X0306 4 2021-12-04 0 0001534133 GRAYBUG VISION, INC. GRAY 0001241009 BREUIL ROBERT S C/O GRAYBUG VISION, INC. 203 REDWOOD SHORES PARKWAY, SUITE 620 REDWOOD CITY CA 94065 0 1 0 0 Chief Financial Officer Common Stock 2021-12-04 4 M 0 5000 A 17717 D Restricted Stock Units 2021-12-04 4 M 0 5000 0.00 D Common Stock 5000 55000 D Each RSU represents a contingent right to receive one share of the Issuer's common stock. The RSUs vested as to 1/4 of the total shares on September 4, 2021 but did not settle until September 22, 2021. 1/12 of the remaining shares shall vest quarterly thereafter such that the RSUs shall be fully vested on September 4, 2024, subject to the continued service of the Reporting Person to the Issuer through each vesting date. The RSUs do not expire; they either vest or are canceled prior to vest date. /s/ Frederic Guerard, as Attorney-in-Fact for Robert S. Breuil 2021-12-07