X0306 4 2020-06-09 1 0001337013 InfuSystem Holdings, Inc INFU 0001535264 AWM Investment Company, Inc. 527 MADISON AVENUE SUITE 2600 NEW YORK NY 10022 0 0 1 0 Common Stock 2000000 I By Limited Partnership AWM Investment Company, Inc., a Delaware corporation (AWM), is the investment adviser to Special Situations Life Sciences Fund, L.P. (LS), (LS, the Fund). As the investment adviser to the Fund, AWM holds sole voting and investment power over 2,000,000 shares of Common Stock of the Issuer (the Shares) held by LS. Austin W. Marxe (Marxe), David M. Greenhouse (Greenhouse) and Adam C. Stettner (Stettner) are the controlling principals of AWM. The reporting person disclaims beneficial ownership of the Shares, except to the extent of its pecuniary interest therein. This report shall not be deemed an admission that the reporting person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. As a result of a change in shares outstanding, AWM Investment Company Inc. beneficially owns less than 10%. No additional filings are required at this time. Adam Stettner 2020-06-09