UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

SCHEDULE 14A

(Rule 14a-101)

INFORMATION REQUIRED IN PROXY STATEMENT

SCHEDULE 14A INFORMATION

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Securities Exchange Act of 1934

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☐ Soliciting Material Pursuant to §240.14a-12

CALCIMEDICA, INC.

(Name of Registrant as Specified In Its Charter)

N/A

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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Your control numberYour votematters!Meeting Materials: Notice of Meeting and ProxyStatement & Annual Report on Form 10-KImportant Notice Regarding the Availabilityof Proxy Materials for the StockholdersMeeting To Be Held On June 24, 2025 ForStockholders of Record as of April 28, 2025To order paper materials, use one of thefollowing methods.Internet:www.investorelections.com/CALCCall:1-866-648-8133Email:paper@investorelections.com* If requesting material by e-mail, please send a blank e-mail with the12 digit control number (located below) in the subject line. No otherrequests, instructions OR other inquiries should be included with youre-mail requesting material.Have the 12 digit control number located in thebox above available when you access thewebsite and follow the instructions.Copyright © 2025 BetaNXT, Inc. or its affiliates. All Rights ReservedCalciMedica, Inc.Annual Meeting of StockholdersTuesday, June 24, 2025 9:00 AM, Pacific TimeAnnual Meeting to be held live via the Internet—please visit www.proxydocs.com/CALC formore details.You must register to attend the meeting online and/or participate atwww.proxydocs.com/CALCFor a convenient way to view proxy materials, VOTE, and obtaindirections to attend the meeting go to www.proxydocs.com/CALCTo vote your proxy while visiting this site, you will need the 12 digitcontrol number in the box below.This communication presents only an overview of the more complete proxy materials that areavailable to you on the Internet. This is not a ballot. You cannot use this notice to vote yourshares. We encourage you to access and review all of the important information contained inthe proxy materials before voting.Under United States Securities and Exchange Commission rules, proxy materials do not haveto be delivered in paper. Proxy materials can be distributed by making them available on theinternet.If you want to receive a paper or e-mail copy of the proxy material, you must request one.There is no charge to you for requesting a copy. In order to receive a paper package in timefor this year’s meeting, you must make this request on or before June 13, 2025.styleINAP.O. BOX 8016, CARY, NC 27512-9903SEE REVERSE FOR FULL AGENDA

PROPOSAL1. To elect three Class II directors, each to serve a three-year term through the 2028 annual meeting of stockholders following the 2025 annualmeeting of stockholders and until a successor has been elected and qualified or until earlier resignation or removal.1.01 A. Rachel Leheny, Ph.D.1.02 Eric W. Roberts1.03 Frederic Guerard, Pharm.D.2. To ratify the appointment of Moss Adams LLP as our independent registered public accounting firm for the fiscal year ending December 31,2025.3. To approve an amendment to the CalciMedica, Inc. Amended 2023 Equity Incentive Plan, to, among other things, increase the number of sharesof our common stock authorized for issuance under the 2023 Plan by 600,000 shares.THE BOARD OF DIRECTORS RECOMMENDS A VOTEFOR each of the nominees for director listed below and FOR Proposal 2 and 3CalciMedica, Inc. Annual Meeting of Stockholders