The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
9 METERS BIOPHARMA INC COM 654405109 661 564,527 SH   DFND 1 0 564,527 0
9 METERS BIOPHARMA INC COM 654405959 3,065 26,197 SH Put DFND 1 0 26,197 0
ACTINIUM PHARMACEUTICALS INC COM 00507W956 76 100 SH Put DFND 1 0 100 0
ACUTUS MEDICAL INC COM 005111109 1,772 132,522 SH   DFND 1 0 132,522 0
ADAMIS PHARMACEUTICALS CORP COM 00547W958 285 3,034 SH Put DFND 1 0 3,034 0
ADITX THERAPEUTICS INC COM 007025109 424 166,363 SH   DFND 1 0 166,363 0
ADITX THERAPEUTICS INC COM 007025959 1,383 5,423 SH Put DFND 1 0 5,423 0
AETERNA ZENTARIS INC COM 007975902 53 462 SH Call DFND 1 0 462 0
AETERNA ZENTARIS INC COM 007975952 227 1,994 SH Put DFND 1 0 1,994 0
AETERNA ZENTARIS INC COM 007975402 682 598,442 SH   DFND 1 0 598,442 0
AGRIFY CORP COM 00853E107 266 21,342 SH   DFND 1 0 21,342 0
AMARIN CORP PLC ADR 023111956 200 322 SH Put DFND 1 0 322 0
AMARIN CORP PLC ADR 023111206 1,050 169,136 SH   DFND 1 0 169,136 0
AMARIN CORP PLC ADR 023111906 3,436 5,533 SH Call DFND 1 0 5,533 0
AMPLITECH GROUP INC *W 03211Q119 1,500 342,425 SH   DFND 1 0 342,425 0
APPLIED GENETIC TECHNOLOGIES COM 03820J950 1,914 3,775 SH Put DFND 1 0 3,775 0
ARCADIA BIOSCIENCES INC COM 039014204 185 67,136 SH   DFND 1 0 67,136 0
ARCADIA BIOSCIENCES INC COM 039014954 1,052 3,820 SH Put DFND 1 0 3,820 0
ARK ETF 00214Q954 1,367 114 SH Put DFND 1 0 114 0
ASENSUS SURGICAL INC COM 04367G903 2,131 6,556 SH Call DFND 1 0 6,556 0
ASENSUS SURGICAL INC COM 04367G953 2,262 6,959 SH Put DFND 1 0 6,959 0
ASENSUS SURGICAL INC COM 04367G103 7,478 2,301,061 SH   DFND 1 0 2,301,061 0
ASLAN PHARMACEUTICALS ADS 04522R101 2,738 817,165 SH   DFND 1 0 817,165 0
ATOSSA THERAPEUTICS INC COM 04962H506 511 242,237 SH   DFND 1 0 242,237 0
ATOSSA THERAPEUTICS INC COM 04962H956 2,674 12,673 SH Put DFND 1 0 12,673 0
AURINIA PHARMACEUTICALS COM 05156V902 609 469 SH Call DFND 1 0 469 0
AURINIA PHARMACEUTICALS COM 05156V102 1,112 85,625 SH   DFND 1 0 85,625 0
AUTOLUS THERAPEUTICS LTD ADS 05280R100 3,010 525,230 SH   DFND 1 0 525,230 0
AVEO PHARMACEUTICALS INC COM 053588307 79 10,815 SH   DFND 1 0 10,815 0
AVEO PHARMACEUTICALS INC COM 053588957 454 620 SH Put DFND 1 0 620 0
BARCLAYS BANK PLC ETF 06746P621 5,985 525,000 SH   DFND 1 0 525,000 0
BARCLAYS BANK PLC ETF 06746P901 16,343 14,336 SH Call DFND 1 0 14,336 0
BIO PATH HLDGS INC COM 09057N300 505 71,920 SH   DFND 1 0 71,920 0
BIOCEPT INC COM 09072V501 313 61,464 SH   DFND 1 0 61,464 0
BIOCEPT INC COM 09072V951 528 1,037 SH Put DFND 1 0 1,037 0
BIOGEN INC COM 09062X953 2,798 100 SH Put DFND 1 0 100 0
BIOGEN INC COM 09062X903 42,466 1,518 SH Call DFND 1 0 1,518 0
BIO-KEY INTL INC COM 09060C408 117 33,487 SH   DFND 1 0 33,487 0
BIO-KEY INTL INC COM 09060C958 547 1,566 SH Put DFND 1 0 1,566 0
BIOPHYTIS SA ADS 09076G104 1,182 92,345 SH   DFND 1 0 92,345 0
BRAINSTORM CELL COM 10501E201 523 136,610 SH   DFND 1 0 136,610 0
BRAINSTORM CELL COM 10501E951 1,694 4,424 SH Put DFND 1 0 4,424 0
BRIACELL THERAPEUTICS COM 10778Y302 618 160,182 SH   DFND 1 0 160,182 0
BUTTERFLY NETWORK INC COM 124155102 556 33,047 SH   DFND 1 0 33,047 0
BUTTERFLY NETWORK INC COM 124155902 668 397 SH Call DFND 1 0 397 0
CALADRIUS BIOSCIENCES INC COM 128058203 936 484,970 SH   DFND 1 0 484,970 0
CALADRIUS BIOSCIENCES INC COM 128058953 2,307 11,954 SH Put DFND 1 0 11,954 0
CARDIFF ONCOLOGY INC COM 14147L958 156 169 SH Put DFND 1 0 169 0
CARDIFF ONCOLOGY INC COM 14147L908 255 275 SH Call DFND 1 0 275 0
CBAK ENERGY TECHNOLOGY COM 14986C952 5,932 11,632 SH Put DFND 1 0 11,632 0
CELLECTAR BIOSCIENCES INC COM 15117F500 626 389,061 SH   DFND 1 0 389,061 0
CEL-SCI CORP COM 150837957 2,202 1,448 SH Put DFND 1 0 1,448 0
CEL-SCI CORP COM 150837907 2,677 1,760 SH Call DFND 1 0 1,760 0
CHINA JO JO DRUGSTORES INC COM 16949A206 28 25,000 SH   DFND 1 0 25,000 0
CITIUS PHARMACEUTICALS INC COM 17322U207 559 314,000 SH   DFND 1 0 314,000 0
CLEVELAND BIOLABS INC COM 185860202 2,514 478,941 SH   DFND 1 0 478,941 0
COLLPLANT BIOTECHNOLOGIES LTD ADS 19516R107 229 17,045 SH   DFND 1 0 17,045 0
CONTRAFECT CORP COM 212326300 798 166,175 SH   DFND 1 0 166,175 0
CURIS INC COM 231269900 912 985 SH Call DFND 1 0 985 0
DAXOR CORP COM 239467103 1,437 118,736 SH   DFND 1 0 118,736 0
DIGINEX LTD SHS Y2074E959 649 592 SH Put DFND 1 0 592 0
DIGITAL ALLY INC COM 25382P908 50 309 SH Call DFND 1 0 309 0
DIGITAL ALLY INC COM 25382P208 1,129 692,350 SH   DFND 1 0 692,350 0
DIGITAL ALLY INC COM 25382P958 1,666 10,220 SH Put DFND 1 0 10,220 0
EKSO BIONICS HLDGS INC COM 282644301 2,612 423,360 SH   DFND 1 0 423,360 0
EXELA TECHNOLOGIES COM 30162V409 1,635 750,000 SH   DFND 1 0 750,000 0
HEPION PHARMACEUTICALS INC COM 426897954 254 1,382 SH Put DFND 1 0 1,382 0
HEPION PHARMACEUTICALS INC COM 426897104 564 306,338 SH   DFND 1 0 306,338 0
HUMANCO ACQUISITION CORP *W 44487N117 183 141,136 SH   DFND 1 0 141,136 0
HUMANCO ACQUISITION CORP UNIT 44487N208 717 67,974 SH   DFND 1 0 67,974 0
HUMANCO ACQUISITION CORP COM 44487N109 3,345 336,211 SH   DFND 1 0 336,211 0
INFINITY PHARMACEUTICALS INC COM 45665G903 219 679 SH Call DFND 1 0 679 0
INFINITY PHARMACEUTICALS INC COM 45665G303 1,712 530,000 SH   DFND 1 0 530,000 0
INTEC PHARMA LTD SHS M53644148 164 37,501 SH   DFND 1 0 37,501 0
IONIS PHARMACEUTICALS COM 462222900 1,924 428 SH Call DFND 1 0 428 0
IONIS PHARMACEUTICALS COM 462222100 2,459 54,688 SH   DFND 1 0 54,688 0
IONIS PHARMACEUTICALS COM 462222950 3,732 830 SH Put DFND 1 0 830 0
ISHARES RUSSELL 2000 ETF 464287655 524 2,372 SH   DFND 1 0 2,372 0
ISHARES RUSSELL 2000 ETF 464287955 46,486 2,104 SH Put DFND 1 0 2,104 0
IT TECH PACKAGING INC COM 46527C950 177 2,684 SH Put DFND 1 0 2,684 0
KANDI TECHNOLOGIES GROUP INC COM 483709951 6,711 10,737 SH Put DFND 1 0 10,737 0
KEMPHARM INC COM 488445906 3,858 4,193 SH Call DFND 1 0 4,193 0
KEMPHARM INC COM 488445956 4,621 5,023 SH Put DFND 1 0 5,023 0
LEXARIA BIOSCIENCE CORP *W 52886N117 695 291,000 SH   DFND 1 0 291,000 0
LIXTE BIOTECHNOLOGY HLDGS INC COM 539319202 262 79,735 SH   DFND 1 0 79,735 0
LIXTE BIOTECHNOLOGY HLDGS INC *W 539319111 128 157,374 SH   DFND 1 0 157,374 0
MACROGENICS INC COM 556099959 580 182 SH Put DFND 1 0 182 0
MACROGENICS INC COM 556099909 917 288 SH Call DFND 1 0 288 0
MEATECH 3D LTD ADS 583435102 501 53,695 SH   DFND 1 0 53,695 0
MIRATI THERAPEUTICS INC COM 60468T105 1,456 8,500 SH   DFND 1 0 8,500 0
MIRATI THERAPEUTICS INC COM 60468T905 2,484 145 SH Call DFND 1 0 145 0
MMTEC INC SHS G6181K106 3,458 1,350,870 SH   DFND 1 0 1,350,870 0
MOGO INC COM 60800C109 2,260 265,828 SH   DFND 1 0 265,828 0
MOGO INC COM 60800C959 5,357 6,302 SH Put DFND 1 0 6,302 0
NABRIVA THERAPEUTICS PLC SHS G63637953 77 463 SH Put DFND 1 0 463 0
NABRIVA THERAPEUTICS PLC SHS G63637113 272 164,007 SH   DFND 1 0 164,007 0
NEMAURA MEDICAL INC COM 640442958 383 501 SH Put DFND 1 0 501 0
NEWAGE INC COM 650194103 6,763 2,364,694 SH   DFND 1 0 2,364,694 0
NUZEE INC COM 67073S208 3,368 965,139 SH   DFND 1 0 965,139 0
OCEAN POWER TECHNOLOGIES INC COM 674870956 1,375 4,153 SH Put DFND 1 0 4,153 0
OCULAR THERAPEUTIX INC COM 67576A100 152 9,250 SH   DFND 1 0 9,250 0
OCULAR THERAPEUTIX INC COM 67576A900 1,585 966 SH Call DFND 1 0 966 0
OCULAR THERAPEUTIX INC COM 67576A950 2,018 1,230 SH Put DFND 1 0 1,230 0
ODONATE THERAPEUTICS INC COM 676079106 2,171 634,728 SH   DFND 1 0 634,728 0
ORAMED PHARMACEUTICALS INC COM 68403P953 1,713 1,686 SH Put DFND 1 0 1,686 0
PAINREFORM LTD SHS M77798102 1,459 330,000 SH   DFND 1 0 330,000 0
PENN NATIONAL GAMING INC COM 707569109 4,235 40,399 SH   DFND 1 0 40,399 0
PENN NATIONAL GAMING INC COM 707569959 7,664 731 SH Put DFND 1 0 731 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 52 15,000 SH   DFND 1 0 15,000 0
PHIO PHARMACEUTICALS INC COM 71880W303 62 23,007 SH   DFND 1 0 23,007 0
PHIO PHARMACEUTICALS INC COM 71880W953 427 1,591 SH Put DFND 1 0 1,591 0
PLURISTEM THERAPEUTICS INC COM 72940R300 242 50,822 SH   DFND 1 0 50,822 0
PLURISTEM THERAPEUTICS INC COM 72940R950 830 1,739 SH Put DFND 1 0 1,739 0
POLARITYTE INC COM 731094958 150 1,355 SH Put DFND 1 0 1,355 0
POLARITYTE INC COM 731094108 234 210,562 SH   DFND 1 0 210,562 0
PURPLE BIOTECH LTD ADS 74638P109 78 18,847 SH   DFND 1 0 18,847 0
PURPLE BIOTECH LTD ADS 74638P959 805 1,948 SH Put DFND 1 0 1,948 0
REDHILL BIOPHARMA LTD ADS 757468103 4,621 631,287 SH   DFND 1 0 631,287 0
REVIVA PHARMACEURICALS HLDGS INC COM 76152G100 2,402 418,437 SH   DFND 1 0 418,437 0
REVIVA PHARMACEURICALS HLDGS INC *W 76152G118 161 350,000 SH   DFND 1 0 350,000 0
REWALK ROBOTICS LTD SHS M8216Q950 835 3,449 SH Put DFND 1 0 3,449 0
REWALK ROBOTICS LTD SHS M8216Q200 3,126 1,291,893 SH   DFND 1 0 1,291,893 0
RIOT BLOCKCHAIN INC COM 767292105 959 18,000 SH   DFND 1 0 18,000 0
RIOT BLOCKCHAIN INC COM 767292955 4,794 900 SH Put DFND 1 0 900 0
SAGE THERAPEUTICS INC COM 78667J958 1,243 166 SH Put DFND 1 0 166 0
SALARIUS PHARMACEUTICALS INC COM 79400X107 395 266,955 SH   DFND 1 0 266,955 0
SEANERGY MARITIME HLDGS CORP SHS Y73760194 2,114 1,994,783 SH   DFND 1 0 1,994,783 0
SECOND SIGHT MEDICAL PRODS INC COM 81362J209 7,608 922,193 SH   DFND 1 0 922,193 0
SORRENTO THERAPEUTICS INC COM 83587F202 8,807 1,064,933 SH   DFND 1 0 1,064,933 0
SORRENTO THERAPEUTICS INC COM 83587F952 15,139 18,306 SH Put DFND 1 0 18,306 0
SPDR GOLD TRUST SHS 78463V907 15,452 966 SH Call DFND 1 0 966 0
SPDR S&P 500 ETF TR ETF 78462F953 33,054 834 SH Put DFND 1 0 834 0
SPDR SERIES TRUST ETF 78464A870 1,185 8,735 SH   DFND 1 0 8,735 0
SPDR SERIES TRUST ETF 78464A950 33,221 2,449 SH Put DFND 1 0 2,449 0
SPI ENERGY CO LTD SHS G8651P110 989 131,898 SH   DFND 1 0 131,898 0
SPI ENERGY CO LTD SHS G8651P950 70,355 5,568 SH Put DFND 1 0 5,568 0
STEALTH BIOTHERAPEUTICS CORP ADS 85789A105 473 301,575 SH   DFND 1 0 301,575 0
TANZANIAN GOLD CORP COM 87601A957 89 1,515 SH Put DFND 1 0 1,515 0
THE9 LTD ADS 88337K302 259 8,293 SH   DFND 1 0 8,293 0
THE9 LTD ADS 88337K952 487 156 SH Put DFND 1 0 156 0
THE9 LTD ADS 88337K902 524 168 SH Call DFND 1 0 168 0
THERAPEUTICSMD INC COM 88338N107 1,072 800,000 SH   DFND 1 0 800,000 0
TITAN PHARMACEUTICALS INC COM 888314956 376 1,263 SH Put DFND 1 0 1,263 0
TRICIDA INC COM 89610F101 1,877 354,755 SH   DFND 1 0 354,755 0
TRILLIUM THERAPEUTICS INC COM 89620X956 625 582 SH Put DFND 1 0 582 0
TRILLIUM THERAPEUTICS INC COM 89620X906 694 646 SH Call DFND 1 0 646 0
TRILLIUM THERAPEUTICS INC COM 89620X506 2,143 199,569 SH   DFND 1 0 199,569 0
UCOMMUNE INTL LTD COM G9449A100 386 128,564 SH   DFND 1 0 128,564 0
VASCULAR BIOGENICS LTD COM M96883959 165 825 SH Put DFND 1 0 825 0
VAXCYTE INC COM 92243G108 3,535 178,992 SH   DFND 1 0 178,992 0
VINCERX PHARMA INC COM 92731L106 1,601 82,948 SH   DFND 1 0 82,948 0
VIRPAX PHARMACEUTICALS INC COM 928251107 942 200,000 SH   DFND 1 0 200,000 0
VIRTRA INC COM 92827K301 3,451 561,088 SH   DFND 1 0 561,088 0
WIMI HOLOGRAM CLOUD INC ADS 97264L950 1,213 1,838 SH Put DFND 1 0 1,838 0
WIMI HOLOGRAM CLOUD INC ADS 97264L100 6,473 980,786 SH   DFND 1 0 980,786 0
XPRESSPA GROUP INC COM 98420U953 2,386 12,967 SH Put DFND 1 0 12,967 0