The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
9 METERS BIOPHARMA INC COM 654405959 1,272 14,813 SH Put DFND 1 0 14,813 0
ACTINIUM PHARMACEUTICALS INC COM 00507W956 297 381 SH Put DFND 1 0 381 0
ACTINIUM PHARMACEUTICALS INC COM 00507W906 1,020 1,308 SH Call DFND 1 0 1,308 0
ACUTUS MEDICAL INC COM 005111109 2,233 77,500 SH   DFND 1 0 77,500 0
ADAMIS PHARMACEUTICALS CORP COM 00547W958 76 1,562 SH Put DFND 1 0 1,562 0
ALLENA PHARMACEUTICALS INC COM 018119107 345 269,836 SH   DFND 1 0 269,836 0
ALTERITY THERAPEUTICS LTD ADR 02155X106 249 185,843 SH   DFND 1 0 185,843 0
AMARIN CORP PLC ADR 023111906 2,546 5,207 SH Call DFND 1 0 5,207 0
AMBOW EDUCATION HOLDING LTD ADS 02322P200 329 151,772 SH   DFND 1 0 151,772 0
ARCADIA BIOSCIENCES INC COM 039014954 61 242 SH Put DFND 1 0 242 0
ARCADIA BIOSCIENCES INC COM 039014204 82 32,503 SH   DFND 1 0 32,503 0
ASTRAZENECA PLC ADR 046353958 17,457 3,492 SH Put DFND 1 0 3,492 0
ASTRAZENECA PLC ADR 046353108 18,246 365,000 SH   DFND 1 0 365,000 0
ASTROTECH CORP COM 046484200 1,123 634,297 SH   DFND 1 0 634,297 0
AURINIA PHARMACEUTICALS INC COM 05156V102 774 55,943 SH   DFND 1 0 55,943 0
AURINIA PHARMACEUTICALS INC COM 05156V952 1,047 757 SH Put DFND 1 0 757 0
AVEO PHARMACEUTICALS INC COM 053588307 393 68,092 SH   DFND 1 0 68,092 0
AVEO PHARMACEUTICALS INC COM 053588957 4,311 7,471 SH Put DFND 1 0 7,471 0
BARCLAYS BANK PLC ETF 06746P901 6,256 3,726 SH Call DFND 1 0 3,726 0
BELLICUM PHARMACEUTICALS INC COM 079481404 563 159,500 SH   DFND 1 0 159,500 0
BIOCEPT INC COM 09072V501 140 31,578 SH   DFND 1 0 31,578 0
BIOCEPT INC COM 09072V951 211 476 SH Put DFND 1 0 476 0
BIOGEN INC COM 09062X103 28,641 116,970 SH   DFND 1 0 116,970 0
BIOGEN INC COM 09062X953 49,560 2,024 SH Put DFND 1 0 2,024 0
BIOGEN INC COM 09062X903 67,630 2,762 SH Call DFND 1 0 2,762 0
BIOHAVEN PHARMACEUTICAL HLDG COM G11196905 454 53 SH Call DFND 1 0 53 0
BIOLASE INC COM 090911207 26 62,748 SH   DFND 1 0 62,748 0
BRAINSTORM CELL THERAPEUTICS COM 10501E951 1,073 2,371 SH Put DFND 1 0 2,371 0
BRISTOL MYERS SQUIBB COM 110122157 207 300,000 SH   DFND 1 0 300,000 0
CALADRIUS BIOSCIENCES COM 128058953 16 110 SH Put DFND 1 0 110 0
CARDIFF ONCOLOGY COM 14147L908 4,717 2,622 SH Call DFND 1 0 2,622 0
CARDIFF ONCOLOGY COM 14147L958 5,163 2,870 SH Put DFND 1 0 2,870 0
CASTOR MARITIME INC COM Y1146L109 527 2,850,634 SH   DFND 1 0 2,850,634 0
CATABASIS COM 14875P206 231 108,026 SH   DFND 1 0 108,026 0
CBAK ENERGY COM 14986C952 629 2,938 SH Put DFND 1 0 2,938 0
CELLECTAR BIOSCIENCES COM 15117F500 1,038 499,030 SH   DFND 1 0 499,030 0
CEL-SCI CORP COM 150837907 1,482 1,271 SH Call DFND 1 0 1,271 0
CEL-SCI CORP COM 150837607 3,616 310,155 SH   DFND 1 0 310,155 0
CEL-SCI CORP COM 150837957 6,417 5,503 SH Put DFND 1 0 5,503 0
CHINA JO JO DRUGSTORES COM 16949A206 51 50,000 SH   DFND 1 0 50,000 0
CORDMEDIX INC COM 21900C908 623 839 SH Call DFND 1 0 839 0
CORDMEDIX INC COM 21900C958 664 894 SH Put DFND 1 0 894 0
CYCLO THERAPEUTICS INC *W 23254X110 208 193,012 SH   DFND 1 0 193,012 0
DAXOR CORP COM 239467103 1,605 128,398 SH   DFND 1 0 128,398 0
EMAGIN CORP COM 29076N956 137 829 SH Put DFND 1 0 829 0
EMERALD BIOSCIENCE INC COM 29102Y101 579 14,480,000 SH   DFND 1 0 14,480,000 0
ENERGY FOCUS INC COM 29268T959 48 120 SH Put DFND 1 0 120 0
EVOKE PHARMA INC COM 30049G104 168 65,004 SH   DFND 1 0 65,004 0
EVOKE PHARMA INC COM 30049G954 289 1,120 SH Put DFND 1 0 1,120 0
GEOVAX LABS INC *W 373678119 283 275,695 SH   DFND 1 0 275,695 0
GEOVAX LABS INC COM 373678507 191 56,380 SH   DFND 1 0 56,380 0
GLOBUS MARITIME LTD COM Y27265126 1,659 290,535 SH   DFND 1 0 290,535 0
HEPION PHARMACEUTICALS INC COM 426897954 201 919 SH Put DFND 1 0 919 0
HUMANCO ACQUISITION CORP UNIT 44487N208 1,047 95,050 SH   DFND 1 0 95,050 0
INOVIO PHARMACEUTICALS COM 45773H901 114 129 SH Call DFND 1 0 129 0
INOVIO PHARMACEUTICALS COM 45773H201 2,526 285,388 SH   DFND 1 0 285,388 0
INOVIO PHARMACEUTICALS COM 45773H951 2,805 3,170 SH Put DFND 1 0 3,170 0
INSPIREMD INC COM 45779A853 60 174,813 SH   DFND 1 0 174,813 0
INTEC PHARMA LTD COM M53644148 35 10,199 SH   DFND 1 0 10,199 0
INTRA-CELLULAR THERAPIES COM 46116X901 318 100 SH Call DFND 1 0 100 0
INTRA-CELLULAR THERAPIES COM 46116X101 1,113 35,000 SH   DFND 1 0 35,000 0
IONIS PHARMACEUTICALS COM 462222950 1,199 212 SH Put DFND 1 0 212 0
IONIS PHARMACEUTICALS COM 462222900 2,420 428 SH Call DFND 1 0 428 0
ISHARES RUSSELL 2000 ETF 464287905 8,999 459 SH Call DFND 1 0 459 0
ISHARES RUSSELL 2000 ETF 464287955 32,115 1,638 SH Put DFND 1 0 1,638 0
KANDI TECHNOLOGIES GROUP INC COM 483709101 729 105,714 SH   DFND 1 0 105,714 0
KANDI TECHNOLOGIES GROUP INC COM 483709951 7,040 10,203 SH Put DFND 1 0 10,203 0
LIXTE BIOTECHNOLOGY HLDGS INC *W 539319111 306 339,542 SH   DFND 1 0 339,542 0
MARINUS PHARMACEUTICALS INC COM 56854Q200 1,230 100,800 SH   DFND 1 0 100,800 0
MICT INC COM 55328R109 111 53,559 SH   DFND 1 0 53,559 0
MIRATI THERAPEUTICS INC COM 60468T105 659 3,000 SH   DFND 1 0 3,000 0
MIRATI THERAPEUTICS INC COM 60468T905 3,185 145 SH Call DFND 1 0 145 0
MODERNA INC COM 60770K907 7,480 716 SH Call DFND 1 0 716 0
MODERNA INC COM 60770K107 12,119 116,000 SH   DFND 1 0 116,000 0
MODERNA INC COM 60770K957 39,072 3,740 SH Put DFND 1 0 3,740 0
NABRIVA THERAPEUTICS PLC COM G63637953 29 120 SH Put DFND 1 0 120 0
NABRIVA THERAPEUTICS PLC COM G63637113 629 260,000 SH   DFND 1 0 260,000 0
NANOVIBRONIX INC COM 63008J108 446 583,415 SH   DFND 1 0 583,415 0
NEMAURA MEDICAL INC COM 640442208 1,864 494,297 SH   DFND 1 0 494,297 0
NEUROBO PHARMACEUTICALS COM 64132R107 748 142,400 SH   DFND 1 0 142,400 0
ODONATE THERAPEUTICS INC COM 676079106 921 47,945 SH   DFND 1 0 47,945 0
ORAMED PHARMACEUTICALS INC COM 68403P953 420 991 SH Put DFND 1 0 991 0
PAINREFORM LTD SHS M77798102 275 61,606 SH   DFND 1 0 61,606 0
PELOTON INTERACTIVE INC COM 70614W950 4,551 300 SH Put DFND 1 0 300 0
PENN NATL GAMING INC COM 707569959 6,314 731 SH Put DFND 1 0 731 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 218 65,000 SH   DFND 1 0 65,000 0
POLARITYTE INC COM 731094108 163 239,200 SH   DFND 1 0 239,200 0
POLARITYTE INC COM 731094958 163 2,392 SH Put DFND 1 0 2,392 0
PULMATRIX INC COM 74584P202 2,351 1,975,309 SH   DFND 1 0 1,975,309 0
REVIVA PHARMACEURICALS COM 76152G100 3,133 358,300 SH   DFND 1 0 358,300 0
REWALK ROBOTICS LTD SHS M8216Q200 254 192,382 SH   DFND 1 0 192,382 0
ROCKWELL MEDICAL INC COM 774374102 618 611,992 SH   DFND 1 0 611,992 0
SORRENTO THERAPEUTICS INC COM 83587F902 4,274 6,262 SH Call DFND 1 0 6,262 0
SORRENTO THERAPEUTICS INC COM 83587F952 6,254 9,164 SH Put DFND 1 0 9,164 0
SPDR GOLD TRUST SHS 78463V907 40,702 2,282 SH Call DFND 1 0 2,282 0
SPDR S&P 500 ETF TR ETF 78462F953 37,388 1,000 SH Put DFND 1 0 1,000 0
SPDR SERIES TRUST ETF 78464A950 28,395 2,017 SH Put DFND 1 0 2,017 0
SPI ENERGY CO LTD SHS G8651P950 238 302 SH Put DFND 1 0 302 0
SUPERCOM LTD SHS M87095119 1,524 1,480,000 SH   DFND 1 0 1,480,000 0
TRANSENTERIX INC COM 89366M950 53 855 SH Put DFND 1 0 855 0
TRICIDA INC COM 89610F101 1,413 200,437 SH   DFND 1 0 200,437 0
TRILLIUM THERAPEUTICS INC COM 89620X506 1,765 119,996 SH   DFND 1 0 119,996 0
TRILLIUM THERAPEUTICS INC COM 89620X506 3,500 2,379 SH Put DFND 1 0 2,379 0
XPRESSPA GROUP INC COM 98420U703 3,992 3,354,960 SH   DFND 1 0 3,354,960 0
XPRESSPA GROUP INC COM 98420U953 506 4,251 SH Put DFND 1 0 4,251 0
ZOOM VIDEO COMMUNICATIONS COM 98980L951 6,746 200 SH Put DFND 1 0 200 0