCADIA BIOSCIENCES INC COM 039014204 263 252,953 SH   DFND 1 0 252,953 0
ASLAN PHARMACEUTICALS LIMITED ADR 04522R101 1,008 899,850 SH   DFND 1 0 899,850 0
ATHERSYS INC COM 04744L106 105 116,444 SH   DFND 1 0 116,444 0
ATHERSYS INC COM 04744L906 364 4,036 SH Call DFND 1 0 4,036 0
ATHERSYS INC COM 04744L956 28 307 SH Put DFND 1 0 307 0
ATOSSA THERAPEUTICS INC COM 04962H906 360 2,248 SH Call DFND 1 0 2,248 0
ATOSSA THERAPEUTICS INC COM 04962H956 1,979 12,370 SH Put DFND 1 0 12,370 0
AURINIA PHARMACEUTICALS INC COM 05156V902 1,073 469 SH Call DFND 1 0 469 0
AUTOLUS THERAPEUTICS PLC ADS 05280R100 712 137,239 SH   DFND 1 0 137,239 0
BARCLAYS BANK PLC IPTH 06747R477 4,633 250,000 SH   DFND 1 0 250,000 0
BARCLAYS BANK PLC IPTH 06747R907 12,938 6,982 SH Call DFND 1 0 6,982 0
BIOCEPT INC COM 09072V501 68 18,664 SH   DFND 1 0 18,664 0
BIO-KEY INTL INC COM 09060C408 78 35,474 SH   DFND 1 0 35,474 0
BIO-KEY INTL INC COM 09060C958 324 1,468 SH Put DFND 1 0 1,468 0
BIOPHYTIS ADR 09076G104 569 106,577 SH   DFND 1 0 106,577 0
BIORESTORATIVE THERAPIES INC COM 090655606 43 10,000 SH   DFND 1 0 10,000 0
BIOVIE INC COM 09074F207 2,917 648,245 SH   DFND 1 0 648,245 0
BIT DIGITAL INC SHS G1144A105 25,632 4,215,852 SH   DFND 1 0 4,215,852 0
BIT DIGITAL INC SHS G1144A955 6,678 10,983 SH Put DFND 1 0 10,983 0
BIT MINING LTD ADR 055474900 12,280 2,000,000 SH   DFND 1 0 2,000,000 0
BIT MINING LTD ADR 055474950 615 1,002 SH Put DFND 1 0 1,002 0
BONE BIOLOGICS CORP *W 098070113 116 165,476 SH   DFND 1 0 165,476 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 2,053 513,211 SH   DFND 1 0 513,211 0
BRAINSTORM CELL THERAPEUTICS COM 10501E951 2,071 5,177 SH Put DFND 1 0 5,177 0
BRIACELL THERAPEUTICS CORP COM 10778Y952 3,561 4,301 SH Put DFND 1 0 4,301 0
CALADRIUS BIOSCIENCES INC COM 128058203 1,352 1,606,918 SH   DFND 1 0 1,606,918 0
CALADRIUS BIOSCIENCES INC COM 128058953 225 2,669 SH Put DFND 1 0 2,669 0
CANAAN INC COM 134748102 2,766 537,000 SH   DFND 1 0 537,000 0
CANAAN INC COM 134748952 5,491 10,662 SH Put DFND 1 0 10,662 0
CARDIFF ONCOLOGY INC COM 14147L958 102 170 SH Put DFND 1 0 170 0
CARDIOL THERAPEUTICS INC COM 14161Y200 184 99,440 SH   DFND 1 0 99,440 0
CASTOR MARITIME INC COM Y1146L955 193 1,358 SH Put DFND 1 0 1,358 0
CASTOR MARITIME INC COM Y1146L125 444 312,641 SH   DFND 1 0 312,641 0
CATALYST BIOSCIENCES INC COM 14888D208 1,040 1,138,334 SH   DFND 1 0 1,138,334 0
CBAK ENERGY TECHNOLOGY INC COM 14986C102 262 167,774 SH   DFND 1 0 167,774 0
CBAK ENERGY TECHNOLOGY INC COM 14986C952 374 2,398 SH Put DFND 1 0 2,398 0
CINGULATE INC *W 17248W113 355 500,000 SH   DFND 1 0 500,000 0
CINGULATE INC COM 17248W105 2,446 886,254 SH   DFND 1 0 886,254 0
CITIUS PHARMACEUTICALS INC COM 17322U207 48 30,863 SH   DFND 1 0 30,863 0
CITIUS PHARMACEUTICALS INC COM 17322U957 129 838 SH Put DFND 1 0 838 0
COCRYSTAL PHARMA INC COM 19188J300 3,730 5,738,120 SH   DFND 1 0 5,738,120 0
CONTEXT THERAPEUTICS INC COM 21077P108 3,274 1,230,830 SH   DFND 1 0 1,230,830 0
CONTRAFECT CORPORATION COM 212326300 504 191,675 SH   DFND 1 0 191,675 0
CURIS INC COM 231269200 1,078 226,525 SH   DFND 1 0 226,525 0
CURIS INC COM 231269900 1,329 2,793 SH Call DFND 1 0 2,793 0
CYREN LTD COM M26895108 464 1,587,199 SH   DFND 1 0 1,587,199 0
DAXOR CORP COM 239467103 237 20,996 SH   DFND 1 0 20,996 0
DIGITAL ALLY INC COM 25382P908 38 354 SH Call DFND 1 0 354 0
DIGITAL ALLY INC COM 25382P958 298 2,787 SH Put DFND 1 0 2,787 0
DIGITAL ALLY INC COM 25382P208 645 602,877 SH   DFND 1 0 602,877 0
DIGITAL WORLD ACQUISITION CO COM 25400Q955 5,030 978 SH Put DFND 1 0 978 0
ECOARK HOLDINGS INC COM 27888N307 7,159 32,103 SH   DFND 1 0 32,103 0
EKSO BIONICS HOLDINGS INC COM 282644301 1,322 498,730 SH   DFND 1 0 498,730 0
EQONEX LTD COM Y2074E109 39 20,799 SH   DFND 1 0 20,799 0
ESPERION THERAPEUTICS COM 29664W105 4,702 940,400 SH   DFND 1 0 940,400 0
EVOFEM BIOSCIENCES INC COM 30048L954 52 1,380 SH Put DFND 1 0 1,380 0
EVOKE PHARMA INC COM 30049G104 48 87,925 SH   DFND 1 0 87,925 0
EXELA TECHNOLOGIES INC COM 30162V409 182 207,093 SH   DFND 1 0 207,093 0
EXELA TECHNOLOGIES INC COM 30162V959 378 4,311 SH Put DFND 1 0 4,311 0
FLORA GROWTH CORP COM 339764102 2,638 1,482,242 SH   DFND 1 0 1,482,242 0
FLUX POWER HOLDINGS COM 344057302 976 227,599 SH   DFND 1 0 227,599 0
FUELCELL ENERGY INC COM 35952H901 104 200 SH Call DFND 1 0 200 0
GILEAD SCIENCES COM 375558903 39,856 5,489 SH Call DFND 1 0 5,489 0
GLOBUS MARITIME LIMITED COM Y27265956 128 608 SH Put DFND 1 0 608 0
GLOBUS MARITIME LIMITED COM Y27265126 1,504 716,376 SH   DFND 1 0 716,376 0
GREAT PANTHER MINING LTD COM 39115V101 2,522 11,504,492 SH   DFND 1 0 11,504,492 0
GROM SOCIAL *W 39878L118 7 12,737 SH   DFND 1 0 12,737 0
GUARDFORCE AI CO LTD COM G4236L112 136 125,875 SH   DFND 1 0 125,875 0
GUARDFORCE AI CO LTD *W G4236L120 541 1,060,209 SH   DFND 1 0 1,060,209 0
HARBOR CUSTOM DEV INC PFD SR 41150T207 168 10,700 PRN   DFND 1 0 10,700 0
HARBOR CUSTOM DEV INC *W 41150T124 1,471 1,910,774 SH   DFND 1 0 1,910,774 0
HEARTBEAM INC *W 42238H116 270 360,391 SH   DFND 1 0 360,391 0
HEARTBEAM INC COM 42238H108 1,489 483,320 SH   DFND 1 0 483,320 0
HEPION PHARMACEUTICALS COM 426897104 23 20,479 SH   DFND 1 0 20,479 0
HEPION PHARMACEUTICALS COM 426897954 24 212 SH Put DFND 1 0 212 0
HUMANCO ACQUISITION CORP *W 44487N117 176 200,314 SH   DFND 1 0 200,314 0
HUMANCO ACQUISITION CORP CL A 44487N109 3,953 404,185 SH   DFND 1 0 404,185 0
INFINITY PHARMACEUTICALS INC COM 45665G903 972 4,321 SH Call DFND 1 0 4,321 0
INHIBIKASE THERAPEUTICS INC COM 45719W106 625 425,014 SH   DFND 1 0 425,014 0
ION GEOPHYSICAL CORP COM 462044957 310 3,520 SH Put DFND 1 0 3,520 0
ION GEOPHYSICAL CORP NOTE 462044AJ7 221,404 3,150,000 PRN   DFND 1 0 3,150,000 0
ISHARES RUSSELL 2000 ETF 464287905 11,745 528 SH Call DFND 1 0 528 0
ISHARES RUSSELL 2000 ETF 464287955 45,313 2,037 SH Put DFND 1 0 2,037 0
IT TECH PACKAGING INC COM 46527C100 3 11,570 SH   DFND 1 0 11,570 0
IT TECH PACKAGING INC COM 46527C950 6 254 SH Put DFND 1 0 254 0
JUPITER WELLNESS INC COM 48208F105 85 95,241 SH   DFND 1 0 95,241 0
KANDI TECHNOLGIES INC COM 483709101 1,296 403,724 SH   DFND 1 0 403,724 0
KANDI TECHNOLGIES INC COM 483709951 1,933 6,021 SH Put DFND 1 0 6,021 0
KEMPHARM INC COM 488445206 174 20,000 SH   DFND 1 0 20,000 0
KEMPHARM INC COM 488445956 2,536 2,866 SH Put DFND 1 0 2,866 0
KIROMIC BIOPHARMA INC COM 497634105 956 625,000 SH   DFND 1 0 625,000 0
LEXARIA BIOSCIENCE *W 52886N117 613 408,814 SH   DFND 1 0 408,814 0
MARATHON DIGITAL HOLDINGS INC COM 565788106 1,907 58,049 SH   DFND 1 0 58,049 0
MARATHON DIGITAL HOLDINGS INC COM 565788956 6,562 1,997 SH Put DFND 1 0 1,997 0
MIRATI THERAPEUTICS INC COM 60468T905 2,831 193 SH Call DFND 1 0 193 0
MMEX RESOURCES CORP COM 55314K506 129 547,448 SH   DFND 1 0 547,448 0
MMTEC INC COM G6181K106 499 755,413 SH   DFND 1 0 755,413 0
MOGO INC COM 60800C959 167 489 SH Put DFND 1 0 489 0
NABRIVA THERAPEUTICS PLC COM G63637953 40 670 SH Put DFND 1 0 670 0
NABRIVA THERAPEUTICS PLC COM G63637113 40 67,051 SH   DFND 1 0 67,051 0
NANOVIBRONIX INC COM 63008J108 10 10,000 SH   DFND 1 0 10,000 0
NEMAURA MEDICAL INC COM 640442958 125 275 SH Put DFND 1 0 275 0
NEUROBO PHARMACEUTICALS INC COM 64132R107 862 706,946 SH   DFND 1 0 706,946 0
NEWAGE INC COM 650194903 1,147 11,132 SH Call DFND 1 0 11,132 0
NEWAGE INC COM 650194103 2,467 2,395,153 SH   DFND 1 0 2,395,153 0
NISUN INTL ENT DVPMT GP CO LTD CL A G6593L106 5,049 1,572,805 SH   DFND 1 0 1,572,805 0
NISUN INTL ENTERPRISES COM G6593L106 5,309 1,654,006 SH   DFND 1 0 1,654,006 0
NOVAN INC COM 66988N205 80 19,132 SH   DFND 1 0 19,132 0
NRX PHARMACEUTICALS INC COM 629444950 1,150 2,406 SH Put DFND 1 0 2,406 0
NUZEE INC COM 67073S958 80 193 SH Put DFND 1 0 193 0
OCEAN PWR TECHNOLOGIES INC COM 674870956 414 2,795 SH Put DFND 1 0 2,795 0
OLB GROUP INC COM 67086U307 1,115 420,723 SH   DFND 1 0 420,723 0
ONION GLOBAL LTD ADS 68277G107 3,328 1,320,750 SH   DFND 1 0 1,320,750 0
ORBITAL ENERGY GROUP INC COM 68559A109 405 185,025 SH   DFND 1 0 185,025 0
UCOMMUNE INTERNATIONAL LTD COM G9449A100 69 100,000 SH   DFND 1 0 100,000 0
PALISADE BIO INC COM 696389105 68 52,500 SH   DFND 1 0 52,500 0
PDS BIOTECHNOLOGY CORP COM 70465T957 305 376 SH Put DFND 1 0 376 0
PDS BIOTECHNOLOGY CORP COM 70465T907 756 933 SH Call DFND 1 0 933 0
PHARMACYTE BIOTECH INC COM 71715X903 108 431 SH Call DFND 1 0 431 0
PHARMACYTE BIOTECH INC COM 71715X953 166 665 SH Put DFND 1 0 665 0
PHARMACYTE BIOTECH INC COM 71715X203 3,045 1,217,828 SH   DFND 1 0 1,217,828 0
POWER & DIGITAL COM 739190906 1,220 1,114 SH Call DFND 1 0 1,114 0
PROGENITY INC COM 74319F907 576 2,757 SH Call DFND 1 0 2,757 0
PROGENITY INC COM 74319F957 1,613 7,718 SH Put DFND 1 0 7,718 0
PROGENITY INC COM 74319F107 2,265 1,083,746 SH   DFND 1 0 1,083,746 0
PROSHARES TR COM 74347G440 1,907 66,000 SH   DFND 1 0 66,000 0
PROSHARES TR COM 74347G950 9,063 3,136 SH Put DFND 1 0 3,136 0
PULMATRIX INC COM 74584P202 1,583 3,617,043 SH   DFND 1 0 3,617,043 0
PURPLE BIOTECH LTD ADS 74638P959 366 940 SH Put DFND 1 0 940 0
RECON TECHNOLOGY LTD CL A G7415M124 3,529 2,693,705 SH   DFND 1 0 2,693,705 0
RED CAT HOLDINGS INC COM 75644T900 65 312 SH Call DFND 1 0 312 0
RED CAT HOLDINGS INC COM 75644T100 2,809 1,350,589 SH   DFND 1 0 1,350,589 0
REWALK ROBOTICS LIMITED SHS M8216Q950 482 3,915 SH Put DFND 1 0 3,915 0
REWALK ROBOTICS LIMITED SHS M8216Q200 1,270 1,032,207 SH   DFND 1 0 1,032,207 0
RIOT BLOCKCHAIN INC COM 767292105 4,445 199,064 SH   DFND 1 0 199,064 0
RIOT BLOCKCHAIN INC COM 767292955 4,875 2,183 SH Put DFND 1 0 2,183 0
ROCKETFUEL BLOCKCHAIN INC COM 77313J108 180 750,353 SH   DFND 1 0 750,353 0
RTI SURGICAL INC COM 86882C105 215 299,412 SH   DFND 1 0 299,412 0
SECOND SIGHT MEDICAL PRODUCTS COM 81362J959 348 2,132 SH Put DFND 1 0 2,132 0
SECOND SIGHT MEDICAL PRODUCTS COM 81362J209 802 491,973 SH   DFND 1 0 491,973 0
SORRENTO THERAPEUTICS INC COM 83587F202 10,182 2,189,700 SH   DFND 1 0 2,189,700 0
SORRENTO THERAPEUTICS INC COM 83587F952 13,193 21,897 SH Put DFND 1 0 21,897 0
SPDR S&P 500 ETF TR ETF 78462F903 58,278 1,227 SH Call DFND 1 0 1,227 0
SPDR SERIES TRUST ETF 78464A950 7,031 628 SH Put DFND 1 0 628 0
SPHERE 3D CORP COM 84841L908 56 179 SH Call DFND 1 0 179 0
SPHERE 3D CORP COM 84841L308 655 209,820 SH   DFND 1 0 209,820 0
SPHERE 3D CORP COM 84841L958 2,717 8,709 SH Put DFND 1 0 8,709 0
SPI ENERGY CO LTD SHS G8651P950 1,079 2,988 SH Put DFND 1 0 2,988 0
SPLASH BEVERAGE GROUP INC *W 84862C112 156 503,266 SH   DFND 1 0 503,266 0
STATERA BIOPHARMA INC COM 857561104 885 384,597 SH   DFND 1 0 384,597 0
STRAN & COMPANY INC COM 86260J102 4,538 750,000 SH   DFND 1 0 750,000 0
SURGALIGN HOLDINGS INC COM 86882C105 121 169,587 SH   DFND 1 0 169,587 0
SURGALIGN HOLDINGS INC COM 86882C955 127 1,773 SH Put DFND 1 0 1,773 0
TAKUNG ART LTD COM 87407Q207 2,336 576,729 SH   DFND 1 0 576,729 0
TANTECH HOLDINGS LTD COM G8675X107 2,845 6,187,797 SH   DFND 1 0 6,187,797 0
THE9 LIMITED ADS 88337K302 840 125,327 SH   DFND 1 0 125,327 0
THE9 LIMITED ADS 88337K902 82 123 SH Call DFND 1 0 123 0
THE9 LIMITED ADS 88337K952 860 1,284 SH Put DFND 1 0 1,284 0
TRICIDA INC COM 89610F951 1,067 1,116 SH Put DFND 1 0 1,116 0
TRICIDA INC COM 89610F901 3,153 3,298 SH Call DFND 1 0 3,298 0
TWIN VEE POWERCATS CO COM 90177C101 364 90,656 SH   DFND 1 0 90,656 0
VINCERX PHARMA INC COM 92731L106 2,638 258,889 SH   DFND 1 0 258,889 0
VIRPAX PHARMACEUTICALS COM 928251107 3,008 876,834 SH   DFND 1 0 876,834 0
VISTAGEN THERAP INC COM 92840H952 651 3,337 SH Put DFND 1 0 3,337 0
WIMI HOLOGRAM CLOUD INC ADS 97264L100 43 14,204 SH   DFND 1 0 14,204 0
WIMI HOLOGRAM CLOUD INC ADS 97264L950 603 1,982 SH Put DFND 1 0 1,982 0
XPRESSPA GROUP INC COM 98420U953 2,423 11,997 SH Put DFND 1 0 11,997 0