The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
9 METERS BIOPHARMA COM 654405959 145 1,773 SH Put DFND 1 0 1,773 0
ACADIA PHARMACEUTICALS INC COM 004225108 4,122 99,921 SH   DFND 1 0 99,921 0
ACTINIUM PHARMACEUTICALS COM 00507W957 159 164 SH Put DFND 1 0 164 0
ACUTUS MEDICAL INC COM 005111109 1,480 49,656 SH   DFND 1 0 49,656 0
ADAMIS PHARMACEUTICALS CORP COM 00547W958 122 1,565 SH Put DFND 1 0 1,565 0
ADITX THERAPEUTICS INC COM 007025109 439 224,971 SH   DFND 1 0 224,971 0
AKERS BIOSCIENCES INC COM 00973E409 675 299,913 SH   DFND 1 0 299,913 0
ALTIMMUNE INC COM 02155H200 182 13,800 SH   DFND 1 0 13,800 0
ALTIMMUNE INC COM 02155H950 1,005 761 SH Put DFND 1 0 761 0
AMARIN CORP PLC ADR 023111906 643 5,083 SH Call DFND 1 0 5,083 0
ARCADIA BIOSCIENCES INC COM 039014204 770 275,123 SH   DFND 1 0 275,123 0
ASTRAZENECA PLC ADR 046353908 2,855 521 SH Call DFND 1 0 521 0
ASTRAZENECA PLC ADR 046353108 8,107 147,945 SH   DFND 1 0 147,945 0
ASTRAZENECA PLC ADR 046353958 16,851 3,075 SH Put DFND 1 0 3,075 0
AURINIA PHARMACEUTICALS COM 05156V102 200 13,544 SH   DFND 1 0 13,544 0
AURINIA PHARMACEUTICALS COM 05156V902 1,037 704 SH Call DFND 1 0 704 0
AVEO PHARMACEUTICALS INC COM 053588307 155 26,039 SH   DFND 1 0 26,039 0
AVEO PHARMACEUTICALS INC COM 053588957 4,040 6,801 SH Put DFND 1 0 6,801 0
BARCLAYS BANK PLC ETF 06746P621 2,490 100,000 SH   DFND 1 0 100,000 0
BARCLAYS BANK PLC ETF 06746P901 4,920 1,976 SH Call DFND 1 0 1,976 0
BAUDAX BIO INC COM 07160F957 114 410 SH Put DFND 1 0 410 0
BELLUS HEALTH INC NEW COM 07987C204 1,999 880,400 SH   DFND 1 0 880,400 0
BENITEC BIOPHARMA INC COM 08205P100 75 11,863 SH   DFND 1 0 11,863 0
BIO KEY INTL INC COM 09060C309 44 100,000 SH   DFND 1 0 100,000 0
BIOGEN INC COM 09062X103 12,634 44,536 SH   DFND 1 0 44,536 0
BIOGEN INC COM 09062X953 66,920 2,359 SH Put DFND 1 0 2,359 0
BIOGEN INC COM 09062X903 95,146 3,354 SH Call DFND 1 0 3,354 0
BIOLASE INC COM 090911207 92 333,458 SH   DFND 1 0 333,458 0
BRAINSTORM CELL THERAPEUTICS COM 10501E951 7,519 4,444 SH Put DFND 1 0 4,444 0
BRICKELL BIOTECH INC COM 10802T105 652 721,887 SH   DFND 1 0 721,887 0
CALADRIUS BIOSCIENCES COM 128058203 173 96,001 SH   DFND 1 0 96,001 0
CALADRIUS BIOSCIENCES COM 128058953 293 1,630 SH Put DFND 1 0 1,630 0
CARDIFF ONCOLOGY COM 14147L908 450 317 SH Call DFND 1 0 317 0
CARDIFF ONCOLOGY COM 14147L958 5,516 3,887 SH Put DFND 1 0 3,887 0
CATABASIS PHARMS COM 14875P906 171 277 SH Call DFND 1 0 277 0
CATABASIS PHARMS COM 14875P956 552 891 SH Put DFND 1 0 891 0
CELLDEX THERAPEUTIC COM 15117B902 2,064 1,392 SH Call DFND 1 0 1,392 0
CEL-SCI CORP COM 150837607 1,375 107,878 SH   DFND 1 0 107,878 0
CEL-SCI CORP COM 150837907 5,871 4,605 SH Call DFND 1 0 4,605 0
CEL-SCI CORP COM 150837957 9,911 7,773 SH Put DFND 1 0 7,773 0
CENTOGENE N V COM N1976T109 1,724 182,275 SH   DFND 1 0 182,275 0
CHECKPOINT THERAPEUTICS COM 162828107 2,496 931,240 SH   DFND 1 0 931,240 0
CHINA JO JO DRUGSTORES COM 16949A206 48 50,000 SH   DFND 1 0 50,000 0
CINEDIGM CORP COM 172406209 2,755 4,875,949 SH   DFND 1 0 4,875,949 0
CITIUS PHARMACEUTICALS COM 17322U207 92 88,711 SH   DFND 1 0 88,711 0
COCRYSTAL PHARMA INC COM 19188J300 2,480 2,667,293 SH   DFND 1 0 2,667,293 0
CORDMEDIX INC COM 21900C958 66 109 SH Put DFND 1 0 109 0
CORDMEDIX INC COM 21900C908 142 236 SH Call DFND 1 0 236 0
CURIS INC COM 231269900 132 1,131 SH Call DFND 1 0 1,131 0
CURIS INC COM 231269200 1,380 1,179,600 SH   DFND 1 0 1,179,600 0
CYCLACEL PHARMACEUTICALS COM 23254L603 458 125,578 SH   DFND 1 0 125,578 0
CYTOKINETICS INC COM 23282W905 340 157 SH Call DFND 1 0 157 0
DAXOR CORP COM 239467103 1,928 122,406 SH   DFND 1 0 122,406 0
EMAGIN CORP NEW COM 29076N956 149 1,172 SH Put DFND 1 0 1,172 0
EMERALD BIOSCIENCE INC COM 29102Y101 633 14,936,716 SH   DFND 1 0 14,936,716 0
ENERGY FOCUS COM 29268T959 82 120 SH Put DFND 1 0 120 0
EVOKE PHARMA INC COM 30049G104 105 22,382 SH   DFND 1 0 22,382 0
EVOKE PHARMA INC COM 30049G954 712 1,519 SH Put DFND 1 0 1,519 0
EYENOVIA INC COM 30234E104 1,899 608,720 SH   DFND 1 0 608,720 0
FIBROGEN INC COM 31572Q808 1,219 29,654 SH   DFND 1 0 29,654 0
FIBROGEN INC COM 31572Q958 5,831 1,418 SH Put DFND 1 0 1,418 0
GENOCEA BIOSCIENCES INC COM 372427901 236 1,032 SH Call DFND 1 0 1,032 0
GENOCEA BIOSCIENCES INC COM 372427401 716 312,666 SH   DFND 1 0 312,666 0
GEOVAX LABS INC *W 373678119 169 191,657 SH   DFND 1 0 191,657 0
GEOVAX LABS INC COM 373678507 768 240,654 SH   DFND 1 0 240,654 0
HEPION PHARMACEUTICALS COM 426897104 178 57,309 SH   DFND 1 0 57,309 0
HEPION PHARMACEUTICALS COM 426897954 184 591 SH Put DFND 1 0 591 0
IMMUNOMEDICS INC COM 452907108 4,252 50,000 SH   DFND 1 0 50,000 0
INOVIO PHARMACEUTICALS COM 45773H201 1,449 124,884 SH   DFND 1 0 124,884 0
INOVIO PHARMACEUTICALS COM 45773H951 2,814 2,426 SH Put DFND 1 0 2,426 0
INSPIREMD INC COM 45779A853 77 243,900 SH   DFND 1 0 243,900 0
INTRA-CELLULAR THERAPIES COM 46116X101 2,951 115,000 SH   DFND 1 0 115,000 0
IONIS PHARMACEUTICALS COM 462222950 1,006 212 SH Put DFND 1 0 212 0
IONIS PHARMACEUTICALS COM 462222900 2,031 428 SH Call DFND 1 0 428 0
ISHARES NASDAQ BIOTECH ETF 464287556 1,540 11,372 SH   DFND 1 0 11,372 0
ISHARES NASDAQ BIOTECH ETF 464287906 2,559 189 SH Call DFND 1 0 189 0
ISHARES NASDAQ BIOTECH ETF 464287956 12,498 923 SH Put DFND 1 0 923 0
ISHARES RUSSELL 2000 ETF 464287905 15,728 1,050 SH Call DFND 1 0 1,050 0
ISHARES RUSSELL 2000 ETF 464287955 32,774 2,188 SH Put DFND 1 0 2,188 0
LIPOCINE INC NEW COM 53630X954 21 150 SH Put DFND 1 0 150 0
LIPOCINE INC NEW COM 53630X904 133 941 SH Call DFND 1 0 941 0
LIPOCINE INC NEW COM 53630X104 625 443,469 SH   DFND 1 0 443,469 0
LM FUNDING AMERICA INC COM 502074305 97 147,304 SH   DFND 1 0 147,304 0
MEDIGUS LTD *W 58471G128 93 544,940 SH   DFND 1 0 544,940 0
MODERNA INC COM 60770K907 7,726 1,092 SH Call DFND 1 0 1,092 0
MODERNA INC COM 60770K107 8,630 121,975 SH   DFND 1 0 121,975 0
MODERNA INC COM 60770K957 29,517 4,172 SH Put DFND 1 0 4,172 0
MONAKER GROUP INC COM 609011200 297 134,585 SH   DFND 1 0 134,585 0
NABRIVA THERAPEUTICS PLC SHS G63637955 51 958 SH Put DFND 1 0 958 0
NABRIVA THERAPEUTICS PLC SHS G63637105 143 268,109 SH   DFND 1 0 268,109 0
NEMAURA MEDICAL INC COM 640442208 2,179 613,765 SH   DFND 1 0 613,765 0
NEOVASC INC COM 64065J304 2,160 1,009,406 SH   DFND 1 0 1,009,406 0
NEUROBO PHARMACEUTICALS COM 64132R107 1,026 182,543 SH   DFND 1 0 182,543 0
ODONATE THERAPEUTICS INC COM 676079956 475 354 SH Put DFND 1 0 354 0
ODONATE THERAPEUTICS INC COM 676079106 1,051 78,278 SH   DFND 1 0 78,278 0
OLB GROUP INC COM 67086U307 1,166 311,010 SH   DFND 1 0 311,010 0
PAINREFORM LTD SHS M77798102 2,047 444,941 SH   DFND 1 0 444,941 0
PARETEUM CORP COM 69946T957 20 299 SH Put DFND 1 0 299 0
PAVMED INC *W 70387R122 364 436,973 SH   DFND 1 0 436,973 0
PDS BIOTECHNOLOGY CORP COM 70465T107 978 419,836 SH   DFND 1 0 419,836 0
PFIZER INC COM 717081903 6,668 1,817 SH Call DFND 1 0 1,817 0
PHASEBIO PHARMACEUTICALS COM 717224109 279 79,470 SH   DFND 1 0 79,470 0
PLURISTEM THERAPEUTICS COM 72940R300 629 59,730 SH   DFND 1 0 59,730 0
PLURISTEM THERAPEUTICS COM 72940R950 6,301 5,984 SH Put DFND 1 0 5,984 0
POLARITYTE INC COM 731094958 501 4,816 SH Put DFND 1 0 4,816 0
PULMATRIX INC COM 74584P202 2,071 1,740,663 SH   DFND 1 0 1,740,663 0
ROCKWELL MEDICAL INC COM 774374102 3,847 3,595,415 SH   DFND 1 0 3,595,415 0
SAREPTA THERAPEUTIC COM 803607900 618 44 SH Call DFND 1 0 44 0
SAREPTA THERAPEUTIC COM 803607950 1,067 76 SH Put DFND 1 0 76 0
SCPHARMACEUTICALS INC COM 810648105 316 42,407 SH   DFND 1 0 42,407 0
SEANERGY MARITIME SHS Y73760194 2,443 5,349,284 SH   DFND 1 0 5,349,284 0
SELECT SECTOR SPDR TR ETF 81369Y209 422 4,000 SH   DFND 1 0 4,000 0
SELECT SECTOR SPDR TR ETF 81369Y909 8,797 834 SH Call DFND 1 0 834 0
SELECT SECTOR SPDR TR ETF 81369Y959 48,879 4,634 SH Put DFND 1 0 4,634 0
SENECA BIOPHARMA INC COM 81689B103 229 393,411 SH   DFND 1 0 393,411 0
SORRENTO THERAPEUTICS COM 83587F202 6,760 606,298 SH   DFND 1 0 606,298 0
SORRENTO THERAPEUTICS COM 83587F952 7,964 7,143 SH Put DFND 1 0 7,143 0
SPDR GOLD TRUST ETF 78463V907 826 2,262 SH Call DFND 1 0 2,262 0
SPDR S&P 500 ETF 78462F903 29,035 867 SH Call DFND 1 0 867 0
SPDR S&P 500 ETF 78462F953 31,178 931 SH Put DFND 1 0 931 0
SPDR SERIES TRUST ETF 78464A950 14,898 1,337 SH Put DFND 1 0 1,337 0
SPI ENERGY CO LTD SHS G8651P110 3,065 425,762 SH   DFND 1 0 425,762 0
SUPERCOM LTD COM M87095119 1,125 1,480,000 SH   DFND 1 0 1,480,000 0
TESLA INC COM 88160R951 21,402 435 SH Put DFND 1 0 435 0
TESLA INC COM 88160R901 36,466 850 SH Call DFND 1 0 850 0
TITAN PHARMACEUTICALS COM 888314507 803 4,856,723 SH   DFND 1 0 4,856,723 0
TRANSENTERIX INC COM 89366M950 28 794 SH Put DFND 1 0 794 0
TRILLIUM THERAPEUTICS INC COM 89620X906 2,643 1,860 SH Call DFND 1 0 1,860 0
U S ENERGY CORP WY COM 911805307 333 66,504 SH   DFND 1 0 66,504 0
XPRESSPA GROUP INC COM 98420U953 497 2,522 SH Put DFND 1 0 2,522 0
XPRESSPA GROUP INC COM 98420U703 2,347 1,191,233 SH   DFND 1 0 1,191,233 0
ZOMEDICA PHARMACEUTICALS COM 98979F107 52 470,548 SH   DFND 1 0 470,548 0