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    <nameOfIssuer>10X GENOMICS INC</nameOfIssuer>
    <titleOfClass>CL A COM</titleOfClass>
    <cusip>88025U109</cusip>
    <value>48298250</value>
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      <None>0</None>
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    <nameOfIssuer>ABSCI CORPORATION</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00091E109</cusip>
    <value>2919780</value>
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    <nameOfIssuer>ADLAI NORTYE LTD</nameOfIssuer>
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    <cusip>00704R109</cusip>
    <value>3726150</value>
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      <Sole>538461</Sole>
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      <None>0</None>
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    <nameOfIssuer>AGOMAB THERAPEUTICS NV</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>00860C102</cusip>
    <value>16259500</value>
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      <Sole>1550000</Sole>
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    <nameOfIssuer>ALNYLAM PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>02043Q107</cusip>
    <value>24815250</value>
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      <Sole>75000</Sole>
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      <None>0</None>
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    <nameOfIssuer>BEAM THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>07373V105</cusip>
    <value>32170500</value>
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      <Sole>1350000</Sole>
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    <nameOfIssuer>BIOLIFE SOLUTIONS INC</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>09062W204</cusip>
    <value>113662708</value>
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      <Sole>5957165</Sole>
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    <nameOfIssuer>BRIDGEBIO ONCOLOGY THERAPEUT</nameOfIssuer>
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    <cusip>107924102</cusip>
    <value>2526692</value>
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      <Sole>282312</Sole>
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      <None>0</None>
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    <nameOfIssuer>CENTURY THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>15673T100</cusip>
    <value>2775709</value>
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      <None>0</None>
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    <nameOfIssuer>CONTINEUM THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>21217B100</cusip>
    <value>1937229</value>
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      <Sole>148333</Sole>
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      <None>0</None>
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    <nameOfIssuer>DENALI THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>24823R105</cusip>
    <value>35328000</value>
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    <votingAuthority>
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      <None>0</None>
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    <nameOfIssuer>DISC MEDICINE INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>254604101</cusip>
    <value>4156100</value>
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    <nameOfIssuer>GENEDX HOLDINGS CORP</nameOfIssuer>
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    <cusip>81663L200</cusip>
    <value>193120072</value>
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    <nameOfIssuer>GINKGO BIOWORKS HOLDINGS INC</nameOfIssuer>
    <titleOfClass>CL A NEW</titleOfClass>
    <cusip>37611X209</cusip>
    <value>223702</value>
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      <Sole>36493</Sole>
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      <None>0</None>
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    <nameOfIssuer>GRAIL INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>384747101</cusip>
    <value>11886400</value>
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      <sshPrnamt>230000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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      <Sole>230000</Sole>
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      <None>0</None>
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    <nameOfIssuer>GUARDANT HEALTH INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>40131M109</cusip>
    <value>29096550</value>
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    <votingAuthority>
      <Sole>315000</Sole>
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      <None>0</None>
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    <nameOfIssuer>HIMS &amp; HERS HEALTH INC</nameOfIssuer>
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    <cusip>433000106</cusip>
    <value>14532000</value>
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      <Sole>700000</Sole>
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      <None>0</None>
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    <nameOfIssuer>ILLUMINA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>452327109</cusip>
    <value>65327800</value>
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      <Sole>530000</Sole>
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      <None>0</None>
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    <nameOfIssuer>INTELLIA THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45826J105</cusip>
    <value>4551100</value>
    <shrsOrPrnAmt>
      <sshPrnamt>355000</sshPrnamt>
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    <votingAuthority>
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      <None>0</None>
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    <nameOfIssuer>MAZE THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>578784100</cusip>
    <value>22651881</value>
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      <Sole>758857</Sole>
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      <None>0</None>
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    <nameOfIssuer>MODERNA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>60770K107</cusip>
    <value>3810000</value>
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    <votingAuthority>
      <Sole>75000</Sole>
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      <None>0</None>
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    <nameOfIssuer>MONTE ROSA THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>61225M102</cusip>
    <value>3059930</value>
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    <nameOfIssuer>MOONLAKE IMMUNOTHERAPEUTICS</nameOfIssuer>
    <titleOfClass>CLASS A ORD</titleOfClass>
    <cusip>61559X104</cusip>
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      <sshPrnamtType>SH</sshPrnamtType>
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    <votingAuthority>
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      <None>0</None>
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    <nameOfIssuer>NEUROGENE INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>64135M105</cusip>
    <value>28634478</value>
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    <nameOfIssuer>PACIFIC BIOSCIENCES CALIF IN</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>69404D108</cusip>
    <value>955372</value>
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      <None>0</None>
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    <titleOfClass>COM</titleOfClass>
    <cusip>71535D106</cusip>
    <value>10192000</value>
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      <sshPrnamt>1600000</sshPrnamt>
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    <votingAuthority>
      <Sole>1600000</Sole>
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      <None>0</None>
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    <nameOfIssuer>PRIME MEDICINE INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>74168J101</cusip>
    <value>11021769</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3167175</sshPrnamt>
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      <Sole>3167175</Sole>
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      <None>0</None>
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    <nameOfIssuer>QIAGEN NV</nameOfIssuer>
    <titleOfClass>ORD SHARES</titleOfClass>
    <cusip>N72482156</cusip>
    <value>14414400</value>
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      <sshPrnamt>360000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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      <Sole>360000</Sole>
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    </votingAuthority>
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    <nameOfIssuer>QUEST DIAGNOSTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>74834L100</cusip>
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    <votingAuthority>
      <Sole>50000</Sole>
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    <nameOfIssuer>RECURSION PHARMACEUTICALS IN</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>75629V104</cusip>
    <value>507542</value>
    <shrsOrPrnAmt>
      <sshPrnamt>165323</sshPrnamt>
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      <Sole>165323</Sole>
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    <nameOfIssuer>RELAY THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>75943R102</cusip>
    <value>143464811</value>
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      <sshPrnamt>14418574</sshPrnamt>
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    <nameOfIssuer>REVOLUTION MEDICINES INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>76155X100</cusip>
    <value>250645634</value>
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    <nameOfIssuer>SCHOLAR ROCK HLDG CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>80706P103</cusip>
    <value>17206000</value>
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      <Sole>350000</Sole>
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    </votingAuthority>
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    <nameOfIssuer>SEPTERNA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>81734D104</cusip>
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      <Sole>553268</Sole>
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    <nameOfIssuer>STANDARD BIOTOOLS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>34385P108</cusip>
    <value>81618999</value>
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    <nameOfIssuer>STRUCTURE THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>SPONSORED ADS</titleOfClass>
    <cusip>86366E106</cusip>
    <value>56635000</value>
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    <titleOfClass>COM SHS</titleOfClass>
    <cusip>877619106</cusip>
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    <votingAuthority>
      <Sole>3250000</Sole>
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    <nameOfIssuer>TEMPUS AI INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>88023B103</cusip>
    <value>13300423</value>
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      <Sole>294127</Sole>
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      <None>0</None>
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    <nameOfIssuer>TENAYA THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>87990A106</cusip>
    <value>250627</value>
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      <None>0</None>
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    <titleOfClass>COM</titleOfClass>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
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      <Shared>0</Shared>
      <None>0</None>
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</informationTable>
