X0306 4 2023-03-03 0 0001534133 GRAYBUG VISION, INC. GRAY 0001241009 BREUIL ROBERT S C/O GRAYBUG VISION, INC. 274 REDWOOD SHORES PARKWAY, PO BOX 144 REDWOOD CITY CA 94065 0 1 0 0 Chief Financial Officer Common Stock 2023-03-03 4 M 0 121217 A 208283 D Common Stock 2023-03-03 4 F 0 49434 0.57 D 158849 D Restricted Stock Units 2023-03-03 4 M 0 9937 0.00 D Common Stock 9937 89438 D Restricted Stock Unit 2023-03-03 4 M 0 83155 0.00 D Common Stock 83155 0 D Restricted Stock Unit 2023-03-03 4 M 0 28125 0.00 D Common Stock 28125 393750 D Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Issuer's common stock. The RSUs vested as to 1/4 of the total shares on May 19, 2022, and 1/16 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on May 19, 2025, subject to the continued service of the Reporting Person to the Issuer through each vesting date. The RSUs do not expire; they either vest or are canceled prior to vest date. The RSUs shall vested as to 100% of the total RSUs on February 28, 2023 and settled on March 3, 2023, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The RSUs shall vested as to 6.25% of the total shares on November 16, 2022, and 6.25% of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on August 16, 2026, subject to the continued service of the Reporting Person to the Issuer through each vesting date. /s/ Frederic Guerard, as Attorney-in-Fact for Robert S. Breuil 2023-03-06