Stockholders' Equity (Details - Warrants outstanding) - Warrant [Member] - $ / shares	3 Months Ended
	Mar. 31, 2023	Dec. 31, 2022
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Outstanding	545,401	545,401
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
April 2018 Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 2,079.00
Warrant expiration date	May 31, 2023
Class of Warrant or Right, Outstanding	1,720	1,720
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
April 2018 Placement Agent Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 2,676.00
Warrant expiration date	Apr. 09, 2023
Class of Warrant or Right, Outstanding	117	117
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
October 2018 Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 125.40
Warrant expiration date	Oct. 03, 2025
Class of Warrant or Right, Outstanding	32,486	32,486
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
October 2018 Underwriter Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 156.72
Warrant expiration date	Oct. 01, 2023
Class of Warrant or Right, Outstanding	2,438	2,438
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
Nov 2019 Placement Agent Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 82.50
Warrant expiration date	Nov. 18, 2024
Class of Warrant or Right, Outstanding	1,138	1,138
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
Feb 2020 Registered Direct Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 104.52
Warrant expiration date	Aug. 06, 2025
Class of Warrant or Right, Outstanding	16,425	16,425
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
Feb 2020 Placement Agent Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 132.45
Warrant expiration date	Feb. 04, 2025
Class of Warrant or Right, Outstanding	1,233	1,233
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
Feb 2020 Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 48.00
Warrant expiration date	Feb. 13, 2025
Class of Warrant or Right, Outstanding	110,557	110,557
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
Feb 2020 Underwriter Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 60.00
Warrant expiration date	Feb. 11, 2025
Class of Warrant or Right, Outstanding	12,501	12,501
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
April 2020 Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 26.52
Warrant expiration date	Oct. 02, 2025
Class of Warrant or Right, Outstanding	35,691	35,691
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
April 2020 Placement Agent Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 35.03
Warrant expiration date	Mar. 31, 2025
Class of Warrant or Right, Outstanding	3,481	3,481
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
January 2021 Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 36.00
Warrant expiration date	Jul. 27, 2026
Class of Warrant or Right, Outstanding	285,061	285,061
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
January 2021 Placement Agent Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 46.05
Warrant expiration date	Jul. 27, 2026
Class of Warrant or Right, Outstanding	28,509	28,509
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0
February 2021 Placement Agent Warrants [Member]
Class of Warrant or Right [Line Items]
Class of Warrant or Right, Exercise Price of Warrants or Rights	$ 51.30
Warrant expiration date	Feb. 12, 2026
Class of Warrant or Right, Outstanding	14,044	14,044
Warrants issued, shares	0
Warrants exercised, shares	0
Warrants expired, shares	0