<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-06-27</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001613103</issuerCik>
        <issuerName>Medtronic plc</issuerName>
        <issuerTradingSymbol>MDT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001533098</rptOwnerCik>
            <rptOwnerName>Smith Gregory L</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>710 MEDTRONIC PARKWAY LC300</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>MINNEAPOLIS</rptOwnerCity>
            <rptOwnerState>MN</rptOwnerState>
            <rptOwnerZipCode>55432</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>EVP Global Ops &amp; Supply Chain</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Ordinary Shares</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>28905</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Performance Share Units</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F4"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Performance Share Units</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>9564</value>
                    <footnoteId id="F3"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Performance Share Units</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F4"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Performance Share Units</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>8317</value>
                    <footnoteId id="F5"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>120.25</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2022-04-05</value>
                <footnoteId id="F6"/>
            </exerciseDate>
            <expirationDate>
                <value>2031-04-05</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Ordinary Shares</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>30837</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>131.26</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2022-08-02</value>
                <footnoteId id="F6"/>
            </exerciseDate>
            <expirationDate>
                <value>2031-08-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Ordinary Shares</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>31028</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Performance Share Units</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F4"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F7"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Performance Share Units</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>8762</value>
                    <footnoteId id="F8"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Includes 18,695 restricted stock units that vest on 4/5/23, 3,910 restricted stock units that vest on 8/23/23 and 3,564 restricted stock units that vest on 8/2/24.</footnote>
        <footnote id="F2">Vests on August 3, 2023.</footnote>
        <footnote id="F3">The number of shares to be issued in connection with the performance share units (&quot;PSUs&quot;) will vary depending on the level of certain performance metrics achieved over a three (3) year performance period. If target performance
metrics are achieved, 9,564 shares will be issued.  If minimum performance metrics are not met, such PSUs may vest at 0 shares.</footnote>
        <footnote id="F4">Each Performance Share Unit represents a contingent right to receive one share of Medtronic Common Stock.</footnote>
        <footnote id="F5">The number of shares to be issued in connection with the performance share units (&quot;PSUs&quot;) will vary depending on the level of certain performance metrics achieved over a three (3) year performance period. If target performance
metrics are achieved, 8,317 shares will be issued.  If minimum performance metrics are not met, such PSUs may vest at 0 shares.</footnote>
        <footnote id="F6">These options become exercisable at the rate of 25% of the shares granted per year beginning on the first anniversary of grant.</footnote>
        <footnote id="F7">Vests on August 2, 2024.</footnote>
        <footnote id="F8">The number of shares to be issued in connection with the performance share units (&quot;PSUs&quot;) will vary depending on the level of certain performance metrics achieved over a three (3) year performance period. If target performance
metrics are achieved, 8,762 shares will be issued.  If minimum performance metrics are not met, such PSUs may vest at 0 shares.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Thomas L. Osteraas, attorney-in-fact</signatureName>
        <signatureDate>2022-07-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
