The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1847 GOEDEKER INC COM 28252C109 948 301,751 SH   DFND 1 0 301,751 0
1847 GOEDEKER INC COM 28252C959 2,140 6,816 SH Put DFND 1 0 6,816 0
9 METERS BIOPHARMA INC COM 654405909 475 3,655 SH Call DFND 1 0 3,655 0
9 METERS BIOPHARMA INC COM 654405959 3,168 24,371 SH Put DFND 1 0 24,371 0
ABVC BIOPHARMA INC COM 00091F106 165 71,558 SH   DFND 1 0 71,558 0
ACTINIUM PHARMACEUTICALS INC COM 00507W906 182 205 SH Call DFND 1 0 205 0
ACTINIUM PHARMACEUTICALS INC COM 00507W206 235 26,488 SH   DFND 1 0 26,488 0
ACTINIUM PHARMACEUTICALS INC COM 00507W956 3,329 3,757 SH Put DFND 1 0 3,757 0
ACUTUS MED INC COM 005111109 1,059 119,755 SH   DFND 1 0 119,755 0
ADAMIS PHARMACEUTICALS CORP COM 00547W908 210 2,161 SH Call DFND 1 0 2,161 0
ADAMIS PHARMACEUTICALS CORP COM 00547W958 293 3,024 SH Put DFND 1 0 3,024 0
ADITXT INC COM 007025109 208 122,863 SH   DFND 1 0 122,863 0
ADITXT INC COM 007025959 361 2,135 SH Put DFND 1 0 2,135 0
ADOMANI INC COM 00726A100 232 850,000 SH   DFND 1 0 850,000 0
AMARIN CORP PLC ADR 023111206 759 148,771 SH   DFND 1 0 148,771 0
AMARIN CORP PLC ADR 023111906 4,201 8,238 SH Call DFND 1 0 8,238 0
AMARIN CORP PLC ADR 023111956 2,102 4,122 SH Put DFND 1 0 4,122 0
AMPLITECH GROUP INC COM 03211Q200 1,093 305,255 SH   DFND 1 0 305,255 0
AMPLITECH GROUP INC *W 03211Q119 453 348,673 SH   DFND 1 0 348,673 0
ARCADIA BIOSCIENCES INC COM 039014954 684 3,304 SH Put DFND 1 0 3,304 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 1,225 688,400 SH   DFND 1 0 688,400 0
ASLAN PHARMACEUTICALS LTD ADS 04522R951 54 304 SH Put DFND 1 0 304 0
ATERIAN INC COM 02156U951 1,404 1,296 SH Put DFND 1 0 1,296 0
ATHERSYS INC NEW COM 04744L956 41 307 SH Put DFND 1 0 307 0
ATHERSYS INC NEW COM 04744L106 155 116,444 SH   DFND 1 0 116,444 0
ATHERSYS INC NEW COM 04744L906 881 6,621 SH Call DFND 1 0 6,621 0
ATOSSA THERAPEUTICS INC COM 04962H906 713 2,187 SH Call DFND 1 0 2,187 0
ATOSSA THERAPEUTICS INC COM 04962H956 5,126 15,725 SH Put DFND 1 0 15,725 0
AURINIA PHARMACEUTICALS INC COM 05156V902 1,038 469 SH Call DFND 1 0 469 0
AUTOLUS THERAPEUTICS LTD ADS 05280R900 268 409 SH Call DFND 1 0 409 0
AUTOLUS THERAPEUTICS LTD ADS 05280R100 1,965 300,000 SH   DFND 1 0 300,000 0
BARCLAYS BANK PLC IPTH 06747R477 11,132 400,000 SH   DFND 1 0 400,000 0
BARCLAYS BANK PLC IPTH 06747R907 14,850 5,336 SH Call DFND 1 0 5,336 0
BIO-KEY INTL INC COM 09060C408 70 20,001 SH   DFND 1 0 20,001 0
BIO-KEY INTL INC COM 09060C958 571 1,623 SH Put DFND 1 0 1,623 0
BIOPHYTIS SA ADS 09076G104 893 103,263 SH   DFND 1 0 103,263 0
BIOVIE INC CL A 09074F207 3,378 504,861 SH   DFND 1 0 504,861 0
BIT DIGITAL INC SHS G1144A955 4,039 5,586 SH Put DFND 1 0 5,586 0
BIT DIGITAL INC SHS G1144A105 30,484 4,216,310 SH   DFND 1 0 4,216,310 0
BIT MINING LTD ADR 055474950 2,336 2,859 SH Put DFND 1 0 2,859 0
BIT MINING LTD ADR 055474100 16,340 2,000,000 SH   DFND 1 0 2,000,000 0
BRAINSTORM CELL COM 10501E201 1,572 476,325 SH   DFND 1 0 476,325 0
BRAINSTORM CELL COM 10501E951 1,626 4,928 SH Put DFND 1 0 4,928 0
BUTTERFLY NETWORK INC COM 124155902 3,657 3,503 SH Call DFND 1 0 3,503 0
CALADRIUS BIOSCIENCES INC COM 128058953 776 6,362 SH Put DFND 1 0 6,362 0
CALADRIUS BIOSCIENCES INC COM 128058203 1,164 954,235 SH   DFND 1 0 954,235 0
CANAAN INC ADS 134748952 4,812 7,875 SH Put DFND 1 0 7,875 0
CANAAN INC ADS 134748102 1,515 247,929 SH   DFND 1 0 247,929 0
CARDIFF ONCOLOGY INC COM 14147L958 113 170 SH Put DFND 1 0 170 0
CASTOR MARITIME INC SHS Y1146L955 637 2,612 SH Put DFND 1 0 2,612 0
CASTOR MARITIME INC SHS Y1146L125 666 273,130 SH   DFND 1 0 273,130 0
CATALYST BIOSCIENCES INC COM 14888D908 350 852 SH Call DFND 1 0 852 0
CATALYST BIOSCIENCES INC COM 14888D208 435 105,742 SH   DFND 1 0 105,742 0
CBAK ENERGY TECH INC COM 14986C102 41 17,548 SH   DFND 1 0 17,548 0
CBAK ENERGY TECH INC COM 14986C952 920 3,521 SH Put DFND 1 0 3,521 0
CITIUS PHARMACEUTICALS INC COM 17322U957 100 491 SH Put DFND 1 0 491 0
COCRYSTAL PHARMA INC COM 19188J300 5,424 5,165,416 SH   DFND 1 0 5,165,416 0
COLOR STAR TECH CO LTD SHS G2287A100 3,386 6,177,524 SH   DFND 1 0 6,177,524 0
CONTRAFECT CORP COM 212326300 673 166,175 SH   DFND 1 0 166,175 0
CURIS INC COM 231269200 785 100,200 SH   DFND 1 0 100,200 0
CURIS INC COM 231269900 843 1,087 SH Call DFND 1 0 1,087 0
CYREN LTD SHS M26895108 1,240 2,000,000 SH   DFND 1 0 2,000,000 0
DAXOR CORP COM 239467103 677 57,924 SH   DFND 1 0 57,924 0
DIGINEX LIMITED SHS Y2074E959 41 125 SH Put DFND 1 0 125 0
DIGINEX LIMITED SHS Y2074E109 172 53,055 SH   DFND 1 0 53,055 0
DIGINEX LTD SHS Y2074E959 78 242 SH Put DFND 1 0 242 0
DIGINEX LTD SHS Y2074E109 193 59,478 SH   DFND 1 0 59,478 0
DIGITAL ALLY INC COM 25382P958 1,561 12,899 SH Put DFND 1 0 12,899 0
DIGITAL ALLY INC COM 25382P208 1,854 1,531,958 SH   DFND 1 0 1,531,958 0
ECOARK HOLDINGS INC COM 27888N307 77 14,603 SH   DFND 1 0 14,603 0
EKSO BIONICS HLDGS INC COM 282644301 1,941 420,179 SH   DFND 1 0 420,179 0
ENOCHIAN BIOSCIENCES INC COM 29350E104 534 79,314 SH   DFND 1 0 79,314 0
EVOFEM BIOSCIENCES INCV COM 30048L954 54 725 SH Put DFND 1 0 725 0
EVOKE PHARMA INC COM 30049G104 107 81,975 SH   DFND 1 0 81,975 0
EXELA TECHS INC COM 30162V959 983 5,067 SH Put DFND 1 0 5,067 0
FLUX POWER HOLDINGS COM 344057302 3,317 653,016 SH   DFND 1 0 653,016 0
FLUX PWR HLDGS INC COM 344057302 316 62,195 SH   DFND 1 0 62,195 0
FUELCELL ENERGY INC COM 35952H901 134 200 SH Call DFND 1 0 200 0
GLOBUS MARITIME LTD COM Y27265956 368 1,259 SH Put DFND 1 0 1,259 0
GLOBUS MARITIME LTD COM Y27265126 1,626 556,883 SH   DFND 1 0 556,883 0
GROM SOCIAL ENTERPRISES INC *W 39878L118 32 29,471 SH   DFND 1 0 29,471 0
GUARDFORCE AI CO LTD *W G4236L120 816 1,020,389 SH   DFND 1 0 1,020,389 0
GUARDFORCE AI CO LTD SHS G4236L112 2,881 727,647 SH   DFND 1 0 727,647 0
HARBOR CUSTOM DEVELOPMENT INC *W 41150T116 83 148,975 SH   DFND 1 0 148,975 0
HUMANCO ACQUISITION CORP *W 44487N117 198 200,314 SH   DFND 1 0 200,314 0
HUMANCO ACQUISITION CORP CL A 44487N109 3,997 404,185 SH   DFND 1 0 404,185 0
INFINITY PHARMACEUTICALS COM 45665G303 241 70,431 SH   DFND 1 0 70,431 0
INFINITY PHARMACEUTICALS COM 45665G903 1,318 3,853 SH Call DFND 1 0 3,853 0
INHIBIKASE THERAPEUTICS INC COM 45719W106 808 425,014 SH   DFND 1 0 425,014 0
INSPIRA TECHNOLOGIES OXY BHN *W M53637118 208 253,063 SH   DFND 1 0 253,063 0
INSPIRA TECHNOLOGIES OXY BHN SHS M53637100 275 102,553 SH   DFND 1 0 102,553 0
ION GEOPHYSICAL CORP COM 462044907 92 692 SH Call DFND 1 0 692 0
ION GEOPHYSICAL CORP NOTE 462044AJ7 272,551 3,150,000 PRN   DFND 1 0 3,150,000 0
IONIS PHARMACEUTICALS INC COM 462222950 2,837 846 SH Put DFND 1 0 846 0
IONIS PHARMACEUTICALS INC COM 462222100 2,837 84,600 SH   DFND 1 0 84,600 0
ISHARES RUSSELL 2000 ETF 464287905 32,813 1,500 SH Call DFND 1 0 1,500 0
ISHARES RUSSELL 2000 ETF 464287955 39,244 1,794 SH Put DFND 1 0 1,794 0
IT TECH PACKAGING COM 46527C950 17 254 SH Put DFND 1 0 254 0
JUPITER WELLNESS INC COM 48208F105 582 412,915 SH   DFND 1 0 412,915 0
KADMON HOLDINGS INC COM 48283N106 526 60,351 SH   DFND 1 0 60,351 0
KANDI TECHNOLOGIES GROUP INC COM 483709101 1,502 337,430 SH   DFND 1 0 337,430 0
KANDI TECHNOLOGIES GROUP INC COM 483709951 4,335 9,742 SH Put DFND 1 0 9,742 0
KEMPHARM INC COM 488445206 387 41,531 SH   DFND 1 0 41,531 0
KEMPHARM INC COM 488445956 2,717 2,912 SH Put DFND 1 0 2,912 0
KIROMIC BIOPHARMA INC COM 497634105 1,468 478,122 SH   DFND 1 0 478,122 0
LEXARIA BIOSCIENCE CORP. *W 52886N117 699 332,971 SH   DFND 1 0 332,971 0
MARATHON DIGITAL HOLDINGS INC COM 565788106 2,294 72,643 SH   DFND 1 0 72,643 0
MARATHON DIGITAL HOLDINGS INC COM 565788956 6,269 1,985 SH Put DFND 1 0 1,985 0
MEATECH 3D LTD ADS 583435102 443 72,700 SH   DFND 1 0 72,700 0
MIRATI THERAPEUTICS INC COM 60468T105 885 5,000 SH   DFND 1 0 5,000 0
MIRATI THERAPEUTICS INC COM 60468T905 3,414 193 SH Call DFND 1 0 193 0
MMTEC INC SHS G6181K106 1,303 1,104,286 SH   DFND 1 0 1,104,286 0
MOGO INC COM 60800C109 1,780 412,059 SH   DFND 1 0 412,059 0
MOGO INC COM 60800C959 2,379 5,506 SH Put DFND 1 0 5,506 0
NABRIVA THERAPEUTICS PLC COM G63637113 44 36,735 SH   DFND 1 0 36,735 0
NABRIVA THERAPEUTICS PLC COM G63637953 94 790 SH Put DFND 1 0 790 0
NANOVIBRONIX INC COM 63008J108 21 10,000 SH   DFND 1 0 10,000 0
NEMAURA MEDICAL INC COM 640442958 792 1,318 SH Put DFND 1 0 1,318 0
NEWAGE INC COM 650194103 3,180 2,288,078 SH   DFND 1 0 2,288,078 0
NEWAGE INC COM 650194903 1,489 10,710 SH Call DFND 1 0 10,710 0
NOVAN INC COM 66988N205 156 19,132 SH   DFND 1 0 19,132 0
NRX PHARMACEUTICALS INC COM 629444950 858 926 SH Put DFND 1 0 926 0
NUZEE INC COM 67073S208 1,098 499,047 SH   DFND 1 0 499,047 0
OCEAN POWER TECHS COM 674870956 703 3,029 SH Put DFND 1 0 3,029 0
OCULAR THERAPEUTIX INC COM 67576A100 1,420 142,000 SH   DFND 1 0 142,000 0
OCULAR THERAPEUTIX INC COM 67576A900 5,115 5,115 SH Call DFND 1 0 5,115 0
OCULAR THERAPEUTIX INC COM 67576A950 2,097 2,097 SH Put DFND 1 0 2,097 0
ORAMED PHARMACEUTICALS INC COM 68403P203 887 40,344 SH   DFND 1 0 40,344 0
ORAMED PHARMACEUTICALS INC COM 68403P953 2,136 972 SH Put DFND 1 0 972 0
ORBITAL ENERGY GROUP INC COM 68559A109 1,471 477,500 SH   DFND 1 0 477,500 0
PAINREFORM LTD SHS M77798102 326 117,528 SH   DFND 1 0 117,528 0
PALISADE BIO INC COM 696389105 139 52,500 SH   DFND 1 0 52,500 0
PDS BIOTECHNOLOGY CORP COM 70465T907 1,387 931 SH Call DFND 1 0 931 0
PDS BIOTECHNOLOGY CORP COM 70465T957 423 284 SH Put DFND 1 0 284 0
PHARMACYTE BIOTECH INC COM 71715X203 3,202 1,010,146 SH   DFND 1 0 1,010,146 0
PHARMACYTE BIOTECH INC COM 71715X953 140 441 SH Put DFND 1 0 441 0
PHIO PHARMACEUTICALS CORP COM 71880W303 83 40,684 SH   DFND 1 0 40,684 0
PHIO PHARMACEUTICALS CORP COM 71880W953 281 1,383 SH Put DFND 1 0 1,383 0
PLURISTEM THERAPEUTICS INC COM 72940R950 197 742 SH Put DFND 1 0 742 0
PROGENITY INC COM 74319F957 772 5,077 SH Put DFND 1 0 5,077 0
PURPLE BIOTECH LTD ADS 74638P959 57 125 SH Put DFND 1 0 125 0
RECON TECHNOLOGY LTD SHS G7415M124 3,623 1,280,097 SH   DFND 1 0 1,280,097 0
RECON TECHNOLOGY LTD SHS G7415M954 319 1,128 SH Put DFND 1 0 1,128 0
RED CAT HLDGS INC COM 75644T100 4,731 1,359,385 SH   DFND 1 0 1,359,385 0
REWALK ROBOTICS LTD SHS M8216Q200 2,465 1,632,770 SH   DFND 1 0 1,632,770 0
REWALK ROBOTICS LTD SHS M8216Q950 127 839 SH Put DFND 1 0 839 0
RIOT BLOCKCHAIN INC COM 767292105 2,083 81,052 SH   DFND 1 0 81,052 0
RIOT BLOCKCHAIN INC COM 767292955 2,619 1,019 SH Put DFND 1 0 1,019 0
SECOND SIGHT MEDICAL PRODS INC COM 81362J209 931 291,973 SH   DFND 1 0 291,973 0
SECOND SIGHT MEDICAL PRODS INC COM 81362J959 680 2,132 SH Put DFND 1 0 2,132 0
SORRENTO THERAPEUTICS COM 83587F202 12,957 1,698,107 SH   DFND 1 0 1,698,107 0
SORRENTO THERAPEUTICS COM 83587F952 16,669 21,846 SH Put DFND 1 0 21,846 0
SPDR S&P 500 ETF TR ETF 78462F903 32,186 750 SH Call DFND 1 0 750 0
SPDR S&P 500 ETF TR ETF 78462F953 19,054 444 SH Put DFND 1 0 444 0
SPDR SERIES TRUST ETF 78464A870 440 3,500 SH   DFND 1 0 3,500 0
SPDR SERIES TRUST ETF 78464A950 21,534 1,713 SH Put DFND 1 0 1,713 0
SPHERE 3D CORP COM 84841L958 3,018 5,081 SH Put DFND 1 0 5,081 0
SPI ENERGY CO LTD SHS G8651P950 1,571 3,130 SH Put DFND 1 0 3,130 0
SPLASH BEVERAGE GROUP INC *W 84862C112 321 605,659 SH   DFND 1 0 605,659 0
STATERA BIOPHARMA INC COM 857561104 847 366,460 SH   DFND 1 0 366,460 0
SURGALIGN HOLDINGS INC COM 86882C105 35 31,927 SH   DFND 1 0 31,927 0
SURGALIGN HOLDINGS INC COM 86882C955 193 1,773 SH Put DFND 1 0 1,773 0
TAKUNG ART LTD COM 87407Q207 4,620 608,740 SH   DFND 1 0 608,740 0
TANZANIAN GOLD CORP COM 87601A107 6 12,213 SH   DFND 1 0 12,213 0
TANZANIAN GOLD CORP COM 87601A957 20 404 SH Put DFND 1 0 404 0
THE9 LTD ADS 88337K302 543 52,691 SH   DFND 1 0 52,691 0
THE9 LTD ADS 88337K902 297 288 SH Call DFND 1 0 288 0
THE9 LTD ADS 88337K952 2,330 2,260 SH Put DFND 1 0 2,260 0
TITAN PHARMACEUTICALS INC COM 888314956 34 184 SH Put DFND 1 0 184 0
TRICIDA INC COM 89610F101 2,204 475,000 SH   DFND 1 0 475,000 0
TRICIDA INC COM 89610F901 68 146 SH Call DFND 1 0 146 0
TRILLIUM THERAPEUTICS INC COM 89620X506 1,229 70,000 SH   DFND 1 0 70,000 0
TRILLIUM THERAPEUTICS INC COM 89620X906 211 120 SH Call DFND 1 0 120 0
TRILLIUM THERAPEUTICS INC COM 89620X956 1,947 1,109 SH Put DFND 1 0 1,109 0
TWIN VEE POWERCATS CO COM 90177C101 319 88,777 SH   DFND 1 0 88,777 0
UCOMMUNE INTL LTD COM G9449A100 260 298,798 SH   DFND 1 0 298,798 0
VASCULAR BIOGENICS LTD COM M96883909 41 198 SH Call DFND 1 0 198 0
VAXCYTE INC COM 92243G108 1,687 66,483 SH   DFND 1 0 66,483 0
VINCERX PHARMA INC COM 92731L106 3,234 200,000 SH   DFND 1 0 200,000 0
VIRPAX PHARMACEUTICALS INC COM 928251107 4,766 993,000 SH   DFND 1 0 993,000 0
VISTAGEN THERAPEUTICS INC COM 92840H952 67 244 SH Put DFND 1 0 244 0
WIMI HOLOGRAM CLOUD INC ADS 97264L100 1,581 383,791 SH   DFND 1 0 383,791 0
WIMI HOLOGRAM CLOUD INC ADS 97264L950 1,403 3,405 SH Put DFND 1 0 3,405 0
XPRESSPA GROUP INC COM 98420U953 1,756 11,948 SH Put DFND 1 0 11,948 0