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Table of Contents

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

FORM 10-K

(Mark One)

 

  ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 

For the fiscal year ended December 31, 2022

 

Or

 

  ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

 

For the transition period from                       to                     

 

Commission File Number 001-36304

   

PHIO PHARMACEUTICALS CORP.

(Exact name of registrant as specified in its charter)

   

Delaware 45-3215903

(State or other jurisdiction of

incorporation or organization)

(I.R.S. Employer

Identification No.)

 

257 Simarano Drive, Suite 101, Marlborough, Massachusetts 01752

(Address of principal executive offices and Zip Code)

 

(508) 767-3861

(Registrant’s telephone number, including area code)

 

Securities registered pursuant to Section 12(b) of the Act:

 

Title of each class Trading Symbol(s) Name of each exchange on which registered
Common Stock, par value, $0.0001 per share PHIO The Nasdaq Capital Market

 

Securities registered pursuant to Section 12(g) of the Act:

 

None.

 
Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. ☐ Yes   ☒ No

 

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. ☐ Yes   ☒ No

 

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. ☒ Yes   ☐ No

 

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). ☒ Yes   ☐ No

 

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

 

Large accelerated filer ☐ Accelerated filer ☐
Non-accelerated filer ☒ Smaller reporting company ☒
    Emerging growth company ☐

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

 

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. ☐

 

If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements. ☐

 

Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b). ☐

 

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). ☐ Yes   ☒ No

 

The aggregate market value of the registrant’s common stock, $0.0001 par value per share (“Common Stock”), held by non-affiliates of the registrant, based on the closing sale price of the registrant’s Common Stock on June 30, 2022, was approximately $9.5 million. Shares of Common Stock held by each officer and director and by each person who is known to own 10% or more of the outstanding Common Stock have been excluded in that such persons may be deemed to be affiliates of the registrant. This determination of affiliate status is not necessarily a conclusive determination for other purposes.

 

As of March 9, 2023, the registrant had 1,150,582 shares of Common Stock outstanding.

 

DOCUMENTS INCORPORATED BY REFERENCE

 

None.

 

 

 

   

 

 

TABLE OF CONTENTS

 

PHIO PHARMACEUTICALS CORP.

ANNUAL REPORT ON FORM 10-K

For the Fiscal Year Ended December 31, 2022

 

    Page
PART I.
Item 1. BUSINESS 2
Item 1A. RISK FACTORS 15
Item 1B. UNRESOLVED STAFF COMMENTS 27
Item 2. PROPERTIES 27
Item 3. LEGAL PROCEEDINGS 27
Item 4. MINE SAFETY DISCLOSURES 27
   
PART II.
Item 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES 28
Item 6. RESERVED 28
Item 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS 28
Item 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK 36
Item 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA 36
Item 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE 37
Item 9A. CONTROLS AND PROCEDURES 37
Item 9B. OTHER INFORMATION 38
Item 9C. DISCLOSURE REGARDING FOREIGN JURISDICTIONS THAT PREVENT INSPECTIONS 38
     
PART III.
Item 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE 39
Item 11. EXECUTIVE COMPENSATION 41
Item 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS 45
Item 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE 47
Item 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES 48
   
PART IV.
Item 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES 49
Item 16. FORM 10-K SUMMARY 51
   
Signatures 52

 

 

 

 i 

 

 

FORWARD-LOOKING STATEMENTS

 

This Annual Report on Form 10-K contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as “intends,” “believes,” “anticipates,” “indicates,” “plans,” “expects,” “suggests,” “may,” “would,” “should,” “potential,” “designed to,” “will,” “ongoing,” “estimate,” “forecast,” “target,” “predict,” “could,” and similar references, although not all forward-looking statements contain these words. Forward-looking statements are neither historical facts nor assurances of future performance. These statements are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements as a result of a number of important factors, including, but not limited to:

 

  · we are dependent on the success of our INTASYL™ technology platform, and our product candidates based on this platform, which is unproven and may never lead to approved and marketable products;
  · our product candidates are in an early stage of development and we may fail, experience significant delays, never advance in clinical development or not be successful in our efforts to identify or discover additional product candidates, which may materially and adversely impact our business;
  · we are dependent on collaboration partners for the successful development of our adoptive cell therapy product candidates;
  · if we experience delays or difficulties in identifying and enrolling subjects in clinical trials, it may lead to delays in generating clinical data and the receipt of necessary regulatory approvals;
  · topline data may not accurately reflect or may materially differ from the complete results of a clinical trial;
  · we rely upon third parties for the manufacture of the clinical supply for our product candidates;
  · we are dependent on the patents we own and the technologies we license, and if we fail to maintain our patents or lose the right to license such technologies, our ability to develop new products would be harmed;
  · we will require substantial additional funds to complete our research and development activities;
  · future financing may be obtained through, and future development efforts may be paid for by, the issuance of debt or equity, which may have an adverse effect on our stockholders or may otherwise adversely affect our business; and
  · the price of our common stock has been and may continue to be volatile.

 

The risks set forth above are not exhaustive and additional factors, including those identified in this Annual Report on Form 10-K under the heading “Risk Factors,” for reasons described elsewhere in this Annual Report on Form 10-K and in other filings Phio Pharmaceuticals Corp. periodically makes with the Securities and Exchange Commission, could adversely affect our business and financial performance. Therefore, you should not rely unduly on any of these forward-looking statements. Forward-looking statements contained in this Annual Report on Form 10-K speak as of the date hereof and Phio Pharmaceuticals Corp. does not undertake to update any of these forward-looking statements to reflect a change in its views or events or circumstances that occur after the date of this report, except as required by law.

 

 

 

 1 

 

 

PART I

 

Unless otherwise noted, (1) the term “Phio” refers to Phio Pharmaceuticals Corp. and our subsidiary, MirImmune, LLC and (2) the terms “Company,” “we,” “us” and “our” refer to the ongoing business operations of Phio and MirImmune, LLC, whether conducted through Phio or MirImmune, LLC.

 

ITEM 1. BUSINESS

 

Overview

 

Phio Pharmaceuticals Corp. (“Phio,” “we,” “our” or the “Company”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology platform is designed to make immune cells more effective in killing tumor cells. We are developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems. We are committed to discovering and developing innovative cancer treatments for patients by creating new pathways toward a cancer-free future.

 

INTASYL Platform

 

Overall, RNA is involved in the synthesis, regulation and expression of proteins. RNA takes the instructions from DNA and turns those instructions into proteins within the body’s cells. RNA interference, or RNAi, is a biological process that inhibits the expression of genes or the production of proteins. Diseases are often related to the incorrect protein being made, excessive amounts of a specific protein being made, or the correct protein being made, but at the wrong location or time. RNAi offers a novel approach to drug development because RNAi compounds can be designed to silence any one of the thousands of human genes, many of which are considered “undruggable” by traditional therapeutics.

 

Our development efforts are based on our proprietary INTASYL self-delivering RNAi technology platform. It is a patented platform from which specific patented compounds are developed. INTASYL compounds are comprised of a unique sequence of chemically modified nucleotides (modified small interfering RNA, or siRNAs) that target a broad range of cell types and tissues. The compounds are designed to effectively silence genes that tumors use to evade the immune system.

 

Since the initial discovery of RNAi, drug delivery has been the primary challenge in developing RNAi-based therapeutics. Other siRNA technologies require cell targeting chemical conjugates which limit delivery to specific cell types. INTASYL is based on proprietary chemistry that is designed to maximize the activity and adaptability of the compound and is unique in that it can be delivered to any cell type or tissue without the need to modify the chemistry. This is designed to eliminate the need for formulations or delivery systems (for example, nanoparticles or electroporation). This provides efficient, spontaneous, cellular uptake with potent, long-lasting intracellular activity.

 

We believe that our INTASYL platform provides the following benefits including, but not limited to:

 

  · Ability to target a broad range of cell types and tissues;
  · Ability to target both intracellular and extracellular protein targets;
  · Efficient uptake by target cells, avoiding the need for assisted delivery;
  · Sustained, or long-term, effect in vivo;
  · Ability to target multiple genes in one drug product;
  · Favorable clinical safety profile with local administration; and
  · Readily manufactured under current good manufacturing practices.

 

 

 

 2 

 

 

Our Pipeline

 

INTASYL compounds are designed to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems, and are designed to make immune cells more effective in killing tumor cells. Our efforts are focused on developing immuno-oncology therapeutics using our INTASYL platform. We have demonstrated preclinical activity against multiple gene targets including PD-1, BRD4, CTLA-4, TIGIT and CTGF and have demonstrated preclinical efficacy in both direct-to-tumor injection and adoptive cell therapy (“ACT”) applications with our INTASYL compounds.

 

The following table summarizes our product pipeline. Below we provide important information and context regarding each compound.

 

Chart, bar chart Description automatically generated

 

PH-762

 

PH-762 is an INTASYL compound designed to reduce the expression of cell death protein 1 (“PD-1”). PD-1 is a protein that inhibits T cells’ ability to kill cancer cells and is a clinically validated target in immunotherapy. Decreasing the expression of PD-1 can thereby increase the capacity of T cells, which protect the body from cancer cells and infections, to kill cancer cells.

 

Preclinical studies conducted by the Company have demonstrated that direct-to-tumor application of PH-762 resulted in potent anti-tumoral effects and have shown that direct-to-tumor treatment with PH-762 inhibits tumor growth in a dose dependent fashion in PD-1 responsive and refractory models. Importantly, direct-to-tumor administration of PH-762 resulted in activity against distant untreated tumors, indicative of a systemic anti-tumor response. We believe these data further support the potential for PH-762 to provide a strong local immune response without the dose immune-related adverse effects seen with systemic antibody therapy.

 

 

 

 3 

 

 

PH-762 is currently being evaluated in a Phase 1b dose escalation clinical trial in France that is expected to enroll up to 21 subjects with advanced melanoma. PH-762 will be administered as a neoadjuvant monotherapy intratumorally once a week, for a total of four injections, across five escalating dose levels. Dosing will be followed by tumoral excision after an additional two weeks. The primary study objectives are to evaluate the safety and tolerability, and pharmacokinetics of PH-762; to determine the potential immunologic and pathologic tumor responses; and to determine the recommended dose for later clinical trials. Safety data from the initial cohort of three subjects in the clinical trial was evaluated by a Data Monitoring Committee in the first quarter of 2023. The safety data review disclosed no dose-limiting toxicity, and no drug-related severe or serious adverse events, and the Data Monitoring Committee recommended proceeding to the enrollment of the subsequent dose cohort. The next cohort is now open for enrollment of subjects.

 

In addition to the French clinical trial, we expect to commence a U.S. Phase 1b clinical trial with PH-762 in the second half of 2023. The U.S. trial is expected to focus on the application of PH-762 to treat cutaneous squamous cell carcinoma (“cSCC”) and other selected cutaneous malignancies.

 

Due to INTASYL’s ease of administration, we have shown that our compounds can easily be incorporated into current ACT manufacturing processes. In ACT, T cells are usually taken from a patient's own blood or tumor tissue, grown in large numbers in a laboratory, and then given back to the patient to help the immune system fight cancer. By treating T cells with our INTASYL compounds while they are being grown in the laboratory, we believe our INTASYL compounds can improve these immune cells to make them more effective in killing cancer. Preclinical data generated in collaboration with AgonOx, Inc. (“AgonOx”), a private company developing a pipeline of novel immunotherapy drugs targeting key regulators of the immune response to cancer, demonstrated that treating AgonOx’s “double positive” tumor infiltrating lymphocyte (“DP TIL”) with PH-762 increased by two-fold their tumor killing activity.

 

In March 2021, we entered into a clinical co-development collaboration agreement (the “Clinical Co-Development Agreement”) with AgonOx to conduct a Phase 1 clinical trial using DP TIL and PH-762. Under the Clinical Co-Development Agreement, we paid AgonOx $0.3 million as an upfront payment in December 2022 and have agreed to provide up to $4 million in total financial support to AgonOx to conduct a Phase 1 clinical trial of PH-762 treated DP TIL. Phio is also eligible to receive certain future development milestones and low single-digit sales-based royalty payments from AgonOx’s licensing of its DP TIL technology.

 

PH-762 treated DP TILs are expected to be evaluated in a Phase 1 clinical trial in the United States with up to 18 subjects with advanced melanoma and other advanced solid tumors. The primary study objectives are to evaluate the safety and to study the potential for enhanced therapeutic benefit from the administration of PH-762 treated DP TILs. Enrollment of subjects is expected to commence in the second quarter of 2023.

 

PH-762’s use in ACT is not limited to TILs. We have presented preclinical data showing that PH-762 significantly enhanced the antitumor efficacy of HER2-targeted chimeric antigen receptor (“CAR”) T cells (“HER2CART”) in solid tumors. Analysis of the PH-762 treated HER2CART cells isolated from the tumors suggest that PH-762 enhances CAR-T cell function through multiple mechanisms including enhanced efficiency, degranulation and promotion of memory/stem populations.

 

PH-894

 

PH-894 is an INTASYL compound that is designed to silence BRD4, a protein that controls gene expression in both T cells and tumor cells, thereby effecting the immune system as well as the tumor. Intracellular and/or commonly considered “undruggable” targets, such as BRD4, represent a challenge for small molecule and antibody therapies. Therefore, what sets this compound apart is its dual mechanism: PH-894 suppression of BRD4 in T cells results in T cell activation, and suppression of BRD4 in tumor cells results in tumors becoming more sensitive to being killed by T cells.

 

Preclinical studies conducted have demonstrated that PH-894 resulted in a strong, concentration dependent and durable silencing of BRD4 in T cells and in various cancer cells. Similar to PH-762, preclinical studies have also shown that direct-to-tumor application of PH-894 resulted in potent and statistically significant anti-tumoral effects and demonstrated a systemic anti-tumor response. These preclinical data indicate that PH-894 can reprogram T cells and other cells in the tumor microenvironment to provide enhanced immunotherapeutic activity. The Company has completed the investigational new drug (“IND”)-enabling studies and is in the process of finalizing the study reports required for an IND submission with PH-894. As a result of the reprioritization to advance the Company’s clinical trial with PH-762 in the U.S., the Company has elected to defer the IND submission for PH-894.

  

Phio has also demonstrated in preclinical studies that PH-894 has been shown to improve T cell function and persistence by differentiating T cells into a more active state (stem-cell like memory phenotype). Preclinical data indicates that silencing BRD4 with PH-894 may be used to improve the characteristics of CAR-T cell products during the cell manufacturing process. These data demonstrate that PH-894 could enhance the activity of CAR-T cells by improving the quality of the final CAR-T cell product by overcoming immunosuppression, reversing exhaustion, and preserving the characteristics associated with cell persistence.

 

 

 

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Other Compounds in Discovery

 

PH-804 is an INTASYL compound that is designed to target TIGIT, a protein that inhibits the activity of Natural Killer (“NK”) cells. Preclinical studies conducted have demonstrated that NK cells treated with PH-804 displayed increased activation and enhanced the ability of NK cells to kill cancer cells.  

 

PH-109 is an INTASYL compound that is designed to suppress the connective tissue growth factor (“CTGF”) protein, a protein that regulates a number of cellular functions and is associated with poor prognosis in breast cancer. In a preclinical study, mice were treated with either the drug doxorubicin, a chemotherapeutic which has a high toxicity profile, or with PH-109. In this study, PH-109 reduced tumor growth and reduced metastatic lung lesions, with no evidence of toxicity as compared to the toxicity profile of doxorubicin.

 

Phio has developed an INTASYL compound that is designed to target CTLA-4, a protein that inhibits the ability of T cells to kill tumor cells. The CTLA-4 targeting INTASYL compound demonstrated dose-associated anti-tumor efficacy in two preclinical tumor models. Delivering CTLA-4 by intratumoral injection may avoid or minimize the severe systemic adverse events associated with current CTLA-4 therapeutics.

 

We are also investigating the use of INTASYL to target multiple genes in a single formulation. Unlike other combination approaches, we believe the INTASYL platform can target multiple protein drug targets in a specific therapeutic dose, enhancing potency while maintaining a favorable tolerability and safety profile. Preclinical data has shown that combining PH-762 and PH-894 in a single formulation elicited complete cure of tumors in a liver cancer model and outperformed the efficacy of the small molecule and antibody control treatments toward the same targets. In addition, local INTASYL therapy was shown to induce a systemic anti-tumor response with the clearance of distant untreated tumors. We believe that these data demonstrate that the use of INTASYL to target multiple genes may provide a durable and systemic anti-tumor immune response that can combat tumor growth.

 

Intellectual Property

 

INTASYL compounds have a single-stranded phosphorothioate region, a short duplex region, and contain a variety of nuclease-stabilizing and lipophilic chemical modifications that we believe combines the beneficial properties of both conventional RNAi and antisense technologies. We protect our proprietary information by means of United States and foreign patents, trademarks and copyrights. In addition, we rely upon trade secret protection and contractual arrangements to protect certain of our proprietary information and products. We have pending patent applications that relate to potential drug targets, compounds we are developing to modulate those targets, methods of making or using those compounds and proprietary elements of our drug discovery platform.

 

We have also obtained rights to various patents and patent applications under licenses with third parties, which require us to pay royalties, milestone payments, or both. The degree of patent protection for biotechnology products and processes, including ours, remains uncertain, both in the United States and in other important markets, because the scope of protection depends on decisions of patent offices, courts and lawmakers in these countries. There is no certainty that our existing patents or others, if obtained, will afford us substantial protection or commercial benefit. Similarly, there is no assurance that our pending patent applications or patent applications licensed from third parties will ultimately be granted as patents or that those patents that have been issued or are issued in the future will stand if they are challenged in court. We assess our license agreements on an ongoing basis and may from time to time terminate licenses to technology that we do not intend to employ in our technology platforms, or in our product discovery or development activities.

  

 

 

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Patents and Patent Applications

 

We are actively seeking protection for our intellectual property and are prosecuting a number of patents and pending patent applications covering our compounds and technologies. A combined summary of these patents and patent applications is set forth below in the following table:

 

   

Pending

Applications

    

Issued

Patents

  
United States     9       46  
Canada     6       4  
Europe     12       39  
Japan     9       16  
Other Markets     11       14  

 

Our portfolio includes 119 issued patents, 87 of which cover our INTASYL platform. There are 17 patent families broadly covering both the composition and methods of use of our self-delivering platform technology and uses of our INTASYL compounds targeting immune checkpoint, cellular differentiation and metabolism targets for ex vivo cell-based cancer immunotherapies. These patents are scheduled to expire between 2029 and 2040. Furthermore, there are 47 patent applications, encompassing what we believe to be important new RNAi compounds and their use as therapeutics, chemical modifications of RNAi compounds that improve the compounds’ suitability for therapeutic uses (including delivery) and compounds directed to specific targets (i.e., that address specific disease states). The patents and any patents that may issue from these pending patent applications will, if issued, be set to expire between 2022 and 2040, not including any patent term extensions that may be afforded under the Federal Food, Drug, and Cosmetic Act (“FFDCA”) (and the equivalent provisions in foreign jurisdictions) for any delays incurred during the regulatory approval process relating to human drug products (or processes for making or using human drug products).

 


Key Intellectual Property License Agreements

 

As we develop our own proprietary compounds, we continue to evaluate our in-licensed portfolio as well as the field for new technologies that could be in-licensed to further enhance our intellectual property portfolio and unique intellectual property position.

 

Advanced RNA Technologies, LLC (“Advirna”). In September 2011, the Company entered into an agreement with Advirna, pursuant to which Advirna assigned to us its existing patent and technology rights related to the INTASYL technology in exchange for an annual maintenance fee, a one-time milestone payment upon the future issuance of the first patent with valid claims covering the assigned patent and technology rights and the issuance of shares of common stock of the Company equal to 5% of the Company’s fully-diluted shares outstanding at the time of issuance. In 2012, we issued shares of common stock of the Company to Advirna equal to 5% of our fully-diluted shares outstanding at the time of issuance and paid $350,000 to Advirna upon the issuance of the first patent in 2014. Additionally, we also pay to Advirna an annual maintenance fee of $100,000 and are required to pay low single-digit royalties on any licensing revenue received by us with respect to future licensing of the assigned Advirna patent and technology rights. To date, any royalties owed to Advirna under the agreement have been minimal.

 

Our rights under the Advirna agreement will expire upon the later of: (i) the expiration of the last-to-expire of the “patent rights” (as defined therein) included in the agreement or (ii) the abandonment of the last-to-be abandoned of such patents, unless earlier terminated in accordance with the provisions of the agreement. Further, the Company also granted back to Advirna a license under the assigned patent and technology rights for fields of use outside human therapeutics.

 

 

 

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Manufacturing and Supply

 

We do not have any manufacturing capability and therefore we currently rely on and intend to continue to rely on contract manufacturing organizations to produce our product candidates in accordance with regulatory requirements.

 

We currently rely on and contract with third parties for the manufacture of drug substances and drug products for use in our preclinical studies and clinical trials in accordance with regulatory requirements. We intend that we will continue to rely on and contract with third parties to manufacture our product candidates in the future.

 

Competition

 

The biotechnology and pharmaceutical industries, including the immuno-oncology field, are a constantly evolving landscape with rapidly advancing technologies and significant competition. There are a number of competitors in the immuno-oncology field including large and small pharmaceutical and biotechnology companies, academic institutions, government agencies and other private and public research organizations. Many of these companies are larger than us and have greater financial resources and human capital to develop competing products.

 

Government Regulation

 

Review and Approval of Drugs in the United States

 

The United States and many other countries extensively regulate the preclinical and clinical testing, manufacturing, labeling, storage, record-keeping, advertising, promotion, export, marketing and distribution of drugs and biologic products. The U.S. Food and Drug Administration (“FDA”) regulates pharmaceutical and biologic products under the FFDCA, the Public Health Service Act and other federal statutes and regulations.

  

To obtain approval of our future product candidates from the FDA, we must, among other requirements, submit data supporting safety and efficacy for the intended indication as well as detailed information on the manufacture and composition of the product candidate. In most cases, this will require extensive laboratory tests, preclinical studies and clinical trials. The collection of these data, as well as the preparation of applications for review by the FDA involve significant time and expense. The FDA also may require post-marketing testing to monitor the safety and efficacy of approved products or place conditions on any approvals that could restrict the therapeutic claims and commercial applications of these products. Regulatory authorities may withdraw product approvals if we fail to comply with regulatory standards or if we encounter problems at any time following initial marketing of our products.

 

The first stage of the FDA approval process for a new biologic or drug involves completion of preclinical studies and the submission of the results of these studies to the FDA. These data, together with proposed clinical protocols, manufacturing information, analytical data and other information submitted to the FDA in an IND application, must become effective before human clinical trials may commence. Preclinical studies generally involve FDA regulated laboratory evaluation of product characteristics and animal studies to assess the efficacy and safety of the product candidate.

 

 

 

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After the IND becomes effective, a company may commence human clinical trials. These are typically conducted in three sequential phases, but the phases may overlap. Phase 1 trials consist of testing the product candidate in a small number of patients or healthy volunteers, primarily for safety at one or more doses. Phase 2 trials, in addition to safety, evaluate the efficacy of the product candidate in a patient population somewhat larger than Phase 1 trials. Phase 3 trials typically involve additional testing for safety and clinical efficacy in an expanded population at multiple test sites. A company must submit to the FDA a clinical protocol, accompanied by the approval of the Institutional Review Board (“IRB”) at the institutions participating in the trials, prior to commencement of each clinical trial.

 

To obtain FDA marketing authorization, a company must submit to the FDA the results of the preclinical and clinical testing, together with, among other things, detailed information on the manufacture and composition of the product candidate, in the form of a new drug application (“NDA”), or, in the case of a biologic, a biologics license application (“BLA”).

 

The amount of time taken by the FDA for approval of an NDA or BLA will depend upon a number of factors, including whether the product candidate has received priority review, the quality of the submission and studies presented, the potential contribution that the compound will make in improving the treatment of the disease in question and the workload of the FDA’s staff.

 

The FDA may, in some cases, confer upon an investigational product the status of a fast track product. A fast track product is defined as a new drug or biologic intended for the treatment of a serious or life-threatening condition that demonstrates the potential to address unmet medical needs for this condition. The FDA can base approval of an NDA or BLA for a fast track product utilizing a surrogate endpoint, or on another endpoint that is reasonably likely to predict clinical benefit. If a preliminary review of clinical data suggests that a fast track product may be effective, the FDA may initiate review of entire sections of a marketing application for a fast track product before the sponsor completes the application.

 

We anticipate that our products will be manufactured by our strategic partners, licensees or other third parties. Before approving an NDA or BLA, the FDA will inspect the facilities at which the product is manufactured and will not approve the product unless the manufacturing facilities are in compliance with the FDA’s current good manufacturing practice regulations (“cGMP”), which are regulations that govern the manufacture, holding and distribution of a product. Manufacturers of biologics also must comply with the FDA’s general biological product standards. Our manufacturers also will be subject to regulation under the Occupational Safety and Health Act, the Nuclear Energy and Radiation Control Act, the Toxic Substance Control Act and the Resource Conservation and Recovery Act and other applicable environmental statutes. Following approval, the FDA periodically inspects drug and biologic manufacturing facilities to ensure continued compliance with the cGMP. Our manufacturers will have to continue to comply with those requirements. Failure to comply with these requirements subjects the manufacturer to possible legal or regulatory action, such as suspension of manufacturing or recall or seizure of product. Adverse patient experiences with the product must be reported to the FDA and could result in the imposition of marketing restrictions through labeling changes or market removal. Product approvals may be withdrawn if compliance with regulatory requirements is not maintained or if problems concerning safety or efficacy of the product occur following approval.

  

The labeling, advertising, promotion, marketing and distribution of a drug or biologic product also must be in compliance with FDA and Federal Trade Commission requirements which include, among others, standards and regulations for off-label promotion, industry sponsored scientific and educational activities, promotional activities involving the internet, and direct-to-consumer advertising. We also will be subject to a variety of federal, state and local regulations relating to the use, handling, storage and disposal of hazardous materials, including chemicals and radioactive and biological materials. In addition, we will be subject to various laws and regulations governing laboratory practices and the experimental use of animals. In each of these areas, failure to comply with the applicable requirements could result in administrative or judicial enforcement action, which could include refusal to permit clinical trials, refusal to approve an application, withdrawal of an approval, issuance of a warning letter, product recall, product seizure, suspension of production or distribution, fines, refusals of government contracts, and restitution, disgorgement or civil or criminal penalties. Any agency or judicial enforcement action could have a material adverse effect on us.

 

We will also be subject to a variety of regulations governing clinical trials and sales of our products outside the United States. Whether or not FDA approval has been obtained, approval of a product candidate by the comparable regulatory authorities of foreign countries and regions must be obtained prior to the commencement of marketing the product in those countries. The approval process varies from one regulatory authority to another and the time may be longer or shorter than that required for FDA approval. In the European Union, Canada and Australia, regulatory requirements and approval processes are similar, in principle, to those in the United States.

 

 

 

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Review and Approval of Drugs in the European Union Including France

 

In order to market any pharmaceutical product outside of the United States, a company must also comply with numerous and varying regulatory requirements of other countries and jurisdictions governing, among other things, research and development, testing, manufacturing, quality control, safety, efficacy, clinical trials, marketing authorization, packaging, storage, record keeping, reporting, export and import, advertising and other promotional practices involving pharmaceutical products, as well as commercial sales, distribution and post-approval monitoring and reporting of our products. Whether or not it obtains FDA approval for a pharmaceutical product, the company would need to obtain the necessary approvals by the comparable foreign regulatory authorities before it can commence clinical trials or marketing of the pharmaceutical product in those countries or jurisdictions. The approval process ultimately varies between countries and jurisdictions and can involve additional product testing and additional administrative review periods. The time required to obtain approval in other countries and jurisdictions might differ from and be longer and far more difficult than that required to obtain FDA approval. Regulatory approval in one country or jurisdiction does not ensure regulatory approval in another, but a failure or delay in obtaining regulatory approval in one country or jurisdiction may negatively impact the regulatory process in others.

 

The United Kingdom (“UK”) formally left the European Union (“EU”) on January 31, 2020 and the transition period, during which EU laws continued to apply to the UK, expired on December 31, 2020. This means EU laws now only apply to the UK in respect of Northern Ireland as laid out in the Protocol on Ireland and Northern Ireland. Following the end of the transition period, the EU and the UK concluded a trade and cooperation agreement (“TCA”), which applied provisionally from January 1, 2021 and entered into force on May 1, 2021.

 

The TCA includes provisions affecting the life sciences sector (including on customs and tariffs) but areas for further discussion between the EU and the UK remain. In addition, there are some specific provisions concerning pharmaceuticals. These include the mutual recognition of Good Manufacturing Practice (“GMP”) and issued GMP documents. The TCA does not, however, contain wholesale mutual recognition of UK and EU pharmaceutical regulations and product standards.

 

Since January 1, 2021, the EU laws which have been transposed into UK law through secondary legislation continue to be applicable in the UK as “retained EU law”. As there is no general power to amend these regulations, the UK government has enacted the Medicines and Medical Devices Act 2021. The purpose of the act is to enable the existing regulatory frameworks in relation to human medicines, clinical trials of human medicines, veterinary medicines and medical devices to be updated. The powers under the act may only be exercised in relation to specified matters and must safeguard public health.

 

Specified provisions of the Medicines and Medical Devices Act 2021 entered into force on February 11, 2021. The remaining provisions came into effect within two months of February 11, 2021 or will otherwise come into effect as stipulated in subsequent statutory instruments. The Medicines and Medical Devices Act 2021 supplements the UK Medical Devices Regulations 2002 (the “UK Regulations”), which are based on the EU Medical Devices Directive as amended to reflect the UK’s post-Brexit regulatory regime. Notably, the UK Regulations do not include any of the revisions that have been made by the EU Medical Devices Regulation (EU) 2017/745, which, since May 26, 2021, now applies in all EU Member States.

 

The UK’s Medicines and Healthcare products Regulatory Agency conducted a comprehensive consultation between September and November 2021 on proposals to develop a new UK regime for medical devices in the UK. The proposals include more closely aligning definitions for medical devices and in vitro medical devices with internationally recognized definitions and changing the classification of medical devices according to levels or risk. The proposals are intended to improve patient and public safety and increase the appeal of the UK market. The new regime is planned to come into force on July 1, 2023, which will align with the date from which the UK is due to stop accepting CE marked medical devices and require UKCA (UK Conformity Assessed) marking. It is envisaged that, in Northern Ireland, the amended regime could run in parallel with any existing or future EU rules in accordance with the Protocol on Ireland and Northern Ireland.

 

 

 

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Drug Development Process

 

The conduct of clinical trials is currently governed by the EU Clinical Trials Directive 2001/20/EC (the “Clinical Trials Directive”), and will be gradually replaced by the EU Clinical Trials Regulation (EU) No. 536/2014 (“CTR”). The CTR introduces a complete overhaul of the existing regulation of clinical trials for medicinal products in the EU. It entered into force on January 31, 2022.

 

Under the current regime, which will expire after a transition period of one or three years, respectively, as outlined below in more detail, before a clinical trial can be initiated, it must be approved in each EU Member State in which the clinical trial is to be conducted. The approval must be obtained from two separate entities: the National Competent Authority (“NCA”) and one or more Ethics Committees. The NCA of the EU Member States in which the clinical trial will be conducted must authorize the conduct of the trial, and the independent Ethics Committee must grant a positive opinion in relation to the conduct of the clinical trial in the relevant EU Member State before the commencement of the trial. Any substantial changes to the trial protocol or other information submitted with the clinical trial applications must be submitted to or approved by the relevant NCA and Ethics Committees. Under the current regime all suspected unexpected serious adverse reactions to the investigated drug that occur during the clinical trial must be reported to the NCA and to the Ethics Committees of the EU Member State where they occur.

 

A more unified procedure applies under the new CTR, which came into force on January 31, 2022. A sponsor is able to submit a single application for approval of a clinical trial through a centralized EU clinical trials portal. One national regulatory authority (the reporting EU Member State proposed by the applicant) takes the lead in validating and evaluating the application, and will consult and coordinate with the other concerned Member States. If an application is rejected, it may be amended and resubmitted through the EU clinical trials portal. If an approval is issued, the sponsor may start the clinical trial in all concerned Member States. However, a concerned EU Member State may in limited circumstances declare an “opt-out” from an approval and prevent the clinical trial from being conducted in such Member State. The CTR also aims to streamline and simplify the rules on safety reporting, and introduces enhanced transparency requirements such as mandatory submission of a summary of the clinical trial results to the EU Database (“CTIS”). While Member States will work in CTIS immediately after the system has gone live, the CTR provides for two transition periods for sponsors: For one year, until January 31, 2023, clinical trial sponsors can still choose whether to submit an initial clinical trial application in line with the current system (Clinical Trials Directive) or via CTIS. From January 31, 2023, submission of initial clinical trial applications via CTIS becomes mandatory, and by January 31, 2025, all ongoing trials approved under the current Clinical Trials Directive will be governed by the new Regulation and have to be transitioned to CTIS.

 

 

Under both the current regime and the new CTR, national laws, regulations, and the applicable Good Clinical Practice and Good Laboratory Practice standards must also be respected during the conduct of the trials, including the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use guidelines on Good Clinical Practice (“GCP”) and the ethical principles that have their origin in the Declaration of Helsinki.

 

Marketing Authorization Procedures

 

In the EU and in Iceland, Norway and Liechtenstein (together, the European Economic Area or “EEA”), after completion of all required clinical testing, pharmaceutical products may only be placed on the market after obtaining a Marketing Authorization (“MA”). To obtain a MA of a drug under EU regulatory systems, an applicant can submit a Marketing Authorization Application (“MAA”) through, amongst others, a centralized or decentralized procedure.

 

The centralized procedure provides for the grant of a single MA by the European Commission (“EC”) that is valid for all EU Member States and, after respective national implementing decisions, in the three additional EEA Member States. The centralized procedure is compulsory for specific medicinal products, including for medicines developed by means of certain biotechnological processes, products designated as orphan medicinal products, advanced therapy medicinal products (“ATMP”) and medicinal products with a new active substance indicated for the treatment of certain diseases (AIDS, cancer, neurodegenerative disorders, diabetes, auto-immune and viral diseases).

 

 

 

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For medicinal products containing a new active substance not yet authorized in the EEA before May 20, 2004 and indicated for the treatment of other diseases, medicinal products that constitute significant therapeutic, scientific or technical innovations or for which the grant of a MA through the centralized procedure would be in the interest of public health at EU level, an applicant may voluntarily submit an application for a marketing authorization through the centralized procedure.

 

Under the centralized procedure, the Committee for Medicinal Products for Human Use (“CHMP”), established at the European Medicines Agency (“EMA”), is responsible for conducting the initial assessment of a drug. The CHMP is also responsible for several post-authorization and maintenance activities, such as the assessment of modifications or extensions to an existing marketing authorization. Under the centralized procedure, the timeframe for the evaluation of a MAA by the EMA’s CHMP is, in principle, 210 days from receipt of a valid MAA. However, this timeline excludes clock stops, when additional written or oral information is to be provided by the applicant in response to questions asked by the CHMP, so the overall process typically takes a year or more, unless the application is eligible for an accelerated assessment. Accelerated assessment might be granted by the CHMP in exceptional cases when a medicinal product is of major interest from the point of view of public health and in particular from the viewpoint of therapeutic innovation. On request, the CHMP can reduce the time frame to 150 days if the applicant provides sufficient justification for an accelerated assessment. The CHMP will provide a positive opinion regarding the application only if it meets certain quality, safety and efficacy requirements. However, the EC has final authority for granting the MA within 67 days after receipt of the CHMP opinion.

 

The decentralized procedure permits companies to file identical MA applications for a medicinal product to the competent authorities in various EU Member States simultaneously if such medicinal product has not received marketing approval in any EU Member State before. This procedure is available for pharmaceutical products not falling within the mandatory scope of the centralized procedure.

 

The competent authority of a single EU Member State, known as the reference EU Member State, is appointed to review the application and provide an assessment report. Under this procedure, an applicant submits an application based on identical dossiers and related materials, including a draft summary of product characteristics, and draft labeling and package leaflet, to the reference EU Member State and concerned EU Member States. The reference EU Member State prepares a draft assessment report and drafts of the related materials within 120 days after receipt of a valid application. Subsequently, each concerned EU Member State must decide whether to approve the assessment report and related materials. If an EU Member State cannot approve the assessment report and related materials on the grounds of potential serious risk to public health, the disputed points are subject to a dispute resolution mechanism and may eventually be referred to the EC, whose decision is binding for all EU Member States.

 

All new MAAs must include a Risk Management Plan (“RMP”), describing the risk management system that the company will put in place and documenting measures to prevent or minimize the risks associated with the product. The regulatory authorities may also impose specific obligations as a condition of the MA. RMPs and Periodic Safety Update Reports are routinely available to third parties requesting access, subject to limited redactions.

 

Marketing Authorizations have an initial duration of five years. After these five years, the authorization may subsequently be renewed on the basis of a reevaluation of the risk-benefit balance. Once renewed, the MA is valid for an unlimited period unless the EC or the national competent authority decides, on justified grounds relating to pharmacovigilance, to proceed with only one additional five-year renewal. Applications for renewal must be made to the EMA at least nine months before the five-year period expires.

 

Data and Market Exclusivity in the European Union

 

As in the United States, it may be possible to obtain a period of market and/or data exclusivity in the EU that would have the effect of postponing the entry into the marketplace of a competitor’s generic, hybrid or biosimilar product (even if the pharmaceutical product has already received a MA) and prohibiting another applicant from relying on the MA holder’s pharmacological, toxicological and clinical data in support of another MA for the purposes of submitting an application, obtaining MA or placing the product on the market.

 

 

 

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New medicinal products authorized in the European Union, qualify for eight years of data exclusivity upon marketing authorization and an additional two years of market exclusivity. The overall ten-year period of market exclusivity can be extended to a maximum of eleven years if, during the first eight years of those ten years, the marketing authorization holder obtains an authorization for one or more new therapeutic indications which, during the scientific evaluation prior to their authorization, are held to bring a significant clinical benefit in comparison with existing therapies.

 

The data exclusivity period prevents generic or biosimilar applicants from relying on the preclinical and clinical trial data contained in the dossier of the reference medicinal product when applying for a generic or biosimilar marketing authorization in the EU during a period of eight years from the date on which the reference product was first authorized in the EU. The market exclusivity period prevents a successful generic or biosimilar applicant from commercializing its product in the EU until 10 years have elapsed from the initial authorization of the reference product in the EU.

 

Post-approval Regulation

 

Similar to the United States, both marketing authorization holders and manufacturers of pharmaceutical products are subject to comprehensive regulatory oversight by the EMA, the EC and/or the competent regulatory authorities of the EU Member States.

 

The holder of an EU marketing authorization for a pharmaceutical product must also comply with EU pharmacovigilance legislation and its related regulations and guidelines, which entail many requirements for conducting pharmacovigilance, or the assessment and monitoring of the safety of pharmaceutical products.

 

Failure by us or by any of our third-party partners, including suppliers, manufacturers and distributors to comply with EU laws and the EU Member State laws implementing Directive 2001/83/EC on pharmaceutical products for human use and other core legislation relating to pharmaceutical products, and other EU Member State laws that apply to the conduct of clinical trials, manufacturing approval, marketing authorization of pharmaceutical products and marketing of such products, both before and after grant of marketing authorization, manufacturing of pharmaceutical products, statutory health insurance, bribery and anti-corruption or with other applicable regulatory requirements may result in administrative, civil or criminal penalties. These penalties could include delays or refusal to authorize the conduct of clinical trials or to grant marketing authorization, product withdrawals and recalls, product seizures, suspension, withdrawal or variation of the marketing authorization, total or partial suspension of production, distribution, manufacturing or clinical trials, operating restrictions, injunctions, suspension of licenses, fines and criminal penalties.

 

European Union Data Laws

 

The collection and use of personal health data and other personal information in the EU is governed by the provisions of the General Data Protection Regulation (“GDPR”), which came into force in May 2018, and related implementing laws in individual EU Member States. In addition, following the UK’s formal departure from the EU on January 31, 2020 and the end of the transition period on December 31, 2020, the United Kingdom has become a “third country” for the purposes of EU data protection law. A “third country” is a country other than the EU Member States and the three additional European Economic Area countries (Norway, Iceland and Liechtenstein) that have adopted a national law implementing the GDPR. However, the TCA includes a provision, whereby the transfer of personal data from the EU to the UK will not be considered as a transfer to a “third country” for a period of four months starting from the entry into force of the TCA. This period will be extended by two further months, unless the EU or the UK objects. Under the GDPR, personal data can only be transferred to third countries in compliance with specific conditions for cross-border data transfers. Appropriate safeguards are required to enable transfers of personal data from the EU Member States. This status has a number of significant practical consequences, in particular for international data transfers, competent supervisory authorities and enforcement of the GDPR. The GDPR increased responsibility and liability in relation to personal data that we process.

 

 

 

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The GDPR imposes a number of strict obligations and restrictions on the ability to process (processing includes collection, analysis and transfer of) personal data, including health data from clinical trials and adverse event reporting. The GDPR also includes requirements relating to the consent of the individuals to whom the personal data relates, the information provided to the individuals prior to processing their personal data or personal health data, notification of data processing obligations to the national data protection authorities and the security and confidentiality of the personal data. The GDPR also prohibits the transfer of personal data to countries outside of the EU that are not considered by the EU to provide an adequate level of data protection, except if the data controller meets very specific requirements. These countries include the United States, and following the end of the six month period as laid out in the TCA, it may include the UK if no adequacy decision is given prior to this. Following the Schrems II decision of the Court of Justice of the European Union on July 16, 2020, there is uncertainty as to the general permissibility of international data transfers under the GDPR. In light of the implications of this decision we may face difficulties regarding the transfer of personal data from the EU to third countries. The European Data Protection Board has adopted draft recommendations for data controllers and processors who export personal data to third countries regarding supplementary measures to ensure compliance with the GDPR when transferring personal data outside of the EU. These recommendations were submitted to public consultation until December 21, 2020, however it is unclear when and in which form these recommendations will be published in final form.

 

Failure to comply with the requirements of the GDPR and the related national data protection laws of the EU Member States may result in significant monetary fines, other administrative penalties and a number of criminal offenses (punishable by uncapped fines) for organizations and in certain cases their directors and officers as well as civil liability claims from individuals whose personal data was processed. Data protection authorities from the different EU Member States may still implement certain variations, enforce the GDPR and national data protection laws differently, and introduce additional national regulations and guidelines, which adds to the complexity of processing personal data in the EU. Guidance developed at both EU level and at the national level in individual EU Member States concerning implementation and compliance practices are often updated or otherwise revised.

 

There is, moreover, a growing trend towards required public disclosure of clinical trial data in the EU which adds to the complexity of obligations relating to processing health data from clinical trials. Such public disclosure obligations are provided in the new EU Clinical Trials Regulation, EMA disclosure initiatives and voluntary commitments by industry. Failing to comply with these obligations could lead to government enforcement actions and significant penalties against us, harm to our reputation, and adversely impact our business and operating results. The uncertainty regarding the interplay between different regulatory frameworks, such as the Clinical Trials Regulation and the General Data Protection Regulation, further adds to the complexity that we face with regard to data protection regulation.

 

New Legislation and Regulations

 

From time to time, legislation is drafted, introduced and passed in the EU, its Member States and other states of Europe that could significantly change the statutory provisions governing the testing, approval, manufacturing, marketing, coverage and reimbursement of pharmaceutical products. In addition to new legislation, pharmaceutical regulations and policies are often revised or interpreted by the EMA and national agencies in ways that may significantly affect our business and our products.

 

Environmental Compliance

 

Our research and development activities involve the controlled use of potentially harmful biological materials as well as hazardous materials, chemicals and various radioactive compounds. We are subject to federal, state and local laws and regulations governing the use, storage, handling and disposal of these materials and specific waste products. We are also subject to numerous environmental, health and workplace safety laws and regulations, including those governing laboratory procedures, exposure to blood-borne pathogens and the handling of bio-hazardous materials. The cost of compliance with these laws and regulations could be significant and may adversely affect capital expenditures to the extent we are required to procure expensive capital equipment to meet regulatory requirements. However, to date, compliance with such environmental laws and regulations has not had a material impact on our capital expenditures.

 

 

 

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Human Capital Management

 

As of December 31, 2022, we had nine full-time employees and one part-time employee at our facility in Marlborough, Massachusetts. None of our employees are represented by a labor union or covered by a collective bargaining agreement, nor have we experienced any work stoppages.

 

We expect to add additional employees in fiscal year 2023 to increase our expertise and resources available in our clinical development and administrative areas. We continually evaluate our business needs and weigh the use of in-house expertise and capacity with outsourced expertise and capacity. We currently outsource substantially all preclinical and clinical trial work to third party contract research organizations and drug manufacturing contractors.

 

Our ability to identify, attract, retain and integrate additional qualified key personnel is also critical to our success and the competition for skilled research, product development, regulatory and technical personnel is intense. To attract qualified applicants, we offer a total rewards package consisting of base salary and cash target bonus, a comprehensive benefit package and equity compensation for every employee. Bonus opportunity and equity compensation increase as a percentage of total compensation based on level of responsibility. Actual bonus payouts are based on performance.

 

A majority of Phio’s employees have obtained advanced degrees in their professions and we support our employees’ further development with individualized development plans, mentoring, coaching, group training, conference attendance and financial support including tuition reimbursement.

 

Corporate Information

 

Effective January 26, 2023, the Company completed a 1-for-12 reverse stock split of the Company’s outstanding common stock. The reverse stock split did not reduce the number of authorized shares of the Company’s common or preferred stock. All share and per share amounts have been adjusted to give effect to the reverse stock split.

 

We were incorporated in the state of Delaware in 2011 as RXi Pharmaceuticals Corporation. On November 19, 2018, we changed our name to Phio Pharmaceuticals Corp., to reflect our transition from a platform company to one that is fully committed to developing groundbreaking immuno-oncology therapeutics. Our executive offices are located at 257 Simarano Drive, Suite 101, Marlborough, MA 01752, and our telephone number is (508) 767-3861.

 

The Company’s website address is http://www.phiopharma.com. We make available on our website, free of charge, copies of our annual reports on Form 10-K, our quarterly reports on Form 10-Q and our current reports on Form 8-K, and amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended, (the “Exchange Act”) as soon as reasonably practicable after these reports are filed electronically with, or otherwise furnished to, the Securities and Exchange Commission (the “SEC”). We also make available on our website the charters of our audit, compensation, nominating and governance committees, as well as our corporate code of ethics and conduct.

 

The SEC maintains an internet site that contains reports, proxy and information statements, and other information regarding Phio and other issuers that file electronically with the SEC. The SEC’s website address is http://www.sec.gov. The contents of this website, and our website, are not incorporated by reference into this report and should not be considered to be part of this report.

 

 

 

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ITEM 1A. RISK FACTORS

 

Risks Relating to Our Business and Industry

 

We are dependent on the success of our INTASYL technology platform, and our product candidates based on this platform, which is unproven and may never lead to approved and marketable products.

 

Our efforts have been focused on the development of product candidates based on our INTASYL technology platform. We have invested, and we expect to continue to invest, significant financial resources and efforts developing our product candidates. Our ability to eventually generate revenue is highly dependent on the successful development, regulatory approval and commercialization of our INTASYL product candidates by us or by collaborative partners, which may not occur for the foreseeable future, if ever, and is highly uncertain and depends on a number of factors, many of which are beyond our control. Therefore, it is difficult to accurately predict challenges we may face with our product candidates as they move through the discovery, preclinical and clinical development stages. We will spend large amounts of money developing our INTASYL platform technology and may never succeed in obtaining regulatory approval. In addition, our research methodology may be unsuccessful in identifying product candidates and results from preclinical studies and clinical trials may not predict the results that will be obtained in later phase trials of our product candidates or our product candidates may interact with patients in unforeseen or harmful ways that may make it impractical or impossible to manufacture, receive regulatory approval or commercialize. If we are not successful in bringing an INTASYL product candidate to market, it could negatively impact our business and financial condition and we may not be able to identify and successfully implement an alternative product development strategy.

 

Our product candidates are in an early stage of development and we may fail, experience significant delays, never advance clinical development or not be successful in our efforts to identify or discover additional product candidates, which may materially and adversely impact our business.

 

Our success depends heavily on the successful development of our product candidates, which may never occur. Our product candidates, which are in early stages of development, could be delayed, not advance into the clinic, or unexpectedly fail at any stage of development. Our ability to identify, develop and commercialize product candidates is dependent on extensive preclinical and other non-clinical tests in order to support an IND application in the United States, or the equivalent with regulatory authorities in other jurisdictions. These research programs to identify new product candidates require substantial financial and human resources, are difficult to design and can take many years to complete.

 

We cannot be certain of the outcome of our research studies and clinical trials and the results from these studies and clinical trials may not predict the results that will be obtained in later stages of development and we may focus our efforts and resources on product candidates that may prove to be unsuccessful. There is no assurance that we will be able to successfully develop our product candidates, and we may forego opportunities with certain product candidates or for indications that later prove to have greater commercial potential. If we are not able to successfully develop our product candidates, we may be forced to abandon or delay our development efforts, which may materially and adversely affect our business, financial condition, and results of operations.

 

Further, the FDA, or equivalent foreign regulatory authority, may not accept the results of our preclinical studies or clinical trials and may require us to complete additional studies or impose stricter approval conditions than we expect, which could impact the value of a particular program, the approvability or commercialization of the particular product candidate or product and our Company in general. Because of these factors, it is difficult to predict the time and cost of the development of our product candidates. Any delay or failure in obtaining required approvals may prevent us from completing our preclinical studies or clinical trials and could have a material adverse effect on our ability to initiate or commercialize any drug candidate on a timely basis, or at all. Additionally, preclinical studies and clinical trials are lengthy and expensive and if our cash resources become limited we may not be able to commence, continue or complete such preclinical studies or clinical trials.

 

We are dependent on our collaboration partners for the successful development of our adoptive cell therapy product candidates.

 

We are dependent on third parties that have direct access to the patient or donor cells used in cell therapy and expect to depend on third-party collaborators to support the clinical development of our ACT product candidates. We have entered into a clinical collaboration development agreement with AgonOx, Inc. for the clinical development of our PH-762 product candidate in ACT and have entered into other research agreements with academic and industry collaborators, each of which is terminable by the relevant party at any time, subject to applicable notice periods. The success of our collaborations depends upon the efforts of our collaboration partners, and their performance in achieving the development activities to the extent they are responsible under our collaboration agreements. Each of our partners may not be successful in performing these activities, including completing the required preclinical studies and other information to be included in an IND application (or foreign equivalent), obtaining approval to initiate clinical trials, conducting the necessary clinical trials and arranging for the manufacturing or contract research organization (“CRO”) relationships and obtaining marketing authorization. Our partners work with other companies, potentially including some of our competitors, their corporate objectives may not align with ours, and they may change their strategic focus or pursue alternative technologies. If our collaborations are not successful or a partner terminates our collaboration agreement, our business, financial condition, and results of operations could be materially and adversely affected.

 

 

 

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Further, we may not be successful in negotiating agreements with these collaborators or with future collaborators for the development and commercialization of our ACT product candidates through collaborations such as joint development or licensing agreements. Our ability to successfully negotiate such agreements will depend on, among other things, potential partners’ evaluation of the superiority of our technology over competing technologies, the quality of preclinical data that we have generated, the perceived risks specific to developing our product candidates and our partners’ own strategic and corporate objectives. If we fail to negotiate these agreements, we may not be able commence clinical trials with our ACT product candidates or we may be required to obtain licenses from cell therapy companies and our business, financial condition, and results of operations could be materially and adversely affected.  

 

If we experience delays or difficulties in identifying and enrolling subjects in clinical trials, it may lead to delays in generating clinical data and the receipt of necessary regulatory approvals.

 

Clinical trials of a new drug candidate require the enrollment of a sufficient number of subjects, including subjects who are suffering from the disease or condition the drug candidate is intended to treat and who meet other eligibility criteria. Rates of subject enrollment are affected by many factors, and delays in subject enrollment can result in increased costs and longer development times, which could materially and adversely impact our business and financial condition. We may experience slower than expected subject enrollment, including as a result of the coronavirus pandemic, in our current or future clinical trials. In addition, clinical trials for drug candidates that treat the same indications as our product candidates may result in subjects who would otherwise be eligible for our clinical trials instead enrolling in clinical trials for other drug candidates.

 

Topline data may not accurately reflect or may materially differ from the complete results of a clinical trial.

 

From time to time, we may publicly disclose topline or interim data from our clinical trials based on a preliminary analysis of then-available data, of which the results, related findings and conclusions are subject to change following a more comprehensive review of the data related to the particular trial. We also make assumptions, estimations, calculations and conclusions as part of our analyses of data, and we may not have received or had the opportunity to fully and carefully evaluate all data. Preliminary observations made in early stages of clinical trials are not necessarily indicative of results that will be obtained when full data sets are analyzed or in subsequent clinical trials. As a result, topline data may differ from future results from the same studies or different conclusions may qualify such results once additional data has been received and evaluated. Topline or interim data also remain subject to audit and verification procedures that may result in the final data being materially different from the preliminary data that we publicly disclose and should be viewed with caution until the complete data is available. If the topline data we report differs from future analysis of results, or if others, including regulatory authorities, disagree with the conclusions reached, our business, financial condition, and results of operations could be materially and adversely affected.

  

We rely upon third-parties to conduct our clinical trials and other studies for our product candidates, and if they do not successfully fulfill their obligations, the development of our product candidates may be materially impacted.

 

We depend upon third-party CROs, medical institutions, clinical investigators, consultants and other third-parties to support and conduct our clinical trials and rely on these third-party CROs for the execution of certain of our preclinical studies and expect to continue to do so. Because we rely on these third-parties, we cannot necessarily control the timing, quality of work or amount of resources that our contract partners will devote to these activities. We and our CROs are responsible for ensuring that our clinical trials are conducted in accordance with applicable regulations and protocols. If we or our CROs fail to comply with these applicable regulations, the FDA, or equivalent foreign regulatory authority, may not accept these data and may require us to complete additional preclinical studies and clinical trials, which could result in significant additional costs and delays to us.

 

 

 

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As we only control certain aspects of their activities, we cannot guarantee that these partners will fulfill their obligations to us under these arrangements. If these third-parties do not successfully carry out their responsibilities, as well as within a timely fashion, our clinical trials and preclinical studies may be delayed, unsuccessful or otherwise adversely affected. If we have to enter into alternative arrangements it may delay or adversely affect the development of our product candidates and our business operations. This could be difficult, costly or impossible, and our preclinical studies or clinical trials may need to be extended, delayed, terminated or repeated, and we may not be able to obtain regulatory approval in a timely fashion, or at all, for the applicable drug candidate, or to commercialize such drug candidate being tested in such studies or trials.

 

France adopted the General Data Protection Regulation, a data privacy regulation, and as we are conducting a clinical trial in France we are required to follow this law, which, if violated, could subject us to significant fines.

 

The collection and use of personal health data and other personal information in the European Union is governed by the provisions of the GDPR, which came into force in May 2018 and related implementing laws in individual EU Member States.

 

The GDPR imposes a number of strict obligations and restrictions on the ability to process (processing includes collection, analysis and transfer of) personal data of individuals within the EU and in the EEA, including health data from clinical trials and adverse event reporting. The GDPR also includes requirements relating to the consent of the individuals to whom the personal data relates, the information provided to the individuals prior to processing their personal data or personal health data, notification of data processing obligations to the national data protection authorities and the security and confidentiality of the personal data. EU Member States may also impose additional requirements in relation to health, genetic and biometric data through their national implementing legislation.

 

Under the GDPR, personal data can only be transferred within the EU Member States and the three additional EEA countries (Norway, Iceland and Liechtenstein) that have adopted a national law implementing the GDPR. Appropriate safeguards are required to enable cross-border transfers of personal data from the EU and EEA Member States to a “third country” (a country outside the EU or EEA). This status has a number of significant practical consequences, in particular for international data transfers, competent supervisory authorities and enforcement of the GDPR.

 

The GDPR prohibits the transfer of personal data to countries outside of the EU/EEA (including the United States) that are not considered by the EC to provide an adequate level of data protection, except if the data controller meets very specific requirements such as the use of standard contractual clauses (“SCCs”), issued by the EC. In this respect recent legal developments in Europe have created complexity and compliance uncertainty regarding certain transfers of personal data from the EU/EEA. For example, following the Schrems II decision of the Court of Justice of the EU on July 16, 2020, in which the Court invalidated the Privacy Shield under which personal data could be transferred from the EU/EEA to United States entities who had self-certified under the Privacy Shield scheme, there is uncertainty as to the general permissibility of international data transfers under the GDPR. The Court did not invalidate the then current SCCs, but ruled that data exporters relying on these SCCs are required to verify, on a case-by-case basis, if the law of the third country ensures an adequate level of data protection that is essentially equivalent to that guaranteed in the EU/EEA. In light of the implications of this decision we may face difficulties regarding the transfer of personal data from the EU/EEA to third countries, such as the United States. However, on June 4, 2021 the EC issued a new set of SCCs for data transfers from controllers or processors in the EU/EEA to controllers or processors established outside the EU/EEA. These SCCs replace the old sets of SCCs that were adopted under the previous European Data Protection Directive 95/46. Since September 27, 2021, it is no longer possible to conclude contracts incorporating these previous versions of the SCCs. In addition, for contracts concluded before September 27, 2021, it is still possible to rely on the previous SCCs until the end of an additional 15 months transitional period (until December 27, 2022), provided that the processing operations which are the subject matter of the contract remain unchanged and reliance on previous SCCs ensures that the transfer is subject to appropriate safeguards. On November 11, 2021, the European Data Protection Board adopted recommendations on such appropriate safeguards that supplement transfer mechanisms. These recommendations aim to assist data exporters with their duty to identify and implement appropriate supplementary measures where they are needed to ensure an essentially equivalent level of protection to the personal data they transfer to third countries.

  

 

 

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Failure to comply with the requirements of the GDPR and the related national data protection laws of the EU Member States may result in significant monetary fines for noncompliance of up to €20 million or 4% of the annual global revenues of the noncompliant company, whichever is greater, other administrative penalties and a number of criminal offenses (punishable by uncapped fines) for organizations and in certain cases their directors and officers as well as civil liability claims from individuals whose personal data was processed. Data protection authorities from the different EU Member States may still implement certain variations, enforce the GDPR and national data protection laws differently, and introduce additional national regulations and guidelines, which adds to the complexity of processing personal data in the EU. Guidance developed at both EU level and at the national level in individual EU Member States concerning implementation and compliance practices are often updated or otherwise revised. Ensuring compliance with GDPR is time-intensive and may increase the cost of doing business, and failure to comply with these laws may have a material impact on our operations and financial condition.

 

There is, moreover, a growing trend towards required public disclosure of clinical trial data in the EU which adds to the complexity of obligations relating to processing health data from clinical trials. Such public disclosure obligations are provided in the new EU Clinical Trials Regulation, EMA disclosure initiatives and voluntary commitments by industry. Failing to comply with these obligations could lead to government enforcement actions and significant penalties against us, harm to our reputation, and adversely impact our business and operating results. The uncertainty regarding the interplay between different regulatory frameworks, such as the Clinical Trials Regulation and the GDPR, further adds to the complexity that we face with regard to data protection regulation.

 

On June 28, 2021 the European Commission adopted two adequacy decisions for the UK – one under the GDPR and the other for the Law Enforcement Directive. Personal data may now freely flow from the EU to the UK since the UK is deemed to have an adequate data protection level. Additionally, following the UK's withdrawal from the EU and the EEA, companies also have to comply with the UK’s data protection laws (including the UK GDPR, which is based on the EU GDPR), the latter regime having the ability to separately fine up to the greater of £17.5 million or 4% of global turnover. The adequacy decisions include a ‘sunset clause’ which entails that the decisions will automatically expire four years after their entry into force.

 

A number of different factors could prevent us from advancing into clinical development, obtaining regulatory approval, and ultimately commercializing our product candidates on a timely basis, or at all. 

 

Before obtaining regulatory approval for the sale of any drug candidate, we must conduct extensive preclinical tests and successful clinical trials to demonstrate the safety and efficacy of our product candidates in humans. Before human clinical trials may commence, we must submit to the FDA an IND application, or foreign equivalent. An IND application involves the completion of preclinical studies and the submission of the results, together with proposed clinical protocols, manufacturing information, analytical data and other data in the IND submission. The FDA may require us to complete additional preclinical studies or disagree with our clinical trial study design. Also, animal models may not exist for some of the disease areas we choose to develop our product candidates for. As a result, our clinical trials may be delayed or we may be required to incur more expense than we anticipated.

 

Clinical trials require the review and oversight of IRBs, which approve and continually review clinical investigations and protect the rights and welfare of human subjects. Before our clinical trials can begin, we must also submit to the FDA a clinical protocol accompanied by the approval of the IRB at the institution(s) participating in the clinical trial. An inability or delay in obtaining IRB approval could prevent or delay the initiation and completion of our clinical trials, and the FDA may decide not to consider any data or information derived from a clinical investigation not subject to initial and continuing IRB review and approval.

 

Preclinical studies and clinical trials are lengthy and expensive, and their outcome is highly uncertain. Historical failure rates are high due to a number of factors, such as safety and efficacy of drug candidates. We, our collaborators, the FDA, or an IRB may suspend clinical trials of a drug candidate at any time for various reasons, including if we or they believe the subjects participating in such trials are being exposed to unacceptable health risks. Among other reasons, adverse side effects of a drug candidate on subjects in a clinical trial could result in the FDA or other regulatory authorities suspending or terminating the clinical trial and refusing to approve a particular drug candidate for any or all indications of use.

 

 

 

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We also are subject to numerous foreign regulatory requirements governing the conduct of clinical trials, manufacturing and marketing authorization, pricing and third-party reimbursement. The foreign regulatory approval process includes all of the risks associated with the FDA approval described above, as well as risks attributable to the satisfaction of local regulations in foreign jurisdictions. Approval by the FDA does not assure approval by regulatory authorities outside of the United States.

 

An additional number of factors could affect the timing, cost or outcome of our drug development efforts, including the following:

 

  · Delays in filing or acceptance of initial drug applications for our product candidates;
     
  · Difficulty in securing centers to conduct clinical trials;
     
  · Conditions imposed on us by the FDA or comparable foreign authorities regarding the scope or design of our clinical trials;
     
  · Problems in engaging IRBs to oversee trials or problems in obtaining or maintaining IRB approval of studies;
     
  · Difficulty in enrolling subjects in conformity with required protocols or projected timelines;
     
  · Third-party contractors failing to comply with regulatory requirements or to meet their contractual obligations to us in a timely manner;
     
  · Our drug candidates having unexpected and different chemical and pharmacological properties in humans than in laboratory testing and interacting with human biological systems in unforeseen, ineffective or harmful ways;
     
  · The need to suspend or terminate clinical trials if the participants are being exposed to unacceptable health risks;
     
  · Insufficient or inadequate supply or quality of our product candidates or other necessary materials necessary to conduct our clinical trials;
     
  · Effects of our product candidates not having the desired effects or including undesirable side effects or the product candidates having other unexpected characteristics;
     
  · The cost of our clinical trials being greater than we anticipate;
     
  · Negative or inconclusive results from our clinical trials or the clinical trials of others for similar product candidates or inability to generate statistically significant data confirming the efficacy of the product being tested;
     
  · Changes in the FDA’s requirements for testing during the course of that testing;
     
  · The impact from the ongoing coronavirus pandemic;
     
  · Reallocation of our limited financial and other resources to other clinical programs; and
     
  · Adverse results obtained by other companies developing similar drugs.

 

 

 

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A failure of any preclinical study or clinical trial can occur at any stage of testing. Any delay or failure in obtaining required approvals may prevent us from completing our preclinical studies or clinical trials and could have a material adverse effect on our ability to initiate or commercialize any drug candidate on a timely basis, or at all. Additionally, preclinical studies and clinical trials are lengthy and expensive and if our cash resources become limited we may not be able to commence, continue or complete our clinical trials, which could have a material impact on our business, financial condition, and results of operations.

 

We are subject to significant competition and may not be able to compete successfully.

 

The biotechnology and pharmaceutical industries have intense competition and contain a high degree of risk and there are many other companies actively engaged in the discovery, development and commercialization of products that may compete with our product candidates. We face a number of competitors that have substantially greater experience and greater research and development capabilities, staffing, financial, manufacturing, marketing, technical and other resources than us, and we may not be able to successfully compete with them. These companies include large and small pharmaceutical and biotechnology companies, academic institutions, government agencies and other private and public research organizations.

 

In addition, even if we are successful in developing our product candidates, in order to compete successfully we may need to be first to market or to demonstrate that our products are superior to therapies based on different technologies. Some of our competitors may develop and commercialize products that are introduced to market earlier than our product candidates or on a more cost-effective basis. A number of our competitors have already commenced clinical testing of product candidates and may be more advanced than we are in the process of developing products. If we are not first to market or are unable to demonstrate superiority, on a cost-effective basis or otherwise, any products for which we are able to obtain approval may not be successful.

 

Our competitors also compete with us in acquiring technologies complementary to our INTASYL technology. We may face competition with respect to product efficacy and safety, ease of use and adaptability to modes of administration, acceptance by physicians, timing and scope of regulatory approvals, reimbursement coverage, price and patent position, including dominant patent positions of others. If we are not able to successfully obtain regulatory approval or commercialize our product candidates, we may not be able to establish market share and generate revenues from our technology.

 

If we fail to attract, hire and retain qualified personnel, we may not be able to design, develop, market or sell our products or successfully manage our business.

 

We have a small core management team and are particularly dependent on them. Accordingly, our business prospects are dependent on the principal members of our executive team, the loss of whose services could make it difficult for us to manage our business successfully and achieve our business objectives. While we have entered into an employment agreement with our Chief Executive Officer, they could leave at any time, in addition to our other employees, who are all “at will” employees. Our ability to identify, attract, retain and integrate additional qualified key personnel is also critical to our success. Competition for skilled research, product development, regulatory and technical personnel is intense, and we may not be able to recruit and retain the personnel we need. The loss of the services of any key research, product development, regulatory and technical personnel, or our inability to hire new personnel with the requisite skills, could restrict our ability to develop our product candidates.

 

We are subject to potential liabilities from clinical testing and future product liability claims.

 

The use of our product candidates in clinical trials and, if any of our product candidates receive regulatory approval, the sale of our product candidates for commercial use expose us to the risk of product liability claims. Product liability claims may be brought against us by patients, healthcare providers, consumers or others who come into contact with our product candidates or approved products. We will seek to obtain clinical trial insurance for clinical trials that we conduct, as well as liability insurance for any products that we market. However, there is no assurance that we will be able to obtain insurance in the amounts we seek, or at all. We anticipate that licensees who develop our products will carry liability insurance covering the clinical testing of our product candidates and the marketing of those product candidates, if approved. There is no assurance, however, that any insurance maintained by us or our licensees will prove adequate in the event of a claim against us. If we cannot successfully defend against product liability claims, we could incur substantial liabilities. Even if claims asserted against us are unsuccessful, they may divert management’s attention from our operations and we may have to incur substantial costs to defend such claims. Any of these outcomes could materially impact our business and financial condition.

 

 

 

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We rely upon third parties for the manufacture of the clinical supply for our product candidates.

 

We rely on third-party suppliers and manufacturers to provide us with the materials and services to manufacture our product candidates for certain preclinical studies and for our clinical trials, and we expect that we will continue to rely on third-party manufacturers for the supply of our product candidates in the future. We have limited in-house manufacturing capabilities and resources, and we do not own or lease manufacturing facilities or have our own supply source for the required materials to manufacture our compounds. Further, we have limited current good manufacturing practice (“cGMP”) manufacturing capabilities and limited experience in scale-up of clinical supply as our internal capabilities are limited to small-scale production of research material. Accordingly, we are dependent upon third-party suppliers and contract manufacturers to obtain supplies and manufacture our product candidates and we will need to either develop, contract for, or otherwise arrange for the necessary manufacturers for these supplies.

 

There are a limited number of manufacturers that make oligonucleotides and we currently contract with multiple manufacturers for the supply of our product candidates to reduce the risk of supply interruption or availability. However, there is no assurance that our supply of our product candidates will not be limited, interrupted, of satisfactory quality or be available at acceptable prices. For example, constraints on the supply chain and availability of resources due to the ongoing coronavirus pandemic have resulted in delays and shortages at manufacturing facilities. While we have engaged with multiple manufacturers for the supply of our product candidates in order to mitigate the impact of the loss or delay of any one manufacturer, there can be no assurance that our efforts will be successful. If for any reason we are unable to obtain the clinical supply of our product candidates from our current manufacturers, we would have to seek to contract with another major manufacturer. If we or any of these manufacturers are unable or unwilling to increase its manufacturing capacity or if we are unable to establish alternative arrangements on a timely basis or on acceptable terms, the development and commercialization of such an approved product may be delayed or there may be a shortage in supply. Any inability to manufacture our product candidates or future approved drugs in sufficient quantities when needed would seriously harm our business.

 

Approval of any of our product candidates will not occur unless the manufacturing facilities are in compliance with the FDA’s cGMP regulations, or a foreign equivalent’s regulations, in order to ensure that drug products are safe and that they consistently meet applicable requirements and specifications. These requirements are enforced by the FDA and other regulatory authorities through periodic inspections of the manufacturing facilities and can result in enforcement action, such as warning letters, fines and suspension of production if they are found to not be in compliance with the regulations. If our suppliers or manufacturers do not comply with the FDA or foreign regulations for our product candidates, we may experience delays in timing or supply, be forced to manufacture our product candidates ourselves or seek to contract with another supplier or manufacturer. If we are required to switch suppliers or manufacturers, we will be required to verify that the new supplier or manufacturer maintains facilities and processes in line with cGMP regulations, which may result in delays, additional expenses, and may have a material adverse effect on our ability to complete the development of our product candidates.

 

Unstable market and economic conditions, including elevated and sustained inflation, may have serious adverse consequences on our business, financial condition and stock price.

 

As has been widely reported, we are currently operating in a period of economic uncertainty and capital markets disruption, which has been significantly impacted by domestic and global monetary and fiscal policy, geopolitical instability, an ongoing military conflict between Russia and Ukraine, and historically high domestic and global inflation. In particular, the conflict in Ukraine has exacerbated market disruptions, including significant volatility in commodity prices, as well as supply chain interruptions, and has contributed to record inflation globally. The U.S. Federal Reserve and other central banks may be unable to contain inflation through more restrictive monetary policy and inflation may increase or continue for a prolonged period of time. Inflationary factors, such as increases in the cost of clinical supplies, interest rates, overhead costs and transportation costs may adversely affect our operating results. We continue to monitor these events and the potential impact on our business. Although we do not believe that inflation has had a material impact on our financial position or results of operations to date, we may be adversely affected in the future due to domestic and global monetary and fiscal policy, supply chain constraints, consequences associated with the coronavirus pandemic and the ongoing conflict between Russia and Ukraine, and such factors may lead to increases in the cost of manufacturing our product candidates and delays in initiating studies. In addition, global credit and financial markets have experienced extreme volatility and disruptions in the past several years and the foregoing factors have led to and may continue to cause diminished liquidity and credit availability, declines in consumer confidence, declines in economic growth, uncertainty about economic stability and increased inflation.

 

 

 

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There can be no assurance that further deterioration in credit and financial markets and confidence in economic conditions will not occur. Our general business strategy may be adversely affected by any such economic downturn, volatile business environment or continued unpredictable and unstable market conditions. If the current equity and credit markets deteriorate, or do not improve, it may make any necessary debt or equity financing more difficult, more costly, and more dilutive. Failure to secure any necessary financing in a timely manner and on favorable terms could have a material adverse effect on our growth strategy, financial performance and stock price and could require us to delay or abandon clinical development plans. In addition, there is a risk that one or more of our current service providers, manufacturers and other partners may not survive these difficult economic times, which could directly affect our ability to attain our operating goals.

 

Natural disasters, epidemic or pandemic disease outbreaks, trade wars, political unrest or other events could disrupt our business or operations or those of our development partners, manufacturers, regulators or other third parties with whom we conduct business now or in the future.

 

A wide variety of events beyond our control, including natural disasters, epidemic or pandemic disease outbreaks (such as the coronavirus pandemic), trade wars, political unrest or other events could disrupt our business or operations or those of our manufacturers, regulatory authorities, or other third parties with whom we conduct business. These events may cause businesses and government agencies to be shut down, supply chains to be interrupted, slowed, or rendered inoperable, and individuals to become ill, quarantined, or otherwise unable to work and/or travel due to health reasons or governmental restrictions. These limitations could negatively affect our business operations and continuity, and could negatively impact our development timelines and ability to timely perform basic business functions, including preparing and filing financial reports. If our operations or those of third parties with whom we have business are impaired or curtailed as a result of these events, the development and commercialization of our products and product candidates could be impaired or halted, which could have a material adverse impact on our business.

 

Risks Relating to Our Intellectual Property

 

We may be involved in litigation to protect our patents and intellectual property rights and our ability to protect our patents and intellectual property rights is uncertain and may subject us to potential liabilities.

 

We have filed patent applications, have pending patents that we have licensed and those that we own and expect to continue to file patent applications. We may also need to license patents and patent applications from research sponsored by us with third-parties. There is no assurance that these applications will result in any issued patents or that those patents would withstand possible legal challenges or protect our technologies from competition. The patent granting authorities have upheld stringent standards for the RNAi patents that have been prosecuted so far and, consequently, pending patents that we have licensed and those that we own may continue to experience long and difficult prosecution challenges and may ultimately issue with much narrower claims than those in the pending applications.

 

In addition, others may challenge the patents or patent applications that we currently license or may license in the future or that we own and, as a result, these patents could be narrowed, invalidated or rendered unenforceable, which would negatively affect our ability to exclude others from using the technologies described in these patents. There is no assurance that these patents or other pending applications or issued patents we license or that we own will withstand possible legal challenges. Moreover, the laws of some foreign countries may not protect our proprietary rights to the same extent as do the laws of the United States. Our efforts to enforce and maintain our intellectual property rights may not be successful and may result in substantial costs and diversion of management and key employee’s time. If we are unable to defend our licensed or owned intellectual property, it may have a materially and adverse impact on our business, results of operations and financial condition.

 

Third-parties may claim that we infringe their patents, which may result in substantial liabilities and prevent us from pursuing the development of our product candidates.

 

Because the field we operate in is constantly changing and patent applications are still being processed by government patent offices around the world, there is a great deal of uncertainty about which patents will issue, when, to whom and with what claims. Although we are not aware of any blocking patents or other proprietary rights, it is likely that there will be significant litigation and other proceedings, such as interference and opposition proceedings in various patent offices, relating to patent rights in the field we operate. Further, many patents in the fields we are pursuing have already been exclusively licensed to third-parties, including our competitors. It is possible that we may become a party to such proceedings.

 

 

 

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If a claim should be brought against us and we are found to infringe the rights of others, we may be required to pay substantial damages, be forced to stop the development of product candidates affected by the claim, and/or establish licenses or similar arrangements. Furthermore, any such licenses may not be available when needed, on commercially reasonable terms or at all. Whether an infringement claim is successful or not, the cost of these proceedings may be significant and divert the attention of management and other key employees. As a result, we cannot be certain that our patents or those we license will not be challenged by others, which could have a material adverse effect on our business, results of operations and financial condition.

 

We are dependent on the patents we own and the technologies we license, and if we fail to maintain our patents or lose the right to license such technologies, our ability to develop new products would be harmed.

 

Our success depends upon our ability to obtain and maintain intellectual property protection for our product candidates. Any patents issued to us or our licensors may not provide us with any competitive advantages, and there is no assurance that the patents of others will not have an adverse effect on our ability to do business or to continue to develop our product candidates freely. Pending patents that we have licensed and those that we own may continue to experience long and difficult prosecution challenges and may ultimately issue with much narrower claims than those in the pending applications. Because of the extensive time required for development, testing, and regulatory review of a potential product, it is possible that, before any of our product candidates can be commercialized, any related patent may expire or remain in force for only a short period following commercialization, thus reducing any advantage provided by the patent. Further, even if our rights are valid, enforceable and broad in scope, competitors may develop products based on technology that is not covered by our licenses or patents or patent applications that we own. If we are unable to derive value from our licensed or owned intellectual property, it may have a materially and adverse impact on our business, results of operations and financial condition.

 

Third parties may hold or seek to obtain additional patents that could make it more difficult or impossible for us to develop products based on our technologies without obtaining a license to such patents, which licenses may not be available on attractive terms, or at all. If there is any dispute or issue of non-performance between us and the respective licensing partner regarding the rights or obligations under the license agreements, the ability to develop and commercialize the affected product candidate may be adversely affected. Moreover, if any of our existing licenses are terminated, the development of the product candidates contemplated by the licenses could be delayed or terminated and we may not be able to negotiate additional licenses on acceptable terms, if at all, which would have a material adverse effect on our business. To the extent that we are required and are able to obtain multiple licenses from third parties to develop or commercialize a product candidate, the aggregate licensing fees and milestones and royalty payments made to these parties may materially reduce our economic returns or even cause us to abandon development or commercialization of a product candidate.

   

Risks Relating to Our Financial Condition

 

We will require substantial additional funds to complete our research and development activities.

 

We have used substantial funds to develop our product candidates and will need to raise additional substantial funds to continue our drug development efforts and support our operations. Our future capital requirements and the period for which our existing resources are able to support our operations may vary significantly from what we expect. We anticipate that we will need to raise substantial amounts of money to fund a variety of future activities integral to the development of our business, which may include but is not limited to the following:

 

  · To conduct research and development to successfully develop our product candidates;
     
  · To obtain regulatory approval for our product candidates;
     
  · To file and prosecute patent applications and to defend and assess patents to protect our technologies;
     
  · To retain qualified employees, particularly in light of intense competition for qualified personnel;
     
  · To manufacture products ourselves or through third parties;
     
  · To market our products, either through building our own sales and distribution capabilities or relying on third parties; and
     
  · To acquire new technologies, licenses or products.

 

 

 

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We are dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity or strategic opportunities, in order to maintain our operations. We cannot assure you that additional financing will be available to us on acceptable terms, or at all. If we cannot, or are limited in the ability to, issue equity, incur debt or enter into strategic collaborations, we may be unable to fund the discovery and development of our product candidates or improve our technology. If we fail to obtain additional funding when needed, we may ultimately be unable to continue to develop and potentially commercialize our product candidates, and we may be forced to scale back or terminate our operations or seek to merge with or be acquired by another company.

 

We have a history of net losses, and we expect to continue to incur net losses for the foreseeable future and may not achieve or maintain profitability.

 

We have generated significant losses to date, have not generated any product revenue and may not generate product revenue in the foreseeable future, or ever. We expect to incur significant operating losses as we advance our product candidates through drug development and the regulatory process. Our ability to achieve profitability, if ever, will depend on, among other things, us or our collaborators, obtaining regulatory approvals and successfully commercializing our drug candidates. Even if we are able to successfully commercialize our drug candidates, we may not be able to achieve or sustain profitability, which could have a material adverse effect on our business, financial condition and results of operations.

 

Future financing may be obtained through, and future development efforts may be paid for by, the issuance of debt or equity, which may have an adverse effect on our stockholders or may otherwise adversely affect our business.

 

If we raise funds through the issuance of debt or equity, any debt securities or preferred stock issued will have rights, preferences and privileges senior to those of holders of our common stock in the event of a liquidation. In such event, there is a possibility that once all senior claims are settled, there may be no assets remaining to pay out to the holders of common stock. The terms of debt securities may also impose restrictions on our operations, which may include limiting our ability to incur additional indebtedness, to pay dividends on or repurchase our capital stock, or to make certain acquisitions or investments. In addition, we may be subject to covenants requiring us to satisfy certain financial tests and ratios, and our ability to satisfy such covenants may be affected by events outside of our control. If we raise funds through the issuance of additional equity, whether through private placements or public offerings, such an issuance would dilute current stockholders’ ownership in us, perhaps substantially. The issuance of a significant amount of shares of common stock could cause the market price of our common stock to decline or become highly volatile.

 

We expect to continue to incur significant research and development expenses, which may make it difficult for us to attain profitability, and may lead to uncertainty as to our ability to continue as a going concern.

 

We expend substantial funds to develop our technologies, and additional substantial funds will be required for further research and development, including preclinical testing and clinical trials of any product candidates, and to manufacture and market any products that are approved for commercial sale. Because the successful development of our products is uncertain, we are unable to precisely estimate the actual funds we will require to develop and potentially commercialize them. In addition, we may not be able to generate enough revenue, even if we are able to commercialize any of our product candidates, to become profitable.

 

Changes in our operating plans, our existing and anticipated working capital needs, the acceleration or modification of our expansion plans, increased expenses, potential acquisitions or other events will all affect our ability to continue as a going concern. The Company has limited cash resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through an equity offering, debt offering or strategic opportunity to fund its operations. There can be no assurance that the Company will be successful in accomplishing these plans in order to continue as a going concern. Any such inability to continue as a going concern may result in our common stockholders losing their entire investment. There is no guarantee that we will become profitable or secure additional financing.

 

 

 

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Our ability to utilize net operating loss carryforwards and other tax benefits may be limited.

 

We have historically incurred net losses and may never achieve or sustain profitability. Under the Internal Revenue Code of 1986, as amended (the “Code”), a corporation is generally allowed a deduction for net operating losses carried forward from a prior taxable year. Under that provision, we can carryforward our net operating losses to offset our future taxable income, if any, until such net operating losses are used or expire. Net operating losses incurred in tax years beginning after December 31, 2017 may be carried forward indefinitely, but are limited to offset up to 80% of future taxable income. Certain of our net operating loss carryforwards predating December 31, 2017 could expire unused before offsetting potential future income tax liabilities.

 

Additionally, an ownership change, as defined by Section 382 and 383 of the Code, results from transactions increasing the ownership of certain stockholders or public groups in the stock of a corporation by more than 50% over a three-year period. Pursuant to Section 382 and 383 of the code, if the Company has experienced a change of control at any time since inception, utilization of the Company’s net operating loss or tax credit carryforwards then in existence would be subject to an annual limitation. Any limitation may result in expiration of a portion of the net operating loss or tax credit carryforwards before utilization.

 

During 2021, the Company completed an assessment of the available net operating loss and tax credit carryforwards under Section 382 and 383 and determined that the Company underwent multiple ownership changes during the period from 2012 to 2021. As a result, our net operating losses and tax credit carryforwards are subject to substantial annual limitations under Section 382 and 383 due to these ownership changes. The Company has adjusted its net operating loss and tax credit carryforwards to address the impact of the ownership changes. The Company assesses the need to conduct an ownership change analysis to determine whether any changes occurred in ownership that would limit net operating loss or tax credit carryforwards on an annual basis. We may experience ownership changes in the future as a result of subsequent shifts in our stock ownership, some of which may be outside of our control. If an ownership change occurs and our ability to use our net operating loss and tax credit carryforwards is materially limited, it could harm our future operating results by effectively increasing our future tax obligations.

 

Risks Relating to Our Securities

 

The price of our common stock has been and may continue to be volatile.

 

Our stock price has historically fluctuated widely and is likely to continue to be volatile. Because we are at an early stage of development and in the absence of product revenue as a measure of operating performance, we anticipate that the market price for our common stock may be influenced by, but not limited to, such factors as:

 

  · Announcements regarding the initiation or completion, and the results of preclinical studies and clinical trials of our product candidates;
     
  · Announcements regarding clinical trial results or development announcements concerning our competitors product candidates;
     
  · Regulatory or legal developments in the United States and other countries;
     
  · The recruitment or departure of key personnel;
     
  · The issuance of competitive patents or disallowance or loss of our patent rights;
     
  · Our ability to raise additional capital and the terms on which additional capital is raised;
     
  · To acquire new technologies, licenses or products;
     
  · Natural disasters and calamities, including the coronavirus pandemic; and
     
  · General economic, industry and market conditions.

 

 

 

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The stock markets, in general, and the markets for drug delivery and pharmaceutical company stocks, in particular, have experienced extreme volatility, that has often been unrelated to the operating performance of particular companies. These broad market fluctuations may adversely affect the trading price of our common stock and could result in the loss of all or part of your investment. In addition, the limited trading volume of our stock may contribute to its volatility. Moreover, if we are unable to trade above $1.00 for a certain period of time, or fulfill the other continued listing standards, The Nasdaq Stock Market may delist our common stock. Delisting our common stock from Nasdaq would adversely affect our trading volume and would likely negatively impact our trading price.

 

Our Board of Directors has the authority to issue shares of “blank check” preferred stock and the terms of the preferred stock may reduce the value of our common stock.

 

We are authorized to issue up to 10,000,000 shares of preferred stock in one or more series and as of the year ended December 31, 2022 had one share of Series D Preferred Stock outstanding, which was subsequently redeemed in full in January 2023 and is no longer outstanding. Our Board of Directors (the “Board”) may determine the terms of future preferred stock offerings without further action by our stockholders. The issuance of our preferred stock could affect the rights of existing stockholders or reduce the value of our outstanding preferred stock or common stock. In particular, rights granted to holders of certain series of preferred stock may include voting rights, preferences as to dividends and liquidation, conversion and redemption rights and restrictions on our ability to merge with or sell our assets to a third party.

 

We may acquire other businesses or form joint ventures that may be unsuccessful and could dilute your ownership interest in the Company.

 

As part of our business strategy, we may pursue future acquisitions of other complementary businesses and technology licensing arrangements. We also may pursue strategic alliances. We have limited experience with respect to acquiring other companies and with respect to the formation of collaborations, strategic alliances and joint ventures. We may not be able to integrate such acquisitions successfully into our existing business, and we could assume unknown or contingent liabilities. We also could experience adverse effects on our reported results of operations from acquisition related charges, amortization of acquired technology and other intangibles and impairment charges relating to write-offs of goodwill and other intangible assets from time to time following the acquisition. Integration of an acquired company requires management resources that otherwise would be available for ongoing development of our existing business. We may not realize the anticipated benefits of any acquisition, technology license or strategic alliance. There is no assurance that we will be successful in developing such assets, and a failure to successfully develop such assets could diminish our prospects.

 

To finance future acquisitions, we may choose to issue shares of our common stock or preferred stock as consideration, which would dilute current stockholders’ ownership interest in us. Alternatively, it may be necessary for us to raise additional funds through public or private financings. Additional funds may not be available on terms that are favorable to us and, in the case of equity financings, may result in dilution to our stockholders. Any future acquisitions by us also could result in large and immediate write-offs, the incurrence of contingent liabilities or amortization of expenses related to acquired intangible assets, any of which could harm our operating results.

  

Provisions of our certificate of incorporation and bylaws and Delaware law might discourage, delay or prevent a change of control of the Company or changes in our management and, as a result, depress the trading price of our common stock.

 

Our certificate of incorporation and bylaws contain provisions that could discourage, delay or prevent a change of control of the Company or changes in our management that the stockholders of the Company may deem advantageous. These provisions:

 

  · Authorize the issuance of “blank check” preferred stock that our Board could issue to increase the number of outstanding shares and to discourage a takeover attempt;
     
  · Prohibit stockholder action by written consent, which requires all stockholder actions to be taken at a meeting of our stockholders;
     
  · Provide that the Board is expressly authorized to adopt, alter or repeal our bylaws; and
     
  · Establish advance notice requirements for nominations for election to our Board or for proposing matters that can be acted upon by stockholders at stockholder meetings.

 

 

 

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Although we believe these provisions collectively provide for an opportunity to receive higher bids by requiring potential acquirers to negotiate with our Board, they would apply even if the offer may be considered beneficial by some stockholders. In addition, these provisions may frustrate or prevent any attempts by our stockholders to replace or remove our current management team by making it more difficult for stockholders to replace members of our Board, which is responsible for appointing the members of our management.

 

Moreover, because we are incorporated in Delaware, we are governed by the provisions of Section 203 of the Delaware General Corporation Law, which prohibits a person who owns in excess of 15% of our outstanding voting stock from merging or combining with us for a period of three years after the date of the transaction in which the person acquired in excess of 15% of our outstanding voting stock, unless the merger or combination is approved in a prescribed manner.

 

ITEM 1B. UNRESOLVED STAFF COMMENTS

 

None.

 

ITEM 2. PROPERTIES

 

On December 17, 2013, we entered into a lease (the “Lease”), as subsequently amended on January 22, 2019, with 257 Simarano Drive, LLC, Brighton Properties, LLC, Robert Stubblebine 1, LLC and Robert Stubblebine 2, LLC to lease office and laboratory space in the building known as the “Main Building” located at 257 Simarano Drive, Marlborough, Massachusetts, covering 7,581 square feet. The premises are used by the Company for office and laboratory space. The term of the Lease commenced on April 1, 2014 and expires on March 31, 2024, for a total of a ten year lease term. The base rent for the premises is $124,865 per annum, payable on a monthly basis. Each year thereafter, the base rent shall increase by approximately 3% over the base rent from the prior year. With six months’ advance notice, either party had the option to terminate the lease on March 31, 2021, paying the non-terminating party six months’ rent as a penalty or on March 31, 2022, paying the non-terminating party three months’ rent as a penalty. The option to terminate the Lease early was not exercised by either party and has expired.

 

We believe that our facilities are suitable for our current needs.

 

ITEM 3. LEGAL PROCEEDINGS

 

From time to time, we may become a party to various legal proceedings and complaints arising in the ordinary course of business. To our knowledge, we are not currently a party to any actual or threatened material legal proceedings.

 

ITEM 4. MINE SAFETY DISCLOSURES

 

Not applicable.

 

 

 

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PART II.

 

ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES

 

Market Information

 

Our common stock is listed on The Nasdaq Capital Market under the symbol “PHIO.”

 

Holders

 

At March 9, 2023, there were approximately 19 holders of record of our common stock. Because many of our shares are held by brokers and other institutions on behalf of stockholders, we are unable to estimate the total number of individual stockholders represented by these holders of record.

 

Dividends

 

We have never paid any cash dividends and do not anticipate paying any cash dividends on our common stock in the foreseeable future. We expect to retain future earnings, if any, for use in our development activities and the operation of our business. The payment of any future dividends will be subject to the discretion of our Board of Directors (the “Board”) and will depend upon, among other things, our results of operations, financial condition, cash requirements, prospects and other factors that our Board may deem relevant.

 

Recent Sales of Unregistered Sales of Securities

 

No sales or issues of unregistered securities occurred that have not previously been disclosed in a Quarterly Report on Form 10-Q or in a Current Report on Form 8-K.

 

Purchases of Equity Securities by the Issuer and Affiliated Purchases

 

We did not repurchase any shares of our common stock during the years ended December 31, 2022 or 2021.

 

ITEM 6. RESERVED

 

ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

 

The following discussion of our financial condition and results of operations should be read in conjunction with our consolidated financial statements and the notes to those consolidated financial statements included in Item 8 of this Annual Report on Form 10-K. This discussion contains forward-looking statements that involve significant risks and uncertainties. As a result of many factors, such as those set forth under “Risk Factors” and elsewhere in this Annual Report on Form 10-K, our actual results may differ materially from those anticipated in these forward-looking statements. Please refer to the discussion under the heading “Forward-Looking Statements” above.

 

 

 

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Overview

 

Phio Pharmaceuticals Corp. (“Phio,” “we,” “our” or the “Company”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology platform is designed to make immune cells more effective in killing tumor cells. We are developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems. We are committed to discovering and developing innovative cancer treatments for patients by creating new pathways toward a cancer-free future.

 

Our development efforts are based on our proprietary INTASYL self-delivering RNAi technology platform. INTASYL compounds are designed to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems, and are designed to make immune cells more effective in killing tumor cells. Our efforts are focused on developing immuno-oncology therapeutics using our INTASYL platform. We have demonstrated preclinical efficacy in both direct-to-tumor injection and adoptive cell therapy (“ACT”) applications with our INTASYL compounds.

 

PH-762

 

PH-762 is an INTASYL compound designed to reduce the expression of cell death protein 1 (“PD-1”). PD-1 is a protein that inhibits T cells’ ability to kill cancer cells and is a clinically validated target in immunotherapy. Decreasing the expression of PD-1 can thereby increase the capacity of T cells, which protect the body from cancer cells and infections, to kill cancer cells.

 

Preclinical studies conducted by the Company have demonstrated that direct-to-tumor application of PH-762 resulted in potent anti-tumoral effects and have shown that direct-to-tumor treatment with PH-762 inhibits tumor growth in a dose dependent fashion in PD-1 responsive and refractory models. Importantly, direct-to-tumor administration of PH-762 resulted in activity against distant untreated tumors, indicative of a systemic anti-tumor response. We believe these data further support the potential for PH-762 to provide a strong local immune response without the dose immune-related adverse effects seen with systemic antibody therapy.

 

PH-762 is currently being evaluated in a Phase 1b dose escalation clinical trial in France that is expected to enroll up to 21 subjects with advanced melanoma. PH-762 will be administered as a neoadjuvant monotherapy intratumorally once a week, for a total of four injections, across five escalating dose levels. Dosing will be followed by tumoral excision after an additional two weeks. The primary study objectives are to evaluate the safety and tolerability, and pharmacokinetics of PH-762; to determine the potential immunologic and pathologic tumor responses; and to determine the recommended dose for later clinical trials. Safety data from the initial cohort of three subjects in the clinical trial was evaluated by a Data Monitoring Committee in the first quarter of 2023. The safety data review disclosed no dose-limiting toxicity, and no drug-related severe or serious adverse events, and the Data Monitoring Committee recommended proceeding to the enrollment of the subsequent dose cohort. The next cohort is now open for enrollment of subjects.

 

In addition to the French clinical trial, we expect to commence a U.S. Phase 1b clinical trial with PH-762 in the second half of 2023. The U.S. trial is expected to focus on the application of PH-762 to treat cutaneous squamous cell carcinoma (“cSCC”) and other selected cutaneous malignancies.

 

Due to INTASYL’s ease of administration, we have shown that our compounds can easily be incorporated into current ACT manufacturing processes. In ACT, T cells are usually taken from a patient's own blood or tumor tissue, grown in large numbers in a laboratory, and then given back to the patient to help the immune system fight cancer. By treating T cells with our INTASYL compounds while they are being grown in the laboratory, we believe our INTASYL compounds can improve these immune cells to make them more effective in killing cancer. Preclinical data generated in collaboration with AgonOx, Inc. (“AgonOx”), a private company developing a pipeline of novel immunotherapy drugs targeting key regulators of the immune response to cancer, demonstrated that treating AgonOx’s “double positive” tumor infiltrating lymphocyte (“DP TIL”) with PH-762 increased by two-fold their tumor killing activity.

 

 

 

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In March 2021, we entered into a clinical co-development collaboration agreement (the “Clinical Co-Development Agreement”) with AgonOx to conduct a Phase 1 clinical trial using DP TIL and PH-762. Under the Clinical Co-Development Agreement, we paid AgonOx $0.3 million as an upfront payment in December 2022 and have agreed to provide up to $4 million in total financial support to AgonOx to conduct a Phase 1 clinical trial of PH-762 treated DP TIL. Phio is also eligible to receive certain future development milestones and low single-digit sales-based royalty payments from AgonOx’s licensing of its DP TIL technology.

 

PH-762 treated DP TILs are expected to be evaluated in a Phase 1 clinical trial in the United States with up to 18 subjects with advanced melanoma and other advanced solid tumors. The primary study objectives are to evaluate the safety and to study the potential for enhanced therapeutic benefit from the administration of PH-762 treated DP TILs. Enrollment of subjects is expected to commence in the second quarter of 2023.

 

PH-894

 

PH-894 is an INTASYL compound that is designed to silence BRD4, a protein that controls gene expression in both T cells and tumor cells, thereby effecting the immune system as well as the tumor. Intracellular and/or commonly considered “undruggable” targets, such as BRD4, represent a challenge for small molecule and antibody therapies. Therefore, what sets this compound apart is its dual mechanism: PH-894 suppression of BRD4 in T cells results in T cell activation, and suppression of BRD4 in tumor cells results in tumors becoming more sensitive to being killed by T cells.

 

Preclinical studies conducted have demonstrated that PH-894 resulted in a strong, concentration dependent and durable silencing of BRD4 in T cells and in various cancer cells. Similar to PH-762, preclinical studies have also shown that direct-to-tumor application of PH-894 resulted in potent and statistically significant anti-tumoral effects and demonstrated a systemic anti-tumor response. These preclinical data indicate that PH-894 can reprogram T cells and other cells in the tumor microenvironment to provide enhanced immunotherapeutic activity. The Company has completed the investigational new drug (“IND”)-enabling studies and is in the process of finalizing the study reports required for an IND submission with PH-894. As a result of the reprioritization to advance the Company’s clinical trial with PH-762 in the U.S., the Company has elected to defer the IND submission for PH-894.

  

Impact of the Coronavirus Pandemic

 

The Company continues to respond to and monitor the ongoing coronavirus pandemic. The Company believes that the coronavirus pandemic has not had a significant impact on our financial condition and results of operations, however, the extent to which the coronavirus pandemic may materially impact our financial results and operations will depend on a number of factors, including the availability of supplies and services we rely on, the ability to enroll subjects in our clinical trials, the emergence of variant strains of the coronavirus, the development, availability, and public acceptance of effective treatments and vaccines, and the duration of the coronavirus pandemic, which remain difficult to predict and are highly uncertain.

 

Impact of Inflation

 

Inflation has increased during the period covered by this Annual Report and is expected to continue to remain at elevated levels or even increase in the near future. Inflation generally affects us by increasing our cost of labor and third party contract costs. We do not believe inflation has had a material effect on our results of operations during year ended December 31, 2022.

 

 

 

 30 

 

 

Critical Accounting Policies and Estimates

 

The discussion and analysis of our financial condition and results of operations are based upon our consolidated financial statements, which have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”). The preparation of these consolidated financial statements requires us to make estimates and judgments that affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. On an ongoing basis, we evaluate our estimates and base our estimates on historical experience and various other assumptions that are believed to be reasonable under the circumstances. Actual results may differ from these estimates under different assumptions or conditions and could have a material impact on our reported results. While our significant accounting policies are more fully described in Note 1 to our consolidated financial statements included elsewhere in this Annual Report, we believe the following addresses the Company’s accounting policies to be the most critical in understanding the judgments and estimates we use in preparing our financial statements.

 

Research and Development Expenses

 

Research and development expenses are charged to expense as incurred. Payments made by the Company in advance for research and development services not yet provided and/or for materials not yet received are recorded as prepaid expenses and expensed when the service has been performed or when the goods have been received. Accrued liabilities are recorded with respect to services provided and/or materials that we have received for which vendors have not yet billed us. The financial terms of these contracts are subject to negotiation, vary from provider to provider and may result in uneven payment flows. There may be instances in which payments made to our vendors exceed the level of services provided and result in a prepayment of the expense. In other instances, payment depends on factors such as the successful completion of milestones.

 

We are required to estimate our accrued research and development expenses, of which a significant portion relate to third party providers the Company has contracted with to perform various research activities on our behalf for the continued development of our product candidates. This process includes reviewing open contracts and purchase orders, estimating the service performed and the associated cost incurred for research and development services not yet billed or otherwise notified of actual cost. Accrued liabilities for the services provided by contract research organizations are recorded during the period incurred based on such estimates and assumptions as expected cost, passage of time, the level of effort to be expended in each period, the achievement of milestones and other information available to us. Estimates of our research and development accruals are assessed on a quarterly basis based on an evaluation of the progress to completion of specific tasks using information and data provided to us by our vendors and facts and circumstances known to us at that time, and adjusted accordingly.

 

Actual results may differ from these estimates and could have a material impact on the Company’s reported results. The Company’s historical accrual estimates have not been materially different from our actual costs. Due to the nature of estimates, we cannot provide assurance that we will not make changes to our estimates in the future as we become aware of additional information about the conduct of our research activities.

 

Collaborative Arrangements

 

The Company follows the provisions of the Financial Accounting Standards Board (the “FASB”) Accounting Standards Codification (“ASC”) Topic 808, “Collaborative Arrangements,” (“Topic 808”) when collaboration agreements involve joint operating activities in which both parties are active participants and that are also both exposed to significant risks and rewards. The Company also considers the guidance in the FASB ASC Topic 606, “Revenue from Contracts with Customers,” (“Topic 606”) in determining the appropriate treatment for activities between the Company and our collaborative partners that are more reflective of a vendor-customer relationship and therefore, within the scope of Topic 606. Under Topic 808, we determine an appropriate recognition method, either by analogy to appropriate accounting literature or by applying a reasonable accounting policy election. Generally, the classification of transactions under the collaborative arrangement is determined based on the nature and contractual terms of the arrangement along with the nature of the operations of the participants. The Company recognizes its share of costs arising from research and development activities performed by collaborators in the period its collaborators incur such expense. Payments or reimbursements that are the result of a collaborative relationship instead of a customer relationship, such as co-development activities, are evaluated on a quarterly basis and recorded as an offset to research and development expense incurred.

 

 

 

 31 

 

 

Financial Operations Overview

 

Revenues

 

To date, we have primarily generated revenues through government grants. We have not generated any commercial product revenue and do not expect to do so in the foreseeable future.

 

In the future, we may generate revenue from a combination of government grants, research and development agreements, license fees and other upfront payments, milestone payments, product sales and royalties in connection with future strategic collaborators and partners. We expect that any revenue we generate will fluctuate from period to period as a result of the timing of the achievement of any preclinical, clinical or commercial milestones and the timing and amount of payments received relating to those milestones and the extent to which any of our product candidates are approved and successfully commercialized by us or strategic collaborators and partners. If the Company or any future partner fails to develop product candidates in a timely manner or obtain regulatory approval for them, then our ability to generate future revenue and our results of operations and financial position would be adversely affected.

 

Research and Development Expenses

 

Research and development expenses relate to compensation and benefits for research and development personnel, facility-related expenses, supplies, external services, costs to acquire technology licenses, research activities under our research collaborations, expenses associated with preclinical and clinical development activities and other operating costs. Our research and development programs are focused on the development of immuno-oncology therapeutics based on our INTASYL therapeutic platform. Since we commenced operations, research and development expenses have been a significant portion of our total operating expenses and are expected to constitute the majority of our spending for the foreseeable future.

 

General and Administrative Expenses

 

General and administrative expenses relate to compensation and benefits for general and administrative personnel, facility-related expenses, professional fees for legal, audit, tax and consulting services, as well as other general corporate expenses.

 

Other (Expense) Income, net

 

Other (expense) income consists primarily of interest income and expense and various income or expense items of a non-recurring nature.

 

Results of Operations

 

The following table summarizes our results of operations for the periods indicated, in thousands:

 

   Years Ended
December 31,		   Dollar 
   2022   2021   Change 
Operating expenses  $11,462   $13,511   $(2,049)
Operating loss   (11,462)   (13,511)   2,049 
Net loss  $(11,480)  $(13,287)  $1,807 

 

 

 

 32 

 

 

Comparison of the Years Ended December 31, 2022 and 2021

 

Operating Expenses

 

The following table summarizes our total operating expenses, for the periods indicated, in thousands:

 

   Years Ended
December 31,		   Dollar 
   2022   2021   Change 
Research and development  $7,012   $8,886   $(1,874)
General and administrative   4,450    4,625    (175)
Total operating expenses  $11,462   $13,511   $(2,049)

  

Research and Development Expenses

 

Research and development expenses for the year ended December 31, 2022 decreased 21% compared with the year ended December 31, 2021. The decrease in research and development expenses was primarily driven by manufacturing related costs of approximately $2,000,000 for our PH-762 and PH-894 compounds and approximately $195,000 in preclinical studies with PH-762 that were required for the Company’s clinical trial in France, both of which were completed in the prior year period, offset by increases in clinical-related costs for the Company’s clinical trials with PH-762 in France and in ACT with our partner AgonOx of approximately $334,000.

 

The Company anticipates research and development expenses to increase as a result of clinical-related activities as our pipeline programs progress in clinical development.

 

General and Administrative Expenses

 

General and administrative expenses for the year ended December 31, 2022 decreased 4% compared with the year ended December 31, 2021. The decrease in general and administrative expenses was primarily due to decreases in total payroll-related expenses of approximately $156,000 as a result of the departure of our former Chief Executive Officer and a reduction in the use of consultants and outside professional services of approximately $141,000 offset by approximately $55,000 in executive search fees.

 

Total Other (Expense) Income

 

Total other income for the year ended December 31, 2022 decreased by $242,000 as compared with the year ended December 31, 2021, primarily due to the full forgiveness of our Paycheck Protection Program (“PPP”) loan in 2021.

 

Liquidity and Capital Resources

 

Historically, our primary source of funding has been through the sale of our securities. In the future, we will be dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity or strategic opportunities, in order to maintain our operations. We have reported recurring losses from operations since inception and expect that we will continue to have negative cash flows from our operations for the foreseeable future. At December 31, 2022, we had cash of $11,781,000 as compared with $24,057,000 at December 31, 2021.

 

 

 

 33 

 

 

In August 2019, we entered into a purchase agreement (the “Purchase Agreement”) with Lincoln Park Capital, LLC (“LPC”), pursuant to which we had the right to sell to LPC up to $10,000,000 in shares of our common stock, subject to certain limitations and conditions set forth in the Purchase Agreement. The Purchase Agreement expired in May 2022 and no shares of common stock were sold to LPC under the Purchase Agreement.

 

The Company has limited cash resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of the financial statements included elsewhere in this Annual Report. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through equity offerings, debt offerings or strategic opportunities to fund its operations. There can be no assurance that the Company will be successful in accomplishing any of these plans in order to continue as a going concern. The financial statements included elsewhere in this Annual Report do not include any adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.

 

The following table summarizes our cash flows for the periods indicated, in thousands:

 

   Years Ended
December 31,		 
   2022   2021 
Net cash used in operating activities  $(12,129)  $(11,858)
Net cash used in investing activities   (121)   (51)
Net cash (used in) provided by financing activities   (26)   21,722 
Net (decrease) increase in cash and restricted cash  $(12,276)  $9,813 

 

Net Cash Flow from Operating Activities

 

Net cash used in operating activities for the year ended December 31, 2022 increased as compared with the year ended December 31, 2021, primarily due to an increase of $2,246,000 in the changes in operating assets and liabilities primarily due to payments made for the preclinical studies conducted for PH-894 and for the manufacturing of our PH-762 and PH-894 compounds and an increase of $168,000 in non-cash related items primarily as a result of the full forgiveness of the Company’s PPP loan in the prior year period offset by a decrease in net loss of $1,807,000.

 

Net Cash Flow from Investing Activities

 

Net cash used in investing activities for the year ended December 31, 2022 increased as compared with the year ended December 31, 2021, primarily due to an increase of $70,000 in laboratory and computer equipment purchases for the Company’s facility as compared to the prior year period.

 

Net Cash Flow from Financing Activities

 

Net cash from financing activities for the year ended December 31, 2022 decreased as compared with the year ended December 31, 2021, primarily due to the net proceeds of $21,722,000 received by the Company from capital raising activities and warrant exercises in the comparable prior year period.

 

 

 

 34 

 

 

Contractual Obligations

 

Commitments

 

In March 2021, we entered into a Clinical Co-Development Agreement with AgonOx to develop a T cell-based therapy using PH-762, and AgonOx’s DP TIL technology. Under the Clinical Agreement, we committed to make future payments of up to $4,000,000 to reimburse AgonOx for expenses incurred to support the Phase 1 clinical trial with PH-762 treated DP TIL. During the year ended December 31, 2022, the Company paid AgonOx $250,000 as an upfront payment. No amounts were paid to AgonOx during the year ended December 31, 2021 under the Clinical Co-Development Agreement.

 

License Commitments

 

We enter into licensing agreements with third parties that often require milestone and royalty payments based on the progress of the asset through development stages. Milestone payments may be required, for example, upon progress through clinical trials, upon approval of the product by a regulatory agency and/or upon a percentage of sales of the product pursuant to such agreements. The expenditures required under these arrangements may be material individually in relation to any product candidates covered by the intellectual property licensed under any such arrangement, and material in the aggregate in the unlikely event that milestones for multiple products covered by these arrangements were reached in the same period. During the years ended December 31, 2022 and 2021, we did not trigger any milestone payments.

 

Our contractual license obligations that will require future cash payments as of December 31, 2022 are $700,000, which result from payments expected in connection with annual license fees.

 

Lease Commitments

 

Future lease payments under our non-cancellable operating lease are expected to be approximately $175,000 over the remaining duration of our lease, or through March 31, 2024.

 

For further information regarding our future cash commitments see Note 8 to our consolidated financial statements.

 

 

 

 35 

 

 

ITEM 7A. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

 

As a smaller reporting company, we are not required to provide this information.

 

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

 

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

 

   

Page

  
       
Report of Independent Registered Public Accounting Firm (BDO USA, LLP; Boston, Massachusetts; PCAOB ID# 243)   F-1  
Consolidated Balance Sheets as of December 31, 2022 and 2021   F-2  
Consolidated Statements of Operations for the Years Ended December 31, 2022 and 2021   F-3  
Consolidated Statements of Preferred Stock and Stockholders’ Equity for the Years Ended December 31, 2022 and 2021   F-4  
Consolidated Statements of Cash Flows for the Years Ended December 31, 2022 and 2021   F-5  
Notes to Consolidated Financial Statements   F-6  

 

 

 

 

 

 

 36 

 

 

Report of Independent Registered Public Accounting Firm

 

Shareholders and Board of Directors

Phio Pharmaceuticals Corp.

Marlborough, Massachusetts

 

Opinion on the Consolidated Financial Statements

 

We have audited the accompanying consolidated balance sheets of Phio Pharmaceuticals Corp. (the “Company”) as of December 31, 2022 and 2021, the related consolidated statements of operations, preferred stock and stockholders’ equity, and cash flows for each of the years then ended, and the related notes (collectively referred to as the “consolidated financial statements”). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2022 and 2021, and the results of its operations and its cash flows for the years then ended, in conformity with accounting principles generally accepted in the United States of America.

 

Going Concern Uncertainty

 

The accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the consolidated financial statements, the Company does not generate revenues and continues to suffer recurring losses from operations that raise substantial doubt about its ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

 

Basis for Opinion

 

These consolidated financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s consolidated financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (“PCAOB”) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

 

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.

 

Our audits included performing procedures to assess the risks of material misstatement of the consolidated financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the consolidated financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the consolidated financial statements. We believe that our audits provide a reasonable basis for our opinion.

 

Critical Audit Matter

 

Critical audit matters are matters arising from the current period audit of the consolidated financial statements that were communicated or required to be communicated to the audit committee and that: (1) relate to accounts or disclosures that are material to the consolidated financial statements and (2) involved our especially challenging, subjective, or complex judgments. We determined that there are no critical audit matters.

 

We have served as the Company's auditor since 2011.

 

/s/ BDO USA, LLP

 

Boston, Massachusetts

March 22, 2023

 

 

 

 F-1 

 

 

PHIO PHARMACEUTICALS CORP.

CONSOLIDATED BALANCE SHEETS

(Amounts in thousands, except share data)

 

         
   December 31,
2022		   December 31,
2021		 
ASSETS          
Current assets:          
Cash  $11,781   $24,057 
Restricted cash   50    50 
Prepaid expenses and other current assets   615    620 
Total current assets   12,446    24,727 
Right of use asset   161    283 
Property and equipment, net   183    133 
Other assets   24    27 
Total assets  $12,814   $25,170 
LIABILITIES, PREFERRED STOCK AND STOCKHOLDERS’ EQUITY          
Current liabilities:          
Accounts payable  $779   $283 
Accrued expenses   1,025    2,660 
Lease liability   135    125 
Total current liabilities   1,939    3,068 
Lease liability, net of current portion   35    170 
Total liabilities   1,974    3,238 
Commitments and contingencies (Footnote 8)   –     –  
Series D Preferred Stock, $0.0001 par value; 1 and 0 shares authorized, issued and outstanding at December 31, 2022 and December 31, 2021, respectively   2    – 
Stockholders’ equity:          
Common stock, $0.0001 par value, 100,000,000 shares authorized; 1,139,024 and 1,127,917 shares issued and outstanding at December 31, 2022 and December 31, 2021, respectively   –    – 
Additional paid-in capital   139,218    138,832 
Accumulated deficit   (128,380)   (116,900)
Total stockholders’ equity   10,838    21,932 
Total liabilities, preferred stock and stockholders’ equity  $12,814   $25,170 

 

See accompanying notes to consolidated financial statements.

 

 

 

 F-2 

 

 

PHIO PHARMACEUTICALS CORP.

CONSOLIDATED STATEMENTS OF OPERATIONS

(Amounts in thousands, except share and per share data)

 

         
   Year Ended
December 31,		 
   2022   2021 
Operating expenses:          
Research and development  $7,012   $8,886 
General and administrative   4,450    4,625 
Total operating expenses   11,462    13,511 
Operating loss   (11,462)   (13,511)
Total other (expense) income, net   (18)   224 
Loss before income taxes   (11,480)   (13,287)
Provision for income taxes   –    – 
Net loss  $(11,480)  $(13,287)
Net loss per common share:          
Basic  $(10.10)  $(12.43)
Diluted  $(10.10)  $(12.43)
Weighted average number of common shares outstanding          
Basic   1,136,566    1,069,234 
Diluted   1,136,566    1,069,234 

 

See accompanying notes to consolidated financial statements.

 

 

 

 F-3 

 

 

PHIO PHARMACEUTICALS CORP.

CONSOLIDATED STATEMENTS OF PREFERRED STOCK AND STOCKHOLDERS’ EQUITY

(Amounts in thousands, except share data)

 

                             
   Series D Preferred Stock   Common Stock   Additional
Paid-in		   Accumulated     
   Shares   Amount   Shares   Amount   Capital   Deficit   Total 
Balance at December 31, 2020   –   $–    481,749   $–   $116,630   $(103,613)  $13,017 
Issuance of common stock, pre-funded warrants and warrants in connection with private placement, net of offering costs   –    –    368,405    –    12,669    –    12,669 
Issuance of common stock in registered direct offering, net of offering costs   –    –    187,232    –    6,908    –    6,908 
Issuance of common stock upon the exercise of warrants   –    –    90,276    –    2,146    –    2,146 
Issuance of common stock upon vesting of restricted stock units   –    –    279    –    –    –    – 
Shares withheld for payroll taxes   –    –    (24)   –    (1)   –    (1)
Stock-based compensation expense   –    –    –    –    480    –    480 
Net loss   –    –    –    –    –    (13,287)   (13,287)
Balance at December 31, 2021   –   $–    1,127,917   $–   $138,832   $(116,900)  $21,932 
Issuance of common stock upon vesting of restricted stock units   –    –    14,043    –    –    –    – 
Shares withheld for payroll taxes   –    –    (2,936)   –    (28)   –    (28)
Issuance of preferred stock   1    2    –    –    –    –    – 
Stock-based compensation expense   –    –    –    –    414    –    414 
Net loss   –    –    –    –    –    (11,480)   (11,480)
Balance at December 31, 2022   1   $2    1,139,024   $–   $139,218   $(128,380)  $10,838 

 

See accompanying notes to consolidated financial statements.

 

 

 

 F-4 

 

 

PHIO PHARMACEUTICALS CORP.

CONSOLIDATED STATEMENTS OF CASH FLOWS

(Amounts in thousands)

 

         
  

Year Ended

December 31,

 
   2022   2021 
Cash flows from operating activities:          
Net loss  $(11,480)  $(13,287)
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation and amortization   71    75 
Amortization of right of use asset   122    117 
Non-cash stock-based compensation   414    480 
Forgiveness of debt   –    (233)
Changes in operating assets and liabilities:          
Prepaid expenses and other assets   8    241 
Accounts payable   496    (445)
Accrued expenses   (1,635)   1,310 
Lease liability   (125)   (116)
Net cash used in operating activities   (12,129)   (11,858)
Cash flows from investing activities:          
Cash paid for purchase of property and equipment   (121)   (51)
Net cash used in investing activities   (121)   (51)
Cash flows from financing activities:          
Net proceeds from the issuance of common stock and warrants   –    19,577 
Net proceeds from the exercise of warrants   –    2,146 
Payments of taxes for net share settled restricted stock unit issuances   (28)   (1)
Net proceeds from the issuance of preferred stock   2    – 
Net cash (used in) provided by financing activities   (26)   21,722 
Net (decrease) increase in cash and restricted cash   (12,276)   9,813 
Cash and restricted cash at the beginning of period   24,107    14,294 
Cash and restricted cash at the end of period  $11,831   $24,107 

 

The following table provides a reconciliation of cash and restricted cash reported within the consolidated balance sheets to the totals above:

           
   December 31, 
   2022   2021 
Cash  $11,781   $24,057 
Restricted cash   50    50 
Total cash and restricted cash  $11,831   $24,107 

 

See accompanying notes to consolidated financial statements.

 

 

 

 F-5 

 

 

PHIO PHARMACEUTICALS CORP.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

 

 

1. Organization and Significant Accounting Policies

 

Nature of Operations

 

Phio Pharmaceuticals Corp. (“Phio,” “we,” “our” or the “Company”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology platform is designed to make immune cells more effective in killing tumor cells. We are developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems. We are committed to discovering and developing innovative cancer treatments for patients by creating new pathways toward a cancer-free future.

 

The Company continues to respond to and monitor the ongoing coronavirus pandemic. The Company believes that the coronavirus pandemic has not had a significant impact on its financial condition and results of operations, however, the extent to which the coronavirus pandemic may materially impact our financial results and operations will depend on a number of factors, including the availability of supplies and services we rely on, the ability to enroll subjects in our clinical trials, the emergence of variant strains of the coronavirus, the development, availability, and public acceptance of effective treatments and vaccines, and the duration of the coronavirus pandemic, which remain difficult to predict and are highly uncertain.

 

Liquidity

 

The Company has reported recurring losses from operations since its inception and expects to continue to have negative cash flows from operations for the foreseeable future. Historically, the Company’s primary source of funding has been from sales of its securities. The Company’s ability to continue to fund its operations is dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity, or strategic opportunities, in order to maintain its operations. This is dependent on a number of factors, including the market demand or liquidity of the Company’s common stock, which may be adversely impacted by the coronavirus pandemic, rates of inflation and the ongoing conflict between Russia and Ukraine. There is no guarantee that debt, additional equity or other funding will be available to us on acceptable terms, or at all. If we fail to obtain additional funding when needed, we would be forced to scale back or terminate our operations or seek to merge with or to be acquired by another company.

 

The Company has limited cash resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through an equity offering, debt offering or strategic opportunity to fund its operations. There can be no assurance that the Company will be successful in accomplishing these plans in order to continue as a going concern. These financial statements do not include any adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.

 

Basis of Presentation

 

The accompanying financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”).

 

 

 

 F-6 

 

 

Principles of Consolidation

 

The consolidated financial statements include the accounts of Phio and its wholly-owned subsidiary, MirImmune, LLC. All material intercompany accounts have been eliminated in consolidation.

 

Reverse Stock Split

 

Effective January 26, 2023, the Company completed a 1-for-12 reverse stock split of the Company’s outstanding common stock. All share and per share amounts in the financial statements have been retroactively adjusted for all periods presented to give effect to the reverse stock split, including reclassifying an amount equal to the reduction in par value to additional paid-in capital. Unless otherwise noted, shares of common stock issued and outstanding, shares underlying warrants and stock awards, shares reserved, conversion price of convertible securities, exercise prices of warrants and stock awards and loss per share have been proportionately adjusted to reflect the reverse stock split. The reverse stock split did not reduce the number of authorized shares of the Company’s common stock or preferred stock.

 

Uses of Estimates in Preparation of Financial Statements

 

The preparation of financial statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. The areas subject to significant estimates and judgement include, among others, those related to the fair value of equity awards, accruals for research and development expenses, useful lives of property and equipment, income taxes, and the valuation allowance on our deferred tax assets. On an ongoing basis we evaluate our estimates and base our estimates on historical experience and other relevant assumptions that we believe are reasonable under the circumstances. Actual results could differ materially from these estimates.

 

Restricted Cash

 

Restricted cash consists of certificates of deposit held by financial institutions as collateral for the Company’s corporate credit cards.

 

Concentrations of Credit Risk

 

Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash. The Company maintains cash balances in several accounts with a financial institution that management believes is creditworthy, which at times are in excess of federally insured limits. These accounts are insured by the Federal Deposit Insurance Corporation for up to $250,000 per institution.

 

Property and Equipment

 

Property and equipment are stated at cost and depreciated using the straight-line method based on the estimated useful lives of the related assets. The Company provides for depreciation over the assets’ estimated useful lives as follows:

 
Computer equipment 3 years
Machinery & equipment 5 years
Furniture & fixtures 5 years
Leasehold improvements Lesser of remaining lease term or 5 years

 

 

 

 F-7 

 

 

Impairment of Long-Lived Assets

 

The Company reviews long-lived assets for impairment annually or whenever an event or change in circumstance occurs in which the related carrying amounts may not be recoverable. An impairment loss would be recognized based on the difference between the carrying value of the asset and its estimated fair value, which would be determined based on either discounted future cash flows or other appropriate fair value methods. As of December 31, 2022 and 2021, the Company believes no impairment existed.

  

Leases

 

At the inception of a contract, the Company determines whether the contract is or contains a lease based on all relevant facts and circumstances. For contracts that contain a lease, the Company identifies the lease and non-lease components, determines the consideration in the contract and recognizes the classification of the lease as operating or financing. For leases with a term greater than one year, the Company recognizes a liability to make lease payments and an asset representing the right to use the underlying asset during the lease term at the commencement date of the lease.

 

Lease liabilities and the corresponding right of use assets are recorded based on the present value of lease payments to be made over the lease term. The discount rate used to calculate the present value is the rate implicit in the lease, or if not readily determinable, the Company’s incremental borrowing rate. The Company’s incremental borrowing rate is the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. Certain adjustments to the right of use asset may be required for items such as initial direct costs or incentives received. Lease payments on operating leases, including scheduled increases, are recognized on a straight-line basis over the expected term of the lease. Lease payments on financing leases are recognized using the effective interest method.

 

Derivative Financial Instruments

 

Financial instruments that meet the definition of a derivative are classified as an asset or liability and measured at fair value on the issuance date and are revalued on each subsequent balance sheet date. The changes in fair value are recognized as current period income or loss. Financial instruments that do not meet the definition of a derivative are classified as equity and measured at fair value and recorded as additional paid-in capital in stockholders’ equity at the date of issuance. No further adjustments to their valuation are made.

 

Research and Development Expenses

 

Research and development expenses relate to compensation and benefits for research and development personnel, facility-related expenses, supplies, external services, costs to acquire technology licenses, research activities under our research collaborations, expenses associated with preclinical and clinical development activities and other operating costs. Research and development expenses are charged to expense as incurred. Payments made by the Company in advance for research and development services not yet provided and/or for materials not yet received are recorded as prepaid expenses and expensed when the service has been performed or when the goods have been received.

 

Accrued liabilities are recorded related to those expenses for which vendors have not yet billed the Company with respect to services provided and/or materials that it has received. Accrued liabilities for the services provided by contract research organizations are recorded during the period incurred based on such estimates and assumptions as expected cost, passage of time, the achievement of milestones and other information available to us and are assessed on a quarterly basis. Actual results may differ from these estimates and could have a material impact on the Company’s reported results. The Company’s historical accrual estimates have not been materially different from its actual costs.

 

 

 

 F-8 

 

 

Collaborative Arrangements

 

The Company follows the provisions of the Financial Accounting Standards Board (the “FASB”) Accounting Standards Codification (“ASC”) Topic 808, “Collaborative Arrangements,” (“Topic 808”) when collaboration agreements involve joint operating activities in which both parties are active participants and that are also both exposed to significant risks and rewards. The Company also considers the guidance in the FASB ASC Topic 606, “Revenue from Contracts with Customers,” (“Topic 606”) in determining the appropriate treatment for activities between the Company and its collaborative partners that are more reflective of a vendor-customer relationship and therefore, within the scope of Topic 606. Under Topic 808, the Company determines an appropriate recognition method, either by analogy to appropriate accounting literature or by applying a reasonable accounting policy election. Generally, the classification of transactions under the collaborative arrangements is determined based on the nature and contractual terms of the arrangement along with the nature of the operations of the participants. The Company recognizes its share of costs arising from research and development activities performed by collaborators in the period its collaborators incur such expense. Payments or reimbursements that are the result of a collaborative relationship instead of a customer relationship, such as co-development activities, are evaluated on a quarterly basis and recorded as an offset to research and development expense incurred.

 

Patents and Patent Application Costs

 

Although the Company believes that its patents and underlying technology have continuing value, the amount of future benefits to be derived from the patents is uncertain. Patent costs are, therefore, expensed as general and administrative costs as incurred.

 

Stock-based Compensation

 

The Company follows the provisions of the FASB ASC Topic 718, “Compensation — Stock Compensation” (“ASC 718”), which requires the measurement and recognition of compensation expense for all stock-based payment awards. The fair value of restricted stock units (“RSUs”) is based upon the Company’s closing stock price at the grant date. The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options at the grant date. The Black-Scholes valuation model requires the input of valuation assumptions to calculate the value of stock options, including expected volatility, expected term, risk-free interest rate and expected dividends. Stock-based compensation expense is recognized on a straight-line basis over the requisite service period, which generally represents the vesting period, and commences at the date of grant based on the fair value of the award.

 

Stock-based compensation expense recognized in the financial statements is based on awards that are ultimately expected to vest. Accordingly, we are also required to estimate forfeitures at the time of grant and to revise those estimates in subsequent periods if actual forfeitures differ from estimates. We use historical data to estimate pre-vesting award forfeitures and record stock-based compensation expense only for those awards that are expected to vest. Our forfeiture rate estimates are based on an analysis of our actual forfeiture experience, employee turnover behavior, and other factors. The impact of any adjustments to our forfeiture rates or to the extent that actual forfeitures differ from our estimates, is recorded as a cumulative adjustment in the period the estimates are revised.

 

Income Taxes

 

The Company recognizes assets or liabilities for the deferred tax consequences of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements in accordance with the FASB ASC Topic 740, “Accounting for Income Taxes” (“ASC 740”). These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled. Those temporary differences referred to as deferred tax assets and liabilities are determined at the end of each period using the tax rate expected to be in effect when taxes are actually paid or recovered. Valuation allowances are established if, based on the weight of available evidence, it is more likely than not that all or a portion of a deferred tax asset will not be realized. The provision for income taxes, if any, represents the tax payable for the period and the change in deferred income tax assets and liabilities during the period.

 

 

 

 F-9 

 

 

Comprehensive Loss

 

The Company’s comprehensive loss is equal to its net loss for all periods presented.

 

Net Loss per Share

 

Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding. Diluted net loss per share is computed by dividing the Company’s net loss by the weighted average number of common shares outstanding and the impact of all dilutive potential common shares outstanding, except where such dilutive potential common shares would be anti-dilutive. Dilutive potential common shares primarily consist of warrants, RSUs and stock options.

 

Recent Accounting Pronouncements

 

In May 2021, the FASB issued Accounting Standards Update 2021-04, “Earnings per Share (Topic 260), Debt – Modifications and Extinguishments (Subtopic 470-50), Compensation – Stock Compensation (Topic 718), and Derivatives and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40)” (“ASU 2021-04”). The amendments in the updates are intended to clarify and reduce diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options that remain equity classified after modification or exchange. The amendments in ASU 2021-04 are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. An entity should apply the amendments prospectively to modifications or exchanges occurring on or after the effective date of the amendments. The Company adopted ASU 2021-04 on January 1, 2022. The adoption of this standard had no impact on the Company’s consolidated financial statements.

 

2. Collaboration and License Agreements

 

AgonOx, Inc. (“AgonOx”)

 

In March 2021, the Company entered into a clinical co-development collaboration agreement (the “Clinical Agreement”) with AgonOx, a private company developing a pipeline of novel immunotherapy drugs targeting key regulators of the immune response to cancer. Under the Clinical Agreement, Phio and AgonOx are working to develop a T cell-based therapy using the Company’s lead product candidate, PH-762, and AgonOx’s “double positive” TIL (“DP TIL”) technology. Per the terms of the Clinical Agreement, the Company committed to make future payments of up to $4,000,000 to reimburse AgonOx for expenses incurred to support the Phase 1 clinical trial with the DP TIL technology and PH-762.

 

The Company will recognize its share of costs arising from research and development activities performed by AgonOx in the Company’s financial statements in the period AgonOx incurs such expense. Phio will be entitled to certain future development milestones and low single-digit sales-based royalty payments from AgonOx’s licensing of its DP TIL technology. The Company recognized approximately $130,000 of expense in connection with these efforts during the year ended December 31, 2022. No expense under the Clinical Agreement was recognized during the year ended December 31, 2021. There was approximately $120,000 recorded as prepaid expenses and other current assets as of December 31, 2022.

 

Advanced RNA Technologies, LLC (“Advirna”)

 

In September 2011, the Company entered into an agreement with Advirna, pursuant to which Advirna assigned to us its existing patent and technology rights related to the INTASYL technology in exchange for an annual maintenance fee of $100,000, a one-time milestone payment upon the future issuance of the first patent with valid claims covering the assigned patent and technology rights and the issuance of shares of common stock of the Company equal to 5% of the Company’s fully-diluted shares outstanding at the time of issuance. The one-time milestone payment and the issuance of shares of common stock in the Company were completed in 2014 and 2012, respectively. Additionally, the Company is required to pay low single-digit royalties to Advirna on any licensing revenue received by the Company with respect to future licensing of the assigned Advirna patent and technology rights. To date, any royalties owed to Advirna under the agreement have been minimal.

 

Phio’s rights under the Advirna agreement will expire upon the later of: (i) the expiration of the last-to-expire of the “patent rights” (as defined therein) included in the agreement; or (ii) the abandonment of the last-to-be abandoned of such patents, unless earlier terminated in accordance with the provisions of the agreement. Further, the Company also granted back to Advirna a license under the assigned patent and technology rights for fields of use outside human therapeutics.

 

 

 

 F-10 

 

 

3. Fair Value of Financial Instruments

 

The Company follows the provisions of the FASB ASC Topic 820, “Fair Value Measurement,” for the Company’s financial assets and liabilities that are re-measured and reported at fair value each reporting period and are re-measured and reported at fair value at least annually using a fair value hierarchy that is broken down into three levels. Level inputs are defined as follows:

 

Level 1 – quoted prices in active markets for identical assets or liabilities.

 

Level 2 – other significant observable inputs for the assets or liabilities through corroboration with market data at the measurement date.

 

Level 3 – significant unobservable inputs that reflect management’s best estimate of what market participants would use to price the assets or liabilities at the measurement date.

 

At December 31, 2022 and 2021, the Company categorized its restricted cash of $50,000 as Level 2 hierarchy. The assets classified as Level 2 have initially been valued at the applicable transaction price and subsequently valued, at the end of each reporting period, using other market observable data. Observable market data points include quoted prices, interest rates, reportable trades and other industry and economic events.

 

The carrying amounts of cash, accounts payable and accrued expenses of the Company approximate their fair values due to their short-term nature.

 

4. Property and Equipment

 

The following table summarizes the Company’s major classes of property and equipment, in thousands:

        
   December 31, 
   2022   2021 
Computer equipment  $116   $108 
Machinery & equipment   1,077    1,035 
Furniture & fixtures   119    49 
Leasehold improvements   46    46 
Total gross fixed assets   1,358    1,238 
Less: accumulated depreciation and amortization   (1,175)   (1,105)
Property and equipment, net  $183   $133 

 

Depreciation and amortization expense for the years ended December 31, 2022 and 2021 was $71,000 and $75,000, respectively.

 

 

 

 F-11 

 

 

5. Accrued Expenses

 

Accrued expenses consist of the following, in thousands:

               
    December 31,  
    2022     2021  
Compensation and benefits   $ 408     $ 572  
Professional fees     97       102  
Research and development costs     501       1,986  
Other     19       –  
Total accrued expenses   $ 1,025     $ 2,660  

 

6. Leases

 

In January 2019, the Company amended the lease for its corporate headquarters and primary research facility in Marlborough, Massachusetts. The lease is for a total of 7,581 square feet of office and laboratory space and will expire on March 31, 2024. The lease contains an option to terminate after two or three years by providing advance written notice of termination pursuant to the terms of the agreement. The exercise of this option was not determined to be reasonably certain and thus was not included in the lease liability on the Company’s balance sheet. The Company did not exercise its option to terminate in either the second or third year of the lease, and the option to terminate has expired. Additionally, the lease agreement did not contain information to determine the borrowing rate implicit in the lease. As such, the Company calculated its incremental borrowing rate based on what the Company would have to pay to borrow on a collateralized basis over the lease term for an amount equal to the remaining lease payments, taking into consideration such assumptions as, but not limited to, the U.S. treasury yield rate and borrowing rates from a creditworthy financial institution using the above lease factors.

 

The lease for our corporate headquarters represents all of our significant lease obligations. The amounts reported in the consolidated balance sheets for operating leases in which the Company is the lessee and other supplemental balance sheet information is set forth as follows, in thousands, except the lease term (number of years) and discount rate:

        
   December 31, 
   2022   2021 
Assets        
Right of use asset  $161   $283 
Liabilities          
Lease liability, current   135    125 
Lease liability, non-current   35    170 
Total lease liability  $170   $295 
Lease Term and Discount Rate          
Weighted average remaining lease term   1.25    2.25 
Weighted average discount rate   4.70%    4.70% 

 

Operating lease costs included in operating expense were $132,000 for the years ended December 31, 2022 and 2021, respectively.

  

 

 

 F-12 

 

 

Cash paid for the amounts included in the measurement of the operating lease liability on the Company’s consolidated balance sheets and included within changes in the lease liability in the operating activities of our consolidated statements of cash flows was $135,000 and $132,000 for the years ended December 31, 2022 and 2021, respectively.

 

Future lease payments for our non-cancellable operating leases and a reconciliation to the carrying amount of the operating lease liability presented in the consolidated balance sheet as of December 31, 2022 is as follows, in thousands:

    
2023  $140 
2024   35 
Total lease payments   175 
Less: Imputed interest   (5)
Total operating lease liabilities (includes current portion)  $170 

 

7. Debt

 

In May 2020, the Company received loan proceeds pursuant to the Paycheck Protection Program (the “PPP”) under the Coronavirus Aid, Relief, and Economic Security Act. The Company followed the guidance under the FASB ASC Topic 470, “Debt,” (“ASC 470”) in assessing the accounting for the PPP loan proceeds. Per ASC 470, the Company recorded a liability on the balance sheet for the full amount of the PPP loan proceeds received and accrued interest over the term of the loan. The Company believed it used the loan proceeds for eligible purposes and applied for full loan forgiveness. In February 2021, the Small Business Administration approved the Company’s application for full loan forgiveness, and the full amount of the PPP loan was remitted to the lender for forgiveness. Upon loan forgiveness, the Company recognized a gain on the extinguishment of debt of $233,000 for the loan proceeds received and interest accrued in the consolidated statements of operations for the year ended December 31, 2021.

 

8. Commitments and Contingencies

 

Commitments

 

In March 2021, the Company entered into a Clinical Agreement with AgonOx to develop a T cell-based therapy using the Company’s lead product candidate, PH-762, and AgonOx’s DP TIL technology. Per the terms of the Clinical Agreement, the Company committed to make future payments of up to $4,000,000 to reimburse AgonOx for expenses incurred to support the Phase 1 clinical trial with the DP TIL technology and PH-762. Refer to Note 2 for further details on the Clinical Agreement with AgonOx.

 

The Company applies the disclosure provisions of the FASB ASC Topic 460, “Guarantor’s Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others” (“ASC 460”), to its agreements that contain guarantee or indemnification clauses. The Company provides: (i) indemnifications of varying scope and size to certain investors and other parties for certain losses suffered or incurred by the indemnified party in connection with various types of third-party claims; and (ii) indemnifications of varying scope and size to officers and directors against third-party claims arising from the services they provide to us. These indemnifications give rise only to the disclosure provisions of ASC 460. To date, the Company has not incurred costs as a result of these obligations and does not expect to incur material costs in the future. Accordingly, the Company has not accrued any liabilities in its consolidated financial statements related to these indemnifications.

 

Refer to Note 6 for more information about the Company’s obligations under its non-cancellable lease for its corporate headquarters.

 

 

 

 F-13 

 

 

License Commitments

 

As part of its business, the Company enters into licensing agreements with third parties that often require milestone and royalty payments based on the progress of the asset through development stages. Milestone payments may be required, for example, upon progress through clinical trials, upon approval of the product by a regulatory agency and/or upon a percentage of sales of the product pursuant to such agreements. The expenditures required under these arrangements may be material individually in relation to any product candidates covered by the intellectual property licensed under any such arrangement, and material in the aggregate in the unlikely event that milestones for multiple products covered by these arrangements were reached in the same period. Due to the contingent nature of these payments, they are not included in the table of contractual obligations shown below.

 

During the years ended December 31, 2022 and 2021, the Company did not trigger any milestone payments.

 

The Company’s contractual license obligations that will require future cash payments as of December 31, 2022, which result from payments expected in connection with annual license fees, are as follows, in thousands:

       
Year Ending December 31,
2023   $ 100  
2024     100  
2025     100  
2026     100  
2027     100  
Thereafter     200  
Total   $ 700  

 

Litigation

 

From time to time, the Company may become a party to various legal proceedings and complaints arising in the ordinary course of business. To the Company’s knowledge, it is not currently a party to any actual or threatened material legal proceedings. Accordingly, there were no contingent liabilities recorded as of the year ended December 31, 2022.

 

9. Preferred Stock

 

The Company has authorized up to 10,000,000 shares of preferred stock, $0.0001 par value per share, for issuance. The Company’s Board of Directors is authorized under the Company’s Amended and Restated Articles of Incorporation, to designate the authorized preferred stock into one or more series and to fix and determine such rights, preferences, privileges and restrictions of any series of preferred stock, including voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences, as shall be determined by the Company’s Board of Directors upon its issuance. At December 31, 2022, the Company had designated one share of preferred stock as Series D Preferred Stock and the remaining authorized shares were undesignated.

 

On November 16, 2022, the Company issued and sold one share of the Company’s Series D Preferred Stock, par value $0.0001 per share (the “Series D Preferred Stock”) to Robert Bitterman, then its interim Executive Chairman and current Chief Executive Officer, for $1,750. The Series D Preferred Stock was entitled to 17,500,000 votes per share exclusively with respect to any proposal to amend the Company’s Amended and Restated Certificate of Incorporation (as may be amended and/or restated from time to time, the “Amended Certificate”) to effect a reverse stock split of the Company’s common stock (“Reverse Stock Split”). The terms of the Series D Preferred Stock provided that it would be voted, without action by the holder, on any such proposal in the same proportion as shares of the Company’s common stock were voted. The Series D Preferred Stock otherwise had no voting rights except as otherwise required by the General Corporation Law of the State of Delaware.

 

 

 

 F-14 

 

 

The Series D Preferred Stock was not convertible into, or exchangeable for, shares of any other class or series of stock or other securities of the Company. The Series D Preferred Stock had no rights with respect to any distribution of assets of the Company, including upon a liquidation, bankruptcy, reorganization, merger, acquisition, sale, dissolution or winding up of the Company, whether voluntarily or involuntarily. The holder of the Series D Preferred Stock was not entitled to receive dividends of any kind.

 

Under its terms, the outstanding share of Series D Preferred Stock was to be redeemed in whole, but not in part, at any time: (i) if such redemption was approved by the Board of Directors in its sole discretion or (ii) automatically and effective upon the approval by the Company's stockholders of a Reverse Stock Split. Upon such redemption, the holder of the Series D Preferred Stock was entitled to receive consideration of $1,750 in cash.

 

The Series D Preferred Stock has been classified outside of permanent equity (within the mezzanine section between liabilities and equity on the balance sheets) as the Company may not be able to control the actions necessary to provide for a redemption in full of the then outstanding Series D Preferred Stock.

 

The Series D Preferred Stock was redeemed in whole on January 4, 2023, upon the approval by the Company’s stockholders of a Reverse Stock Split.

 

10. Stockholders’ Equity

 

January 2021 Private Placement — In January 2021, the Company completed a private placement of 368,405 shares of the Company’s common stock at a purchase price per share of $36.84, pre-funded warrants to purchase an aggregate of 11,672 shares of the Company’s common stock at a purchase price per pre-funded warrant of $36.828 and warrants to purchase an aggregate of 285,061 shares of the Company’s common stock with an exercise price of $36.00 per warrant (the “Private Placement”). In connection with the Private Placement, the Company issued warrants to the placement agent, H.C. Wainwright & Co., LLC (“HCW”), to purchase a total of 28,509 shares of the Company’s common stock at an exercise price of $46.05 per warrant. Net proceeds to the Company from the Private Placement were $12,669,000 after deducting placement agent fees and offering expenses.

 

February 2021 Registered Direct Offering — In February 2021, the Company completed a registered direct offering of 187,232 shares of the Company’s common stock at a purchase price of $41.04 per share (the “Offering”). In connection with the Offering, the Company issued warrants to the placement agent, HCW, to purchase a total of 14,044 shares of the Company’s common stock at an exercise price of $51.30 per warrant. Net proceeds to the Company from the Offering were $6,908,000 after deducting placement agent fees and offering expenses.

 

Warrants

 

The Company first assesses the warrants it issues under the FASB ASC Topic 480, “Distinguishing Liabilities from Equity” (“ASC 480”) to determine whether they are within the scope of ASC 480. As there are no instances outside of the Company’s control that could require cash settlement from the warrants issued by the Company, the outstanding warrants are outside the scope of ASC 480.

 

The Company then applies and follows the applicable accounting guidance in the FASB ASC Topic 815, “Derivatives and Hedging.” Financial instruments are accounted for as either derivative liabilities or equity instruments depending on the specific terms of the agreement. The warrants issued by the Company do not meet the definition of a derivative instrument as they are indexed to the Company’s common stock and classified within stockholders’ equity. Based on this determination, the Company’s warrants are classified within stockholders’ equity.

 

 

 

 F-15 

 

 

The following table summarizes the Company’s outstanding equity-classified warrants at December 31, 2022:

                                                  
      Exercise    Expiration    Balance December 31,    Warrants    Warrants    Warrants   

Balance

December 31,

   
Description    Price    Date    2021    Issued    Exercised    Expired    2022   
April 2018 Warrants    $  2,079.00    5/31/2023    1,720    –     –     –     1,720   
April 2018 Placement Agent Warrants    $  2,676.00    4/9/2023    117    –     –     –     117   
October 2018 Warrants    $  125.40    10/3/2025    32,486    –     –     –     32,486   
October 2018 Underwriter Warrants    $  156.72    10/1/2023    2,438    –     –     –     2,438   
November 2019 Placement Agent Warrants    $  82.50    11/18/2024    1,138    –     –     –     1,138   
February 2020 Registered Direct Warrants    $  104.52    8/6/2025    16,425    –     –     –     16,425   
February 2020 Placement Agent Warrants    $  132.45    2/4/2025    1,233    –     –     –     1,233   
February 2020 Warrants    $  48.00    2/13/2025    110,557    –     –     –     110,557   
February 2020 Underwriter Warrants    $  60.00    2/11/2025    12,501    –     –     –     12,501   
April 2020 Warrants    $  26.52    10/2/2025    35,691    –     –     –     35,691   
April 2020 Placement Agent Warrants    $  35.0256    3/31/2025    3,481    –     –     –     3,481   
January 2021 Warrants    $  36.00    7/27/2026    285,061    –     –     –     285,061   
January 2021 Placement Agent Warrants    $  46.05    7/27/2026    28,509    –     –     –     28,509   
February 2021 Placement Agent Warrants    $  51.30    2/12/2026    14,044    –     –     –     14,044   
                     545,401    –     –     –     545,401   

 

No warrants were exercised during the year ended December 31, 2022. The Company received net proceeds of $2,146,000 from the exercise of warrants during the year ended December 31, 2021.

 

11. Stock-based Compensation

 

Stock Plans

 

The Company’s approved equity plans include the Phio Pharmaceuticals Corp. 2020 Long Term Incentive Plan (the “2020 Plan”) and the Phio Pharmaceuticals Corp. 2012 Long Term Incentive Plan (the “2012 Plan”). These plans are administered by our Board of Directors and provide for the grant of incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock awards, RSU awards, performance stock awards, and performance cash awards. Upon adoption of the 2020 Plan, shares that remained available for grant under the 2012 Plan and shares that were subject to outstanding awards under the 2012 Plan were included in the authorized shares available for grant under the 2020 Plan. Further, upon adoption of the 2020 Plan, the Company no longer grants new equity awards under the 2012 Plan.

 

As of December 31, 2022, there were an aggregate of 105,640 shares of common stock reserved under the 2020 Plan, including 141 shares subject to outstanding stock options and 47,328 shares subject to unvested RSUs and 43,807 shares available for future grants. RSUs granted by the Company to employees vest annually over 3 years after the grant date, stock options granted by the Company to employees generally vest annually over 4 years after the grant date and, in the instance of stock options, expire within ten years of issuance.

 

 

 

 F-16 

 

 

Restricted Stock Units

 

RSUs are issued under the 2020 Plan or as inducement grants issued outside of the 2020 Plan to new employees. RSUs are generally subject to graded vesting and the satisfaction of service requirements. Upon vesting, each outstanding RSU will be settled for one share of the Company’s common stock. Employee RSU recipients may elect to net share settle upon vesting, in which case the Company pays the employee’s income taxes due upon vesting and withholds a number of shares of equal value. The fair value of the RSUs awarded are based upon the Company’s closing stock price at the grant date and are expensed over the requisite service period.

 

The following table summarizes the activity of the Company’s RSUs for the year ended December 31, 2022:

               
    Number
of Shares		     Weighted-
Average
Grant Date Fair Value
Per Share		  
Unvested units at December 31, 2021     30,592     $ 38.52  
Granted     61,250       10.08  
Vested     (14,043 )     39.72  
Forfeited     (30,471 )      17.40  
Unvested units at December 31, 2022     47,328     $ 15.00  

 

The weighted-average fair value of RSUs granted during the years ended December 31, 2022 and 2021 was $10.08 and $35.28, respectively.

 

Stock-based compensation expense related to RSUs was $401,000 and $443,000 for the years ended December 31, 2022 and 2021, respectively.

  

The aggregate fair value of awards that vested during the years ended December 31, 2022 and 2021 was $138,000 and $9,000, which represents the market value of the Company’s common stock on the date that the RSUs vested.

 

As of December 31, 2022, the compensation expense for all unvested RSUs in the amount of approximately $458,000 will be recognized in the Company’s results of operations over a weighted average period of 1.60 years.

 

Stock Options

 

Stock options are available for issuance under the 2020 Plan or as inducement grants issued outside of the 2020 Plan to new employees. Stock options are generally subject to graded vesting and the satisfaction of service requirements. Upon the exercise of a stock option, the Company issues new shares and delivers them to the recipient. The Company does not expect to repurchase shares to satisfy stock option exercises.

 

The Company uses the Black-Scholes option-pricing model to determine the fair value of all its option grants. The risk-free interest rate used for each grant was based upon the yield on zero-coupon U.S. Treasury securities with a term similar to the expected life of the related option. The Company’s expected stock price volatility assumption is based upon the Company’s own implied volatility. As the Company has limited stock option exercise information, the expected life assumption used for option grants is based upon the simplified method provided for under ASC 718. The dividend yield assumption is based upon the fact that the Company has never paid cash dividends and presently has no intention of paying cash dividends.

 

 

 

 F-17 

 

 

The Company did not grant stock options during the years ended December 31, 2022 and 2021. The following table summarizes the activity of the Company’s stock option plan for the year ended December 31, 2022:

                               
    Total Number
of Shares		     Weighted-
Average
Exercise
Price
Per Share		     Weighted-
Average
Remaining
Contractual
Term		     Aggregate
Intrinsic
Value		  
Balance at December 31, 2021     208     $ 40,822.80                  
Granted     –       –                  
Exercised     –       –                  
Unvested shares cancelled     (6 )     1,181.40                  
Vested shares cancelled     (61 )     93,016.68                  
Balance at December 31, 2022     141     $ 19,761.12       5.18 years     $ –  
Exercisable at December 31, 2022     141     $ 19,761.12       5.18 years     $ –  

 

Stock-based compensation expense related to stock options for the years ended December 31, 2022 and 2021 was $13,000 and $37,000, respectively.

 

As of December 31, 2022, the compensation expense for all unvested stock options was recognized in the Company’s results of operations.

 

There is no income tax benefit as the Company is currently operating at a loss and an actual income tax benefit may not be realized.

 

Compensation Expense Related to Equity Awards

 

The following table sets forth total stock-based compensation expense for the years ended December 31, 2022 and 2021, in thousands:

        
   December 31, 
   2022   2021 
Research and development  $154   $117 
General and administrative   260    363 
Total stock-based compensation  $414   $480 

 

12. Income Taxes

 

The provision for income taxes for the years ended December 31, 2022 and 2021 are as follows, in thousands:

               
    Years Ended December 31,  
    2022     2021  
Current                
Federal   $ –     $ –  
State     –       –  
Total current     –       –  
Deferred                
Federal     (1,733 )     (3,016 ) 
State     (553 )     (1,329 )
Total deferred     (2,286 )     (4,345 )
Valuation allowance     2,286       4,345  
Total provision for income taxes   $ –     $ –  

  

 

 

 F-18 

 

 

The following table presents a reconciliation of the U.S. statutory tax rate to the Company’s actual effective income tax rate:

        
   Years Ended December 31, 
   2022   2021 
Federal statutory rate   21.0%    21.0% 
State income taxes, net of federal benefit   7.4    8.5 
Non-deductible expenses    (0.8)    0.2 
Income tax credits   3.2    4.3 
Valuation allowance   (30.8)   (34.0)
Effective tax rate   0.0%    0.0% 

 

The Company recognizes deferred tax assets and liabilities to reflect the tax effects of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements in accordance with ASC 740. These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled.

 

ASC 740 requires that a valuation allowance be established when management determines that it is more likely than not that all or a portion of a deferred asset will not be realized. The Company evaluates the realizability of its net deferred income tax assets and valuation allowances as necessary, at least on an annual basis. During this evaluation, the Company reviews its forecasts of income in conjunction with other positive and negative evidence surrounding the realizability of its deferred income tax assets to determine if a valuation allowance is required. Adjustments to the valuation allowance will increase or decrease the Company’s income tax provision or benefit.

 

The significant components of the Company’s net deferred tax assets and liabilities are as follows, in thousands:

        
   Years Ending December 31, 
   2022   2021 
Deferred tax assets:          
Net operating loss carryforwards  $11,808   $10,150 
Tax credit carryforwards   1,227    946 
Stock-based compensation   435    1,363 
Capitalized research and development expenses   1,662    – 
License fees   1,680    2,018 
Lease liability   46    79 
Other timing differences   120    169 
Deferred tax assets   16,978    14,725 
Deferred tax liabilities:          
Right of use asset   (43)   (76)
Deferred tax liability   (43)   (76)
Valuation allowance   (16,935)   (14,649)
Net deferred tax asset  $–   $– 

 

 

 

 F-19 

 

 

The Tax Cuts and Jobs Act of 2017 included a provision that requires the capitalization and amortization of research and development costs incurred in tax years beginning after December 31, 2021. Under this provision, U.S.-based research and development expenses are amortized over a period of five years and non-U.S.-based research and development expenses are amortized over a period of 15 years. The deferred tax assets as of December 31, 2022 included capitalized research and development expenses of $1,662,000.

 

The Company evaluated the realizability of its net deferred tax assets and concluded that, in accordance with the applicable accounting standards, that it is more likely than not that the Company may not realize the benefit of all of its deferred tax assets. Accordingly, a valuation allowance against 100% of its deferred tax assets has been recorded. Significant judgment is required in the evaluation of deferred tax benefits and differences in future results from our estimates could result in material differences in the realization of these assets.

 

As of December 31, 2022, the Company had federal net operating loss (“NOL”) carryforwards of approximately $49,200,000 and state NOL carryforwards of approximately $23,200,000 to reduce future taxable income. The utilization of the federal carryforwards as an available offset to future taxable income is subject to limitations under federal income tax laws. Under current federal income tax law, the Company’s federal NOLs generated in tax years beginning after December 31, 2017, totaling approximately $48,879,000, may be carried forward indefinitely, but are limited to offset up to 80% of future taxable income. The remaining federal NOLs generated, totaling approximately $321,000, will begin to expire in 2037 and the Company’s available state NOL carryforwards will begin to expire in 2038. In addition, the Company had federal and state research and development credits of approximately $819,000 and $517,000, respectively, which will begin to expire in 2041 and 2036, respectively.

 

Ownership changes may limit the amount of NOL carryforwards or tax credit carryforwards that can be utilized to offset future taxable income or tax liability. Pursuant to Sections 382 and 383 of the Internal Revenue Code of 1986, as amended (the “Code”), NOL and tax credit carryforwards may be subject to annual limitations in the event a cumulative change in ownership of more than 50% occurs within a three-year period. Any limitation may result in expiration of a portion of the NOL carryforwards or tax credit carryforwards before utilization.

 

During 2021, the Company completed an assessment of the available NOL and tax credit carryforwards under Sections 382 and 383 of the Code and determined that the Company underwent six ownership changes during the period from 2012 to 2021. As a result, NOL and tax credit carryforwards attributable to the pre-ownership changes are subject to substantial annual limitations under Section 382 and 383 of Code due to the ownership changes. The Company adjusted its NOL and tax credit carryforwards to address the impact of the ownership changes. For the years ended prior to December 31, 2021, federal and state NOLs of $55,000,000 and $70,000,000, respectively, were reduced and federal and state tax credit carryforwards of $1,400,000 and $700,000, respectively, were also reduced.

 

The Company assesses the need to conduct an ownership change analysis to determine whether any changes occurred in ownership that would limit NOL or tax credit carryforwards on an annual basis. Due to the minimal number of share issuances during the year, the Company did not conduct an ownership change analysis in 2022. The Company may experience ownership changes in the future as a result of subsequent shifts in stock ownership, some of which may be outside of the Company’s control.

 

The recognition and measurement of benefits related to the Company’s tax positions requires significant judgment, as uncertainties often exist with respect to new laws, new interpretations of existing laws, and rulings by taxing authorities. The Company follows a more-likely-than not threshold for financial statement recognition and measurement of a tax position taken, or expected to be taken in a tax return. The guidance relates to, amongst other things, classification, accounting for interest and penalties associated with tax positions, and disclosure requirements. Any interest and penalties accrued related to uncertain tax positions are recorded as tax expense. Differences between actual results and the Company’s assumptions or changes in the Company’s assumptions in future periods are recorded in the period they become known. The Company has not recorded any uncertain tax positions as of December 31, 2022 or 2021. The Company does not believe there will be any material changes in its unrecognized tax positions over the next 12 months.

 

The Company has not incurred any interest or penalties. In the event that the Company is assessed interest or penalties at some point in the future, they will be classified in the financial statements as general and administrative expenses.

  

 

 

 F-20 

 

 

The Company files income tax returns in the United States, Massachusetts and New Jersey. The Company is subject to tax examinations for federal and state purposes for tax years 2014 through 2022.

 

13. Net Loss per Share

 

The following table sets forth the potential common shares excluded from the calculation of net loss per common share because their inclusion would be anti-dilutive:

  December 31, 
   2022   2021 
Options to purchase common stock   141    208 
Unvested restricted stock units   47,328    30,592 
Warrants to purchase common stock   545,401    545,401 
Total   592,870    576,201 

 

 

 

 

 

 F-21 

 

 

ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURE

 

None.

 

ITEM 9A. CONTROLS AND PROCEDURES

 

Evaluation of Disclosure Controls and Procedures

 

Our management, with the participation of our Principal Executive Officer (who is also acting as our Principal Financial Officer), evaluated the effectiveness of disclosure controls and procedures (as defined in Rules 13a-15(e) and 15d-15(e) under the Securities Exchange Act of 1934, as amended (the “Exchange Act”)) as of the end of the period covered by this report to ensure that information that we are required to disclose in reports that we file or submit under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the SEC rules and forms.

 

Our disclosure controls and procedures are designed to provide reasonable assurance of achieving their objectives. We believe that a control system, no matter how well designed and operated, cannot provide absolute assurance that the objectives of the control system are met, and no evaluation of controls can provide absolute assurance that all control issues and instances of fraud, if any, within a company have been detected. Based on the evaluation of our disclosure controls and procedures as of the end of the period covered by this report, management, with the participation of our Principal Executive Officer (who is also acting as our Principal Financial Officer), concluded that our disclosure controls and procedures were effective at the reasonable assurance level as of such date.

 

Management’s Annual Report on Internal Control Over Financial Reporting

 

Our management is responsible for establishing and maintaining adequate internal control over financial reporting. A company’s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles.

 

There are inherent limitations in the effectiveness of any system of internal control, including the possibility of human error and the circumvention or overriding of controls. Accordingly, even effective internal controls can provide only reasonable assurances with respect to financial statement preparation. Further, because of changes in conditions, the effectiveness of internal control may vary over time.

 

Our management assessed the effectiveness of our internal control over financial reporting as of December 31, 2022. In making this assessment, management used the criteria set forth in Internal Control – Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework). Based on this assessment, management, with the participation of our Principal Executive Officer (who is also acting as our Principal Financial Officer), concluded that, as of December 31, 2022, our internal control over financial reporting was effective.

 

Attestation Report of the Registered Public Accounting Firm

 

This Annual Report on Form 10-K provides only management’s report. As a smaller reporting company, we are not required to provide an attestation report by our independent registered public accounting firm regarding our internal control over financial reporting.

 

 

 

 37 

 

 

Changes in Internal Control Over Financial Reporting

 

There have been no changes in our internal control over financial reporting that occurred during the fiscal quarter ended December 31, 2022 that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

  

ITEM 9B. OTHER INFORMATION

 

None.

 

ITEM 9C. DISCLOSURE REGARDING FOREIGN JURISDICTIONS THAT PREVENT INSPECTIONS

 

Not applicable.

 

 

 

 38 

 

 

PART III

 

ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

 

Board of Directors

 

The size of the Board is currently set at six directors. Biographical and other information regarding our directors, whose terms expire at the 2023 Annual Meeting of Stockholders, is set forth below.

 

Director Name

and Year First Became a Director

  Age   Position(s) with
the Company
Robert J. Bitterman (2012)   72   President, Chief Executive Officer and Chairman of the Board of Directors
Patricia A. Bradford (2022)   72   Director
Geert Cauwenbergh, Dr. Med. Sc. (2012)   69   Director
Robert L. Ferrara (2019)   71   Director
Jonathan E. Freeman, Ph.D. (2017)   54   Director
Curtis A. Lockshin, Ph.D. (2013)   62   Director

 

Robert J. Bitterman has served as a member and the Chairman of our Board since 2012 and as our President and Chief Executive Officer since February 2023. Mr. Bitterman served as the Interim Executive Chairman of the Company from September 2022 to February 2023 until his appointment to President and Chief Executive Officer. Mr. Bitterman served as the President and Chief Executive Officer of Cutanea Life Sciences, Inc., a private company he founded in 2005 that focused on developing innovative technologies to treat diseases and disorders of the skin and subcutaneous tissue, until its acquisition by Biofrontera, Inc., USA in March 2019. Since leaving Cutanea, Mr. Bitterman was retired until commencing the Interim Executive Chairman role with the Company in September 2022. Prior to his role at Cutanea Life Sciences, Inc., Mr. Bitterman also held the position of President and Chief Executive Officer of Isolagen, Inc., President and General Manager of Dermik Laboratories and various positions of increasing responsibility in financial and commercial capacities within Aventis S.A. Mr. Bitterman holds an A.B. degree in Economics from The College of the Holy Cross and a Master of Business Administration degree from Boston University. He also holds a Doctor of Humane Letters (Honoris Causa) from the New York College of Podiatric Medicine.

 

Patricia A. Bradford has served as a member of our Board since 2022. Ms. Bradford served as Senior Vice President Global Human Resources at Unisys Corporation, a global information technology solutions company, where her total service at Unisys spanned from 1982 until her retirement in 2013. In her role at Unisys, Ms. Bradford strategically led all global human resource programs and initiatives, including talent management, at multiple levels of the organization. Ms. Bradford’s roles at Unisys progressively included all areas of human resources, including an overseas assignment at the Unisys European headquarters where she provided human resources leadership to the region. Prior to Unisys, Ms. Bradford was employed by Deloitte, an audit, consulting, tax, and advisory services firm, from 1978 to 1982. Since 2014, Ms. Bradford has maintained a consulting practice focused on individual coaching for senior executives and high potential employees recommended by management. Ms. Bradford received a B.S. degree with an emphasis on accounting and statistics from Walsh College and is a Certified Public Accountant.

 

Geert Cauwenbergh, Dr. Med. Sc. has served as a member of our Board since 2012 and served as our Interim Principal Executive and Financial Officer from May 2022 to September 2022. He previously served as our President and Chief Executive Officer from April 2012 to November 2018, and as our Chief Executive Officer from November 2018 until his retirement in March 2019. Dr. Cauwenbergh served as Chairman and Chief Executive Officer of RHEI Pharmaceuticals, Inc., a private company that develops and commercializes proprietary drug therapies, from 2008 to 2011. In 2001, Dr. Cauwenbergh founded Barrier Therapeutics, Inc., a biopharmaceutical company focused on dermatology drug development, until its acquisition by Stiefel Laboratories, Inc. in 2008. Prior to Barrier Therapeutics, Inc. Dr. Cauwenbergh was employed by Johnson & Johnson for 23 years where he held a number of ascending senior management positions. He currently serves as a director of Legacy Health Care (Switzerland). Dr. Cauwenbergh received his Doctorate in Medical Sciences from the Catholic University of Leuven, Faculty of Medicine (Belgium), where he also completed his masters and undergraduate work.

 

 

 

 39 

 

 

Robert L. Ferrara has served as a member of our Board since 2019 and currently serves as our Lead Independent Director. He most recently served as the Chief Financial Officer of Cutanea Life Sciences, Inc., a private company focused on developing innovative technologies to treat diseases and disorders of the skin and subcutaneous tissue, from January 2012 to his retirement in June 2019. Prior to Cutanea, Mr. Ferrara served as the Chief Financial Officer of Storeroom Solutions Inc., a venture capital financed, technology enhanced, integrated supply chain solutions company, from 2004 to 2011, and NER Data Products, Inc., an IT service management company, from 2000 to 2003, as well as holding other senior level financial positions in national and international public companies in the greater Philadelphia area. Mr. Ferrara received a B.S. in Accounting from Lehigh University and is a Certified Public Accountant.

 

Jonathan E. Freeman, Ph.D. has served has a member of our Board since 2017. Dr. Freeman currently serves as the Chief Operating Officer of Anthos Therapeutics Inc., a clinical-stage biopharmaceutical company developing therapies for cardiovascular patients, a position he has held since July 2021. Anthos Therapeutics Inc. was launched by Novartis and Blackstone Life Sciences, a private investment firm, where Dr. Freeman has also served as a Senior Advisor since July 2018. From 2017 to June 2018, Dr. Freeman held the position of Chief Business Officer of Vedanta Biosciences, a clinical-stage company developing therapies for immune-mediated diseases. Prior to his role with Vedanta Biosciences, Dr. Freeman was the Senior Vice President of Strategy and Portfolio Management and Head of Business Development and Licensing at Merck KGaA, a leading science and technology company, from 2008 to 2016. Dr. Freeman received a Ph.D. in Molecular Pharmacology and Drug Metabolism from the Imperial Cancer Research Fund (now CRUK), an M.A. and First Class Honours in Biochemistry from Cambridge University and a MBA with a finance major from Webster, St. Louis.

 

Curtis A. Lockshin, Ph.D. has served as a member of our Board since 2013. Dr. Lockshin currently serves as the Chief Scientific Officer of Xenetic Biosciences, Inc., a biopharmaceutical company focused on the development of novel oncology therapeutics, a position he has held since January 2017. Prior to this appointment, Dr. Lockshin served as Xenetic Biosciences, Inc.’s Vice President of Research and Operations from March 2014 to January 2017. From July 2016 to December 2016, Dr. Lockshin served as Chief Technical Officer of VBI Vaccines, Inc., a company developing vaccines in infectious disease and immuno-oncology. VBI Vaccines, Inc. merged with SciVac Therapeutics, Inc. and its subsidiary SciVac, Ltd., a commercial-stage biologics and vaccine company, in July 2016 where Dr. Lockshin had served as its Chief Executive Officer and director since September 2014. Since May 2013, Dr. Lockshin has also served as President and Chief Executive Officer of Guardum Pharmaceuticals, LLC, a private pharmaceutical company. Dr. Lockshin holds a S.B. degree in Life Sciences and a Ph.D. in Biological Chemistry from the Massachusetts Institute of Technology.

 

Executive Officers

 

As of the date of this Annual Report on Form 10-K, we have only one executive officer, Robert Bitterman, who serves as our President and Chief Executive Officer. Certain biographical information regarding Mr. Bitterman is set forth above. There are no family relationships among any of our directors or executive officers.

 

Audit Committee

 

We have a separately-designated standing audit committee established in accordance with Section 3(a)(58)(A) of the Exchange Act. The Audit Committee is comprised of Mr. Ferrara (Chairman), Ms. Bradford and Dr. Freeman. The Board has determined that all members of the Audit Committee satisfy the current independence and experience requirements of Rule 10A-3 of the Securities Exchange Act of 1934, as amended, (the “Exchange Act”) and the current Nasdaq independence standards, and the Board has determined that Mr. Ferrara is an “audit committee financial expert,” as the Securities and Exchange Commission (the “SEC”) has defined that term in Item 407 of Regulation S-K.

 

Code of Business Conduct and Ethics

 

We have adopted a Code of Business Conduct and Ethics that applies to all employees, including our principal executive officer, principal financial officer, principal accounting officer or controller, or persons performing similar functions. Our Code of Business Conduct and Ethics, as well as other corporate governance materials, is located on our website at www.phiopharma.com. Waivers of our Code of Business Conduct and Ethics may only be granted by the Board. We intend to disclose on our website any amendments to, or waivers from, the Code of Business Conduct and Ethics that are required to be disclosed pursuant to the disclosure requirements of Item 5.05 of Form 8-K within four business days following the date of the amendment or waiver.

 

 

 

 40 

 

 

Delinquent Section 16(a) Reports

 

Section 16(a) of the Exchange Act requires the Company’s directors, executive officers and greater-than-10% stockholders to file forms with the SEC to report their ownership of Company securities and any changes in ownership. We have reviewed all forms filed electronically with the SEC. Based on that review and on written information given to us by our officers and directors, we believe that all of our directors, officers and greater-than-10% stockholders filed the required reports on a timely basis under Section 16(a) during 2022, except for director Patricia Bradford, who on September 26, 2022 filed a Form 4 that was due August 11, 2022.

 

ITEM 11. EXECUTIVE COMPENSATION

 

The following describes the compensation earned by each of the executive officers identified below in the Summary Compensation Table, who are referred to collectively as our “named executive officers.” Our named executive officers with respect to the fiscal year that ended on December 31, 2022 are Robert J. Bitterman, Geert Cauwenbergh, Dr. Med. Sc., our former interim Principal Executive and Financial officer and Gerrit Dispersyn, Dr. Med. Sc., our former President and Chief Executive Officer.

 

Summary Compensation Table

 

Name and principal position   Year   Salary
($)		   Stock
awards
($)(1)		   Non-equity
incentive plan
compensation
($)(2)		   All other
compensation
($)(3)		   Total
($)		  
Robert J. Bitterman (4)   2022   77,885   31,464   –   31   109,380  
President and Chief Executive Officer   2021   47,500   30,800   –   –   78,300  
Geert Cauwenbergh, Dr. Med. Sc.(5)   2022   68,750   8,612   –   –   77,362  
Former interim Principal Executive and Financial Officer   2021   27,500   30,800   –   –   58,300  
Gerrit Dispersyn, Dr. Med. Sc.(6)   2022   178,514   108,511   –   202,744   489,769  
Former President and Chief Executive Officer   2021   403,390   210,826   136,688   575   751,479  

 

(1) The amounts shown reflect the grant date fair value of restricted stock units (“RSUs”) computed in accordance with the Financial Accounting Standards Board (the “FASB”) Accounting Standards Codification (“ASC”) Topic 718, “Compensation — Stock Compensation” for the indicated year.
(2) The amounts shown reflect the annual cash bonus earned for performance for each respective year under the Company’s Incentive Bonus Program. The annual cash bonus for fiscal years 2022 and 2021 was paid in March of the subsequent year, respectively.
(3) Represents amounts for the dollar value of life insurance premiums paid, except as noted in footnote 6 below.
(4) Mr. Bitterman has served as a member of the Company’s Board of Directors since 2012 and served as the Company’s Interim Executive Chairman from September 2022 to February 2023 and was appointed as our President and Chief Executive Officer in February 2023. The amounts listed in fiscal year 2021 reflect the compensation paid to Mr. Bitterman as a member of our Board of Directors. The amounts listed in fiscal year 2022 reflect the compensation paid to Mr. Bitterman as a member of our Board of Directors, totaling $46,112, and as our Interim Executive Chairman, totaling $63,268.
(5) Dr. Cauwenbergh has served as a member of the Company’s Board of Directors since 2012 and served as the Company’s interim Principal Executive and Financial Officer from May 2022 to September 2022. Dr. Cauwenbergh was paid $37,500 in compensation in fiscal year 2022 as the Company’s interim Principal Executive and Financial Officer, which is included within the “Salary” heading of the Summary Compensation Table. All other compensation listed in the Summary Compensation Table reflects the compensation paid to Dr. Cauwenbergh as a member of our Board of Directors.
(6) Dr. Dispersyn served as the Company’s President and Chief Executive Officer from March 2019 to May 2022. Included within the “All Other Compensation” heading of the Summary Compensation Table is $202,500 in severance payments made to Dr. Dispersyn in connection with his termination consistent with and subject to the conditions set forth in his employment agreement.

 

 

 

 41 

 

 

Outstanding Equity Awards at Fiscal Year-End

 

The following table shows information regarding outstanding equity awards as of December 31, 2022 for our named executive officers:

 

        Option Awards   Stock Awards  
Name  

Grant

Date

  

Number of
Securities
Underlying
Unexercised
Options

(#)
Exercisable

  

Number of
Securities
Underlying
Unexercised
Options

(#)
Unexercisable

  

Option
Exercise
Price

($)

   Option
Expiration
Date		  

Number of
Shares or
Units of
Stock That
Have Not
Vested

(#)

  

Market Value of Shares or
Units of
Stock That
Have Not
Vested

($)

  

Equity
Incentive
Plan
Awards:
Number of
Unearned
Shares or
Units of
Stock That
Have Not
Vested

(#)

   Equity
Incentive
Plan
Awards:
Market Value of
Unearned
Shares or
Units of
Stock That
Have Not
Vested
($)(1)		  
Robert J. Bitterman (2)   6/7/2013   1   –   396,000.00   6/7/2023   –   –   –   –  
    6/2/2014   1   –   188,100.00   6/2/2024   –   –   –   –  
    6/1/2015   1   –   25,080.00   6/1/2025   –   –   –   –  
    2/10/2016   1   –   18,876.00   2/10/2026   –   –   –   –  
    2/1/2017   1   –   4,151.40   2/1/2027   –   –   –   –  
    2/15/2022   –   –   –   –   –   –   834   3,720  
    10/1/2022   –   –   –   –   –   –   3,334   14,870  
Geert Cauwenbergh, Dr. Med. Sc. (3)   6/7/2013   3   –   396,000.00   6/7/2013   –   –   –   –  
    6/2/2014   3   –   188,100.00   6/2/2014   –   –   –   –  
    6/1/2015   3   –   25,080.00   6/1/2025   –   –   –   –  
    2/10/2016   3   –   18,876.00   2/10/2026   –   –   –   –  
    2/1/2017   2   –   4,151.40   2/1/2027   –   –   –   –  
    8/1/2018   32   –   1,181.40   8/1/2028   –   –   –   –  
    2/15/2022   –   –   –   –   –   –   834   3,720  
Gerrit Dispersyn, Dr. Med. Sc.   –   –   –   –   –   –   –   –   –  

 

 

(1) Value is based on the closing price of $4.46 of the Company’s common stock on December 31, 2022.
(2) The equity awards granted to Mr. Bitterman vest in one installment on the first anniversary of the grant date.
(3) The equity awards granted to Dr. Cauwenbergh from 2013 and 2018 vested over four years commencing on the first anniversary of the grant date. The equity award granted to Dr. Cauwenbergh in 2022 vests in one installment on the first anniversary of the grant date.

 

 

 

 42 

 

 

Base Salary

 

When reviewing and approving our executive compensation arrangements, including the base salaries paid to our executive officers, the Compensation Committee of the Company's Board of Directors (the “Compensation Committee”) considers a number of factors, including, but not limited to: the performance of the executive officer to the Company’s overall performance, the performance of the executive officer against the Company’s corporate objectives, the executive officer’s skills, experience and qualifications in such executive officer’s role, review of compensation surveys of base salaries paid by comparable organizations and market compensation data. These factors provide the framework for decisions regarding the base salary compensation for each executive officer. No single factor is determinative in setting base salary levels, nor was the impact of any factor on the determination of pay levels quantifiable.

 

Incentive Compensation

 

Annual Incentive Bonus

 

Annual bonuses are based on the achievement of corporate goals typically comprised of a mix of clinical development, discovery, financial, business development, and investor relations related performance objectives. The corporate goals are approved by the Board on an annual basis at the start of each year. Annual bonuses for all employees, including executive officers, take into account the achievement of specified business objectives and individual performance objectives, with the exception of the Company's President and Chief Executive Officer, whose annual bonus is determined solely by the achievement of business objectives. The Compensation Committee reviews our achievements against these corporate goals and their assessment of the goals and recommendations regarding funding is presented to our full Board for approval. The Compensation Committee maintains full discretion in determining overall performance under the annual bonus and may adjust bonus payouts based on factors it deems relevant. Annual incentive bonus payouts to our named executive officers are disclosed in the Summary Compensation Table above.

 

Equity Incentive

 

We maintain our 2020 Long Term Incentive Plan (“2020 Plan”) pursuant to which we currently grant RSU awards to eligible participants. Grants of restricted stock units under this plan to our named executive officers are disclosed in the Summary Compensation Table and Outstanding Equity Awards at Fiscal Year-End table above.

 

Employment and Change of Control Agreements

 

The following provides descriptions of the employment agreements that are currently or were in effect for our named executive officers:

 

Robert J. Bitterman

 

Mr. Bitterman was appointed President and Chief Executive Officer and entered into an employment agreement, dated February 20, 2023, pursuant to which he will be entitled to an initial annual base salary of $440,000 and will be eligible to receive an annual bonus of up to 40% of his annual base salary, based on the achievement of certain performance goals established annually by the Board. In connection with his appointment, the Company granted Mr. Bitterman RSUs settleable for 11,000 shares of the Company's common stock under the Company's 2020 Plan. The RSUs will vest in two equal annual installments, commencing on the first anniversary of the date of grant, subject to Mr. Bitterman’s continuous service with the Company through each such vesting date. 

  

 

 

 43 

 

 

If Mr. Bitterman’s employment is terminated by the Company due to death or disability, the Company shall pay to Mr. Bitterman or to his estate, as applicable, any earned, but unpaid, base salary and any amounts owed to Mr. Bitterman for reimbursement of expenses properly incurred which are reimbursable, in each case as earned or incurred, as applicable through the date of termination (the “Accrued Benefits”), as well as pay any accrued but unpaid bonus then due to Mr. Bitterman and all equity awards that have been granted will immediately vest on a pro-rata basis. If Mr. Bitterman’s employment is terminated by the Board for cause or by Mr. Bitterman without good reason, the Company shall pay to Mr. Bitterman the Accrued Benefits through the date of termination. If Mr. Bitterman’s employment is terminated by Mr. Bitterman for good reason or by the Company other than as a result of death or disability and other than for cause, then the Company shall pay to Mr. Bitterman the Accrued Benefits through the date of termination, continue to pay Mr. Bitterman his base salary for three months from the date of separation, pay any accrued but unpaid bonus and if, and only if, such termination occurs within one year of a change in control all equity awards that have been granted but are not exercisable at the time of such termination shall immediately become exercisable in full. 

  

Mr. Bitterman is eligible to participate in the Company’s 2020 Plan and other benefits available to the Company’s executive officers.

 

Geert Cauwenbergh, Dr. Med. Sc.

 

In connection with his appointment as the Company’s interim Principal Executive Officer and Principal Financial Officer, Dr. Cauwenbergh received a monthly cash payment of $7,500.

 

Gerrit Dispersyn, Dr. Med. Sc.

 

We entered into an employment agreement with Dr. Dispersyn effective April 24, 2017 as our Chief Development Officer. As Chief Development Officer, Dr. Dispersyn was entitled to receive an initial base salary of $285,000 per annum, as well as a performance bonus of up to 30% of his base salary, subject to the achievement of performance goals to be established annually. In connection with Dr. Dispersyn’s appointment to Chief Development Officer, he received a stock option entitling him to purchase 14 shares of the Company’s common stock, which were subject to vesting in equal monthly installments over four years following the date of grant.

 

Dr. Dispersyn served as the Company’s President and Chief Executive Officer from March 2019 to May 2022. As President and Chief Executive Officer, Dr. Dispersyn was entitled to an initial base salary of $380,000 per annum, as well as a performance bonus of up to 50% of his base salary, subject to the achievement of performance goals to be established annually. As a one-time award in connection with his appointment on March 1, 2019, Dr. Dispersyn received RSUs settleable for 617 shares of the Company’s common stock, which was subject to vesting in equal annual installments over four years.

 

Dr. Dispersyn’s employment agreement provided that, upon termination of Dr. Dispersyn’s employment without cause by us, he would be entitled to payment of: (1) any accrued but unpaid salary and unused vacation as of the date of his termination; (2) six months of salary from the date of termination; and (3) continued participation, at our expense, during the applicable six-month severance period in our sponsored group medical and dental plans. Effective May 5, 2022, Dr. Dispersyn’s employment with the Company ended, which was treated as a termination without “cause,” and Dr. Dispersyn became entitled to receive severance benefits totaling $202,500 consistent with the above and subject to the conditions set forth in the separation agreement between Dr. Dispersyn and the Company.

 

Director Compensation

 

Non-Employee Director Compensation Policy

 

We compensate our non-employee directors for their service as a member of our Board. Each non-employee director is entitled to receive an annual cash retainer of $35,000. The chairs of our Board and Audit Committee are entitled to receive an additional annual cash retainer of $15,000 and the chairs of the Compensation, Governance and Nominating Committees are entitled to receive an additional cash retainer of $7,500. In addition, the Lead Independent Director, if any, is entitled to receive an additional annual cash retainer of $12,500. Each non-employee director is also entitled to receive 1,667 RSUs, which vest in full on the one-year anniversary of the respective date of grant.

 

The Compensation Committee and the Board reassess the appropriate levels of cash and equity compensation for non-employee directors on an annual basis.

 

 

 

 44 

 

 

Non-employee directors are also reimbursed for their travel and reasonable out-of-pocket expenses incurred in connection with attending Board and committee meetings and in attending continuing education seminars, to the extent that attendance is required by the Board or the committee(s) on which that director serves.

 

Non-Employee Director Compensation Table

 

The following table shows the compensation to the Company’s non-employee directors in fiscal year 2022. We compensate our non-employee directors for their service as a member of our Board. Compensation paid to Robert J. Bitterman, the Company's President, Chief Executive Officer and Chairman of the Board, and Geert Cauwenbergh, Dr. Med. Sc., who served as the Company’s interim Principal Executive Officer and interim Principal Financial Officer from May 2022 to September 2022, in connection with their service as directors of the Company is set forth above in the Summary Compensation Table due to Mr. Bitterman and Dr. Cauwenbergh’s status as named executive officers of the Company.

 

Name  Fees Earned or
Paid in Cash ($)		  

Stock Awards

($)(1)

  

Total

($)

 
Patricia A. Bradford   27,292    15,000    42,292 
H. Paul Dorman(2)   16,667    8,612    25,279 
Robert L. Ferrara   49,375    8,612    57,987 
Jonathan E. Freeman, Ph.D.   31,250    8,612    39,862 
Curtis A. Lockshin, Ph.D.   38,750    8,612    47,362 

 

(1) The amounts shown reflect the grant date fair value of RSUs computed in accordance with the FASB ASC Topic 718, “Compensation — Stock Compensation”.
(2) Mr. Dorman did not be stand for reelection at the 2022 Annual Stockholder Meeting held on August 8, 2022 and served as a director until the end of his term.
   

As of December 31, 2022, the aggregate number of shares underlying stock options and RSUs by our non-employee directors is as follows: Patricia A. Bradford — 1,667 RSUs, Robert L. Ferrara — 834 RSUs, Jonathan E. Freeman, Ph.D. — 1 option award and 834 RSUs, and Curtis A. Lockshin, Ph.D. — 5 option awards and 834 RSUs. Mr. Bitterman and Dr. Cauwenbergh’s outstanding equity awards are also included in the Outstanding Equity Awards at Fiscal Year-End table above due to their status as named executive officers during the fiscal year ended December 31, 2022.

 

Upon his appointment to President and Chief Executive Officer of the Company effective February 20, 2023, Mr. Bitterman ceased receiving compensation in connection with his positions as a director of the Company, including as Chairman of the Board.

 

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS

 

Security Ownership of Certain Beneficial Owners and Management

 

Based on information available to us and filings with the SEC, the following table sets forth certain information regarding the beneficial ownership (as defined by Rule 13d-3 under the Exchange Act) of our outstanding common stock for (i) each of our directors, (ii) each of our named executive officers, (iii) all of our directors and executive officers as a group and (iv) persons known to us to beneficially own more than 5% of our outstanding common stock. The following information is presented as of February 28, 2023 or such other date as may be reflected below.

 

Beneficial ownership and percentage ownership are determined in accordance with the rules of the SEC and include voting or investment power with respect to shares of stock. This information does not necessarily indicate beneficial ownership for any other purpose. Under these rules, shares of common stock not outstanding but deemed beneficially owned by virtue of the right of a person to acquire them as of February 28, 2023, or within 60 days of February 28, 2023, are deemed outstanding for the purpose of computing the percentage ownership of each person, but are not deemed outstanding for the purpose of computing the percentage ownership of any other person.

 

 

 

 45 

 

 

Unless otherwise indicated and subject to applicable community property laws, to our knowledge, each stockholder named in the following table possesses sole voting and investment power over their shares of common stock, except for those jointly owned with that person’s spouse. Unless otherwise indicated below, the address of each person listed on the table is c/o Phio Pharmaceuticals Corp., 257 Simarano Drive, Suite 101, Marlborough, MA 01752.

 

    Shares Beneficially Owned  
Name and Address of Beneficial Owner   Number (1)     Percent of
Class (2) 		 
Greater than 5% Holders                
Intracoastal Capital LLC(3)     67,654       5.6%  
Directors and Named Executive Officers:                
Robert J. Bitterman (4)     2,883       *  
Patricia A. Bradford     –       *  
Geert Cauwenbergh, Dr. Med. Sc.(5)     2,782       *  
Robert Ferrara     2,500       *  
Jonathan E. Freeman, Ph.D. (6)     1,698       *  
Curtis A. Lockshin, Ph.D. (7)     1,702       *  
All current directors and executive officers as a group (six persons)     11,565       1.02%  
                 
* Indicates less than 1%.
(1) Represents shares of common stock held as of February 28, 2023 plus shares of common stock that may be acquired upon the exercise of options and warrants within 60 days of February 28, 2023.
(2) Based on 1,137,318 shares of common stock that were issued and outstanding as of February 28, 2023. Shares not outstanding but deemed beneficially owned by virtue of the right of a person to acquire them as of February 28, 2023, or within 60 days of February 28, 2023, are treated as outstanding only when determining the ownership and voting power for each person (or all directors and executive officers as a group).
(3)

Based solely on information set forth in a Schedule 13G/A filed with the SEC on February 8, 2023 by Intracoastal Capital LLC (“Intracoastal”), Mitchell P. Kopin (“Mr. Kopin”) and Daniel B. Asher (“Mr. Asher”). Each of Intracoastal, Mr. Kopin and Mr. Asher may be deemed to have beneficial ownership of 67,654 shares of common stock consisting of (i) 17,845 shares of common stock issuable upon exercise of a warrant held by Intracoastal (“Intracoastal Warrant 1”), (ii) 19,271 shares of common stock issuable upon exercise of a second warrant held by Intracoastal (“Intracoastal Warrant 2”), (iii) 30,538 shares of common stock issuable upon exercise of a third warrant held by Intracoastal (“Intracoastal Warrant 3”), and all such shares of common stock represented beneficial ownership of approximately 5.6% of the common stock, based on (1) 1,138,997 shares of common stock outstanding as of November 17, 2022, as reported by the Issuer, plus (2) 17,845 shares of common stock issuable upon exercise of Intracoastal Warrant 1, (3) 19,271 shares of common stock issuable upon exercise of Intracoastal Warrant 2 and (4) 30,538 shares of common stock issuable upon exercise of Intracoastal Warrant 3. The foregoing excludes (I) 4,625 shares of common stock issuable upon exercise of a fourth warrant held by Intracoastal (“Intracoastal Warrant 4”) because Intracoastal Warrant 4 contains a blocker provision under which the holder thereof does not have the right to exercise Intracoastal Warrant 4 to the extent (but only to the extent) that such exercise would result in beneficial ownership by the holder thereof, together with the holder’s affiliates, and any other persons acting as a group together with the holder or any of the holder’s affiliates, of more than 4.99% of the common stock and (II) 342 shares of common stock issuable upon exercise of a fifth warrant held by Intracoastal (“Intracoastal Warrant 5”) because Intracoastal Warrant 5 contains a blocker provision under which the holder thereof does not have the right to exercise Intracoastal Warrant 5 to the extent (but only to the extent) that such exercise would result in beneficial ownership by the holder thereof, together with the holder’s affiliates, and any other persons acting as a group together with the holder or any of the holder’s affiliates, of more than 4.99% of the common stock. Without such blocker provisions, each of the Reporting Persons may have been deemed to have beneficial ownership of 72,621 shares of common stock. The principal business office of Mr. Kopin and Intracoastal is 245 Palm Trail, Delray Beach, Florida 33483. The principal business office of Mr. Asher is 111 W. Jackson Boulevard, Suite 2000, Chicago, Illinois 60604.

(4) Includes 5 stock options exercisable within 60 days of February 28, 2023.
(5) Includes 46 stock options exercisable within 60 days of February 28, 2023.
(6) Includes 1 stock option exercisable within 60 days of February 28, 2023.
(7) Includes 5 stock options exercisable within 60 days of February 28, 2023.
                   

 

 

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Equity Compensation Plan Information

 

The following table sets forth certain information, as of December 31, 2022, about the securities authorized for issuance under our equity compensation plans, which consisted of our 2020 Plan and our 2013 Employee Stock Purchase Plan. Upon adoption of the 2020 Plan, shares that remained available for grant under our prior Phio Pharmaceuticals Corp. 2012 Long-Term Incentive Plan (the “2012 Plan”) and shares that were subject to outstanding awards under the 2012 Plan were included in the authorized shares available for grant under the 2020 Plan. Further, upon adoption of the 2020 Plan, the Company no longer grants new equity awards under the 2012 Plan.

 

Plan Category   Number of Securities
to be Issued Upon
Exercise of
Outstanding Options,
Warrants and
Rights		     Weighted-Average
Exercise Price of
Outstanding Options,
Warrants and Rights		     Number of Securities
Remaining Available for
Future Issuance
Under Equity Compensation
Plans (Excluding
Securities Reflected in
First Column)		  
Equity compensation plans approved by security holders(1)     47,469     $ 19,761.12       43,807  
Equity compensation plans not approved by security holders     –       –       –  
Total     47,469     $ 19,761.12       43,807  

___________________

(1) Includes options outstanding representing 141 shares of common stock under the 2020 Plan. Also includes 47,328 RSUs subject to the 2020 Plan.

 

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE

 

Our Board, with the assistance of the Audit Committee, reviews and approves all transactions with directors, officers and holders of more than 5% of our voting securities and their affiliates. Prior to the Board’s consideration of a transaction with such a related party, the material facts as to the related party’s relationship or interest in the transaction must be disclosed to the Board, and the transaction will not be considered approved by the Board unless a majority of the directors who are not interested in the transaction (if applicable) approve the transaction. Furthermore, when stockholders are entitled to vote on a transaction with a related party, the material facts of the related party’s relationship or interest in the transaction must be disclosed to the stockholders, who must approve the transaction in good faith.

 

Since the past two years, there has not been, nor is there currently proposed, any transaction or series of related transactions to which we were or will be a party in which the amount involved exceeded or will exceed the lesser of (i) $120,000 or (ii) one percent of the average of Company's total assets at yearend for the last two completed fiscal years and in which the other parties included or will include any of our directors, executive officers, holders of 5% or more of our voting securities, or any member of the immediate family of any of the foregoing persons, other than compensation arrangements with directors and executive officers, which are described where required in Item 11. Executive Compensation of this Annual Report on Form 10-K.

 

Indemnification Agreements

 

We have entered into indemnification agreements with each of our executive officers and directors. These agreements provide that, subject to limited exceptions and among other things, we will indemnify each of our executive officers and directors to the fullest extent permitted by law and advance expenses to each indemnitee in connection with any proceeding in which a right to indemnification is available.

 

 

 

 47 

 

 

Director Independence

 

We believe that the Company benefits from having a strong and independent Board. For a director to be considered independent, the Board must determine that the director does not have any direct or indirect material relationship with the Company that would affect his or her exercise of independent judgment. On an annual basis, the Board reviews the independence of all directors under the applicable Nasdaq listing standards. The Board also considers each director’s affiliations with the Company and members of management, as well as significant holdings of Company securities. This review considers all known relevant facts and circumstances in making an independence determination. Based on this review, the Board has made an affirmative determination that all directors are independent, other than our President and Chief Executive Officer and Chairman of the Board, Mr. Bitterman.

 

In addition, Nasdaq listing standards require that, subject to specified exceptions, each member of our Audit, Compensation, Governance and Nominating Committees be independent and that our Audit Committee members also satisfy independence criteria set forth in Rule 10A-3 under the Exchange Act. Our Board has determined that all members of the Audit Committee, Compensation Committee, Governance Committee, and Nominating Committee are independent under the applicable Nasdaq listing standards and the Exchange Act.

 

ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES

 

The following is a summary of the fees billed and expected to be billed to the Company by BDO USA, LLP (“BDO”), our independent registered public accounting firm, for professional services rendered for the fiscal years ended December 31, 2022 and 2021. All fees incurred in fiscal years 2022 and 2021 for services rendered by BDO were approved in accordance with the pre-approval policies and procedures described below.

 

    2022     2021  
Audit Fees   $ 215,974     $ 187,352  
Audit-Related Fees     –       –  
Tax Fees     –       36,250  
All Other Fees     –       –  
Total All Fees:   $ 215,974     $ 223,602  

 

Audit Fees consist of fees for the audit of the Company’s financial statements included in our annual reports on Form 10-K, the review of the Company’s financial statements included in our quarterly reports on Form 10-Q and other statutory and regulatory filings, including auditor consents.

 

Audit-Related Fees consist of fees billed for assurance and related services that are also performed by our independent registered public accounting firm.

 

Tax Fees consist of services rendered for tax compliance, tax advice and tax planning.

 

All Other Fees consist of the aggregate fees billed for products and services provided by BDO and not otherwise included in Audit Fees, Audit-Related Fees or Tax Fees.

 

Pre-Approval Policies and Procedures

 

Under the Sarbanes-Oxley Act of 2002, all audit and permissible non-audit services provided by our auditors must be approved in advance by our Audit Committee to ensure that such services do not impair the auditors’ independence from us. Accordingly, the Audit Committee reviews and pre-approves all audit and non-audit services performed by its independent registered public accounting firm, as well as the fees charged for such services. In its review of non-audit service fees, the Audit Committee considers, among other things, the possible impact of the performance of such services on the auditor’s independence.

 

 

 

 48 

 

 

PART IV

 

ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

 

Financial Statements

 

Our consolidated financial statements are set forth in Item 8 to this Annual Report on Form 10-K.

 

Financial Statement Schedules

 

Certain schedules are omitted because they are not applicable, or are not required by smaller reporting companies.

 

Exhibits

 

Exhibit       Incorporated by Reference Herein
Number   Description   Form   Date
             
3.1    Amended and Restated Certificate of Incorporation of Phio Pharmaceuticals Corp.    Current Report on Form 8-K (File No. 001-36304)    November 19, 2018
                    
3.2    Certificate of Amendment to the Amendment and Restated Certificate of Incorporation of Phio Pharmaceuticals Corp.    Current Report on Form 8-K (File No. 001-36304)    January 14, 2020
             
3.3   Certificate of Amendment to the Amendment and Restated Certificate of Incorporation of Phio Pharmaceuticals Corp.   Current Report on Form 8-K (File No. 001-36304)   January 25, 2023
             
3.4   Certificate of Designation of Series D Preferred Stock, dated November 16, 2022.   Current Report on Form 8-K (File No. 001-36304)   November 16, 2022
             
3.5   Amended and Restated Bylaws of Phio Pharmaceutical Corp.   Current Report on Form 8-K (File No. 001-36304)   May 2, 2022
             
4.1   Form of Warrant.   Current Report on Form 8-K (File No. 001-36304)   April 11, 2018
             
4.2   Form of Placement Agent Warrant.   Current Report on Form 8-K (File No. 001-36304)   April 11, 2018
             
4.3   Form of Warrant.   Amendment No. 1 to the Registration Statement on Form S-1 (File No. 333-221173)   September 28, 2018
             
4.4   Form of Underwriter Warrant.   Current Report on Form 8-K (File No. 001-36304)   October 5, 2018
             
4.5   Form of Placement Agent Warrant.   Current Report on Form 8-K (File No. 001-36304)   November 19, 2019
             

 

 

 49 

 

 

4.6   Form of Warrant.   Current Report on Form 8-K (File No. 001-36304)   February 6, 2020
             
4.7   Form of Warrant.   Current Report on Form 8-K (File No. 001-36304)   February 13, 2020
             
4.8   Form of Underwriter Warrant.   Current Report on Form 8-K (File No. 001-36304)   February 13, 2020
             
4.9   Form of Warrant.   Current Report on Form 8-K (File No. 001-36304)   April 2, 2020
             
4.10   Form of Common Stock Warrant.   Current Report on Form 8-K (File No. 001-36304)   January 25, 2021
             
4.11   Form of Placement Agent Warrant.   Current Report on Form 8-K (File No. 001-36304)   February 17, 2021
             
4.12   Description of Securities Registered Pursuant to Section 12(b) of the Securities Exchange Act of 1934.*   Annual Report on Form 10-K (File. 001-36304)   March 26, 2020
             
10.1   Patent and Technology Assignment Agreement between RXi Pharmaceuticals Corporation (formerly RNCS, Inc.) and Advirna, LLC, effective as of September 24, 2011.   Registration Statement on Form S-1 (File No. 333-177498)   October 25, 2011
             
10.2   Clinical Co-development Agreement, dated February 26, 2021, by and between Phio Pharmaceuticals Corp. and AgonOx, Inc.*+        
             
10.3   Phio Pharmaceuticals Corp. 2020 Long Term Incentive Plan.#   Registration Statement on Form S-8 (File No. 333-251670)   December 23, 2020
             
10.4   Form of Restricted Stock Unit Award under the Company’s 2020 Long Term Incentive Plan.#   Annual Report on Form 10-K (File. 001-36304)   March 25, 2021
             
10.5   Phio Pharmaceuticals Corp. 2012 Long Term Incentive Plan.#   Quarterly Report on Form 10-Q (File No. 001-36304)   November 12, 2019
             
10.6   Form of Restricted Stock Unit Award under the Company’s 2012 Long Term Incentive Plan.#   Amendment No. 2 to the Registration Statement on Form S-1 (File No. 333-177498)   December 29, 2011
             
10.7   Form of Incentive Stock Option Award under the Company’s 2012 Long Term Incentive Plan, as amended.#   Registration Statement on Form S-1 (File No. 333-191236)   September 18, 2013
             
10.8   Form of Non-Qualified Stock Option Award under the Company’s 2012 Long Term Incentive Plan, as amended.#   Registration Statement on Form S-1 (File No. 333-191236)   September 18, 2013
             
10.9   RXi Pharmaceuticals Corporation Employee Stock Purchase Plan.#   Registration Statement on Form S-8 (File No. 333-277013)   August 24, 2018
             

 

 

 50 

 

 

10.10   Form of Indemnification Agreement.#   Amendment No. 3 to the Registration Statement on Form S-1 (File No. 333-177498)   January 23, 2012
             
10.11   Separation Agreement, date May 5, 2022, by and between Phio Pharmaceuticals Corp. and Gerrit Dispersyn, Dr. Med. Sc.#*        
             
10.12   Employment Agreement, dated February 20, 2023, by and between Phio Pharmaceuticals Corp. and Robert Bitterman.#   Current Report on Form 8-K (File No. 001-36304)   February 22, 2023
             
10.13   Subscription and Investment Representation Agreement, dated November 16, 2022, by and between Phio Pharmaceuticals Corp. and Robert Bitterman.   Current Report on Form 8-K (File No. 001-36304)   November 16, 2022
             
10.14   Lease Agreement dated December 17, 2013 between RXi Pharmaceuticals Corporation and 257 Simarano Drive, LLC, Brighton Properties, LLC, Robert Stubblebine 1, LLC and Robert Stubblebine 2, LLC.   Current Report on Form 8-K (File No. 000-54910)   December 20, 2013
             
10.15   First Amendment to Lease dated January 22, 2019.   Current Report on Form 8-K (File No. 001-36304)   January 28, 2019
             
10.16   Registration Rights Agreement, dated January 21, 2021, by and between the Company and the Purchasers signatory therein.   Current Report on Form 8-K (File No. 001-36304)   January 25, 2021
             
23.1   Consent of BDO USA, LLP, an Independent Registered Public Accounting Firm.*        
             
31.1   Sarbanes-Oxley Act Section 302 Certification of Principal Executive Officer and Principal Financial Officer.*        
             
32.1   Sarbanes-Oxley Action Section 906 Certification of Principal Executive Officer and Principal Financial Officer.**        
             
101.INS   Inline XBRL Instance Document.*        
101.SCH   Inline XBRL Taxonomy Extension Schema Document.*        
101.CAL   Inline XBRL Taxonomy Extension Calculation Linkbase Document.*        
101.DEF   Inline XBRL Taxonomy Extension Definition Linkbase Document.*        
101.LAB   Inline XBRL Taxonomy Extension Label Linkbase Document.*        
101.PRE   Inline XBRL Taxonomy Extension Presentation Linkbase Document.*        
104   The cover page for this report, formatted in Inline XBRL (included in Exhibit 101).*        

 

_________________

* Filed herewith.  
** Furnished herewith.  
# Indicates a management contract or compensatory plan or arrangement.  
+ Certain portions of this Exhibit have been redacted pursuant to Item 601(b)(10) of Regulation S-K. The Company agrees to furnish supplementally an unredacted copy of this Exhibit to the SEC upon request.  

 

ITEM 16. FORM 10-K SUMMARY

 

None.

 

 

 

 51 

 

 

SIGNATURES

 

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

 

  PHIO PHARMACEUTICALS CORP.
     
  By:

/s/ Robert J. Bitterman

    Robert J. Bitterman
   

President and Chief Executive Officer

(as Principal Executive and Financial Officer)

   
  Date: March 22, 2023

 

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

 

Signatures Title Date
     

/s/ Robert J. Bitterman

Robert J. Bitterman

President, Chief Executive Officer and Director

(Principal Executive Officer and Principal Financial Officer)

 March 22, 2023
     

/s/ Caitlin Kontulis

Caitlin Kontulis

Vice President of Finance and Administration and Secretary

(Principal Accounting Officer)

 March 22, 2023
     

/s/ Patricia Bradford

Patricia Bradford

 Director March 22, 2023
     

/s/ Geert Cauwenbergh

Geert Cauwenbergh, Dr. Med. Sc.

 Director March 22, 2023

 

/s/ Robert L. Ferrara

Robert L. Ferrara

 

Director

 

March 22, 2023

     

/s/ Jonathan E. Freeman

Jonathan E. Freeman, Ph.D.

 Director March 22, 2023
     

/s/ Curtis A. Lockshin

Curtis A. Lockshin, Ph.D.

 Director March 22, 2023

 

 

 

 52 

 EX-10.2 2 phio_ex1002.htm CLINICAL CO-DEVELOPMENT AGREEMENT

Exhibit 10.2

 

*** Certain identified information has been excluded from this exhibit because it is both not material and the type the registrant treats as private or confidential

 

CLINICAL CO-DEVELOPMENT AGREEMENT

 

This Clinical Co-Development Agreement (“Agreement”), entered into as of February 26, 2021 (the “Effective Date”), is by and between Phio Pharmaceuticals Corp., a Delaware corporation, having its principal offices at 257 Simarano Dr., Marlborough, MA 01752 (“Phio”), and AgonOx, Inc., an Oregon corporation, having its principal offices at 4805 NE Glisan St., Portland, OR 97213 (“AgonOx”). Phio and AgonOx may be referred to herein each individually as a “Party” and collectively as the “Parties.”

 

WHEREAS, Phio and AgonOx have expertise in certain development activities as set forth herein;

 

WHEREAS, Phio and AgonOx desire to collaborate to co-conduct a Phase I/II Clinical Trial (as hereinafter defined) in the United States to evaluate the safety and efficacy of the Product (as hereinafter defined) and DP TIL (as hereinafter defined) for the Indication (as hereinafter defined) with the objective of achieving the Phase I/II Success Criteria (as hereinafter defined) upon the terms as set forth herein;

 

WHEREAS, Phio and AgonOx desire to enter into this Agreement to govern research and development activities related to the Product, and the protection of confidential information and other proprietary materials, information and intellectual property developed during, such collaboration; and

 

NOW THEREFORE, in consideration of the mutual agreements contained herein and other good and valuable consideration, the sufficiency of which is hereby acknowledged, the Parties agree as follows:

 

1.     DEFINITIONS.

 

1.1.          Defined Terms. Initially capitalized terms will have the meaning ascribed to such terms in this Agreement, including the following terms which will have the following respective meanings:

 

1.1.1.“AAA” has the meaning ascribed to such term in Section 13.9.2.
   
1.1.2.“Additional CMC Activities” has the meaning ascribed to such term in Section 5.1.2.
   
1.1.3.“Advance” has the meaning ascribed to such term in Section 2.2.2.

 

1.1.4.       “Affiliate” means, with respect to a Party, any Person that, directly or indirectly, through one or more intermediaries, controls, is controlled by or is under common control with such Party. For purposes of this definition, “control” and, with correlative meanings, the terms “controlled by” and “under common control with” mean (a) the possession, directly or indirectly, of the power to direct the management or policies of a business entity, whether through the ownership of voting securities, by contract relating to voting rights or corporate governance, or otherwise; or (b) the ownership, directly or indirectly, of fifty percent (50%) or more of the voting securities or other ownership interest of a business entity (or, with respect to a limited partnership or other similar entity, its general partner or controlling entity).

 

 

 

 1 

 

 

1.1.5.“Agreement” has the meaning ascribed to such term in the Preamble.

 

1.1.6.       “Applicable Law” means the applicable laws, rules and regulations, including any rules, regulations, guidelines, or other requirements of any Governmental Authorities (including any Regulatory Authorities), that may be in effect from time to time in any country or regulatory jurisdiction, including GCP and GMP. For clarity, Applicable Law will include all laws, regulations and guidelines, including all applicable ICH guidelines applicable to the countries in which the Phase I/II Clinical Trial is being conducted.

 

1.1.7.“Approved CRO” has the meaning ascribed to such term in Section 2.5.
   
1.1.8.“Approved Vendor” has the meaning ascribed to such term in Section 2.5.
   
1.1.9.“Approved Vendor Agreement” has the meaning ascribed to such term in Section 2.5
   
1.1.10.“AgonOx” has the meaning ascribed to such term in the Preamble.

 

1.1.11.     “AgonOx Background IP” means Intellectual Property under the Control of AgonOx that was developed or acquired (other than from Phio) by AgonOx prior to the Effective Date or independently and outside the activities contemplated by this Agreement without reference to or use of Phio’s Confidential Information or Background IP, and in each case that is necessary for Phio to perform its obligations under this Agreement. For clarity, AgonOx Background IP shall include intellectual property covering DP TIL.

 

1.1.12.     “AgonOx Development Activities” means those Development Activities to be conducted by or on behalf of AgonOx, its Affiliates, Approved CROs or Approved Vendors, in accordance with the Clinical Development Plan

 

1.1.13.     “AgonOx DP TIL Net Sales” means all gross revenue derived through AgonOx, licensee or sublicensees or any assignee of AgonOx Background IP covering DP TIL from its use or exploitation of DP TIL. Net Sales excludes the following items (but only as they pertain to the making, using, importing, or selling of DP TIL; are included in gross revenue; and are separately billed):

 

(A)import, export, excise and sales taxes, and custom duties;
   
 (B)costs of insurance, packing, and transportation from the place of manufacture to the customer’s premises or point of installation;
   
(C)costs of installation at the place of use; and
   
(D)credit for returns, allowances, or trades.

 

1.1.14.     “AgonOx FTE Costs” means the full-time equivalent hours worked by AgonOx employees or contractors that are specifically identifiable or reasonably allocable to the conduct of AgonOx’s Development Activities under the Clinical Development Plan.

 

1.1.15.     “AgonOx Intellectual Property” means Intellectual Property invented, developed, generated or conceived or otherwise arising based exclusively on AgonOx Background IP or created exclusively by AgonOx or any of its Affiliates, agents, or representatives in connection with this Agreement (without reference to any Phio Background IP, Phio Intellectual Property, or INTASYL PH-762 ). For clarity, any Intellectual Property invented, developed, generated or conceived by either Party (or its Affiliates) that relates to DP TIL (and not INTASYL PH-762 ) shall be AgonOx Intellectual Property.

 

 

 

 2 

 

 

1.1.16.     “AgonOx Licensing Event” means any sale, license, sublicense, or other transfer of rights granted by AgonOx to any Third Party for its use or exploitation of any DP TIL Data.

 

1.1.17.     “AgonOx Licensing Revenue” means any payments, including upfront payments and milestone payments, but excluding any payments received as reimbursements for Development Costs or for AgonOx FTE Costs, received by AgonOx in exchange for any sale, license, sublicense, or other transfer of rights granted by AgonOx to any Third Party for its use or exploitation of any DP TIL Data.

 

1.1.18.“AgonOx Patent” means any Patent within the AgonOx Intellectual Property.

 

1.1.19.     “Business Day” means a day that is not a Saturday, Sunday or a day on which banking institutions in (a) London, England, (b) New York, NY, United States or (c) Mölndal, Sweden are required or permitted by Applicable Law to remain closed.

 

 1.1.20.“Budget” and “Budget Limit” have the meanings ascribed to such terms in Section 2.2.1.
   
1.1.21.“CAPA” has the meaning ascribed to such term in Section 5.2.1.5.
   
1.1.22.“Claim” means any claim, demand, suit or cause of action.
   
1.1.23.“Clinical Development Plan” has the meaning ascribed to such term in Section 2.3.1.
   
1.1.24.“Clinical Development Plan Outline” has the meaning ascribed to such term in Section 2.3.1 and as set forth in Schedule 2.

 

1.1.25.     “Clinical Trial” means the Phase I/II Clinical Trial as described in the Clinical Development Plan and in accordance with the Protocol.

 

1.1.26.     “Clinical Trial Data” means all data (including raw data) and results collected, generated or otherwise resulting from the Phase I/II Clinical Trial, including any and all data collected and maintained in the Trial Databases and Trial Master Files in accordance with Section 2.8.

 

1.1.27.“Clinical Trial Registries” has the meaning ascribed to such term in Section 3.3.
   
1.1.28.“CMC” means chemistry, manufacturing and controls.

 

1.1.29.     “CMC Information” means the CMC information required for the submission of a CTA or an IND, as applicable.

 

1.1.30.     “Commercially Reasonable Efforts” means, with respect to the performance of activities under this Agreement, such reasonably diligent and good faith efforts and resources (which shall include the assignment of appropriate personnel to the activities and project management designed to achieve the Timeline, as applicable) that a Party and its Affiliates would typically devote to such activities under similar circumstances for products of similar market potential at a similar stage in development or product life with similar market potential at a similar stage in development, taking into account efficacy, safety, approved labeling, the then- current competitive environment (based on market conditions then prevailing) and all other relevant scientific, commercial and other factors that a Party and such Affiliates would normally take into account in similar circumstances for products of similar market potential at a similar stage in development or product life.

 

 

 

 3 

 

 

1.1.31.     “Confidential Information” means all Know-How and other information and materials not generally available to the public that is provided or disclosed (including in written form, electronic form or otherwise) by, or on behalf of, either Party or any of its Affiliates to the other Party, its Affiliates, agents or representatives in connection with this Agreement, including Manufacturing, Proprietary CMC Information, pricing, distribution, cost and sales data and descriptions.

 

1.1.32.     “Control” or “Controlled” means (a) for Intellectual Property, a Party has sufficient rights to grant the applicable licenses, sublicenses or other rights to the other Party as set forth herein, and (b) for materials and documents, a Party has sufficient rights to provide the other Party with, or provide the other Party with access to, such materials or documents, as contemplated herein, in each case, without violating any contractual obligations to a Third Party.

 

1.1.33.“CRO” means contract research organization.
   
1.1.34.“CRO Agreement” has the meaning ascribed to such term in Section 2.5.

 

1.1.35.     “CTA” means a clinical trial application submitted to a Regulatory Authority, the submission and approval of which is necessary to initiate or conduct clinical testing of a pharmaceutical product in humans in the applicable jurisdiction, including in the United States, an IND.

 

1.1.36.     “Develop” means, with respect to the Product and DP TIL, those activities that are necessary or useful to research and develop the Product and DP TIL to obtain and maintain the CTA for the Phase I/II Clinical Trial, and Regulatory Approval(s) for the IND including research, analysis, testing, pre-clinical activities, clinical trial, supporting Manufacturing activities and related regulatory activities.

 

1.1.37.“Development” shall have a correlative meaning to Develop.

 

1.1.38.     “Development Activities” means, with respect to a given Party, those activities conducted by such Party, its Affiliates or Third Party subcontractors as specified in the Clinical Development Plan in accordance therewith.

 

1.1.39.     “Development Costs” means the internal and external costs of a Party that are specifically identifiable or reasonably allocable to the conduct of such Party’s Development Activities under the Clinical Development Plan, including AgonOx FTE Costs.

 

1.1.40.     “Development Term” means the period commencing on the Effective Date and ending on the date on which all Development Activities have been completed, including completion or early termination of the Phase I/II Clinical Trial, as marked by the completion and archival of a full Trial Master File.

 

1.1.41.“Disclosing Party” has the meaning ascribed to such term in Section 7.1.
   
1.1.42.“Dispute” has the meaning ascribed to such term in Section 13.9.
   
 1.1.43.“DP TIL” means AgonOx’s proprietary double-positive CD8 tumor infiltrating lymphocytes.
   
1.1.44.“DP TIL Data” means the subset of the Clinical Trial Data that relates to DP TIL.

 

1.1.45.     “DP TIL Manufacturer” means the party (either AgonOx or Providence Cancer Institute as mutually agreed upon by the Parties) that will Manufacture DP TIL.

 

 

 

 4 

 

 

1.1.46.“DP TIL Payments” has the meaning ascribed to such term in Section 6.1.
   
1.1.47.“Effective Date” has the meaning ascribed to such term in the Preamble.
   
 1.1.48.“EMA” means the European Medicines Agency and any successor agency thereto.

 

1.1.49.     “FDA” means the United States Food and Drug Administration and any successor Regulatory Authority in the United States, as applicable.

 

1.1.50.“FDA Regulation” has the meaning ascribed to such term in Section 3.6.5.
   
1.1.51.“Financial Audit” has the meaning ascribed to such term in Section 6.5.

 

1.1.52.     “Good Clinical Practices” or “GCP” means all applicable good clinical practice standards for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials promulgated and published by FDA, EMA or any other applicable Regulatory Authorities having jurisdiction over the Development, Manufacture or Commercialization of INTASYL PH-762 , DP TIL, or the Product, as applicable, pursuant to its regulations, guidelines or otherwise, including, as applicable, (a) the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (“ICH”) Harmonised Tripartite Guideline for Good Clinical Practice (CPMP/ICH/135/95) and any other guidelines for good clinical practice for clinical trials on medicinal products in the EU; and (b) the equivalent Applicable Law in any relevant country, each as may be amended and applicable from time to time and in each case, that provide for, among other things, assurance that the clinical data and reported results are credible and accurate and protect the rights, integrity, and confidentiality of trial subjects.

 

1.1.53.     “Good Pharmacovigilance Practices” or “GPV” means all applicable good pharmacovigilance practices promulgated and published by FDA, EMA or any other Regulatory Authorities having jurisdiction over the Development, Manufacture or Commercialization of INTASYL PH-762 , DP TIL, or the Product, as applicable, pursuant to its regulations, guidelines or otherwise, including as applicable, major pharmacovigilance process and product and/or population specific considerations as defined in (a) European Commission Regulation code relating to medicinal products for human use, Directives 2010/84/EU and 2012/26/EU respectively, as well as by the Commission Implementing Regulation (EU) No 520/2012 on the Performance of Pharmacovigilance Activities Provided for in Regulation (EC) No 726/2004 and Directive 2001/83/EC, Title IX of the Directive, Article 108a (a) of Directive 2001/83/EC, and principles detailed in the ICH guidelines for pharmacovigilance as well as (b) principles detailed in the United States 21 CFR and Guidance for Industry Good Pharmacovigilance Practices and Pharmacoepidemiological Assessment.

 

1.1.54.     “Government Official” means (a) any elected or appointed government official (e.g., a member of a ministry of health); (b) any employee or person acting for or on behalf of a government official, agency, or enterprise performing a governmental function; (c) any non- United States political party officer, employee, or person acting for or on behalf of a non-United States political party or candidate for public office; (d) any employee or person acting for or on behalf of a public international organization; (e) all government employees and employees of state-owned enterprises; or (f) any person otherwise categorized as a government official under local law; where “government” is meant to include all levels and subdivisions of non-United States governments (i.e., local, regional, or national and administrative, legislative, or executive).

 

1.1.55.     “Governmental Authority” means any supranational, federal, national, state or local court, agency, authority, department, regulatory body or other governmental instrumentality.

 

1.1.56.“ICH” has the meaning ascribed to such term in Section 1.1.48.
   
1.1.57.“IDMC” means the independent data monitoring committee.

 

 

 

 5 

 

 

1.1.58.     “IND” means an Investigational New Drug Application submitted under the United States Federal Food, Drug, and Cosmetic Act, as amended, and the rules and regulations promulgated thereunder, or an analogous application or submission with any analogous agency or Regulatory Authority outside of the United States for the purposes of obtaining permission to conduct clinical trials, including an Investigational Medicinal Product Dossier.

 

1.1.59.     “Indication” means the treatment of patients with melanoma, head and neck cancer or other solid malignancies.

 

1.1.60.     “Informed Consent” means the master form of informed consent document for each Phase I/II Clinical Trial.

 

1.1.61.     “INTASYL PH-762” means Phio’s proprietary self-delivering RNAi (INTASYL™) targeting PD-1 gene expression.

 

1.1.62.     “IST Agreement” means the investigator sponsored trial agreement or clinical trial agreement with the Principal Investigator and the Site for the Phase I/II Clinical Trial.

 

1.1.63.     “Intellectual Property” means any and all intellectual property rights arising from or associated with the following, whether protected, created or arising under the laws of the United States or any other jurisdiction: any patents, patent applications, copyrights, trade secrets, technical information, designs, drawings, processes, algorithms, procedures, formulae, test data, know-how, improvements, plans (engineering or otherwise), or any other compilation of information whatsoever, whether or not in written form and whether or not marked confidential, secret, or the like, which are not generally available to the public or for use by the public.

 

1.1.64.“IRB” means institutional review board.

 

1.1.65.     “Joint Intellectual Property” means Intellectual Property invented, developed, generated or conceived or otherwise arising from the Phase I/II Clinical Trial or the performance of Development Activities in accordance with the Clinical Development Plan, that is not Phio Background Intellectual Property, Phio Intellectual Property, AgonOx Background Intellectual Property, or AgonOx Intellectual Property. For clarity, any Intellectual Property invented, developed, generated or conceived by either Party (or its Affiliates) that relates to the Product (and not DP TIL alone or INTASYL PH-762 alone) shall be Joint Intellectual Property.

 

1.1.66.“Joint Patent” means any Patent within the Joint Intellectual Property.
   
1.1.67.“JSC” has the meaning ascribed to such term in Section 4.1.
   
1.1.68.“JSC Chairperson” has the meaning ascribed to such term in Section 4.1.
   
1.1.69.“JSC Representative(s)” has the meaning ascribed to such term in Section 4.1.

 

1.1.70.     “Know-How” means all proprietary technical information and know-how, including data, results, inventions, discoveries, trade secrets, specifications, instructions, processes, methods, protocols, procedures, formulae, techniques, practices, ideas, skills, expertise, designs, drawings, computer programs, apparatuses, materials, and other technology applicable to formulations, compositions or products or to their manufacture, development, registration, use or marketing or processes for their manufacture, formulations containing them or compositions incorporating or comprising them, and including all biological, chemical, pharmacological, biochemical, toxicological, pharmaceutical, physical and analytical, safety, quality control, manufacturing, preclinical and clinical data and information.

 

 

 

 6 

 

 

1.1.71.“License Payments” has the meaning ascribed to such term in Section 6.1.

 

1.1.72.     “Manufacture” or “Manufacturing” means those activities related to the production, manufacture, processing, filling, finishing, assembly, packaging and labelling, shipping and holding of INTASYL PH-762 , DP TIL, or Product, as applicable, or any intermediate thereof, including process development, process qualification and validation, scale-up, pre-clinical, clinical and commercial manufacture and analytic development, product characterization, stability testing, quality assurance and quality control, in each case, as required in the context of this Agreement.

 

1.1.73.“Material Safety Concern” has the meaning ascribed to such term in Section 3.5.1.
   
1.1.74.“Minimum Enrollment Rate” has the meaning ascribed to such term in Section 2.6.2.
   
1.1.75.“Opt-Out” has the meaning ascribed to such term in Section 8.2.4.
   
1.1.76.“Party” or “Parties” has the meaning ascribed to such term in the Preamble.

 

1.1.77. “Patents” means any and all (a) U.S. or foreign patent applications, including all provisional and priority applications, substitutions, continuations, continuations-in-part, divisions, renewals, and all patents granted thereon, (b) all U.S. or foreign patents, registrations, invention certificates, renewals, reissues, revalidations, reexaminations and extensions or restorations by existing or future extension or restoration mechanisms, including supplementary protection certificates or the equivalent thereof, and (c) any other form of government-issued right substantially similar to any of the foregoing.

 

1.1.78.“Phio” has the meaning ascribed to such term in the Preamble.

 

1.1.79.     “Phio Background IP” means Intellectual Property under the Control of Phio that was developed or acquired (other than from AgonOx) by Phio prior to the Effective Date or independently and outside the activities contemplated by this Agreement without reference to or use of AgonOx’s Confidential Information or Background IP, and in each case that is necessary for AgonOx to perform its obligations under this Agreement. For clarity, Phio Background IP shall include intellectual property covering INTASYL, INTASYL PH-762 and Phio’s self-delivering RNAi therapeutic platform.

 

1.1.80.     “Phio Development Activities” means those Development Activities to be conducted by or on behalf of Phio, its Affiliates, Approved CRO or Approved Vendors in accordance with the Clinical Development Plan.

 

1.1.81.     “Phio Intellectual Property” means Intellectual Property invented, developed, generated or conceived or otherwise arising based exclusively on Phio Background IP or created exclusively by Phio or any of its Affiliates, agents, or representatives in connection with this Agreement (without reference to any AgonOx Background IP, AgonOx Intellectual Property, or DP TIL). For clarity, any Intellectual Property invented, developed, generated or conceived by either Party (or its Affiliates) that relates to INTASYL PH-762 (and not DP TIL) shall be Phio Intellectual Property.

 

1.1.82.“Phio Patent” means any Patent within the Phio Intellectual Property.

 

 

 

 7 

 

 

1.1.83.     “Phio Net Sales” means all gross revenue derived through Phio, licensee or sublicensees from its use or exploitation of INTASYL PH-762 , the Product, or Product Data.

 

Net Sales excludes the following items (but only as they pertain to the making, using, importing, or selling of INTASYL PH-762 , the Product, or Product Data; are included in gross revenue; and are separately billed):

 

(A)import, export, excise and sales taxes, and custom duties;
   
 (B)costs of insurance, packing, and transportation from the place of manufacture to the customer’s premises or point of installation;
   
(C)costs of installation at the place of use; and
   
(D)credit for returns, allowances, or trades.

 

1.1.84.     “Person” means any individual, corporation, general or limited partnership, limited liability company, joint venture, estate, trust, association, organization, labor union, or other entity or Governmental Authority.

 

1.1.85.     “Personally Identifiable Information” means any information relating to an identified or, in combination with other information, identifiable person or persons captured in an electronic or hardcopy format, including such information as it relates to Subjects (including key- coded patient data), physicians, clinicians, healthcare professionals, consultants, or other persons participating in the Phase I/II Clinical Trial, and any equivalent definition in the Applicable Law to the extent that such definition is broader than that provided here. For clarity, Personally Identifiable Information will include the initials of each Subject.

 

1.1.86.     “Phase I Clinical Trial” means a human clinical trial, the principal purpose of which is a preliminary determination of the metabolism and pharmacologic actions of a product in humans, the side effects associated with increasing doses or a similar clinical study prescribed by the Regulatory Authorities, from time to time, pursuant to Applicable Law or otherwise, including the trials referred to in 21 C.F.R. § 312.21(a).

 

1.1.87.     “Phase II Clinical Trial” means a human clinical trial, the principal purpose of which is a preliminary determination of safety and efficacy and identifying the optimal dose(s) for a product in a Phase III clinical trial or pivotal trial in the target patient population or a similar clinical study prescribed by the Regulatory Authorities, from time to time, pursuant to Applicable Law or otherwise, including the trials referred to in 21 C.F.R. § 312.21(b).

 

1.1.88.     “Phase I/II Clinical Trial” means a human clinical trial, combining the principles of a Phase I Clinical Trial and a Phase II Clinical Trial in which the safety, side effects, and best dose of Product and DP TIL in the Indication is being tested, as prescribed by the Regulatory Authorities, from time to time, pursuant to Applicable Law or otherwise, including the trials referred to in 21 C.F.R. § 312.21(b).

 

1.1.89.     “Phase I/II Success Criteria” means the success criteria for the Product for the Phase I/II Clinical Trial as set forth in the Clinical Development Plan.

 

1.1.90.“Pre-IND Meeting” has the meaning ascribed to such term in Section 3.1.
   
1.1.91.“Principal Investigator” means the principal investigator at the Site.
   
1.1.92.“Product” means DP TIL pretreated with INTASYL PH-762 .

 

 

 

 8 

 

 

1.1.93.     “Product Data” means the subset of the Clinical Trial Data that relates to the Product and not to DP TIL alone.

 

1.1.94.     “Product Manufacturer” means the party (either AgonOx or Providence Cancer Institute as mutually agreed upon by the Parties) that will Manufacture the Product.

 

1.1.95.     “Proprietary CMC Information” means Phio’s highly proprietary processes used by Phio (or any of its Affiliates) to Manufacture INTASYL PH-762 (or any components of thereof) and AgonOx’s highly proprietary processes used by AgonOx (or any of its Affiliates) or an Approved CRO to Manufacture DP TIL (or any components of thereof) and the highly proprietary processes used by the Product Manufacturer to Manufacture the Product.

 

1.1.96.“Protocol” has the meaning ascribed to such term in Section 2.4.1.

 

1.1.97.     “Providence Cancer Institute” means Providence Cancer Institute, a non-profit corporation, having its principal offices at 4805 NE Glisan, Portland, OR 97213.

 

1.1.98.“Publication” has the meaning ascribed to such term in Section 7.6.
   
1.1.99.“Receiving Party” has the meaning ascribed to such term in Section 7.1.

 

1.1.100.  “Reference Safety Information” means a list of medical terms detailing the adverse reactions that are expected for the Product, as applicable; provided that, as it applies to conduct of a Clinical Trial, the list details serious adverse reactions (SARs) that are expected for such Product, as applicable, and is to be used by investigators as a reference point when assessing a SAR to determine whether it is a suspected unexpected serious adverse reaction.

 

1.1.101.  “Regulatory Approval” means all approvals necessary for the Manufacture of the Product and DP TIL for the Indication in the United States (including an IND), which may include satisfaction of all applicable regulatory and notification requirements.

 

1.1.102.  “Regulatory Authority” means, in a particular country or regulatory jurisdiction, any applicable Governmental Authority involved in granting approval to initiate or conduct clinical testing in humans, or any regulatory approval to manufacture, market, import or sell a pharmaceutical product in such country or jurisdiction, including the FDA and the EMA, as applicable.

 

1.1.103.“Regulatory Strategy” has the meaning ascribed to such term in Section 3.1.

 

1.1.104.   “Site” means the study site, Providence Cancer Institute, for a Phase I/II Clinical Trial, to be approved by the JSC in accordance with Section 2.7.

 

1.1.105.“Subject” means any human subject enrolled in a Phase I/II Clinical Trial.
   
1.1.106.“Target Enrollment Rate” has the meaning ascribed to such term in Section 2.6.2.

 

1.1.107.  “Tax” means any form of tax or taxation, levy, duty, charge, social security charge, contribution, or withholding of whatever nature (including any related fine, penalty, surcharge or interest) imposed by, or payable to, a Tax Authority.

 

1.1.108.  “Tax Authority” means any government, state or municipality, or any local, state, federal or other fiscal, revenue, customs, or excise authority, body or official anywhere in the world, authorized to levy Tax.

 

 

 

 9 

 

 

1.1.109.“Term” has the meaning ascribed to such term in Section 12.1.

 

1.1.110.   “Third Party” means any Person other than Phio, AgonOx and their respective Affiliates.

 

1.1.111.“Timeline” has the meaning ascribed to such term in Section 2.1.1.
   
1.1.112.“Trial Database” has the meaning ascribed to such term in Section 2.8.1.
   
1.1.113.“Trial Master File” has the meaning ascribed to such term in Section 2.8.1.

 

1.1.114.   “TIL(s)” means autologous human polyclonal T-cell populations derived from solid tumors and consisting primarily of human T-cells and substantially free of natural killer (NK) cells, dendritic cells (DC) and macrophages, which are not manipulated for specific neoantigen reactivity by genetic modifications or other methods.

 

1.1.115.   “United States” means the United States of America, its territories and possessions, including Puerto Rico.

 

1.1.116.   “VAT” means value added taxes, sales taxes, consumption taxes and other similar taxes required by law to be disclosed on the invoice.

 

1.2.           Construction. Except where the context otherwise requires, wherever used, the singular shall include the plural, the plural the singular, the use of any gender shall be applicable to all genders and the word “or” is used in the inclusive sense (and/or). Whenever this Agreement refers to a number of days, unless otherwise specified, such number refers to calendar days. The captions of this Agreement are for convenience of reference only and in no way define, describe, extend or limit the scope or intent of this Agreement or the intent of any provision contained in this Agreement. Whenever the words “include”, “includes” or “including” are used in this Agreement, they shall be deemed to be followed by the words “without limitation”, whether or not they are in fact followed by those words or words of like import. The language of this Agreement shall be deemed to be the language mutually chosen by the Parties and no rule of strict construction shall be applied against either Party hereto. References to the terms “Section,” or “Schedule” are to a Section or Schedule of this Agreement unless otherwise specified. The terms “hereof,” “hereby,” “hereto,” and derivative or similar words refer to this entire Agreement. The word “or” will not be exclusive. References to “written” or “in writing” include in electronic form. The word “will” will be construed to have the same meaning and effect as the word “shall”. A reference to any Person includes such Person’s successors and permitted assigns.

 

1.3.           Conflicts. In the event of any conflict between the terms of this Agreement, a Protocol or any other Schedule, such Protocol will control (as applicable), followed by the terms of this Agreement, and followed by any applicable other Schedule.

 

2.     DEVELOPMENT.

 

2.1.           Development Activities.

 

2.1.1.        Timeline. The timeline for conducting the Development Activities for the Phase I/II Clinical Trial will be set forth in the Clinical Development Plan (a “Timeline”). In conducting the Phase I/II Clinical Trial, each Party will use Commercially Reasonable Efforts to complete each activity by the date specified in the applicable Timeline, any such Development Activities so specified for AgonOx shall be referred to as “AgonOx Development Activities” and for Phio as “Phio Development Activities.” Each Party will notify the JSC in writing, and shall discuss at the next JSC meeting, (a) any material changes to any Timeline for such Party’s Development Activities and (b) any achievement of a material timeline milestone for such Party’s Development Activities in the applicable Timeline.

 

 

 

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2.1.2.        AgonOx Development Activities. AgonOx will complete the AgonOx Development Activities in accordance with this Agreement and the Clinical Development Plan.

 

2.1.3.        Phio Development Activities. Phio will complete the Phio Development Activities in accordance with this Agreement and the Clinical Development Plan.

 

2.2.           Development Costs.

 

2.2.1.         The budget for Development Costs incurred through performance of any AgonOx Development Activities in accordance with this Agreement and the Clinical Development Plan (“Budget”) will be set forth in the Clinical Development Plan. Upon mutual agreement of the Parties, certain Development Costs may be specified on a per Subject basis for Subjects treated in the Phase I/II Clinical Trial. For clarity, the Budget for the Phase I/II Clinical Trial shall not exceed four million dollars ($4,000,000) (“Budget Limit”), unless the Parties otherwise agree in writing. AgonOx’s financial obligation for the performance of its obligations under the Clinical Development Plan, in accordance with Sections 2.2.4 and 2.3.1, shall not [***] of the Budget, unless the Parties otherwise agree in writing.

 

2.2.2.         Development Costs incurred through performance of any AgonOx Development Activities in accordance with this Agreement and the Clinical Development Plan shall be borne by Phio, subject to the Budget to which the Parties have agreed pursuant to the Clinical Development Plan. For clarity, Phio shall bear the cost of all Phio Development Activities. Upon filing of the IND by the applicable Regulatory Authority, Phio shall pay to AgonOx two-hundred and fifty thousand dollars ($250,000) as an advance against Development Costs (“Advance”). On a monthly basis, Phio shall reimburse AgonOx for the Development Costs incurred by or on behalf of AgonOx or any of its Affiliates under this Agreement in accordance with the Clinical Development Plan, which Development Costs exceed the amount of the Advance; provided that the aggregate Development Costs incurred by or on behalf of AgonOx or any of its Affiliates do not exceed the Budget for Development Costs incurred through performance of any AgonOx Development Activities; further provided that AgonOx submits to Phio monthly statements that include reasonable substantiation of the Development Costs incurred in the prior month. Phio shall reimburse AgonOx for the Development Costs incurred by it within 30 days of Phio’s receipt of AgonOx’s submission of its statements that include reasonable substantiation. For clarity, AgonOx shall not be obligated to pay any Phio Development Costs on behalf of Phio.

 

2.2.3.      In the event that the aggregate Development Costs incurred by or on behalf of AgonOx or any of its Affiliates exceed the Budget for Development Costs incurred through performance of any AgonOx Development Activities, the Parties, through the JSC, shall discuss in good faith modification of such AgonOx Development Activities and the Clinical Development Plan to reduce the cost of the AgonOx Development Activities; provided that Phio will have no obligation to reimburse AgonOx for any Development Costs incurred to conduct such AgonOx Development Activities, which Development Costs exceed the Budget, unless the Parties mutually agree in writing or as set forth in Section 2.2.4 (below).

 

2.2.4.      In the event that (1) AgonOx, or any of its Affiliates, delegates to an Approved CRO or Approved Vendor any of its responsibilities with respect to the AgonOx Development Activities, pursuant to Section 2.5, and (2) the aggregate Development Costs incurred through the Approved CRO or Approved Vendor’s performance of such delegated AgonOx Development Activities exceeds the Budget for such delegated AgonOx Development Activities (by more than five percent (5%) of the Budget), such excess Development Costs shall be borne by AgonOx.

 

 

 

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2.3.           Clinical Development Plan.

 

2.3.1.         Clinical Development Plan. The Parties shall conduct the Phase I/II Clinical Trial, and all other Development Activities (including CMC Activities and Manufacturing for supply of materials) under this Agreement in accordance with the Protocol and the written plan for completion of the Phase I/II Clinical Trial (such plan, as amended from time to time in accordance with Section 2.3.2, the “Clinical Development Plan”), which shall include Timeline and the Budget for the conduct of Development Activities and, unless otherwise approved by the JSC, shall be consistent with the high level clinical development plan outline that is attached hereto as Schedule 2 (the “Clinical Development Plan Outline”). The Budget for the conduct of Development Activities, unless otherwise approved by Phio, shall be within five percent (5%) of the budget outlined in the Clinical Development Plan Outline. Prior to the commencement of any Phase I/II Clinical Trial, AgonOx shall prepare and submit the Clinical Development Plan to the JSC for review and approval (for clarity, subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable). The Clinical Development Plan shall include individual plans setting forth the anticipated Development Activities and resource allocation of each Party with respect to the Phase I/II Clinical Trial to be conducted pursuant to the Protocol in accordance with this Section 2.3.1, provided that each such plan, as amended from time to time in accordance with this Agreement, shall be incorporated into the Clinical Development Plan.

 

2.3.2.         Amendments to the Clinical Development Plan. During the Development Term, either Party may propose amendments to the Clinical Development Plan in writing to the JSC for review and approval (for clarity, subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable); provided that unless otherwise approved by the JSC, the Clinical Development Plan shall remain consistent with the Clinical Development Plan Outline and the objectives of the Phase I/II Success Criteria.

 

2.4.           Protocol.

 

2.4.1.         Protocol. As soon as practical prior to commencing the Phase I/II Clinical Trial, but in any event no later than fifteen (15) Business Days prior to protocol finalization, AgonOx shall provide the JSC with a draft of the protocol for such Phase I/II Clinical Trial (“Protocol”) for review and approval (subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable), which Protocol will be based upon discussions with the Regulatory Authorities pursuant to Section 3.2. The Protocol shall be consistent with the Clinical Development Plan. For the avoidance of doubt, upon approval of the Protocol in accordance with this Section 2.4.1, such Protocol will be part of the Clinical Development Plan.

 

2.4.2.         Amendments to the Protocol. Either Party may propose amendments to any Protocol for any study in the Clinical Development Plan in writing to the JSC for review and approval (for clarity, subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable). Without limiting the foregoing, any changes to a given Protocol, including any country-specific amendments required by Applicable Law and changes made in response to any communications with any Regulatory Authorities, that require a submission to a Regulatory Authority, an IRB or other ethics committee, will be prepared by AgonOx (or an Approved CRO) and submitted to the JSC for review and approval (for clarity, subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable); provided, further, that unless otherwise approved by the JSC (for clarity, subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable), the Protocol shall remain consistent with the Clinical Development Plan, Development Costs, Budget, and the objectives of the Phase I/II Success Criteria.

 

2.5.           Approved CROs and Vendors. Except as otherwise provided herein, either Party may delegate any of its responsibilities with respect to the Development Activities to (1) a CRO (each CRO approved in accordance with this Section 2.5, an “Approved CRO”), or (2) a Third Party vendor (each Third Party vendor approved by the JSC in accordance with Section 2.5, an “Approved Vendor”); provided that, prior to delegating any Development Activities to a CRO or Third Party vendor, the Party shall provide the JSC with written notice, identifying the Party’s preferred choice of CRO or Third Party vendor and the Development Activities that the Party proposes to delegate to such CRO or Third Party vendor, for review and approval by the JSC (subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable). The Party shall enter into a written agreement with each Approved CRO (a “CRO Agreement”) and each Approved Vendor (an “Approved Vendor Agreement”). The Party will provide a copy of any such CRO Agreement, Approved Vendor Agreement, and each material amendment thereto, which may be redacted as necessary to protect confidential information and other commercially sensitive information.

 

 

 

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2.6.          Sites and Principal Investigators.

 

2.6.1.        In accordance with the Clinical Development Plan and subject to the review and approval of the JSC, AgonOx will designate the Site, Principal Investigator, and participating investigators (as applicable) to conduct the Phase I/II Clinical Trial.

 

2.6.2.        The target rate (e.g., Subjects per quarter) at which AgonOx will enroll Subjects in the Phase I/II Clinical Trial in accordance with this Agreement and the Clinical Development Plan (“Target Enrollment Rate”) will be set forth in the Clinical Development Plan. AgonOx must enroll Subjects within the time period specified in the Clinical Development Plan at a rate that is at least seventy percent (70%) of the Target Enrollment Rate (the “Minimum Enrollment Rate”).

 

2.7.           Data Management; Development Records.

 

2.7.1.        Trial Master Files and Trial Databases. As set forth in the Timeline, AgonOx or its designated Affiliate or Approved CRO will establish and, during the Development Term, maintain in accordance with this Section 2.8, a trial master file for the Phase I/II Clinical Trial ( “Trial Master File”) and a trial database for the data collected from the Site for the Phase I/II Clinical Trial ( “Trial Database”), in each case, in the format as determined by the JSC (subject to compliance with GCP and any other Applicable Law). For the Phase I/II Clinical Trial, AgonOx shall (a) be responsible for source data verification of data records and (b) perform any quality oversight required in accordance with the Clinical Development Plan, to ascertain completeness, consistency, and accuracy of data. AgonOx will provide Phio with copies of any AgonOx reports relating to source data verification and other types of Clinical Trial audits.

 

2.7.2.        Development Records. Except as otherwise provided herein, each Party will maintain complete and accurate records related to the Phase I/II Clinical Trial for the longer of (a) the time period required by Applicable Law or (b) the expiration or termination of this Agreement. Upon expiration of each retention period described in the foregoing sentence, the retaining Party will notify the other Party in writing prior to destroying the applicable records, so that such other Party may obtain such records, if desired, from such retaining Party at such other Party’s expense.

 

3.     REGULATORY

 

3.1.           Regulatory Strategy. AgonOx will provide the JSC with a written initial regulatory strategy for conducting the Phase I/II Clinical Trial designed to determine whether the Product achieves the Phase I/II Success Criteria (the “Regulatory Strategy”); provided that the Regulatory Strategy shall be consistent with the Clinical Development Plan and shall be subject to review by the JSC. The Parties’ activities under Section 3.2 shall be consistent with the Regulatory Strategy. The Regulatory Strategy shall be updated at least annually by AgonOx in order to incorporate any new scientific or regulatory information, subject to review by the JSC.

 

3.2.           Interactions with Regulatory Authorities.

 

3.2.1.         Subject to the remainder of this Section 3.2, during the Development Term, AgonOx (or Approved CRO), will (a) be the regulatory sponsor for the Phase I/II Clinical Trial and will have all responsibilities of a regulatory sponsor as specified in Applicable Law and (b) be primarily responsible for and control all communications and interactions with the Regulatory Authorities relating to the Phase I/II Clinical Trial and the IND for the Product and DP TIL for the Indication in the United States, including (i) preparing, submitting and maintaining the CTAs required by Applicable Law to conduct the Phase I/II Clinical Trial in the countries for which Sites have been selected pursuant to Section 2.7, and (ii) preparing, submitting and maintaining the IND for the Product and DP TIL for the Indication in the United States; provided that (A) all such interactions with Regulatory Authorities shall be conducted in a manner consistent with the Regulatory Strategy; (B) at AgonOx (or Approved CRO)’s request, Phio will reasonably cooperate with AgonOx (or Approved CRO) with respect to communications and interactions with Regulatory Authorities relating to the Phase I/II Clinical Trial and the IND for the Product for the Indication in the United States, including the preparation of the CMC portion of such IND in accordance with Section 3.2.2; (C) Phio will provide to AgonOx (or Approved CRO) all relevant information, or the requisite right of reference to such information, for any CTAs for the Product; (D) Phio (or any of its Affiliates) will be permitted to appoint up to three (3) observers to attend any meetings with Regulatory Authorities relating to the Phase I/II Clinical Trial or the Product, as applicable; (E) AgonOx shall provide Phio with copies of any material correspondence or other documents received by AgonOx (or Approved CRO) from applicable Regulatory Authorities relating to the Phase I/II Clinical Trial or the Product, as applicable, within three (3) Business Days following AgonOx’s receipt thereof; and (F) during the Development Term, AgonOx shall establish and maintain, and shall require its Affiliates and Approved CROs conducting AgonOx Development Activities to establish and maintain, a log of all submissions to, and communications with, Regulatory Authorities related the Phase I/II Clinical Trial.

 

 

 

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3.2.2.         In connection with AgonOx’s (or an Approved CRO’s) preparation and submission of the CTAs for the Phase I/II Clinical Trial, Phio will in a timely manner (a) either (i) provide to AgonOx or its designated Affiliate an appropriate right of reference to the CMC Information for INTASYL PH-762 , and/or (ii) provide a copy of the CMC Information for INTASYL PH-762 to AgonOx, in each case, to the extent necessary for the submission of each CTA (or any update to such CTA, as applicable), and (b) prepare and provide to AgonOx within two weeks of a request from AgonOx the CMC portion (or any update to such CMC portion) of the IND for the Product for the Indication in the United States (or an appropriate right of reference to such information) in sufficient detail to support the submission of such IND; in each case subject to the terms of Sections 7.1 and 7.2.

 

3.2.3.         Except as otherwise provided in this Article 3, as between the Parties, (a) AgonOx or its applicable Affiliate (or Approved CRO) will be solely responsible for all communications and interactions with the Regulatory Authorities with respect to the Phase I/II Clinical Trial or the Product, (b) Phio will not communicate with Regulatory Authorities directly with regard to the Phase I/II Clinical Trial without the prior consent of AgonOx (or Approved CRO); provided that during the Development Term, Phio will be permitted to appoint up to three (3) observers to the pre-IND Meeting and any other meeting between AgonOx (or Approved CRO) and the Regulatory Authorities in the United States to the extent such meeting relates to the Product for the Indication in the United States, and (c) during the Development Term, AgonOx will provide Phio a copy of any meeting minutes and regulatory interaction logs, in each case, solely to the extent (i) reasonably necessary for the conduct of the Phio’s Development Activities under and in accordance with the Clinical Development Plan or (ii) specifically relating to the Phase I/II Clinical Trial.

 

3.3.           Clinical Trial Registries. AgonOx (or Approved CRO) will be responsible for registering, maintaining and updating any registries pertaining to the Phase I/II Clinical Trial to the extent required by any Applicable Law. AgonOx will ensure that the information on all Clinical Trial Registries relating to the Phase I/II Clinical Trial is correct, consistent and in compliance with all Applicable Law.

 

3.4.           Pharmacovigilance and Safety Information Exchange. The Parties acknowledge and agree that:

 

3.4.1.         Each Party agrees to promptly notify the other Party of any important new safety information (in addition to individual serious adverse event reports) in relation to the Phase I/II Clinical Trial, as applicable.

 

3.4.2.         AgonOx (or Approved CRO) shall (a) be responsible for defining the Reference Safety Information for inclusion in the investigator’s brochure for the Phase I/II Clinical Trial and (b) provide the other Party with core safety information based on the Reference Safety Information for inclusion in the Informed Consent to be prepared by AgonOx. Phio shall reasonably cooperate with AgonOx under this Section 3.4.2 by providing to AgonOx any relevant safety information known to Phio related to INTASYL PH-762 or the use of INTASYL PH-762 to pre-treatment products similar to DP TIL.

 

3.5.           Suspension or Termination of a Clinical Trial.

 

3.5.1.         In the event that either Party, in such Party’s reasonable judgment, determines that there exists an imminent and important health or safety concern for any Subject(s) of the Phase I/II Clinical Trial (a “Material Safety Concern”), such Party may request that the JSC terminate such Clinical Trial by written notice to the JSC, which notice shall specify in reasonable detail the particulars of such alleged health or safety concern with reasonable supporting data. Upon receipt of any such notice with respect to such Clinical Trial in accordance with this Section 3.5.1, the JSC shall promptly, but in any case within fifteen (15) Business Days following receipt of such notice by the JSC, review and determine, following consultation with the Principal Investigator and any applicable IDMC or IRB, whether to authorize the suspension, continued suspension of, or termination of, such Clinical Trial, in each case, consistent with the procedures outlined in the Protocol and otherwise in accordance with Applicable Law.

 

 

 

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3.6.           Inspections by Governmental Authorities and Development Audits.

 

3.6.1.        Noti ce and Inspections. If any Governmental Authority, including any Regulatory Authority, notifies Phio or AgonOx (or Approved CRO) that it intends to inspect, audit, or investigate Phio or AgonOx (or Approved CRO) or take any regulatory action relating to the Phase I/II Clinical Trial, or such Party’s obligations hereunder, the relevant Party will notify the other Party within one (1) Business Day following receipt of such notice. If not prohibited by any Applicable Law, Phio or AgonOx (or Approved CRO), as applicable, may be present during, and participate in, any such inspection, audit, investigation or regulatory action. Each Party will cooperate with the applicable Governmental Authority and the other Party in such inspections, audits, and investigations and will ensure that the records related to the Phase I/II Clinical Trial and this Agreement are maintained in a way that facilitates such activities.

 

3.6.2.        Inspection Findings and Responses. Within five (5) days following receipt, Phio or AgonOx (or Approved CRO), as applicable, will provide the JSC with copies of any inspection findings and any other communications that such Party receives from any Governmental Authority with respect to the Product or DP TIL, as applicable, including any Regulatory Authority in connection with the Phase I/II Clinical Trial and any Manufacturing activities and CMC activities of either Party. To the extent practicable, such Party will permit the other Party to prospectively review and comment on any responses to Governmental Authorities in connection the Phase I/II Clinical Trial, including any Regulatory Authorities.

 

3.6..         Other Governmental Inspections. AgonOx (or Approved CRO), will inform the JSC of any other Governmental Authorities’ inspections of any of the Sites where they intend to review the Phase I /II Clinical Trial, and at the request of the JSC, will provide the JSC with copies of all relevant correspondence from such Governmental Authorities (including any Regulatory Authorities) relating to the Sites.

 

3.6.4.        Development Audits.

 

3.6.4.1.During the conduct of the Phase I/II Clinical Trial, AgonOx will conduct quality assurance audits of the facilities and services of the Affiliates, including Approved CROs, in accordance with its standard operating procedures and pursuant to a quality assurance audit plan, and AgonOx will provide the JSC with copies of all audit reports upon request.

 

3.6.4.2.For clarity, an audit conducted pursuant to this Section 3.6.4 will be subject to the confidentiality obligations set forth in Article 7.

 

3.6.5.         Covered Study. The Phase I/II Clinical Trial is deemed to be a “covered study” for the purpose of the FDA regulation entitled “Financial Disclosure by Principal Investigators” (“FDA Regulation”). AgonOx (or Approved CRO) will coordinate submission from all Principal Investigators engaged in the conduct of the Phase I/II Clinical Trial all relevant financial and other information (including details of equity interests in AgonOx and Phio or any of its associated companies) relating to such Principal Investigators (and where relevant to have spouse, dependents and sub-investigators to disclose such relevant financial and other information to the other Party) in order to comply with the FDA Regulation without delay and prior to Principal Investigators involvement in such Phase I/II Clinical Trial.

 

 

 

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4.     GOVERNANCE.

 

4.1.           Joint Steering Committee.

 

4.1.1.         Representatives. Within thirty (30) days following the Effective Date, the Parties will establish a joint development committee to oversee the conduct of the Phase I/II Clinical Trial (the “JSC”). The JSC will continue to be in effect throughout the Development Term. Each Party initially will appoint three (3) representatives to the JSC (“JSC Representatives”); provided that each JSC Representative of a Party shall be either (i) an employee of such Party, or (ii) subject to each Party’s approval, a consultant engaged by such Party (provided that such consultant shall be subject to confidentiality obligations consistent with the terms of Article 7); provided, further, that each JSC Representative shall have knowledge and expertise regarding developing products similar to the Product and, if an employee of the applicable Party, sufficient seniority within the applicable Party to make decisions within the scope of the JSC’s decision- making authority. In addition to the JSC Representatives, each Party may designate such other nonvoting members of the JSC as may be agreed upon by the Parties (subject to confidentiality obligations consistent with the terms of Article 7). Each Party may replace its JSC Representatives at any time upon written notice to the other Party.

 

4.1.2.         Chairperson. The Parties will designate a chairperson (a “JSC Chairperson”) selected from the JSC Representatives. The JSC Chairperson will designate a JSC Representative to be responsible for drafting and circulating the JSC draft agenda and ensuring minutes are prepared.

 

4.1.3.Meetings.

 

4.1.3.1.Timing.

 

i.From the Effective Date through the Development Term, subject to Section 4.1.3.1(ii) (below), the JSC will meet quarterly (and for clarity, such meetings may be conducted via teleconference) unless the Parties mutually agree otherwise.
   
ii.Prior to the first Subject enrollment in the Phase I/II Clinical Trial, and during the first three months of the Phase I/II Clinical Trial, the JSC will meet approximately once every four (4) weeks (and for clarity, such meetings may be conducted via teleconference) unless the Parties mutually agree otherwise.
   
iii.Either Party may call a special meeting of the JSC (by videoconference or teleconference) during the Development Term by at least five (5) days prior written notice to the other Party in the event such Party reasonably believes that a significant matter must be addressed prior to the next scheduled meeting.

 

4.1.3.2.Participants. The JSC may invite individuals who are not JSC Representatives to participate in JSC meetings; provided that (a) the JSC Representatives of both Parties consent to such non-member’s participation; and (b) such non-member is subject to confidentiality obligations consistent with those described in Article 7 of this Agreement. For clarity, such non-members will have no voting rights at the JSC.
   
4.1.3.3.Costs. For clarity, each Party will bear its own expenses relating to the meetings and activities of the JSC.

 

 

 

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4.1.4.         Notice to be Provided to the JSC. Each Party will promptly notify the JSC of any material event that occurs in connection with any Phase I/II Clinical Trial, that is reasonably likely to affect the quality, integrity, or timeliness of a Phase I/II Clinical Trial; provided that each Party shall notify the JSC within three (3) Business Days following such Party becoming aware of (a) any urgent safety measures taken by an Approved CRO, a Site, a Principal Investigator or Party to protect Subjects against immediate hazard, (b) any confirmed serious breaches of GCP, GPV or the Protocol, or any Applicable Law (including ICH GCP guidelines), (c) any inspection by any Governmental Authority, including any Regulatory Authority, where the scope of the inspection includes a Phase I/II Clinical Trial, (d) any investigations by any Governmental Authority involving a Third Party in connection with any Phase I/II Clinical Trial, and (e) any error or omission in the conduct of a Phase I/II Clinical Trial that could reasonably call into question the validity, or otherwise compromise the quality or integrity, of part or all of a Phase I/II Clinical Trial or activities conducted in connection therewith; provided, further, that with respect to each of the foregoing, the Party responsible for notifying the JSC will also, if applicable, notify any Person to whom notice is required in compliance with any Applicable Law. Following disbandment of the JSC in accordance with Section 4.2 and through the end of the Term, any and all notices required pursuant to this Section 4.1.4 will be provided directly to the Parties in accordance with Section 13.3.

 

4.1.5.Responsibilities and Decision-Making.

 

4.1.5.1.Responsibilities. The JSC’s responsibilities will include:

 

i.reviewing and discussing the Timeline and Budget, including any updates delivered in accordance with Sections 2.1.1 and 2.2;
   
ii.reviewing and approving the Clinical Development Plan, including Timeline, Budget and Protocol, (and any amendments thereto) to the extent inconsistent with the Clinical Development Plan Outline, the objectives of the Phase I/II Success Criteria, and the Budget Limit set forth in Section 2.2.1;
   
iii.reviewing enrollment rates, including setting the Target Enrollment Rate and Minimum Enrollment Rate as set forth in Section 2.6.2, and approving any adjustments required, including but not limited to the number of Sites located in the United States or the percentage of Subjects in Sites located in the United States as set forth in Section 2.6;
   
iv.making a determination of the existence of a Material Safety Concern in accordance with 3.5.1;
   
v.discussing and approving any Additional CMC Activities in accordance with Section 5.1;
   
vi.subject to Section 5.1, determining whether the DP TIL Manufacturer is unable to (a) Manufacture DP TIL that is suitable for use in the Phase I /II Clinical Trial, or (b) generate CMC Information for submission to the applicable Regulatory Authorities in the United States, or determining whether the Product Manufacturer is unable to (a) Manufacture Product that is suitable for use in the Phase I/ II Clinical Trial, or (b) generate CMC Information for submission to the applicable Regulatory Authorities in the United States, determining whether Phio is unable to (a) Manufacture INTASYL PH-762 that is suitable for use in the Phase I /II Clinical Trial, or (b) generate CMC Information for submission to the applicable Regulatory Authorities in the United States; provided that JSC determination and decisions related to CMC activities in support of the Phase I/II Clinical Trial do not affect Phio’s CMC activities for programs outside the Clinical Development Plan. Phio may veto, reasonably invoked, any such CMC activities required by the JSC.
   
vii.facilitating the flow of information between the Parties with respect to the Parties’ respective conduct and progress of the different elements of the Clinical Development Plan;

 

 

 

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viii.reviewing and discussing, on at least a quarterly basis, a high-level summary of the forecasted Development Costs, Budget and Timeline, including any updates delivered in accordance with Sections 2.1.1 and 2.2;
   
ix.subject to Section 2.3 and Section 2.4, as applicable, discussing and approving the Clinical Development Plan and the Timeline, Budget and Protocol (or any amendments thereto);
   
x.reviewing and approving each proposed Approved CRO or Approved Vendor and the Development Activities to be conducted by such Approved CRO or Approved Vendor in accordance with Section 2.5;
   
xi.reviewing and approving the IST Agreement, selection of the Sites, Principal Investigators, and participating investigators (as applicable) for each Phase I/II Clinical Trial;
   
xii.reviewing any updates from any advisory board meetings, investigator meetings or other meetings with the Principal Investigators;
   
xiii.subject to Section 2.8, reviewing and approving the data management plan and form of the Trial Master File and Trial Database;
   
xiv.reviewing the Regulatory Strategy provided pursuant to Section 3.1 (including any updates thereto);
   
xv.reviewing and discussing (as necessary) any results from monitoring, source data verification of data records, and quality oversight quality activities relating to the Trial Master Files and Trial Databases, in accordance with Section 2.8.1;
   
xvi.reviewing and discussing (as necessary) any inspections by Governmental Authorities (including inspection findings), safety reports for the Regulatory Authorities, Principal Investigators, IRBs and any other ethics committees for Phase I/II Clinical Trial, including making a determination to continue the suspension of, or terminate, any Clinical Trial as result of any health or safety concern in accordance with Section 3.5.1;
   
xvii.reviewing and discussing any notices or reports that it receives pursuant to Section 4.1.4, including FDA feedback at the pre-IND Meeting;
   
xviii.reviewing certain data to be provided at each JSC meeting in accordance with all Applicable Law;
   
xix.reviewing and discussing the performance and progress of the Phase I/II Clinical Trial, including Development Costs incurred in connection with such Clinical Trial, and any reports relating to the Clinical Trial or any other activities under the Clinical Development Plan;
   
xx.reviewing quarterly forecasting for INTASYL PH-762 to be supplied and any planning or logistics related to DP TIL Manufacturing;
   
xxi.reviewing and approving a plan for the destruction of any returned or unused INTASYL PH-762 in accordance with Section 5.2.2.2; and
   
xxii.discussing any potential infringement, or allegations of infringement, of Third Party intellectual property pursuant to Section 8.3.4; and
   
xxiii.any other matters the Parties mutually agree in writing will be, or are expressly provided in this Agreement to be, within the responsibilities of the JSC.

 

 

 

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4.1.5.2.Decision-Making. The unanimous approval of the JSC will be required with respect to all matters within its decision-making authority as described in Section 4.1.5.1. Each JSC Representative will have one (1) vote. If the JSC cannot reach consensus on an issue for which it has decision-making authority within fifteen (15) Business Days after it has met and attempted to reach a decision on such issue, then such matter will be escalated to the authorized representatives for resolution in accordance with Section 13.9.1.

 

4.2.           Disbandment.

 

4.2.1.Disbandment of JSC. The JSC will disband upon completion of the Development

Term.

 

5.     CMC PROGRAM; PRODUCT CLINICAL SUPPLY.

 

5.1.           CMC Program.

 

5.1.1.         Phio (or any of its Affiliates) shall use Commercially Reasonable Efforts to (a) Manufacture INTASYL PH-762 that is suitable for use in the Phase I/II Clinical Trial and (b) generate CMC Information for submission to the applicable Regulatory Authorities in the United States in sufficient detail to support the submission of the IND for the Product for the Indication in the United States in accordance with Section 3.2.2; provided, however, that in the event that Phio (or any of its Affiliate, as applicable), in its reasonable determination, is unable through the use of Commercially Reasonable Efforts to (i) Manufacture INTASYL PH-762 that is suitable for use in the Phase I/II Clinical Trial or (ii) generate CMC Information for submission to the applicable Regulatory Authorities in the United States in sufficient detail to support the submission of the IND for the Product for the Indication in the United States, Phio shall deliver written notice to the JSC explaining in reasonable detail the basis for such determination and at the request of AgonOx, the JSC shall discuss any additional activities or remediation that would allow Phio (or any of its Affiliates) to Manufacture such INTASYL PH-762 or generate such CMC Information, as applicable, and, solely to the extent approved by the JSC (subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable), Phio shall, and shall cause its Affiliates (as applicable) to, use Commercially Reasonable Efforts to Manufacture such INTASYL PH-762 or generate such CMC Information suitable for the Phase I/II Trial.

 

5.1.2.         The DP TIL Manufacturer (or any of its Affiliates) shall use Commercially Reasonable Efforts to (a) Manufacture DP TIL that is suitable for use in the Phase I/II Clinical Trial and (b) generate CMC Information for submission to the applicable Regulatory Authorities in the United States in sufficient detail to support the submission of the IND for the Product for the Indication in the United States in accordance with Section 3.2.2; provided, however, that in the event that DP TIL Manufacturer (or any of its Affiliate, as applicable), in its reasonable determination, is unable through the use of Commercially Reasonable Efforts to (i) Manufacture DP TIL that is suitable for use in the Phase I/II Clinical Trial or (ii) generate CMC Information for submission to the applicable Regulatory Authorities in the United States in sufficient detail to support the submission of the IND for the Product for the Indication in the United States, DP TIL Manufacturer shall deliver written notice to AgonOx explaining in reasonable detail the basis for such determination and at the request of AgonOx, the JSC shall discuss any additional activities or remediation that would allow DP TIL Manufacturer (or any of its Affiliates) to Manufacture such DP TIL or generate such CMC Information, as applicable, in accordance with Section 5.1 (“Additional CMC Activities”) and, solely to the extent approved by the JSC (subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable), the DP TIL Manufacturer shall, and shall cause its Affiliates (as applicable) to, use Commercially Reasonable Efforts to conduct such Additional CMC Activities.

 

5.1.3.         The Product Manufacturer (or any of its Affiliates) shall use Commercially Reasonable Efforts to (a) Manufacture Product that is suitable for use in the Phase I/II Clinical Trial and (b) generate CMC Information for submission to the applicable Regulatory Authorities in the United States in sufficient detail to support the submission of the IND for the Product for the Indication in the United States in accordance with Section 3.2.2; provided, however, that in the event that the Product Manufacturer (or any of its Affiliate, as applicable), in its reasonable determination, is unable through the use of Commercially Reasonable Efforts to (i) Manufacture Product that is suitable for use in the Phase I/II Clinical Trial or (ii) generate CMC Information for submission to the applicable Regulatory Authorities in the United States in sufficient detail to support the submission of the IND for the Product for the Indication in the United States, the Product Manufacturer shall deliver written notice to AgonOx explaining in reasonable detail the basis for such determination and at the request of AgonOx, the JSC shall discuss any additional activities or remediation that would allow Product Manufacturer (or any of its Affiliates) to Manufacture such Product or generate such CMC Information, as applicable, in accordance with Section 5.1 (“Additional CMC Activities”) and, solely to the extent approved by the JSC (subject to the dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable), Product Manufacturer shall, and shall cause its Affiliates (as applicable) to, use Commercially Reasonable Efforts to conduct such Additional CMC Activities;.

 

 

 

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5.2.           Clinical Supply.

 

5.2.1.Supply of INTASYL PH-762 .

 

5.2.1.1.Subject to the remainder of this Section 5.2.1, Phio (or any of its Affiliates) will supply INTASYL PH-762 suitable (as required by the applicable Regulatory Authority) for use in the Phase I/II Clinical Trial.

 

5.2.1.2.The Product Manufacturer agrees to procure from Phio, and Phio agrees to supply (at no cost), INTASYL PH-762 to the Product Manufacturer.

 

5.2.1.3.Phio (or any of its Affiliates) will supply or have supplied to Product Manufacturer such quantities of INTASYL PH-762 that are necessary for AgonOx (or Approved CRO) to conduct the Phase I/II Clinical Trial, including overage of INTASYL PH-762 for the Phase I/II Clinical Trial in such quantity determined in accordance with Product Manufacturer’s forecast requirements as provided to the JSC for input from Phio, as required by the applicable Regulatory Authority, and giving consideration to the number and location of countries (and the network of depots/distribution plan).

 

5.2.1.4.Phio will provide to the JSC a quarterly report regarding its forecast and inventory of INTASYL PH-762 and the reasonably anticipated needs for INTASYL PH-762 to ensure that Phio (or any of its Affiliates, as applicable) can supply Product Manufacturer with such quantities of INTASYL PH-762 at such time as required to comply with the applicable Timeline and conduct all activities required to comply with the applicable Protocol.

 

5.2.1.5.During the Development Term, AgonOx may, at its expense, conduct quality oversight inspections and audits of Phio’s (or its Affiliate’s, as applicable) facilities used to Manufacture INTASYL PH-762 for supply pursuant to this Section 5.2.1, in each case, as is reasonable and customary and in accordance with Applicable Law. Except in the case of a “for cause” inspection or audit or to follow up on a Corrective or Preventive Action (“CAPA”) identified at an earlier audit inspection, in no event shall AgonOx conduct more than one (1) such inspection and audit per a given calendar year during the Development Term.

 

5.2.2.Use of INTASYL PH-762 .

 

5.2.2.1.AgonOx or Product Manufacturer, as applicable, will, in conducting each Phase I/II Clinical Trial, only use INTASYL PH-762 supplied by Phio (or its Affiliate, as applicable). AgonOx or Product Manufacturer, as applicable, will only use Phio INTASYL PH-762 , and only provide Phio INTASYL PH-762 to Approved CROs, for the sole purpose of conducting the Phase I/II Clinical Trial and any other AgonOx Development Activities set forth in the Clinical Development Plan, in each case, in accordance with the Protocol and this Agreement.

 

5.2.2.2.Upon completion of the Development Term, the JSC shall discuss and approve a plan for the destruction of any returned or unused INTASYL PH-762 .

 

5.2.3.Supply of DP TIL.

 

5.2.3.1.The DP TIL Manufacturer (or any of its Affiliates) will supply or have supplied such quantities of DP TIL that are necessary for AgonOx (or Product Manufacturer) to conduct the Phase I/II Clinical Trial.

 

5.2.3.2.During the Development Term, Phio may, at its expense, conduct quality oversight inspections and audits of the DP TIL Manufacturer’s (or its Affiliate’s, as applicable) facilities used to Manufacture DP TIL for supply pursuant to this Section 5.2.3, in each case, as is reasonable and customary and in accordance with Applicable Law. Except in the case of a “for cause” inspection or audit or to follow up on a CAPA identified at an earlier audit inspection, in no event shall Phio conduct more than one (1) such inspection and audit per a given calendar year during the Development Term.

 

 

 

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5.3.           Compliance with Laws. For clarity, with respect to INTASYL PH-762 , DP TIL, AgonOx (or Approved CRO), Phio, the DP TIL Manufacturer and the Product Manufacturer (and their respective Affiliates) will comply with all Applicable Law with respect to the storage, handling, disposal and transfer of such INTASYL PH-762 and DP TIL and each Party assumes sole responsibility for its violation thereof.

 

6.     PAYMENTS.

 

6.1.           Payments.

 

6.1.1.        Following an AgonOx Licensing Event, AgonOx will pay Phio the following amounts (“License Payments”): (i) [***] of AgonOx Licensing Revenue until the cumulative License Payments by AgonOx to Phio meet (but do not exceed) the lesser of the actual Development Costs paid by Phio to AgonOx or [***] and then (ii) after the cumulative License Payments by AgonOx to Phio meet (but do not exceed) the lesser of the actual Development Costs paid by Phio to AgonOx or [***] of AgonOx Licensing Revenue.

 

6.1.1.1.In the event the Phase 1/II Clinical Trial is terminated early, the License Payments outlined in Section 6.1.1(i) and 6.1.1(ii) will be prorated based on the percentage of patients treated in the DP TIL only arm at the time of the termination of the Phase I/II Clinical Trial.

 

6.1.2.         AgonOx will pay Phio [***] of AgonOx DP TIL Net Sales (“DP TIL Payments”).

 

6.1.2.1.In the event the Phase 1/II Clinical Trial is terminated early, the DP TIL Payment outlined in Section 6.1.2 will be prorated based on the percentage of patients treated in the DP TIL only arm at the time of the termination of the Phase I/II Clinical Trial.

 

6.1.3.For clarity, AgonOx does not have any rights to any Phio Net Sales.

 

6.2.           Method for Payment. Each payment to a Party hereunder will be made by electronic transfer in immediately available funds via either a bank wire transfer, an ACH (automated clearing house) mechanism, or any other means of electronic funds transfer, at paying Party’s election, to such bank account as the receiving Party will designate in writing to the paying Party at least five (5) Business Days before the payment is due.

 

6.3.           VAT. It is understood and agreed between the Parties that any payments made under this Agreement are exclusive of any VAT. If any VAT is chargeable in respect of any payments, the paying Party shall pay such VAT at the applicable rate in respect of such payments following receipt, where applicable, of a VAT invoice in the appropriate form issued by the receiving Party in respect of those payments. The Parties shall issue invoices for all amounts payable under this Agreement consistent with VAT requirements and irrespective of whether the sums may be netted for settlement purposes. If such amounts of VAT are refunded by the applicable Governmental Authority or other fiscal authority subsequent to payment, the Party receiving such refund will transfer such amount to the paying Party within forty-five (45) days of receipt. The Parties agree to reasonably cooperate to provide any information required by the Party pursuing a refund of indirect Taxes paid.

 

6.4.           Tax Cooperation. The Parties will cooperate and produce on a timely basis any tax forms or reports reasonably requested by the other Party in connection with any payment made under this Agreement. Each Party will provide to the other Party any tax forms that may be reasonably necessary in order for such Party not to withhold tax or to withhold tax at a reduced rate under an applicable bilateral income tax treaty. Each Party will provide to the other Party any tax forms at least thirty (30) days prior to the due date for any such payments. Each Party will provide the other Party with reasonable assistance to enable the recovery, as permitted by law, of withholding taxes, VAT, or similar obligations resulting from payments made under this Agreement, such recovery to be for the benefit of the Party bearing such withholding tax or VAT. Each Party will provide reasonable cooperation to the other Party, at the other Party’s expense, in connection with any official or unofficial tax audit or contest relating to payments made by one Party to the other Party.

 

 

 

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6.5.           Financial Audits.

 

6.5.1.        Upon the written request of Phio and not more than once in each calendar year, AgonOx shall permit an independent certified public accounting firm of nationally recognized standing, selected by Phio and reasonably acceptable to AgonOx, at Phio’s expense, to have access during normal business hours to such of the records of AgonOx as may be reasonably necessary to verify the accuracy of the payment reports and invoices hereunder for any year ending not more than thirty-six (36) months prior to the date of such request, including without limitation as may be necessary to verify the amount of any AgonOx Licensing Revenue, and AgonOx DP TIL Net Sales. The accounting firm shall disclose to Phio only whether the payment reports and invoices are correct or not and the specific details concerning any discrepancies. No other information shall be shared.

 

6.5.2.        If such accounting firm concludes that undercharged or overcharged amounts are owing from one Party to the other for such period, the appropriate Party shall pay such amounts within thirty (30) days of the date Phio delivers to AgonOx such accounting firm’s written report so concluding. The fees charged by such accounting firm shall be paid by Phio; provided, however, if the audit discloses either (a) that the amounts payable by AgonOx for the audited period are more than one hundred ten percent (110%) of the amounts actually paid for such period, or (b) that the amounts charged by AgonOx for the audited period are more than one hundred ten percent (110%) of the amounts actually incurred for such period, then AgonOx shall pay the reasonable fees and expenses charged by such accounting firm.

 

6.5.3.        For clarity, an audit conducted pursuant to this Section 6.5 will be subject to the confidentiality obligations set forth in Article 7.

 

6.6.           Late Payments. All payments due and payable to a Party under this Agreement will earn interest from the date due until paid at a per annum rate equal to three per cent (3%) plus the then-current six (6) month US dollar LIBOR rate on the date payment is due. Interest will be calculated on an actual / three hundred sixty (360) day basis. The payment of such interest will not limit the Parties from exercising any other rights at their disposal as a consequence of any late payments.

 

7.     CONFIDENTIAL INFORMATION.

 

7.1.           Confidentiality. Except to the extent expressly authorized by this Agreement or otherwise agreed in writing by the Parties, each Party and its Affiliates (each, a “Receiving Party”) agrees that, during the Term and for (a) the five (5) year period following the expiration of this Agreement or (b) the ten (10) year period following the earlier termination of this Agreement pursuant to Section 12.2, as applicable, it will keep confidential and will not publish or otherwise disclose and will not use for any purpose other than as provided for in this Agreement (which includes the exercise of any rights or the performance of any obligations hereunder) any Confidential Information furnished to it by the other Party (each, a “Disclosing Party”) pursuant to this Agreement, except for that portion of such information or materials that the Receiving Party can demonstrate:

 

7.1.1.        was publicly disclosed by the Disclosing Party before or after such Confidential Information becomes known to the Receiving Party;

 

7.1.2.        was already known to the Receiving Party or any of its Affiliates, other than under an obligation of confidentiality or non-use, prior to when it was received from the Disclosing Party;

 

7.1.3.        is subsequently disclosed to the Receiving Party or any of its Affiliates by a Third Party lawfully in possession thereof without obligation to keep such Confidential Information confidential;

 

7.1.4.        has been published by a Third Party or otherwise enters the public domain through no fault of the Receiving Party or any of its Affiliates in breach of this Agreement; or

 

7.1.5.        has been independently developed by the Receiving Party or any of its Affiliates, without the aid, application or use of Confidential Information of the other Party demonstrable with verifiable evidence.

 

 

 

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7.2.           Proprietary CMC Information. Notwithstanding Section 7.1, with respect to any Confidential Information that is Proprietary CMC Information of a Party, such information will only be provided by the Disclosing Party to the Receiving Party on a strictly confidential, need- to-know basis under this Agreement; provided, further, that the Receiving Party shall enact and implement technical firewalls and other protective procedures to ensure that only those individuals identified shall have access to any Proprietary CMC Information of the Disclosing Party, including enforcing any employee confidentiality policies and agreements against such individuals obtaining access to any Proprietary CMC Information of the Disclosing Party. The Receiving Party of such Proprietary CMC Information will keep it confidential and will not publish or otherwise disclose it and will not use it for any purpose other than as provided for in this Agreement (which includes the exercise of any rights or the performance of any obligations hereunder), except and until the Receiving Party can demonstrate that such Proprietary CMC Information falls within one of the enumerated exceptions set forth in Sections 7.1.1 to 7.1.5.

 

7.3.           Authorized Disclosure. Each Party may disclose Confidential Information belonging to the other Party (solely or jointly) to the extent such disclosure is reasonably necessary for: (a) the filing or prosecuting of any Patents in connection with this Agreement and in accordance with Section 8.2; (b) submissions, filings or applications and other filings with any Governmental Authorities (including Regulatory Authorities), including filings with the SEC or FDA, with respect to the Product or such Party; (c) prosecuting or defending litigation; (d) complying with Applicable Law, including regulations promulgated by securities exchanges; (e) disclosure to its Affiliates, employees, board members, agents, advisors, licensees, sublicensees and subcontractors, Approved CROs, Approved Vendors and other Third Party contractors engaged by either Party and Sites and their respective personnel and the Principal Investigator, the IDMC, and IRBs, in each case only on a need-to-know basis and solely in connection with the performance of this Agreement; provided that each disclosure in this subsection (e) must be bound by obligations of confidentiality and non-use at least as stringent as, and equivalent in scope to, those set forth in this Article 7 prior to any such disclosure. Notwithstanding the foregoing, in the event a Party is required to make a disclosure of the other Party’s Confidential Information pursuant to the foregoing subsections (a) through (d), such Party will, except where impracticable, give reasonable advance notice to the other Party of such disclosure and use reasonable efforts to secure confidential treatment of such Confidential Information. In any event, the Parties agree to take all reasonable action to avoid disclosure of Confidential Information hereunder.

 

7.4.           Return of Confidential Information. Except as set forth in Sections 2.8.1 and 2.8.2, or otherwise provided herein, upon expiration or earlier termination of this Agreement, all Confidential Information (including any copies thereof) in written or other tangible form will, at the Disclosing Party’s discretion, be returned to the Disclosing Party or destroyed by the Receiving Party (with such destruction being certified in writing by an authorized officer of the Receiving Party), except (a) to the extent such Confidential Information is necessary to exercise any license or rights hereunder that survive such expiration or earlier termination; (b) one (1) copy of each document may be retained by the Receiving Party solely to ascertain any ongoing rights and responsibilities with respect to such Confidential Information, and (c) the Receiving Party will not be required to destroy any computer files created during automatic system back up that are subsequently stored securely by such Receiving Party.

 

7.5.           Confidential Status of the Agreement. Subject to Section 7.5, the terms of this Agreement are deemed to be Confidential Information and will be subject to the confidentiality provisions of this Article 7, with each Party being deemed a Receiving Party for such purposes.

 

7.6.           Publicity. Following the Effective Date, the Parties shall mutually agree on a form of an initial press release regarding the Agreement and the transactions contemplated hereunder, which either Party may, in its sole discretion, release following the Effective Date. During the Term, neither Party (nor any of their respective Affiliates) shall make any public announcements, press releases or other public disclosures, written or oral, whether to the public, the press, stockholders or otherwise, concerning this Agreement or the terms or the subject matter hereof, the performance hereof or the Parties’ activities hereunder except: (a) with the prior written consent of the other Party or (b) to the extent required to comply with Applicable Law (including the regulations of any stock exchange) and which in any event contain only the minimum disclosure necessary to comply with the Applicable Law. Each Party agrees in any event to provide the other Party with a copy of any such proposed press release or public statement as soon as reasonably practicable under the circumstances prior to its scheduled release. Except under extraordinary circumstances, when the following notice may not be possible but in which event the proposed press release or public statement will still be provided to the other Parties for comment before release (which the releasing Party shall use reasonable efforts to provide at least forty-eight (48) hours prior to the intended time of publication), each Party shall provide the other with an advance copy of any such press release or public statement at least seven (7) days prior to its scheduled release. Each Party furthermore shall have the right to review and recommend changes to any such announcement and, except as otherwise required by Applicable Law, the Party whose announcement has been reviewed shall remove any Confidential Information of the reviewing Party that the reviewing Party reasonably deems to be inappropriate for disclosure. Each Party agrees in any event to give the other Parties at least three (3) Business Days (to the extent consistent with Applicable Law) to review all press release or public statement required by Applicable Law to be filed with the Securities and Exchange Commission or similar body prior to submission of such filings, and will give due consideration to any reasonable comments by the non-filing Party relating to such filing, including without limitation the provisions of this Agreement for which confidential treatment should be sought.

 

 

 

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7.7.           Publications. Both Parties shall not, and shall ensure that none of its Affiliates and shall require its Approved CROs and Approved Vendors to not, publish, or present for publication, any document, information, or paper regarding the Phase I/II Clinical Trial, INTASYL PH-762 (or any component thereof), DP TIL (or any component thereof), or the Product (each, a “Publication”) without the prior review and consent of the other Party and compliance with the remainder of this Section 7.6. In the event that either Party or any of its Affiliates, wish to make any Publication, such Party will submit the draft of such Publication to the other Party for review and approval at least thirty (30) days prior to publication or presentation (or fifteen (15) days with respect to any abstract or poster). If the other Party does not respond to such submission for review and comment during such 30-day period (or 15-day period with respect to any abstract or poster), the Party as applicable, may publish such Publication. Without limiting the foregoing, the other Party will have the right to reasonably require amendments to, or postponement of, the Publication in the following circumstances: (a) delaying disclosure for a period of time as reasonably determined by the other Party to permit the filing of any Patents relating thereto or to protect Confidential Information; (b) limiting such Publication to the data and results from the Site with which the Principal Investigator seeking to publish or present is affiliated; (c) remove any information that the other Party reasonably deems to be Confidential Information; or (d) as reasonably necessary to comply with the other Party and its Affiliates’ publication policy. Any publication shall be deemed copyrightable subject matter with the copyrights jointly owned by Phio, AgonOx (as applicable according to the subject matter of the publication) and any authors participating in the Publication.

 

7.7.1.        With respect to any Publications regarding the Phase I/II Clinical Trial by the Principal Investigator, Site and/or participating investigators, AgonOx shall seek to require provisions corresponding to those set forth in Section 7.7 in the IST Agreement with the Principal Investigator, Site and/or participating investigators. Any such IST agreement will be subject to final approval by the JSC.

 

8.     INTELLECTUAL PROPERTY AND PERSONALLY IDENTIFIABLE INFORMATION.

 

8.1.           Ownership.

 

8.1.1.         Background IP. Phio will own and retain all right, title and interest in, to and under all Phio Background IP. AgonOx will own and retain all right, title and interest in, to and under all AgonOx Background IP. Except as set forth in Section 9, neither Party has any right or license to any of the other Party’s Background IP.

 

8.1.2.         Phio Intellectual Property. Phio shall exclusively own all right, title and interest in and to all Phio Intellectual Property. AgonOx hereby assigns and does assign, and shall cause its Affiliates and its and their representatives and contractors to assign, to Phio the entire right, title and interest in and to all Phio Intellectual Property. If AgonOx is not permitted by Applicable Law to assign Phio Intellectual Property to Phio, AgonOx hereby grants Phio a perpetual, irrevocable, exclusive (even as to AgonOx), world-wide, royalty-free, freely-assignable license in all fields to such Phio Intellectual Property (including the right to sell and grant sublicenses to such Phio Intellectual Property) and agrees not to bring any action, claim or proceeding against Phio or any of its sublicensees or assignees for its use or exploitation of such Phio Intellectual Property. Subject to Section 8.2, Phio shall have the exclusive right to prepare applications for, prosecute, maintain and defend, at its own costs, the Phio Intellectual Property. AgonOx shall reasonably assist and cooperate with Phio at Phio’s expense in perfecting, maintaining and defending the rights granted to Phio in this Section 8.1.2, including the provision of any requested documentation necessary for prosecution or maintenance of patents claiming such Phio Intellectual Property, and the execution of any required documents therefor. AgonOx shall not file any patent applications claiming, or amend any patent applications to claim, any Phio Intellectual Property.

 

8.1.3.         AgonOx Intellectual Property. AgonOx shall exclusively own all right, title and interest in and to all AgonOx Intellectual Property. Phio hereby assigns and does assign, and shall cause its Affiliates and its and their representatives and contractors to assign, to AgonOx the entire right, title and interest in and to all AgonOx Intellectual Property. If Phio is not permitted by Applicable Law to assign a AgonOx Intellectual Property to AgonOx, Phio hereby grants AgonOx a perpetual, irrevocable, exclusive (even as to Phio), world-wide, royalty-free, freely- assignable license in all fields to such AgonOx Intellectual Property (including the right to sell and grant sublicenses to such AgonOx Intellectual Property) and agrees not to bring any action, claim or proceeding against AgonOx or any of its sublicensees or assignees for its use or exploitation of such AgonOx Intellectual Property. Subject to Section 8.2, AgonOx shall have the exclusive right to prepare applications for, prosecute, maintain and defend, at its own costs, the AgonOx Intellectual Property. Phio shall reasonably assist and cooperate with AgonOx at AgonOx’s expense in perfecting, maintaining and defending the rights granted to AgonOx in this Section 8.1.3, including the provision of any requested documentation necessary for prosecution or maintenance of patents claiming such AgonOx Intellectual Property, and the execution of any required documents therefor. Phio shall not file any patent applications claiming, or amend any patent applications to claim, any AgonOx Intellectual Property.

 

 

 

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8.1.4.         Joint Intellectual Property. Phio and AgonOx shall jointly own all right, title and interest in and to all Joint Intellectual Property, each Party being free to fully exploit the Joint Intellectual Property throughout the world without accounting to the other Party, subject to Article 9. To the extent necessary to give effect to the preceding sentence, each Party hereby assigns, and shall cause its Affiliates and its and its Affiliates’ representatives and contractors to assign, to the other Party such joint ownership of all right, title and interest in and to any Joint Intellectual Property. Each Party will reasonably assist and cooperate with the other Party in perfecting the rights granted in this Section 8.1.4. For clarity, Phio and AgonOx jointly owning all right, title and interest in and to all Joint Intellectual Property does not grant, by implication, estoppel or otherwise, a Party any ownership, license or right to any of the other Party’s Background IP, Intellectual Property (other than the Joint Intellectual Property) or Confidential Information. In the event that, for any Joint Patent, a Party Opts-Out pursuant to Section 8.2.4, (a) the Opt-Out Party agrees to assign, and hereby assigns, and shall cause its Affiliates and its and their representatives and contractors to assign, to the remaining Party the entire right, title and interest in and to that Joint Patent and (b) automatically (without any requirement for the remaining Party to provide notice), the remaining Party may grant licenses to a Third Party, and permit sublicenses, to practice and otherwise fully exploit that Joint Patent.

 

8.1.5.Data.

 

8.1.5.1.Phio and AgonOx shall jointly retain all rights to access, use, and exploit, for non-commercial use only, all Clinical Trial Data, other than any Proprietary CMC Information of the other Party. All Clinical Trial Data shall be shared among the Parties as needed to carry out the responsibilities of each Party outlined in this Agreement.
   
8.1.5.2.Phio shall retain all rights to access, use, and exploit, for all purposes, all Product Data.
   
8.1.5.3.AgonOx shall retain all rights to access, use, and exploit, for all purposes, all DP TIL Data.
   
8.1.5.4.Phio shall retain all rights to access and reference any Product Data and DP TIL Data submitted to the applicable Regulatory Authorities for purposes of developing and commercializing INTASYL PH-762 and Phio’s self-delivering RNAi therapeutic platform. For clarity, Phio may not use any DP TIL Data to develop or commercialize DP TIL.

 

8.1.6.         Disclosure. At each meeting of the JSC, each Party shall provide to the other Party a written report detailing any Intellectual Property developed by or on behalf of such Party during the applicable period. Each Party shall include in its written report a reasonable level of detail regarding the applicable Intellectual Property and shall provide such additional information on the Intellectual Property as is reasonably requested by the other Party.

 

8.1.7.         Further Assurances. Inventorship and authorship of Patents that are invented or conceived under this Agreement will be resolved based on the Applicable Law of the United States (without regard to any work for hire doctrine). If either Party, any of its Affiliates, any Approved CRO or Approved Vendor, is assigned or otherwise possesses ownership of any invention or work of authorship to which the other Party is allocated ownership pursuant to this Section 8.1, such Party hereby assigns or will assign to the other Party, and will require such Approved CRO or Approved Vendor to assign, such invention or work of authorship and any and all Intellectual Property therein and will execute any and all assignments and other lawful documents necessary to perfect or record the other Party’s right, title and interest in and to such inventions, and the other Party accepts or will accept such assignment.

 

8.2.           Patent Prosecution.

 

8.2.1.         Patent Filings. Neither Party shall file any patent application in any territory covering any Intellectual Property that it is otherwise permitted or authorized to file pursuant to this Agreement without providing the other Party a copy of the draft patent application at least thirty (30) days in advance of the proposed filing. Without limiting Section 7, neither Party shall use or disclose the other Party’s Intellectual Property or Confidential Information in any patent application without the other Party’s prior written consent.

 

 

 

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8.2.2.         Phio Patents. Phio will have sole discretion and sole responsibility to prepare, file, prosecute and maintain the Phio Patents at its own expense and with counsel of its own selection. At Phio’s request and expense (for reasonable out-of-pocket expenses), AgonOx will reasonably cooperate with Phio in preparing, filing, prosecuting, and maintaining the Phio Patents.

 

8.2.3.         AgonOx Patents. AgonOx will have sole discretion and sole responsibility to prepare, file, prosecute and maintain the AgonOx Patents at its own expense and with counsel of its own selection. At AgonOx’s request and expense (for reasonable out-of-pocket expenses), Phio will reasonably cooperate with Phio in preparing, filing, prosecuting, and maintaining the AgonOx Patents.

 

8.2.4.         Joint Patents. Outside counsel mutually acceptable to both Parties will prepare applications for, prosecute, and maintain any Joint Intellectual Property, including the prosecution and maintenance of Joint Patents (patents claiming such Joint Intellectual Property). AgonOx and Phio shall reasonably assist and cooperate with such outside counsel, including the provision of any requested documentation necessary for prosecution or maintenance of Joint Patents, and the execution of any required documents therefor. Each party will reasonably collaborate on determining the strategy concerning the preparation, filing, prosecution, and maintenance of Joint Patents. The Parties shall share equally any corresponding costs and expenses incurred and AgonOx shall reimburse Phio for fifty percent (50%) of the corresponding costs and expenses incurred by such outside counsel in connection with preparing applications for, prosecuting, and maintaining any Joint Intellectual Property. For any Joint Patent, either Party may decline to bear fifty percent (50%) of the costs and expenses resulting from the filing, prosecution, and maintenance of that Joint Patent (“Opt-Out”); provided that the remaining Party exclusively owns all right, title and interest in and to that Joint Patent as set forth in Section 8.1.4. The remaining Party shall have the exclusive right to prepare continuing applications for, prosecute, maintain and defend, at its own costs, that Joint Patent. The Opt-Out Party shall reasonably assist and cooperate with the remaining Party, at the remaining Party’s expense, including the provision of any requested documentation necessary for prosecution or maintenance of that Joint Patent, and the execution of any required documents therefor.

 

8.3.           Enforcement of Intellectual Property.

 

8.3.1.         Phio Intellectual Property. Phio shall have the exclusive right to bring and control any claim, action or proceeding related to the infringement, misappropriation or other violation of any Phio Intellectual Property and shall retain all damages, recoveries and other amounts awarded in connection therewith. AgonOx shall reasonably assist and cooperate with Phio, at Phio’s expense, in bringing, litigating and settling such claim, action or proceeding, including the provision or execution of any requested documentation. AgonOx acknowledges that it may be a necessary party to any claim, action or proceeding brought by Phio arising from enforcement of Phio Intellectual Property, and, if necessary, AgonOx shall participate in such claim, action or proceeding, at Phio’s sole cost and expense.

 

8.3.2.         AgonOx Intellectual Property. AgonOx shall have the exclusive right to bring and control any claim, action or proceeding related to the infringement, misappropriation or other violation of any AgonOx Intellectual Property and shall retain all damages, recoveries and other amounts awarded in connection therewith. Phio shall reasonably assist and cooperate with AgonOx, at AgonOx’s expense, in bringing, litigating and settling such claim, action or proceeding, including the provision or execution of any requested documentation. Phio acknowledges that it may be a necessary party to any claim, action or proceeding brought by AgonOx arising from enforcement of AgonOx Intellectual Property, and, if necessary, Phio shall participate in such claim, action or proceeding, at AgonOx’s sole cost and expense.

 

8.3.3.         Joint Intellectual Property. The Parties shall meet and decide which Party will bring and control any claim, action or proceeding related to the infringement, misappropriation or other violation of any Joint Intellectual Property. Phio and AgonOx shall each bear fifty percent (50%) of the corresponding costs and expenses. Phio and AgonOx shall each receive fifty percent (50%) of the damages, recoveries and other amounts awarded in connection therewith. Each Party shall reasonably assist and cooperate with the other Party in bringing, litigating and settling such claim, action or proceeding, including the provision or execution of any requested documentation. If either Party elects not to proceed with such claim, action or proceeding (“Non- Electing Party”), and the other Party elects to proceed with such claim, action or proceeding (“Electing Party”), then the Electing Party shall bear all costs and expenses, and shall receive all damages, recoveries and other amounts awarded. The Non-Electing Party shall reasonably assist and cooperate with the Electing Party, at the Electing Party’s expense, in bringing, litigating and settling such claim, action or proceeding, including the provision or execution of any requested documentation.

 

 

 

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8.3.4.         Infringement of Third Party Rights. If either Party learns of Third Party allegations that it or the other Party or any of its or the other Party’s Affiliates, Approved CRO or Approved Vendor, have infringed, misappropriated or otherwise violated, or are infringing, misappropriating or otherwise violating, any Intellectual Property Controlled by a Third Party in connection with the Phase I/II Clinical Trial or performing its obligations or duties hereunder, such Party will promptly notify the other Party. Each Party shall reasonably assist and cooperate with the other Party in defending against any such allegations and any related actions or litigation. Neither Party will enter into any settlement, stipulated judgment or other voluntary final disposition of any enforcement suit without the consent of the other Party if such settlement, stipulated judgment or other voluntary final disposition would require the other Party to be subject to an injunction, admit wrongdoing or make a monetary payment to a Third Party.

 

8.4.           Privacy and Data Protection. In conducting the Phase I/II Clinical Trial and with respect to any of its other obligations hereunder, each Party will comply with all Applicable Law relating to privacy or data protection applicable to data Controlled by such Party or shared with such Party by the other Party, including ensuring that all necessary (a) consents from Principal Investigators, Subjects and any others from whom Personally Identifiable Information will be received are obtained for the Phase I/II Clinical Trial and (b) regulatory notifications or registrations are filed.

 

9.     LICENSES.

 

9.1.           Mutual Development License. During the Term, each Party, on behalf of itself and its Affiliates, grants to the other Party and such other Party’s Affiliates a non-exclusive, royalty- free, irrevocable during the term of the Agreement (except as set forth in Section 12), worldwide license under all such Party’s Background IP, Confidential Information, other Intellectual Property Controlled by either Party necessary to perform such Party’s obligations under this Agreement, and Joint Intellectual Property created in connection with this Agreement solely to the extent necessary to conduct and carry out such other Party’s tasks and obligations contemplated by this Agreement.

 

9.2.           No Out Licensing. During the Term, each Party covenants not to grant any sublicenses to any Joint Intellectual Property; provided that either Party may grant licenses and permit sublicenses to Approved CROs and Approved Vendors exclusively within the scope of its license granted in Section 9.1.

 

9.3.           No Other Licenses or Rights. Except as expressly set forth herein, nothing in this Agreement grants, by implication, estoppel or otherwise, a Party any license or right to any of the other Party’s Intellectual Property or Confidential Information. For clarity, the delivery of any information or materials to a Party hereunder will not be construed to grant the other Party any rights or license to use of the other Party’s Intellectual Property or Confidential Information other than as necessary to comply with its obligations hereunder or as expressly set forth herein.

 

9.4.           Use of Names and Trademarks. Other than as explicitly provided herein, nothing contained in this Agreement will be construed as conferring any right to use in advertising, publicity or other promotional activities any name, trade name, trademark, service mark or other designation of a Party (including any contraction, abbreviation or simulation of any of the foregoing) without the prior written approval of such Party.

 

10.     INDEMNIFICATION AND INSURANCE.

 

10.1.        Indemnification by AgonOx. AgonOx agrees to defend, indemnify and hold harmless Phio, Phio’s Affiliates and their respective representatives from and against any and all losses, liabilities, damages, actions, suits, demands or claims brought by any third party (including amounts paid in settlement, reasonable costs of investigation and reasonable attorneys’ fees and disbursements) (collectively, “Claims”), arising out of or resulting from (a) the gross negligence, bad faith or intentional or willful misconduct of AgonOx or its Affiliates, representatives or permitted subcontractors, (b) any Subject injury claim related to DP TIL, and (c) breach of any of AgonOx’s representations, warranties, covenants or agreements contained herein.

 

 

 

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10.2.        Indemnification by Phio. Phio agrees to defend, indemnify and hold harmless AgonOx, AgonOx’s Affiliates and their respective representatives from and against any Claims, arising out of or resulting from (a) the gross negligence, bad faith or intentional or willful misconduct of Phio or its Affiliates, representatives or permitted subcontractors, (b) any Subject injury claim related to INTASYL PH-762 , and (c) breach of any of Phio’s representations, warranties, covenants or agreements contained herein.

 

10.3.        Indemnification Claims. Each indemnified Party agrees to give the indemnifying Party prompt written notice of any matter upon which such indemnified Party intends to base a claim for indemnification (an “Indemnity Claim”) under this Section 10, provided, however, that any delay in providing or failure to provide such notice shall not relieve the indemnifying Party of any of its obligations hereunder except to the extent that the indemnifying Party is materially prejudiced by such failure. The indemnifying Party shall have the right to participate jointly with the indemnified Party in the indemnified Party’s defense, settlement or other disposition of any Indemnity Claim. With respect to any Indemnity Claim relating solely to the payment of money damages which could not result in the indemnified Party’s becoming subject to injunctive or other equitable relief or otherwise adversely affect the business of the indemnified Party in any manner, and as to which the indemnifying Party shall have acknowledged in writing the obligation to indemnify the indemnified Party hereunder, the indemnifying Party shall have the sole right to defend, settle or otherwise dispose of such Indemnity Claim, on such terms as the indemnifying Party, in its sole discretion, shall deem appropriate; provided that the indemnifying Party shall provide reasonable evidence of its ability to pay any damages claimed and with respect to any such settlement shall have obtained the written release of the indemnified Party from the Indemnity Claim. The indemnifying Party shall obtain the written consent of the indemnified Party, which shall not be unreasonably withheld, prior to ceasing to defend, settling or otherwise disposing of any Indemnity Claim if as a result thereof the indemnified Party would become subject to injunctive or other equitable relief or the business of the indemnified Party would be adversely affected in any manner.

 

10.4.        Limitations of Liability. TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW AND EXCEPT FOR (a) THE PARTIES’ INDEMNIFICATION OBLIGATIONS UNDER THIS AGREEMENT AND (b) BREACHES OF THE CONFIDENTIALITY OBLIGATIONS SET FORTH HEREIN, IN NO EVENT SHALL EITHER PARTY HAVE ANY DAMAGES OR LIABILITY TO THE OTHER PARTY, ANY OF THE OTHER PARTY’S AFFILIATES OR ANY THIRD PARTY ARISING OUT OF, RELATED TO OR IN CONNECTION WITH THIS AGREEMENT, REGARDLESS OF THE FORM OF THE ACTION, WHETHER IN CONTRACT, TORT (INCLUDING NEGLIGENCE), STRICT LIABILITY, PRODUCT LIABILITY OR OTHERWISE:

 

10.4.1.     FOR INCIDENTAL, CONSEQUENTIAL, INDIRECT, SPECIAL, PUNITIVE OR EXEMPLARY DAMAGES OR LIABILITIES OF ANY KIND OR FOR LOSS OF REVENUE OR PROFITS OR LOSS OF BUSINESS; OR

 

10.4.2     . IN AN AGGREGATE AMOUNT IN EXCESS $one million dollars $1,000.000).

 

10.5.        AgonOx’s Maintenance of Insurance. Other than as set forth below in Section 10.7, AgonOx shall maintain at all times during the Term, and at its sole expense such policy or policies of insurance, including general liability and employers liability, as are necessary to cover all loss, destruction or damage for which AgonOx has assumed responsibility under the terms of this Agreement, and shall name Phio as an additional insured with respect to such insurance. AgonOx shall cause its insurance policies to provide a waiver of subrogation in favor of Phio. The policies should be with at least a Standard & Poor’s A+ rated providing limits of no less than $10,000,000.00 per occurrence. AgonOx shall promptly furnish upon request certificates of insurance to Phio evidencing that the insurance required by this paragraph is in full force and effect. The certificates of insurance required hereunder shall contain a clause which provides that there shall be no reduction, cancellation or expiration of, or other material change to the policy without at least thirty (30) days’ prior written notice to Phio.

 

10.6.         Phio’s Maintenance of Insurance. Phio shall maintain at all times during the Term, and at its sole expense such policy or policies of insurance, including general liability and employers liability, as are necessary to cover all loss, destruction or damage for which Phio has assumed responsibility under the terms of this Agreement, and shall name AgonOx as an additional insured with respect to such insurance. Phio shall cause its insurance policies to provide a waiver of subrogation in favor of AgonOx. The policies should be with at least a Standard & Poor’s A+ rated providing limits of no less than $10,000,000.00 per occurrence. Phio shall promptly furnish upon request certificates of insurance to AgonOx evidencing that the insurance required by this paragraph is in full force and effect. The certificates of insurance required hereunder shall contain a clause which provides that there shall be no reduction, cancellation or expiration of, or other material change to the policy without at least thirty (30) days’ prior written notice to AgonOx.

 

 

 

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10.7.         Clinical Trial Insurance. AgonOx shall obtain and shall maintain during the Term applicable clinical trial insurance, including coverage for Subject injury claims, as is necessary to cover all loss, destruction or damage resulting or occurring from or during the Phase I/II Clinical Trial, and shall name Phio as an additional insured with respect to such insurance. The cost of such insurance shall be deemed a Development Cost and included in the Budget. AgonOx shall cause its insurance policies to provide a waiver of subrogation in favor of Phio. The policy should be with at least a Standard & Poor’s A+ rated providing limits of no less than $10,000,000.00 per occurrence. AgonOx shall promptly furnish upon request certificate of insurance to Phio evidencing that the insurance required by this paragraph is in full force and effect. The certificates of insurance required hereunder shall contain a clause which provides that there shall be no reduction, cancellation or expiration of, or other material change to the policy without at least thirty (30) days’ prior written notice to Phio.

 

11.     REPRESENTATIONS, WARRANTIES AND COVENANTS.

 

11.1.        Representations and Warranties of Both Parties. Each Party represents and warrants to the other, as of the Effective Date, and covenants, as follows:

 

11.1.1.      It is duly organized, validly existing, and in good standing under the laws of the jurisdiction of its organization, and has all requisite power and authority, corporate or otherwise, to execute, deliver, and perform this Agreement.

 

11.1.2.      The execution and delivery of this Agreement and the performance by it of the transactions contemplated hereby have been duly authorized by all necessary corporate action, and do not violate (a) such Party’s charter documents, bylaws, or other organizational documents, (b) in any material respect, any agreement, instrument, or contractual obligation to which such Party is bound, (c) any requirement of any Applicable Law, or (d) any order, writ, judgment, injunction, decree, determination, or award of any court or governmental agency presently in effect applicable to such Party.

 

11.1.3.     This Agreement is a legal, valid, and binding obligation of such Party enforceable against it in accordance with its terms and conditions, subject to the effects of bankruptcy, insolvency, or other laws of general application affecting the enforcement of creditor rights, judicial principles affecting the availability of specific performance, and general principles of equity (whether enforceability is considered a proceeding at law or equity).

 

11.1.4.     It is not under any obligation, contractual or otherwise, to any Person that conflicts with or is inconsistent in any material respect with the terms of this Agreement, or that would impede the diligent and complete fulfilment of its obligations hereunder.

 

11.1.5.     Neither it, nor any of its Affiliates, Approved CROs or Approved Vendors are debarred, excluded, disqualified or otherwise in violation under, or the subject of debarment, exclusion, disqualification or other violation proceedings by any Governmental Authority under, subsections 306(a) or (b) of the United States Federal Food Drug and Cosmetic Act (United States Generic Drug Enforcement Act of 1992; 21 USC 335a (a) or (b)), and that it has not and will not use in any capacity the services of any person that is debarred, excluded, disqualified or otherwise in violation under, or that is the subject of debarment, exclusion, disqualification or other violation proceedings by any Governmental Authority under, such law to conduct the Phase I/II Clinical Trial. Each Party further certifies that neither it, nor any of its Affiliates, Approved CROs or Approved Vendors in the United States, are excluded from any federal health care program, including medicare and medicaid. Each Party will notify the other Party immediately if either of these certifications needs to be amended in light of new information.

 

11.1.6.     It has not and will not, and will ensure that none of its Affiliates or Approved CROs, directly or indirectly offer or pay, or authorize such offer or payment, of any money or anything of value to improperly or corruptly seek to influence any Government Official or any other person in order to gain an improper business advantage in performing activities under this Agreement that would violate any applicable anti-corruption laws and laws for the prevention of fraud, racketeering, money laundering or terrorism.

 

 

 

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11.1.7.     Neither it nor any of its Affiliates performing under this Agreement shall commit tax evasion or undertake any activities which would facilitate or otherwise result in another Person committing tax evasion. During the Term, it (and any of its Affiliates performing under this Agreement) shall (a) maintain reasonable procedures designed to prevent any employees, agents or other persons who perform services for or on behalf of it or any of its Affiliates under this Agreement from undertaking any activities which would facilitate or otherwise result in another person committing tax evasion, (b) answer, in reasonable detail, any written or oral inquiry from the other Party related to its compliance with this Section 11.1.7, and (c) co-operate with the other Party, any Tax Authority and any other Governmental Authority, as applicable, in relation to any investigation relating to the matters referred to in this Section 11.1.7. Each Party shall promptly notify the other Party in writing in the event that such Party becomes aware of a breach by such Party of this Section 11.1.7. For purposes of this Section 11.1.7, references to ‘committing tax evasion’ shall include (i) fraudulently or dishonestly failing to pay any amount of Tax to the relevant Tax Authority within any applicable time limit for the payment of such Tax without incurring interest or penalties; and (ii) fraudulently or dishonestly claiming any relief, allowance, credit, deduction, exemption or set off in respect of any Tax (or relevant to the computation of any income, profits or gains for the purposes of any Tax), or any right to or actual repayment of or saving of Tax.

 

11.2.         Representations and Warranties of AgonOx. AgonOx represents and warrants to Phio, as of the Effective Date and at times during the conduct of the Phase I/II Clinical Trial, that AgonOx (a) shall have control and oversight over the conduct of the Phase I/II Clinical Trial and other Development Activities conducted at the Site, as set forth in the IST Agreement, (b) shall have unrestricted access to and control over any and all data (including source data) generated from such the Phase I/II Clinical Trial or otherwise collected from each Site for the Phase I/II Clinical Trial, in each case as set forth in the IST Agreement, and (c) Phio shall have the unrestricted right to access and exploit such data to the full extent contemplated by Section 8.1.5, and as set forth in the IST Agreement.

 

11.3.        DISCLAIMER OF REPRESENTATIONS AND WARRANTIES.

 

11.3.1.     EACH PARTY HEREBY AGREES AND UNDERSTANDS THAT BECAUSE THE CLINICAL TRIALS, INTASYL PH-762 , DP TIL, AND THE PRODUCT ARE EXPERIMENTAL IN NATURE, THE OUTCOME IS INHERENTLY UNCERTAIN AND UNPREDICTABLE. EXCEPT AS SET FORTH IN THIS AGREEMENT, EACH PARTY HEREBY AGREES AND UNDERSTANDS THAT THE OTHER PARTY MAKES NO REPRESENTATION, GUARANTEE OR WARRANTY, EXPRESS OR IMPLIED, REGARDING THE OUTCOME OF ANY CLINICAL RESEARCH ACTIVITIES, THE RESEARCH RESULTS OR THE PATENTABILITY, LEGAL PROTECTABILITY OR USEFULNESS OF ANY INTELLECTUAL PROPERTY ARISING FROM ANY CLINICAL RESEARCH ACTIVITIES.

 

11.3.2.     EXCEPT FOR THE REPRESENTATIONS AND WARRANTIES EXPRESSLY SET FORTH IN THIS AGREEMENT (INCLUDING SECTION 11.1), NEITHER PARTY MAKES ANY REPRESENTATION OR WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING ANY REPRESENTATION OR WARRANTY THAT THE USE OF ANY PHIO BACKGROUND INTELLECTUAL PROPERTY, PHIO INTELLECTUAL PROPERTY, AGONOX BACKGROUND INTELLECTUAL PROPERTY, AGONOX INTELLECTUAL PROPERTY, OR JOINT INTELLECTUAL PROPERTY WILL NOT INFRINGE ANY PATENT OR OTHER PROPRIETARY RIGHT OF A THIRD PARTY OR REGARDING THE USE, RESULTS OR EFFICACY OF INTASYL PH-762 , DP TIL, OR PRODUCT.

 

12.     TERM AND TERMINATION.

 

12.1.         Term. This Agreement shall commence on the Effective Date and, unless terminated earlier pursuant to this Article 12, shall continue in force and effect until the end of the Development Term and all obligations of the Parties for the Phase I/II Clinical Trial have been completed; provided that Article 6 shall continue in force and effect until the expiration date of the last-to-expire patent Controlled by AgonOx at any time during the Development Term, including any Joint Patent, whether not or such patent is sold or otherwise transferred by AgonOx to any Third Party during the Term of this Agreement, that claims DP TIL or its use (the period from the Effective Date until this Agreement expires or is terminated in accordance with this Article, “Term”).

 

 

 

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12.2.         Termination.

 

12.2.1.     Termination for Material Breach. Either Party may terminate this Agreement immediately in the event of a material breach of this Agreement by the other Party (other than with respect to those specific material breaches identified in Section 12.2.2 and Section 12.2.3); provided that the breaching Party has received written notice from the non-breaching Party of such breach, specifying in reasonable detail the particulars of the alleged breach and such breach has not been cured within ninety (90) days following the date of the relevant notice (or such longer period, as may be mutually agreed by the Parties).

 

12.2.2.     AgonOx Additional Termination Rights. AgonOx may terminate this Agreement in the event of any of the following events by written notice to Phio effective immediately upon delivery of such written notice:

 

12.2.2.1.Phio’s breach of its obligation to supply INTASYL PH-762 suitable (GLP or GMP) for use in the Phase I/II Clinical Trials in accordance with the delivery terms as set forth in Section 5.2.1, which breach directly results in:

 

i.a delay of the first dosing of the first Subject enrolled in a Phase I/II Clinical Trial with Product in accordance with the Protocol for a period of longer than six (6) months based on the Timeline for such Phase I/II Clinical Trial (in which case the Timeline has not been adjusted by mutual agreement of the Parties); or
   
ii.at any time following the first dosing of the first Subject enrolled in a Phase I/II Clinical Trial with Product to the final dosing of the Subjects for such Phase I/II Clinical Trial in accordance with the Protocol, a disruption of INTASYL PH-762 Manufacturing and an inability to continue to dose Subjects enrolled in such Phase I/II Clinical Trial with such Product in accordance with the Protocol; provided that, in each case, which delay in supply of INTASYL PH- 762 , results in an enrollment delay of longer than six (6) months, and cannot be resolved by the JSC (subject to dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable);

 

12.2.2.2.Phio’s material breach of its obligation to pay the Development Costs accordance with the applicable payment terms thereof; provided that under 12.2.2.1 or 12.2.2.2, Phio has received written notice from AgonOx specifying in reasonable detail the particulars of such alleged breach, and such breach has not been cured within sixty (60) days following the date of the relevant notice (or such longer period, as may be mutually agreed by the Parties); provided, however, that AgonOx may not exercise a right to terminate this Agreement under this Section 12.2.2 if the alleged breach that is the basis for the exercise of the termination right under this Section 12.2.2 results solely or primarily from (a) a breach of this Agreement by AgonOx, or (b) the gross negligence or willful misconduct of AgonOx or any of its Affiliates.

  

12.2.3.      Phio Additional Termination Rights. Phio may terminate this Agreement in the event of any of the following events by written notice to AgonOx effective immediately upon delivery of such written notice:

 

12.2.3.1.AgonOx’s breach of its obligation to supply DP TIL suitable (as required by the applicable Regulatory Authority) for use in the Phase I/II Clinical Trials in accordance with the delivery terms as set forth in Section 5.2.1, which breach directly results in:

 

i.a delay of the first dosing of the first Subject enrolled in a Phase I/II Clinical Trial with Product in accordance with the Protocol for a period of longer than six (6) months based on the Timeline for such Phase I/II Clinical Trial (in which case the applicable Timelines have not been adjusted by mutual agreement of the Parties); or

 

 

 

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iii.at any time following the first dosing of the first Subject enrolled in a Phase I/II Clinical Trial with Product to the final dosing of the Subjects for such Phase I/II Clinical Trial in accordance with the applicable Protocol, a disruption of Product Manufacturing and an inability to continue to dose Subjects enrolled in such Phase I/II Clinical Trial with such Product in accordance with the Protocol;
   
  provided that, in each case, which delay in supply of DP TIL, results in a enrollment delay of longer than six (6) months, and cannot be resolved by the JSC (subject to dispute resolution procedures in accordance with Section 4.1.5.2 and Section 13.9, as applicable);

 

12.2.3.2.AgonOx’s material breach of its obligation to pay the License Payments or DP TIL Payments in accordance with the applicable payment terms thereof;

 

  provided that under any subsection of 12.2.3.1, AgonOx has received written notice from Phio specifying in reasonable detail the particulars of such alleged breach, and such breach has not been cured within sixty (60) days following the date of the relevant notice (or such longer period, as may be mutually agreed by the Parties); provided, however, that Phio may not exercise a right to terminate this Agreement under this Section 12.2.2 if the alleged breach that is the basis for the exercise of the termination right under this Section 12.2.2 results solely or primarily from (a) a breach of this Agreement by Phio or (b) the gross negligence or willful misconduct of Phio or any of its Affiliates.

 

12.2.3.3.The failure of the Principal Investigator to enroll Subjects in the Phase I/II Clinical Trial at a rate at least equal to the Minimum Enrollment Rate, as set forth in Section 2.6.2.

 

12.2.4.     Termination for Bankruptcy. Either Party may terminate this Agreement upon written notice to the other Party if (a) such other Party makes an assignment for the benefit of creditors, or commences a case or proceeding under any bankruptcy, reorganization, insolvency, or similar laws, has a trustee or receiver or similar officer of any court appointed for such other Party or for a substantial part of the property of such other Party, or bankruptcy, reorganization, insolvency, or liquidation proceedings are instituted by or against such other Party without such proceedings being dismissed, in each of the foregoing cases for a period of at least sixty (60) days and (b) such other Party is no longer able to fulfil its obligations under this Agreement.

 

12.2.5.     Termination for Material Safety Concerns. Either Party may terminate this Agreement (in its entirety) by delivery of written notice to the other Party in the event that the JSC has determined that a Material Safety Concern exists as determined in accordance with Section 3.5.1.

 

12.3.         Effects of Termination.

 

12.3.1.     Termination for Material Breach. Any breach by either Party of their respective obligations under this Agreement (material or otherwise) shall not be subject to any liquidated damages or termination payment and the amount of any damages awarded to the other Party, if any, in connection with such breach shall be determined by the court or arbiter (as applicable) under the normal course, subject to the limitations on liability set forth in Section 10.4, provided that upon breach by Phio under Section 12.2.2.1 or 12.2.2.2, Phio shall pay all Development Costs owed to AgonOx as of the termination date. For clarity, Phio shall only be responsible for Development Costs incurred, as of the termination date, through performance of any AgonOx Development Activities, including customary and reasonable cancellation and similar charges that AgonOx is legally obligated to pay as of the termination date and that AgonOx reasonably incurred in contemplation of performing the AgonOx Development Activities.

 

 

 

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12.3.2.     Wind-Down or Transfer of a Phase I/II Clinical Trial. If this Agreement or a given Phase I/II Clinical Trial is terminated for any reason prior to the completion of the applicable Development Activities for the Phase I/II Clinical Trial, the Parties will meet and discuss the orderly wind-down of the affected Phase I/II Clinical Trial. Subject to the remainder of this Section 12.3.3, each Party shall be responsible for its own costs and expenses incurred in connection with any such wind-down of a Phase I/II Clinical Trial, except in the event of (a) a termination by AgonOx pursuant to Section 12.2.1 or Section 12.2.2, in which case, Phio shall reimburse AgonOx for any of its reasonable costs and expenses incurred in connection with such wind-down or (b) a termination by Phio pursuant to Section 12.2.1 or Section 12.2.3, in which case, AgonOx shall reimburse Phio for any of its reasonable costs and expenses incurred in connection with such wind-down. In the event that a Party desires that the other Party transfer data, information and supplies pertaining to the Phase I/II Clinical Trial to Phio or transfer such Phase I/II Clinical Trial and associated data, information, supplies and inventory (including the applicable Trial Database and the applicable Trial Master File) to such Party or such Third Party designated by such Party to continue to conduct such Phase I/II Clinical Trial, upon mutual agreement of the Parties, the Parties will cooperate to facilitate such transfer; provided that such Party shall be responsible for any of the other Party’s costs and expenses relating to such transfer. Phio and AgonOx agree to take all reasonable actions necessary to carry out any such wind-down or mutually-agreed upon transfer pursuant to this Section 12.3.3; provided, however, that if this Agreement is terminated pursuant to Section 12.2.5, then the Parties will promptly wind-down the Phase I/II Clinical Trial(s) in compliance with Applicable Law (including prompt notification of the relevant Regulatory Authorities) and neither Party shall recommence the affected Phase I/II Clinical Trial unless the Parties mutually agree to recommence such Phase I/II Clinical Trial.

 

12.3.3.     Non-Exclusive Remedy. Notwithstanding anything herein to the contrary, termination of this Agreement by a Party will be without prejudice to other remedies such Party may have at law or equity.

 

12.3.4.     Surviving Obligations. Expiration or earlier termination of this Agreement will not relieve either Party of any obligation accruing prior to or upon such expiration or earlier termination, including that neither Party will be relieved of any payment obligation that may have accrued prior to such expiration or earlier termination. Further, the following provisions of this Agreement, together with any other provisions that expressly specify that they survive, will survive expiration or earlier termination of this Agreement: Article 1 (to the extent necessary to interpret surviving provisions) and Article 13, and 2.7.2, 5.2.2.2, 6.2, 6.3, 6.6, 7.1, 7.2, 7.3, 7.4, 8.1, 8.2.4, 8.3, 10.1, 10.2, 10.3, 10.4, 12.1 (to the extent needed for survival of Article 6),and this Section 12.3.4.

 

13.     MISCELLANEOUS.

 

13.1.        Compliance with Applicable Law. Each Party will comply with all Applicable Law in the course of performing its obligations or exercising its rights pursuant to this Agreement. Neither Party will be required by this Agreement to take or omit to take any action in contravention of any Applicable Law, including any applicable national and international pharmaceutical industry codes of practices. Without limiting the foregoing, and notwithstanding any other provision of this Agreement, neither Party will be required to incur any expense in connection with any activity under this Agreement, that it reasonably believes, in good faith, may violate any Applicable Law (including any, applicable national and international pharmaceutical code of practice) or “corporate integrity” or similar agreement with any Governmental Authority to which it is a party.

 

13.2.        Relationship with Affiliates. Either Party will be permitted to use its Affiliates to perform its obligations and allow its Affiliates to exercise its rights hereunder; provided that any Affiliate so used will be subject to all terms and conditions applicable to such Party hereunder and such Party will remain responsible for any of its responsibilities that it has delegated to an Affiliate.

 

 

 

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13.3.        Notices. Any notice or other communication required or permitted to be given by either Party under this Agreement will be in writing and will be effective when delivered if delivered by email (with a confirmation copy to be sent by registered or certified mail, return receipt requested, postage prepaid), hand or via reputable courier service, or five (5) days after mailing if mailed by registered or certified mail, postage prepaid and return receipt requested, addressed to the other Party at the following addresses or such other address as may be designated by notice pursuant to this Section 13.3:

 

13.3.1.If to Phio:
   
  

Phio Pharmaceuticals Corp.

257 Simarano Dr.

Marlborough, MA 01752

Attention: Gerrit Dispersyn

Email: gdispersyn@phiopharma.com

Telephone: 508-929-3610

 

13.3.2.If to AgonOx:
   
  

AgonOx, Inc.

4805 NE Glisan St. Portland, OR 97213

Attention: Ryan Montler

Email: ryan.montler@agonox.com

Telephone: 503-780-4901

 

13.4.        Force Majeure. Neither Party shall be held liable or responsible to the other Party or be deemed to have defaulted under or breached this Agreement for failure or delay in fulfilling or performing any term of this Agreement (other than an obligation to make payments) when such failure or delay is caused by or results from events beyond the reasonable control of the non-performing Party, including fires, floods, earthquakes, hurricanes, embargoes, shortages, epidemics, quarantines, war, acts of war (whether war be declared or not), terrorist acts, insurrections, riots, civil commotion, strikes, lockouts, or other labor disturbances (whether involving the workforce of the non-performing Party or of any other Person), acts of God or acts, omissions or delays in acting by any governmental authority (except to the extent such delay results from the breach by the non-performing Party or any of its Affiliates of any term or condition of this Agreement). The non-performing Party shall notify the other Party of such force majeure within thirty (30) days following such occurrence by giving written notice to the other Party stating the nature of the event, its anticipated duration, and any action being taken to avoid or minimize its effect. The suspension of performance shall be of no greater scope and no longer duration than is necessary and the non-performing Party shall use Commercially Reasonable Efforts to remedy its inability to perform.

 

13.5.        Use of Names. Neither Party will use the other Party’s nor any of its Affiliates’ names or trademarks (or any names of any of the other Party’s employees) in any promotional materials or advertising without the prior written consent of the other Party except as otherwise expressly permitted in this Agreement. For clarity, use the other Party’s names is allowed in the context of non-promotional materials, such as scientific papers or posters, or corporate presentations.

 

13.6.        Assignment. This Agreement may not be assigned, in whole or in part, by a Party without the prior written consent of the other, except that (a) a Party may assign or delegate its rights or obligations hereunder to any of its Affiliates, and (b) a Party may assign or delegate its rights or obligations hereunder to any Person succeeding to all or substantially all of the business or assets of such Party whether through purchase, merger, consolidation or otherwise. Subject to the foregoing sentence, this Agreement shall bind and inure to the benefit of the Parties hereto and their respective successors and assigns. AgonOx shall not assign or transfer to any Third Party any interest in any patent included in the AgonOx Background IP that claims DP TIL or its use unless such Third Party expressly assumes the obligations of AgonOx under Section 6.1.2 to make the DP TIL Payments pursuant to a written agreement under which Phio is expressly stated to be a third party beneficiary, a copy of which agreement AgonOx shall provide to Phio promptly after such transfer. For clarity, AgonOx may redact any Third Party confidential information unrelated to the Third Party’s obligations under Section 6.1.2 of this Agreement from the agreement with the Third Party prior to providing it to Phio.

 

 

 

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13.7.        Further Assurances. The Parties will execute such further reasonable documents and perform such further reasonable acts as may be necessary to comply with or more fully effectuate the terms of this Agreement.

 

13.8.        Governing Law, Jurisdiction and Venue. The construction and validity of this Agreement and the provisions hereof, and the rights and obligations of the Parties hereunder, will be governed by the laws of the State of Delaware without regard to its conflict of laws principles.

 

13.9.        Dispute Resolution. Any dispute, controversy or claim arising under, out of or in connection with this Agreement (including any subsequent amendment) or the matters contemplated hereunder, including any dispute, controversy or claim with respect to the validity, enforceability, construction, performance or breach hereof (a “Dispute”), shall be resolved by the Parties as follows:

 

13.9.1.     Initial Dispute Resolution. No Dispute under this Agreement will be referred to arbitration proceedings under Section 13.9.2 below until the following procedures in this Section 13.9.1 have been satisfied. The authorized representative of each Party will meet as soon as practicable as reasonably requested by either Party, and in no event later than ten (10) Business Days following such a request, to attempt to resolve such Dispute as promptly as possible. In the event that a Dispute is not resolved by the authorized representatives within fifteen (15) days of the first meeting of the authorized representatives with respect to such Dispute, then either Party may at any time thereafter provide the other Party notice of its decision to commence arbitration proceedings in accordance with the procedures set forth under Sections 13.9.2 through 13.9.3.

 

13.9.2.     General Arbitration. Subject to Sections 13.9.3, 13.9.4 and 13.9.5 below, with respect to any Dispute for which either Party has elected to commence arbitration proceedings in accordance with Section 13.9.1, such Dispute shall be submitted to the American Arbitration Association (“AAA”), with the arbitration proceedings to be conducted in New York, NY by a single arbitrator. In such arbitration, the arbitrator will select an independent expert with significant experience relating to the subject matter of such dispute to advise the arbitrator with respect to the subject matter of the dispute. If the Parties are unable to agree on an arbitrator within (5) days following the receipt of notice to arbitrate by a Party, the Parties will petition AAA to make the appointment of such arbitrator.

 

13.9.3.     Arbitration Logistics; Costs. The Parties agree that the decision of the arbitrator will be the sole, exclusive and binding remedy between them regarding any Dispute presented to the arbitrator, and such decision may be entered in a court of competent jurisdiction for judicial notice and enforcement. The arbitration proceedings and the decision of the arbitrator will be deemed Confidential Information of both Parties under Article 7 above. Unless otherwise mutually agreed upon by the Parties, the arbitration proceedings will be conducted in New York, NY. The Parties agree that they will share equally the cost of the arbitration filing and hearing fees, the cost of the independent expert retained by the arbitrator and the cost of the arbitrator and administrative fees of ICC. Each Party will bear its own costs and attorneys’ and witnesses’ fees and associated costs and expenses.

 

13.9.4.     Timetable for Completion. Unless otherwise agreed to by the Parties in writing, in any arbitration under this Section 13.9, the Parties and the arbitrator will use all reasonable efforts to resolve such Dispute within sixty (60) days following the selection of the arbitrator, or as soon thereafter as is reasonably practicable.

 

13.9.5.     Provisional Remedies. Nothing in this Agreement will limit the right of either Party to seek to obtain in any court of competent jurisdiction any equitable or interim relief or provisional remedy, including injunctive relief. Seeking or obtaining such equitable or interim relief or provisional remedy in a court will not be deemed a waiver of this Agreement to arbitrate. For clarity, any such equitable remedies will be cumulative and not exclusive and are in addition to any other remedies that either Party may have under this Agreement or Applicable Law (except as otherwise limited by Section 10.4).

 

13.9.6.     Continued Performance. For the avoidance of doubt, during the pendency of any Dispute subject to resolution in accordance with this Section 13.9, the Parties shall continue to perform in good faith their respective obligations under and in accordance with this Agreement until such Dispute is resolved in accordance with this Section 13.9.

 

 

 

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13.10.       Stand Still. From the Effective Date through the Development Term:

 

13.10.1.  Phio will not collaborate with other companies on the clinical development and commercialization of TILs utilizing knock-down of PD-1 by PH-762 to enhance the therapeutic activity of said TILs. For the avoidance of doubt, Phio may collaborate with 3rd parties for use of INTASYL compounds and other targets utilizing Phio’s self-delivering RNAi therapeutic platform in areas outside of therapeutic enhancement, for example the optimization of manufacturing process for TILs and other cell-based products.

 

13.10.2.  AgonOx will not collaborate with other companies on the clinical development and commercialization of TILs utilizing knock-down of PD-1 through genetic engineering or gene silencing to enhance the therapeutic activity of said TILs. For the avoidance of doubt, AgonOx may collaborate with 3rd parties for knock-down or knock-out of PD-1 expression or any other target through genetic engineering in areas outside of therapeutic enhancement, for example the optimization of manufacturing process for TILs and other cell-based products.

 

13.10.3.  To the extent that AgonOx conducts other clinical trials at the Site(s) or with the Principal Investigator, AgonOx shall use reasonable efforts to (i) avoid enrolling patients that compete with enrollment of Subjects in the Phase I/II Clinical Trial, and (ii) avoid engaging in other activities related to other clinical trials at the Site(s) or with the Principal Investigator that would interfere with the Timeline for Phase I/II Clinical Trial.

 

13.11.       Cumulative Remedies. Unless expressly set forth in this Agreement, all rights and remedies of the Parties, including all rights to payment, rights of termination, rights to injunctive relief, and other rights provided under this Agreement, will be cumulative and in addition to all other remedies provided for in this Agreement, in law, and in equity.

 

13.12.       Relationship of the Parties.

 

13.12.1.  Independent Contractors. Nothing contained herein will be deemed to create a partnership, joint venture, or similar relationship between the Parties. Neither Party is the agent, employee, joint venturer, partner, franchisee, or representative of the other Party. Each Party specifically acknowledges that it does not have the authority to, and will not, incur any obligations or responsibilities on behalf of the other Party. Notwithstanding anything to the contrary in this Agreement, each Party (and its officers, directors, agents, employees, and members) will not hold themselves out as employees, agents, representatives, or franchisees of the other Party or enter into any agreements on such Party’s behalf.

 

13.12.2.  Direction. Except as set forth herein, neither Party will be subject to the supervisory direction of the other Party in regard to the conduct of the Clinical Trials.

 

13.13.       No Third Party Beneficiaries. Except as set forth in Sections 10.1 and 10.2, this Agreement and the provisions herein are for the benefit of the Parties only, and are not intended to confer any rights or benefits to any Third Party.

 

13.14.       Rights Reserved. No license or any other right is granted to either Party, by implication or otherwise, except as specifically set forth in this Agreement.

 

13.15.       Amendments; No Waiver. Unless otherwise specified herein, no amendment, supplement, or modification of this Agreement will be binding on either Party unless it is in writing and signed by both Parties. No delay or failure on the part of a Party in the exercise of any right under this Agreement or available at law or equity will be construed as a waiver of such right, nor will any single or partial exercise thereof preclude any other exercise thereof. All waivers must be in writing and signed by the Party against whom the waiver is to be effective. Any such waiver will constitute a waiver only with respect to the specific matter described in such writing and will in no way impair the rights of the Party granting such waiver in any other respect or at any other time.

 

 

 

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13.16.      Severability. If any provision (or portion thereof) of this Agreement is determined by a court or arbitration to be unenforceable as drafted by virtue of the scope, duration, extent, or character of any obligation contained herein, it is the Parties’ intention that such provision (or portion thereof) will be construed in a manner designed to effectuate the purposes of such provision to the maximum extent enforceable under such Applicable Law. The Parties will enter into whatever amendment to this Agreement as may be necessary to effectuate such purposes.

 

13.17.       Entire Agreement. This Agreement, including all Schedules thereto, contain the entire understanding of the Parties and their Affiliates and supersede, revoke, terminate, and cancel any and all other arrangements, understandings, agreements, term sheets, or representations and warranties, whether oral or written, between the Parties relating to the subject matter of this Agreement.

 

13.18.       Counterparts. This Agreement will be executed in two (2) counterparts, one (1) for either Party, which, taken together, will constitute one and the same agreement. A facsimile or a portable document format (PDF) copy of this Agreement, including the signature pages, will be deemed an original. This Agreement will not be binding on the Parties or otherwise effective unless and until executed by both Parties.

 

13.19.       Construction. This Agreement has been negotiated by the Parties and their respective counsel. This Agreement will not be construed in favor of or against either Party by reason of the authorship of any provisions hereof.

 

[Signature Page Follows]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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IN WITNESS WHEREOF, the Parties, intending to be legally bound hereby, have caused this Agreement to be executed by their duly authorized representatives as of the Effective Date.

 

 

  PHIO PHARMACEUTICALS CORP.
   
 

/s/ Gerrit Dispersyn

  Gerrit Dispersyn
  President & CEO

 

 

 

  AGONOX, INC.
   
 

/s/ Andy Weinberg

  Andy Weinberg
  President & CSO

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Signature Page to Clinical Co-Development Agreement

 

 

 

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 EX-10.11 3 phio_ex1011.htm SEPARATION AGREEMENT, DATE MAY 5, 2022, BY AND BETWEEN PHIO PHARMACEUTICALS CORP. AND GERRIT DISPERSYN, DR. MED. SC

Exhibit 10.11

 

SEPARATION AGREEMENT

AND GENERAL RELEASE OF CLAIMS

 

 

This SEPARATION AGREEMENT AND GENERAL RELEASE OF CLAIMS (this “Agreement”) is entered into by and between Phio Pharmaceuticals Corp., a Delaware corporation (the “Company”) and Gerrit D. Dispersyn, Dr. Med. Sc. (the “Executive”) (each of the foregoing individually a “Party” and collectively the “Parties”).

 

WHEREAS, Executive’s employment with the Company terminated effective as of May 5, 2022 (the “Separation Date”);

 

WHEREAS, Executive and the Company are parties to that certain Employment Agreement dated April 24, 2017 (the “Employment Agreement”);

 

WHEREAS, in accordance with the terms of the Employment Agreement, the Company wishes to provide Executive with certain separation benefits, which are conditioned upon Executive’s execution, delivery and non-revocation of this Agreement; and

 

NOW, THEREFORE, in consideration of the promises set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged by Executive and the Company, the Parties hereby agree as follows:

 

1.Separation from Employment.

 

(a)            As of the Separation Date, Executive ceased all service as an employee of the Company and each other Company Party (as defined below), and Executive is deemed to have automatically resigned (i) as an officer of the Company and its affiliates (as applicable) and (ii) from the board of directors or similar governing body of each of the Company and its affiliates (as applicable) and any other corporation, limited liability company, trade organization, or other entity in which the Company or any of its affiliates holds an equity interest or with respect to which board or similar governing body Executive served as the designee or other representative of the Company or any of its affiliates.

 

(b)            Executive acknowledges and agrees that, with the exception of any unpaid base salary earned by Executive in the pay period that the Separation Date occurred, Executive has been paid in full all bonuses, been provided all benefits, and otherwise received all wages, compensation and other sums that Executive has been owed by each Company Party. Executive further acknowledges and agrees that Executive has received all leaves (paid and unpaid) that Executive has been entitled to receive from each Company Party.

 

 

 

 

 

 

 

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2.               Separation Payments and Benefits. Provided that Executive: (x) executes this Agreement by June 2, 2022 (which is at least 21 days following the date this Agreement was provided to Executive) and returns a copy of this Agreement that has been executed by Executive to the Company, so that it is received by Caitlin Kontulis, VP, Finance & Administration at 257 Simarano Dr., Ste. 101, Marlborough, MA 01752 (email: ckontulis@phiopharma.com) no later than 5:00 pm ET on June 2, 2022; (y) does not revoke Executive’s acceptance of this Agreement pursuant to Section 7; and (z) remains in compliance with the other terms and conditions set forth in this Agreement (including under Section 5), Executive shall be provided with the following separation payments and benefits in accordance with Section 5(d)(i) of the Employment Agreement:

 

(a)            The Company shall provide Executive with continued payment of Executive’s base salary monthly for a period of six (6) months following the Separation Date; and

 

(b)            Subject to any required employee contribution applicable to Executive as of the Separation Date, the Company shall continue to contribute (on a taxable basis) to the premium cost of Executive’s participation in the Company’s group medical and dental plans provided that Executive timely elects COBRA continuation coverage under such plans.

 

Executive acknowledges and agrees that the consideration referenced in this Section 2 represents the entirety of the amounts Executive is eligible to receive as severance pay and benefits from the Company or any other Company Party pursuant to the Employment Agreement or otherwise.

 

3.Release of Liability for Claims.

 

(a)            For good and valuable consideration, including the consideration set forth in Section 2 (and any portion thereof), Executive knowingly and voluntarily (for Executive, Executive’s family and Executive’s heirs, executors, administrators and assigns) hereby releases and forever discharges the Company (the Company and their respective subsidiaries, collectively, the “Affiliated Entities”) and their respective affiliates, predecessors, successors, subsidiaries and benefits plans, the foregoing entities’ respective equity-holders, officers, directors, managers, members, partners, employees, agents, representatives, and other affiliated persons, and the Company’s and its affiliates’ benefit plans (and the fiduciaries and trustees of such plans) (collectively, the “Company Parties”), from liability for, and Executive hereby waives, any and all claims, damages or causes of action of any kind related to Executive’s ownership of any interest in any Company Party, Executive’s employment with any Company Party, the termination of such employment, and any other acts or omissions related to any matter occurring on or prior to the date that Executive executes this Agreement, including (i) any alleged violation through such time of: (A) any federal, state or local anti-discrimination, anti-harassment or anti-retaliation law, regulation or ordinance, including the Age Discrimination in Employment Act of 1967 (including as amended by the Older Workers Benefit Protection Act), Title VII of the Civil Rights Act of 1964, the Civil Rights Act of 1991, Sections 1981 through 1988 of Title 42 of the United States Code and the Americans with Disabilities Act of 1990; (B) the Employee Retirement Income Security Act of 1974 (“ERISA”); (C) the Immigration Reform Control Act; (D) the National Labor Relations Act; (E) the Occupational Safety and Health Act; (F) the Family and Medical Leave Act of 1993; (G) the New York Equal Pay Law; (H) the New York Whistleblower Law; (I) the New York City Earned Sick Time Act; (J) the New York Workers’ Compensation Law’s anti-retaliation provisions; (K) the New York occupational safety and health laws; (L) the New York wage hour and wage-payment laws; (M) any other law, statute, ordinance, rule, regulation decision or order pertaining to employment or pertaining to discrimination on the basis of age, alienage, race, color, creed, gender, national origin, religion, physical or mental disability, marital status, citizenship, sexual orientation or non-work activities; (N) any federal, state or local wage and hour law; (O) any other local, state or federal law, regulation or ordinance; or (P) any public policy, contract, tort, or common law claims; (ii) any allegation for costs, fees, or other expenses including attorneys’ fees incurred in or with respect to a Released Claim (as defined below); (iii) any and all rights, benefits or claims Executive may have under any employment contract, incentive compensation plan, severance plan or equity-based plan with any Company Party or to any ownership interest in any Company Party (including the Employment Agreement); and (iv) any claim for compensation or benefits of any kind not expressly set forth in this Agreement (each, a “Released Claim,” collectively, the “Released Claims”). This Agreement is not intended to indicate that any such claims exist or that, if they do exist, they are meritorious. Rather, Executive is simply agreeing that, in exchange for any consideration received by the Executive pursuant to Section 2, any and all potential claims of this nature that Executive may have against any of the Company Parties, regardless of whether they actually exist, are expressly settled, compromised and waived. THIS RELEASE INCLUDES MATTERS ATTRIBUTABLE TO THE SOLE OR PARTIAL NEGLIGENCE (WHETHER GROSS OR SIMPLE) OR OTHER FAULT, INCLUDING STRICT LIABILITY, OF ANY OF THE COMPANY PARTIES.

 

 

 

 

 

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(b)            Section 1542 of the Civil Code of the State of California (“Section 1542”) provides:

 

A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS THAT THE CREDITOR OR RELEASING PARTY DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE AND THAT, IF KNOWN BY HIM OR HER, WOULD HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR OR RELEASED PARTY.

 

Executive waives all rights under Section 1542 or any other law or statute of similar effect in any jurisdiction with respect to the Released Claims. Executive acknowledges that Executive understands the significance and specifically assumes the risk regarding the consequences of such release and such specific waiver of Section 1542.

 

(c)            For the avoidance of doubt, nothing in this Agreement releases Executive’s rights to receive payments or benefits pursuant to Section 2. Further, in no event shall the Released Claims include (i) any claim that arises after the date that Executive signs this Agreement; (ii) any claim to vested benefits under an employee benefit plan that is subject to ERISA; and (iii) any claim for breach of, or otherwise arising out of, this Agreement. Further notwithstanding this release of liability, nothing in this Agreement prevents Executive from filing any non-legally waivable claim (including a challenge to the validity of this Agreement) with the Equal Employment Opportunity Commission (“EEOC”) or comparable state or local agency or participating in (or cooperating with) any investigation or proceeding conducted by the EEOC or comparable state or local agency or cooperating in any such investigation or proceeding; however, Executive understands and agrees that Executive is waiving any and all rights to recover any monetary or personal relief from a Company Party as a result of such EEOC or comparable state or local agency or proceeding or subsequent legal actions, and this Agreement further prohibits Executive’s ability to pursue any claims against the Company Parties seeking monetary relief for Executive and/or as a representative on behalf of others. Further, nothing in this Agreement prohibits or restricts Executive from filing a charge or complaint with, or cooperating in any investigation with, the Securities and Exchange Commission, the Financial Industry Regulatory Authority, or any other governmental agency, entity or authority (each, a “Government Agency”). This Agreement does not limit Executive’s right to receive an award for information provided to a Government Agency. Nothing herein shall prevent Executive from discussing or disclosing information regarding unlawful acts in the workplace, such as harassment, discrimination or any other conduct that Executive has reason to believe is unlawful.

 

4.               Representations and Warranties Regarding Claims. Executive represents and warrants, that as of the time at which Executive signs this Agreement, Executive has not filed or joined any claims, complaints, charges, or lawsuits against any of the Company Parties with any governmental agency or with any state or federal court or arbitrator for, or with respect to, a matter, claim, or incident that occurred or arose out of one or more occurrences that took place on or prior to the time at which Executive signs this Agreement. Executive further represents and warrants that Executive has not made any assignment, sale, delivery, transfer or conveyance of any rights Executive has asserted or may have against any of the Company Parties with respect to any Released Claim. Executive covenants and agrees never to sue the Company Parties based on any claim released by Executive under Section 3 of this Agreement, except that, as described in Section 3(c), this Agreement does not limit Executive’s right to file a charge or participate in an investigation or proceeding conducted by the EEOC or the National Labor Relations Board (or another governmental agency with regard to which applicable law bars Executive from waiving and releasing Executive’s right to participate in an investigation or proceeding thereof) or to bring a lawsuit against the Company to challenge the validity of this Agreement.

 

 

 

 

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5.               Covenants.

 

(a)            Executive acknowledges and agrees that Executive has continuing obligations to the Company and its affiliates pursuant to that certain Employment Agreement, including obligations relating to confidentiality, intellectual property, competition, and non-solicitation (collectively, the “Covenants”). In entering into this Agreement, Executive acknowledges the continued effectiveness and enforceability of the Covenants, and Executive expressly reaffirms Executive’s commitment to abide by, and agrees that Executive will abide by, the terms of the Covenants.

 

(b)            Executive shall refrain from publishing any oral or written statements about the Company and any Company Party that (i) are slanderous, libelous, disparaging or defamatory, (ii) disclose confidential information of or regarding any Company Party’s business affairs, directors, officers, managers, members, employees, consultants, agents or representatives, or (iii) place the Company, any Company Party or any of their respective directors, officers, managers, members, employees, consultants, agents or representatives in a false light before the public.

 

(c)            Executive agrees to reasonably cooperate with the Company in any internal investigation, any administrative, regulatory, or judicial proceeding or any dispute with a third party. Executive understands and agrees that Executive’s cooperation may include making Executive available to the Company upon reasonable notice for interviews and factual investigations; appearing at the Company’s request to give testimony without requiring service of a subpoena or other legal process; volunteering to the Company pertinent information received by Executive in Executive’s capacity as an employee; and turning over to the Company all relevant documents which are or may come into Executive’s possession in Executive’s capacity an employee or otherwise, all at times and on schedules that are reasonably consistent with Executive’s other permitted activities and commitments.

 

(d)            Executive agrees that this Agreement, including the severance payments and benefits in Section 2, is confidential and agrees not to disclose any information regarding the terms of this Agreement, except to Executive’s immediate family and any tax, legal or other counsel that Executive has consulted regarding the meaning or effect hereof or as required by law, and Executive will instruct each of the foregoing not to disclose the same to anyone.

 

6.               Executive’s Acknowledgements. By executing and delivering this Agreement, Executive expressly acknowledges that:

 

(a)            Executive has been given at least 21 days to review and consider this Agreement. If Executive signs this Agreement before the expiration of 21 days after Executive’s receipt of this Agreement, Executive has knowingly and voluntarily waived any longer consideration period than the one provided to Executive and such earlier signature was not induced by the Company through fraud, misrepresentation or a threat to withdraw or alter this Agreement prior to the expiration of such 21-day period. No changes (whether material or immaterial) to this Agreement shall restart the running of this 21-day period.

 

(b)            Executive is receiving, pursuant to this Agreement, consideration in addition to anything of value to which Executive is already entitled;

 

(c)            Executive has been advised, and hereby is advised in writing, to discuss this Agreement with an attorney of Executive’s choice and that Executive has had an adequate opportunity to do so prior to executing this Agreement;

 

(d)            Executive fully understands the final and binding effect of this Agreement; the only promises made to Executive to sign this Agreement are those stated herein; Executive is signing this Agreement knowingly, voluntarily and of Executive’s own free will with the full intent of releasing the Company Parties of all claims; Executive acknowledges and agrees that Executive has carefully read this Agreement; and that Executive understands and agrees to each of the terms of this Agreement;

 

 

 

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(e)            The only matters relied upon by Executive in causing Executive to sign this Agreement are the provisions set forth in writing within the four corners of this Agreement; and

 

(f)             No Company Party has provided any tax or legal advice regarding this Agreement, and Executive has had an adequate opportunity to receive sufficient tax and legal advice from advisors of Executive’s own choosing such that Executive enters into this Agreement with full understanding of the tax and legal implications thereof.

 

7.               Revocation Right. Notwithstanding the initial effectiveness of this Agreement, Executive may revoke the delivery (and therefore the effectiveness) of this Agreement within the seven-day period beginning on the date Executive executes this Agreement (such seven-day period being referred to herein as the “Release Revocation Period”). To be effective, such revocation must be in writing signed by Executive and must be delivered personally or by courier to the Company so that it is received by Caitlin Kontulis, VP, Finance & Administration at 257 Simarano Dr., Ste. 101, Marlborough, MA 01752 (email: ckontulis@phiopharma.com) no later than 11:59 pm ET on the last day of the Release Revocation Period. If an effective revocation is delivered in the foregoing manner and timeframe, the release of claims set forth in Section 3 will be of no force or effect, Executive will not receive the payments or benefits set forth in Section 2, and the remainder of this Agreement will remain in full force and effect.

 

8.               Governing Law and Jurisdiction. This Agreement shall be construed and enforced under and be governed in all respects by the laws of the State of Massachusetts, without regard to the conflict of laws principles thereof. The Company and the Executive hereby consent and submit to the personal jurisdiction and venue of any state or federal court located in the city or county of Marlborough, Middlesex County, Massachusetts for resolution of any and all claims, causes of action or disputes arising out of or related to this Agreement.

 

9.               Counterparts. This Agreement may be executed in several counterparts, including by .PDF or .GIF attachment to email or by facsimile, each of which is deemed to be an original, and all of which taken together constitute one and the same agreement.

 

10.             Amendment; Entire Agreement. This Agreement may not be changed orally but only by an agreement in writing agreed to and signed by the Party to be charged. This Agreement, the Award Agreements and the Covenants constitute the entire agreement of the Parties with regard to the subject matter hereof and supersede all prior and contemporaneous agreements and understandings, oral or written, between the Executive and any Company Party with regard to the subject matter hereof.

 

11.             Third-Party Beneficiaries. Executive expressly acknowledges and agrees that each Affiliated Entity that is not a party to this Agreement shall be a third-party beneficiary of Sections 3,5, and 13 and entitled to enforce such provisions as if it were a party hereto.

 

12.               Further Assurances. Executive shall, and shall cause Executive’s affiliates, representatives and agents to, from time to time at the request of the Company and without any additional consideration, furnish the Company with such further information or assurances, execute and deliver such additional documents, instruments and conveyances, and take such other actions and do such other things, as may be reasonably necessary or desirable, as determined in the sole discretion of the Company, to carry out the provisions of the Agreement.

 

13.               Return of Property. Executive represents and warrants that Executive has returned to the Company all property belonging to the Company or any other Company Party, including all computer files, electronically stored information, computers and other materials and items provided to Executive by the Company or any other Company Party in the course of Executive’s employment and Executive further represents and warrants that Executive has not maintained a copy of any such materials or items in any form.

 

14.             Severability. Any term or provision of this Agreement (or part thereof) that renders such term or provision (or part thereof) or any other term or provision (or part thereof) hereof invalid or unenforceable in any respect shall be severable and shall be modified or severed to the extent necessary to avoid rendering such term or provision (or part thereof) invalid or unenforceable, and such modification or severance shall be accomplished in the manner that most nearly preserves the benefit of the Parties’ bargain hereunder.

 

 

 

 5 
 

 

15.             Interpretation. The Section headings have been inserted for purposes of convenience and shall not be used for interpretive purposes. The words “hereof,” “herein” and “hereunder” and other compounds of the word “here” shall refer to the entire Agreement and not to any particular provision hereof. The use herein of the word “including” following any general statement, term or matter shall not be construed to limit such statement, term or matter to the specific items or matters set forth immediately following such word or to similar items or matters, whether or not non-limiting language (such as “without limitation”, “but not limited to”, or words of similar import) is used with reference thereto, but rather shall be deemed to refer to all other items or matters that could reasonably fall within the broadest possible scop of such general statement, term or matter. The word “or” as used herein is not exclusive and is deemed to have the meaning “and/or.” Unless the context requires otherwise, all references herein to a law, agreement, instrument or other document shall be deemed to refer to such law, agreement, instrument or other document as amended, supplemented, modified and restated from time to time to the extent permitted by the provisions thereof. Neither this Agreement nor any uncertainty or ambiguity herein shall be construed against any Party, whether under any rule of construction or otherwise. This Agreement has been reviewed by each of the Parties and shall be construed and interpreted according to the ordinary meaning of the words used so as to fairly accomplish the purposes and intentions of the Parties.

 

16.             No Assignment. No right to receive payments and benefits under this Agreement shall be subject to set off, offset, anticipation, commutation, alienation, assignment, encumbrance, charge, pledge or hypothecation or to execution, attachment, levy, or similar process or assignment by operation of law.

 

17.             Withholdings; Deductions. The Company may withhold and deduct from any payments or benefits made or to be made pursuant to this Agreement (a) all federal, state, local and other taxes as may be required pursuant to any law or governmental regulation or ruling and (b) any deductions consented to in writing by Executive.

 

18.             Section 409A. This Agreement and the benefits provided hereunder are intended to be exempt from, or compliant with, the requirements of Section 409A of the Internal Revenue Code of 1986 and the Treasury regulations and other guidance issued thereunder (collectively, “Section 409A”) and shall be construed and administered in accordance with such intent. Each installment payment under this Agreement shall be deemed and treated as a separate payment for purposes of Section 409A. Notwithstanding the foregoing, the Company makes no representations that the benefits provided under this Agreement are exempt from the requirements of Section 409A and in no event shall the Company or any other Company Party be liable for all or any portion of any taxes, penalties, interest or other expenses that may be incurred by Executive on account of non-compliance with Section 409A.

 

 

 

 

 

 

 6 
 

 

IN WITNESS WHEREOF, the Parties have executed this Agreement as of the dates set forth beneath their names below, effective for all purposes as provided above.

 

 

  PHIO PHARMACEUTICALS CORP
  a Delaware corporation
   
  /s/ Robert Bitterman
  By: Robert Bitterman
  Title: Chairman of the Board of Directors
   
   
  EXECUTIVE
   
  /s/ Gerrit Dispersyn
  Name: Gerrit Dispersyn, Dr. Med.Sc.
 

 

 

 

 

 

 

 7 

 

 EX-23.1 4 phio_ex2301.htm CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 23.1

 

Consent of Independent Registered Public Accounting Firm

 

Phio Pharmaceuticals Corp.

Marlborough, Massachusetts

 

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-251670, 333-189521, 33-215871, 333-227013 and 333-230547) and Form S-3 (Nos. 333-256100 and 333-252588) of Phio Pharmaceuticals Corp. of our report dated March 22, 2023, relating to the consolidated financial statements, which appears in this Annual Report on Form 10-K. Our report contains explanatory paragraph regarding the Company’s ability to continue as a going concern.

 

/s/ BDO USA, LLP

 

Boston, Massachusetts

March 22, 2023

 EX-31.1 5 phio_ex3101.htm CERTIFICATION

Exhibit 31.1

 

CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL FINANCIAL OFFICER

PURSUANT TO

SECURITIES EXCHANGE ACT OF 1934 RULES 13a-14(a) AND 15d-14(a)

AS ADOPTED

PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

 

I, Robert J. Bitterman, certify that:

 

  1. I have reviewed this Annual Report on Form 10-K of Phio Pharmaceuticals Corp.;

 

  2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

 

  3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

 

  4. I am responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a–15(f) and 15d–15(f)) for the registrant and have:

 

  a. Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under my supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to me by others within those entities, particularly during the period in which this report is being prepared;

 

  b. Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under my supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

 

  c. Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report my conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

 

  d. Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

 

  5. I have disclosed, based on my most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

 

  a. All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

 

  b. Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal controls over financial reporting.

 

 

Dated: March 22, 2023

   

/s/ Robert J. Bitterman

  
Robert J. Bitterman  
President and Chief Executive Officer  
(as Principal Executive and Financial Officer)
 EX-32.1 6 phio_ex3201.htm CERTIFICATION

 

Exhibit 32.1

 

CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER AND PRINCIPAL FINANCIAL OFFICER

PURSUANT TO

18 U.S.C. SECTION 1350

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

 

In connection with the Annual Report of Phio Pharmaceuticals Corp. (the “Company”) on Form 10-K for the period ended December 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned officer of the Company certifies, pursuant to 18 U.S.C. § 1350, as adopted pursuant to §906 of the Sarbanes-Oxley Act of 2002, that to their knowledge:

 

  1. The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

 

  2. The information contained in the Report fairly presents, in all material respects, the Company’s financial condition and result of operations.

 

 

Dated: March 22, 2023

 

   
/s/ Robert J. Bitterman  
Robert J. Bitterman  
President and Chief Executive Officer  
(Principal Executive and Financial Officer)

 

 

 

 

 

 

 

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 12 Months Ended
Dec. 31, 2022
Mar. 09, 2023
Jun. 30, 2022
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Document Fiscal Period Focus FY    
Document Fiscal Year Focus 2022    
Current Fiscal Year End Date --12-31    
Entity File Number 001-36304    
Entity Registrant Name PHIO PHARMACEUTICALS CORP.    
Entity Central Index Key 0001533040    
Entity Tax Identification Number 45-3215903    
Entity Incorporation, State or Country Code DE    
Entity Address, Address Line One 257 Simarano Drive    
Entity Address, Address Line Two Suite 101    
Entity Address, City or Town Marlborough    
Entity Address, State or Province MA    
Entity Address, Postal Zip Code 01752    
City Area Code 508    
Local Phone Number 767-3861    
Title of 12(b) Security Common Stock, par value, $0.0001 per share    
Trading Symbol PHIO    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Non-accelerated Filer    
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Entity Public Float     $ 9,500,000
Entity Common Stock, Shares Outstanding   1,150,582  
Documents Incorporated by Reference [Text Block] None    
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Auditor Firm ID 243    
Auditor Name BDO USA, LLP    
Auditor Location Boston, Massachusetts    
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CONSOLIDATED BALANCE SHEETS - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Current assets:    
Cash $ 11,781 $ 24,057
Restricted cash 50 50
Prepaid expenses and other current assets 615 620
Total current assets 12,446 24,727
Right of use asset 161 283
Property and equipment, net 183 133
Other assets 24 27
Total assets 12,814 25,170
Current liabilities:    
Accounts payable 779 283
Accrued expenses 1,025 2,660
Lease liability 135 125
Total current liabilities 1,939 3,068
Lease liability, net of current portion 35 170
Total liabilities 1,974 3,238
Commitments and contingencies (Footnote 8)
Stockholders’ equity:    
Common stock, $0.0001 par value, 100,000,000 shares authorized; 1,139,024 and 1,127,917 shares issued and outstanding at December 31, 2022 and December 31, 2021, respectively 0 0
Additional paid-in capital 139,218 138,832
Accumulated deficit (128,380) (116,900)
Total stockholders’ equity 10,838 21,932
Total liabilities, preferred stock and stockholders’ equity 12,814 25,170
Series D Preferred Stock [Member]    
Temporary Equity Abstract    
Series D Preferred Stock, $0.0001 par value; 1 and 0 shares authorized, issued and outstanding at December 31, 2022 and December 31, 2021, respectively $ 2 $ 0
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CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares
Dec. 31, 2022
Dec. 31, 2021
Common stock, par value $ 0.0001 $ 0.0001
Common stock, shares authorized 100,000,000 100,000,000
Common stock, shares issued 1,139,024 1,127,917
Common stock, shares outstanding 1,139,024 1,127,917
Series D Preferred Stock [Member]    
Temporary Equity, Par or Stated Value Per Share $ 0.0001  
Temporary Equity, Shares Outstanding 1 0
Temporary Equity, Shares Authorized 1 0
Temporary Equity, Shares Issued 1 0
XML 16 R4.htm IDEA: XBRL DOCUMENT v3.23.1
CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Operating expenses:    
Research and development $ 7,012 $ 8,886
General and administrative 4,450 4,625
Total operating expenses 11,462 13,511
Operating loss (11,462) (13,511)
Total other (expense) income, net (18) 224
Loss before income taxes (11,480) (13,287)
Provision for income taxes 0 0
Net loss $ (11,480) $ (13,287)
Net loss per common share:    
Basic $ (10.10) $ (12.43)
Diluted $ (10.10) $ (12.43)
Weighted average number of common shares outstanding    
Basic 1,136,566 1,069,234
Diluted 1,136,566 1,069,234
XML 17 R5.htm IDEA: XBRL DOCUMENT v3.23.1
CONSOLIDATED STATEMENTS OF PREFERRED STOCK AND STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Preferred Stock Series D [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Retained Earnings [Member]
Total
Beginning balance, value at Dec. 31, 2020 $ 116,630 $ (103,613) $ 13,017
Balance at beginning, shares at Dec. 31, 2020 481,749      
Issuance of common stock, pre-funded warrants and warrants in connection with private placement, net of offering costs 12,669 12,669
Issuance of common stock, pre-funded warrants and warrants in connection with private placement, net of offering costs, shares   368,405      
Issuance of common stock in registered direct offering, net of offering costs 6,908 6,908
Issuance of common stock in registered direct offering, net of offering costs, shares   187,232      
Issuance of common stock upon the exercise of warrants 2,146 2,146
Issuance of common stock upon the exercise of warrants, shares   90,276      
Issuance of common stock upon vesting of restricted stock units
Issuance of common stock upon vesting of restricted stock units, shares   279      
Shares withheld for payroll taxes (1) (1)
Shares withheld for payroll taxes, shares   (24)      
Stock-based compensation expense 480 480
Net loss (13,287) (13,287)
Ending balance, value at Dec. 31, 2021 138,832 (116,900) 21,932
Balance at ending, shares at Dec. 31, 2021 1,127,917      
Issuance of common stock upon vesting of restricted stock units
Issuance of common stock upon vesting of restricted stock units, shares   14,043      
Shares withheld for payroll taxes (28) (28)
Shares withheld for payroll taxes, shares   (2,936)      
Issuance of preferred stock 2
Stock-based compensation expense 414 414
Net loss (11,480) (11,480)
Issuance of preferred stock, shares 1        
Ending balance, value at Dec. 31, 2022 $ 2 $ 139,218 $ (128,380) $ 10,838
Balance at ending, shares at Dec. 31, 2022 1 1,139,024      
XML 18 R6.htm IDEA: XBRL DOCUMENT v3.23.1
CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities:    
Net loss $ (11,480) $ (13,287)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 71 75
Amortization of right of use asset 122 117
Non-cash stock-based compensation 414 480
Forgiveness of debt 0 (233)
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 8 241
Accounts payable 496 (445)
Accrued expenses (1,635) 1,310
Lease liability (125) (116)
Net cash used in operating activities (12,129) (11,858)
Cash flows from investing activities:    
Cash paid for purchase of property and equipment (121) (51)
Net cash used in investing activities (121) (51)
Cash flows from financing activities:    
Net proceeds from the issuance of common stock and warrants 0 19,577
Net proceeds from the exercise of warrants 0 2,146
Payments of taxes for net share settled restricted stock unit issuances (28) (1)
Net proceeds from the issuance of preferred stock 2 0
Net cash (used in) provided by financing activities (26) 21,722
Net (decrease) increase in cash and restricted cash (12,276) 9,813
Cash and restricted cash at the beginning of period 24,107 14,294
Cash and restricted cash at the end of period $ 11,831 $ 24,107
XML 19 R7.htm IDEA: XBRL DOCUMENT v3.23.1
Reconciliation of Cash - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Statement of Financial Position [Abstract]      
Cash $ 11,781 $ 24,057  
Restricted cash 50 50  
Total cash and restricted cash $ 11,831 $ 24,107 $ 14,294
XML 20 R8.htm IDEA: XBRL DOCUMENT v3.23.1
Organization and Significant Accounting Policies
 12 Months Ended
Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Organization and Significant Accounting Policies

1. Organization and Significant Accounting Policies

 

Nature of Operations

 

Phio Pharmaceuticals Corp. (“Phio,” “we,” “our” or the “Company”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology platform is designed to make immune cells more effective in killing tumor cells. We are developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems. We are committed to discovering and developing innovative cancer treatments for patients by creating new pathways toward a cancer-free future.

 

The Company continues to respond to and monitor the ongoing coronavirus pandemic. The Company believes that the coronavirus pandemic has not had a significant impact on its financial condition and results of operations, however, the extent to which the coronavirus pandemic may materially impact our financial results and operations will depend on a number of factors, including the availability of supplies and services we rely on, the ability to enroll subjects in our clinical trials, the emergence of variant strains of the coronavirus, the development, availability, and public acceptance of effective treatments and vaccines, and the duration of the coronavirus pandemic, which remain difficult to predict and are highly uncertain.

 

Liquidity

 

The Company has reported recurring losses from operations since its inception and expects to continue to have negative cash flows from operations for the foreseeable future. Historically, the Company’s primary source of funding has been from sales of its securities. The Company’s ability to continue to fund its operations is dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity, or strategic opportunities, in order to maintain its operations. This is dependent on a number of factors, including the market demand or liquidity of the Company’s common stock, which may be adversely impacted by the coronavirus pandemic, rates of inflation and the ongoing conflict between Russia and Ukraine. There is no guarantee that debt, additional equity or other funding will be available to us on acceptable terms, or at all. If we fail to obtain additional funding when needed, we would be forced to scale back or terminate our operations or seek to merge with or to be acquired by another company.

 

The Company has limited cash resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through an equity offering, debt offering or strategic opportunity to fund its operations. There can be no assurance that the Company will be successful in accomplishing these plans in order to continue as a going concern. These financial statements do not include any adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.

 

Basis of Presentation

 

The accompanying financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”).

 

Principles of Consolidation

 

The consolidated financial statements include the accounts of Phio and its wholly-owned subsidiary, MirImmune, LLC. All material intercompany accounts have been eliminated in consolidation.

 

Reverse Stock Split

 

Effective January 26, 2023, the Company completed a 1-for-12 reverse stock split of the Company’s outstanding common stock. All share and per share amounts in the financial statements have been retroactively adjusted for all periods presented to give effect to the reverse stock split, including reclassifying an amount equal to the reduction in par value to additional paid-in capital. Unless otherwise noted, shares of common stock issued and outstanding, shares underlying warrants and stock awards, shares reserved, conversion price of convertible securities, exercise prices of warrants and stock awards and loss per share have been proportionately adjusted to reflect the reverse stock split. The reverse stock split did not reduce the number of authorized shares of the Company’s common stock or preferred stock.

 

Uses of Estimates in Preparation of Financial Statements

 

The preparation of financial statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. The areas subject to significant estimates and judgement include, among others, those related to the fair value of equity awards, accruals for research and development expenses, useful lives of property and equipment, income taxes, and the valuation allowance on our deferred tax assets. On an ongoing basis we evaluate our estimates and base our estimates on historical experience and other relevant assumptions that we believe are reasonable under the circumstances. Actual results could differ materially from these estimates.

 

Restricted Cash

 

Restricted cash consists of certificates of deposit held by financial institutions as collateral for the Company’s corporate credit cards.

 

Concentrations of Credit Risk

 

Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash. The Company maintains cash balances in several accounts with a financial institution that management believes is creditworthy, which at times are in excess of federally insured limits. These accounts are insured by the Federal Deposit Insurance Corporation for up to $250,000 per institution.

 

Property and Equipment

 

Property and equipment are stated at cost and depreciated using the straight-line method based on the estimated useful lives of the related assets. The Company provides for depreciation over the assets’ estimated useful lives as follows:

 
Computer equipment 3 years
Machinery & equipment 5 years
Furniture & fixtures 5 years
Leasehold improvements Lesser of remaining lease term or 5 years

 

Impairment of Long-Lived Assets

 

The Company reviews long-lived assets for impairment annually or whenever an event or change in circumstance occurs in which the related carrying amounts may not be recoverable. An impairment loss would be recognized based on the difference between the carrying value of the asset and its estimated fair value, which would be determined based on either discounted future cash flows or other appropriate fair value methods. As of December 31, 2022 and 2021, the Company believes no impairment existed.

  

Leases

 

At the inception of a contract, the Company determines whether the contract is or contains a lease based on all relevant facts and circumstances. For contracts that contain a lease, the Company identifies the lease and non-lease components, determines the consideration in the contract and recognizes the classification of the lease as operating or financing. For leases with a term greater than one year, the Company recognizes a liability to make lease payments and an asset representing the right to use the underlying asset during the lease term at the commencement date of the lease.

 

Lease liabilities and the corresponding right of use assets are recorded based on the present value of lease payments to be made over the lease term. The discount rate used to calculate the present value is the rate implicit in the lease, or if not readily determinable, the Company’s incremental borrowing rate. The Company’s incremental borrowing rate is the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. Certain adjustments to the right of use asset may be required for items such as initial direct costs or incentives received. Lease payments on operating leases, including scheduled increases, are recognized on a straight-line basis over the expected term of the lease. Lease payments on financing leases are recognized using the effective interest method.

 

Derivative Financial Instruments

 

Financial instruments that meet the definition of a derivative are classified as an asset or liability and measured at fair value on the issuance date and are revalued on each subsequent balance sheet date. The changes in fair value are recognized as current period income or loss. Financial instruments that do not meet the definition of a derivative are classified as equity and measured at fair value and recorded as additional paid-in capital in stockholders’ equity at the date of issuance. No further adjustments to their valuation are made.

 

Research and Development Expenses

 

Research and development expenses relate to compensation and benefits for research and development personnel, facility-related expenses, supplies, external services, costs to acquire technology licenses, research activities under our research collaborations, expenses associated with preclinical and clinical development activities and other operating costs. Research and development expenses are charged to expense as incurred. Payments made by the Company in advance for research and development services not yet provided and/or for materials not yet received are recorded as prepaid expenses and expensed when the service has been performed or when the goods have been received.

 

Accrued liabilities are recorded related to those expenses for which vendors have not yet billed the Company with respect to services provided and/or materials that it has received. Accrued liabilities for the services provided by contract research organizations are recorded during the period incurred based on such estimates and assumptions as expected cost, passage of time, the achievement of milestones and other information available to us and are assessed on a quarterly basis. Actual results may differ from these estimates and could have a material impact on the Company’s reported results. The Company’s historical accrual estimates have not been materially different from its actual costs.

 

Collaborative Arrangements

 

The Company follows the provisions of the Financial Accounting Standards Board (the “FASB”) Accounting Standards Codification (“ASC”) Topic 808, “Collaborative Arrangements,” (“Topic 808”) when collaboration agreements involve joint operating activities in which both parties are active participants and that are also both exposed to significant risks and rewards. The Company also considers the guidance in the FASB ASC Topic 606, “Revenue from Contracts with Customers,” (“Topic 606”) in determining the appropriate treatment for activities between the Company and its collaborative partners that are more reflective of a vendor-customer relationship and therefore, within the scope of Topic 606. Under Topic 808, the Company determines an appropriate recognition method, either by analogy to appropriate accounting literature or by applying a reasonable accounting policy election. Generally, the classification of transactions under the collaborative arrangements is determined based on the nature and contractual terms of the arrangement along with the nature of the operations of the participants. The Company recognizes its share of costs arising from research and development activities performed by collaborators in the period its collaborators incur such expense. Payments or reimbursements that are the result of a collaborative relationship instead of a customer relationship, such as co-development activities, are evaluated on a quarterly basis and recorded as an offset to research and development expense incurred.

 

Patents and Patent Application Costs

 

Although the Company believes that its patents and underlying technology have continuing value, the amount of future benefits to be derived from the patents is uncertain. Patent costs are, therefore, expensed as general and administrative costs as incurred.

 

Stock-based Compensation

 

The Company follows the provisions of the FASB ASC Topic 718, “Compensation — Stock Compensation” (“ASC 718”), which requires the measurement and recognition of compensation expense for all stock-based payment awards. The fair value of restricted stock units (“RSUs”) is based upon the Company’s closing stock price at the grant date. The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options at the grant date. The Black-Scholes valuation model requires the input of valuation assumptions to calculate the value of stock options, including expected volatility, expected term, risk-free interest rate and expected dividends. Stock-based compensation expense is recognized on a straight-line basis over the requisite service period, which generally represents the vesting period, and commences at the date of grant based on the fair value of the award.

 

Stock-based compensation expense recognized in the financial statements is based on awards that are ultimately expected to vest. Accordingly, we are also required to estimate forfeitures at the time of grant and to revise those estimates in subsequent periods if actual forfeitures differ from estimates. We use historical data to estimate pre-vesting award forfeitures and record stock-based compensation expense only for those awards that are expected to vest. Our forfeiture rate estimates are based on an analysis of our actual forfeiture experience, employee turnover behavior, and other factors. The impact of any adjustments to our forfeiture rates or to the extent that actual forfeitures differ from our estimates, is recorded as a cumulative adjustment in the period the estimates are revised.

 

Income Taxes

 

The Company recognizes assets or liabilities for the deferred tax consequences of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements in accordance with the FASB ASC Topic 740, “Accounting for Income Taxes” (“ASC 740”). These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled. Those temporary differences referred to as deferred tax assets and liabilities are determined at the end of each period using the tax rate expected to be in effect when taxes are actually paid or recovered. Valuation allowances are established if, based on the weight of available evidence, it is more likely than not that all or a portion of a deferred tax asset will not be realized. The provision for income taxes, if any, represents the tax payable for the period and the change in deferred income tax assets and liabilities during the period.

 

Comprehensive Loss

 

The Company’s comprehensive loss is equal to its net loss for all periods presented.

 

Net Loss per Share

 

Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding. Diluted net loss per share is computed by dividing the Company’s net loss by the weighted average number of common shares outstanding and the impact of all dilutive potential common shares outstanding, except where such dilutive potential common shares would be anti-dilutive. Dilutive potential common shares primarily consist of warrants, RSUs and stock options.

 

Recent Accounting Pronouncements

 

In May 2021, the FASB issued Accounting Standards Update 2021-04, “Earnings per Share (Topic 260), Debt – Modifications and Extinguishments (Subtopic 470-50), Compensation – Stock Compensation (Topic 718), and Derivatives and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40)” (“ASU 2021-04”). The amendments in the updates are intended to clarify and reduce diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options that remain equity classified after modification or exchange. The amendments in ASU 2021-04 are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. An entity should apply the amendments prospectively to modifications or exchanges occurring on or after the effective date of the amendments. The Company adopted ASU 2021-04 on January 1, 2022. The adoption of this standard had no impact on the Company’s consolidated financial statements.

 
XML 21 R9.htm IDEA: XBRL DOCUMENT v3.23.1
Collaboration and License Agreements
 12 Months Ended
Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Collaboration and License Agreements

2. Collaboration and License Agreements

 

AgonOx, Inc. (“AgonOx”)

 

In March 2021, the Company entered into a clinical co-development collaboration agreement (the “Clinical Agreement”) with AgonOx, a private company developing a pipeline of novel immunotherapy drugs targeting key regulators of the immune response to cancer. Under the Clinical Agreement, Phio and AgonOx are working to develop a T cell-based therapy using the Company’s lead product candidate, PH-762, and AgonOx’s “double positive” TIL (“DP TIL”) technology. Per the terms of the Clinical Agreement, the Company committed to make future payments of up to $4,000,000 to reimburse AgonOx for expenses incurred to support the Phase 1 clinical trial with the DP TIL technology and PH-762.

 

The Company will recognize its share of costs arising from research and development activities performed by AgonOx in the Company’s financial statements in the period AgonOx incurs such expense. Phio will be entitled to certain future development milestones and low single-digit sales-based royalty payments from AgonOx’s licensing of its DP TIL technology. The Company recognized approximately $130,000 of expense in connection with these efforts during the year ended December 31, 2022. No expense under the Clinical Agreement was recognized during the year ended December 31, 2021. There was approximately $120,000 recorded as prepaid expenses and other current assets as of December 31, 2022.

 

Advanced RNA Technologies, LLC (“Advirna”)

 

In September 2011, the Company entered into an agreement with Advirna, pursuant to which Advirna assigned to us its existing patent and technology rights related to the INTASYL technology in exchange for an annual maintenance fee of $100,000, a one-time milestone payment upon the future issuance of the first patent with valid claims covering the assigned patent and technology rights and the issuance of shares of common stock of the Company equal to 5% of the Company’s fully-diluted shares outstanding at the time of issuance. The one-time milestone payment and the issuance of shares of common stock in the Company were completed in 2014 and 2012, respectively. Additionally, the Company is required to pay low single-digit royalties to Advirna on any licensing revenue received by the Company with respect to future licensing of the assigned Advirna patent and technology rights. To date, any royalties owed to Advirna under the agreement have been minimal.

 

Phio’s rights under the Advirna agreement will expire upon the later of: (i) the expiration of the last-to-expire of the “patent rights” (as defined therein) included in the agreement; or (ii) the abandonment of the last-to-be abandoned of such patents, unless earlier terminated in accordance with the provisions of the agreement. Further, the Company also granted back to Advirna a license under the assigned patent and technology rights for fields of use outside human therapeutics.

 
XML 22 R10.htm IDEA: XBRL DOCUMENT v3.23.1
Fair Value of Financial Instruments
 12 Months Ended
Dec. 31, 2022
Fair Value Disclosures [Abstract]  
Fair Value of Financial Instruments

3. Fair Value of Financial Instruments

 

The Company follows the provisions of the FASB ASC Topic 820, “Fair Value Measurement,” for the Company’s financial assets and liabilities that are re-measured and reported at fair value each reporting period and are re-measured and reported at fair value at least annually using a fair value hierarchy that is broken down into three levels. Level inputs are defined as follows:

 

Level 1 – quoted prices in active markets for identical assets or liabilities.

 

Level 2 – other significant observable inputs for the assets or liabilities through corroboration with market data at the measurement date.

 

Level 3 – significant unobservable inputs that reflect management’s best estimate of what market participants would use to price the assets or liabilities at the measurement date.

 

At December 31, 2022 and 2021, the Company categorized its restricted cash of $50,000 as Level 2 hierarchy. The assets classified as Level 2 have initially been valued at the applicable transaction price and subsequently valued, at the end of each reporting period, using other market observable data. Observable market data points include quoted prices, interest rates, reportable trades and other industry and economic events.

 

The carrying amounts of cash, accounts payable and accrued expenses of the Company approximate their fair values due to their short-term nature.

 
XML 23 R11.htm IDEA: XBRL DOCUMENT v3.23.1
Property and Equipment
 12 Months Ended
Dec. 31, 2022
Property, Plant and Equipment [Abstract]  
Property and Equipment

4. Property and Equipment

 

The following table summarizes the Company’s major classes of property and equipment, in thousands:

        
   December 31, 
   2022   2021 
Computer equipment  $116   $108 
Machinery & equipment   1,077    1,035 
Furniture & fixtures   119    49 
Leasehold improvements   46    46 
Total gross fixed assets   1,358    1,238 
Less: accumulated depreciation and amortization   (1,175)   (1,105)
Property and equipment, net  $183   $133 

 

Depreciation and amortization expense for the years ended December 31, 2022 and 2021 was $71,000 and $75,000, respectively.

 
XML 24 R12.htm IDEA: XBRL DOCUMENT v3.23.1
Accrued Expenses
 12 Months Ended
Dec. 31, 2022
Payables and Accruals [Abstract]  
Accrued Expenses

5. Accrued Expenses

 

Accrued expenses consist of the following, in thousands:

               
    December 31,  
    2022     2021  
Compensation and benefits   $ 408     $ 572  
Professional fees     97       102  
Research and development costs     501       1,986  
Other     19       –  
Total accrued expenses   $ 1,025     $ 2,660  

 
XML 25 R13.htm IDEA: XBRL DOCUMENT v3.23.1
Leases
 12 Months Ended
Dec. 31, 2022
Leases [Abstract]  
Leases

6. Leases

 

In January 2019, the Company amended the lease for its corporate headquarters and primary research facility in Marlborough, Massachusetts. The lease is for a total of 7,581 square feet of office and laboratory space and will expire on March 31, 2024. The lease contains an option to terminate after two or three years by providing advance written notice of termination pursuant to the terms of the agreement. The exercise of this option was not determined to be reasonably certain and thus was not included in the lease liability on the Company’s balance sheet. The Company did not exercise its option to terminate in either the second or third year of the lease, and the option to terminate has expired. Additionally, the lease agreement did not contain information to determine the borrowing rate implicit in the lease. As such, the Company calculated its incremental borrowing rate based on what the Company would have to pay to borrow on a collateralized basis over the lease term for an amount equal to the remaining lease payments, taking into consideration such assumptions as, but not limited to, the U.S. treasury yield rate and borrowing rates from a creditworthy financial institution using the above lease factors.

 

The lease for our corporate headquarters represents all of our significant lease obligations. The amounts reported in the consolidated balance sheets for operating leases in which the Company is the lessee and other supplemental balance sheet information is set forth as follows, in thousands, except the lease term (number of years) and discount rate:

        
   December 31, 
   2022   2021 
Assets        
Right of use asset  $161   $283 
Liabilities          
Lease liability, current   135    125 
Lease liability, non-current   35    170 
Total lease liability  $170   $295 
Lease Term and Discount Rate          
Weighted average remaining lease term   1.25    2.25 
Weighted average discount rate   4.70%    4.70% 

 

Operating lease costs included in operating expense were $132,000 for the years ended December 31, 2022 and 2021, respectively.

  

Cash paid for the amounts included in the measurement of the operating lease liability on the Company’s consolidated balance sheets and included within changes in the lease liability in the operating activities of our consolidated statements of cash flows was $135,000 and $132,000 for the years ended December 31, 2022 and 2021, respectively.

 

Future lease payments for our non-cancellable operating leases and a reconciliation to the carrying amount of the operating lease liability presented in the consolidated balance sheet as of December 31, 2022 is as follows, in thousands:

    
2023  $140 
2024   35 
Total lease payments   175 
Less: Imputed interest   (5)
Total operating lease liabilities (includes current portion)  $170 

 
XML 26 R14.htm IDEA: XBRL DOCUMENT v3.23.1
Debt
 12 Months Ended
Dec. 31, 2022
Debt Disclosure [Abstract]  
Debt

7. Debt

 

In May 2020, the Company received loan proceeds pursuant to the Paycheck Protection Program (the “PPP”) under the Coronavirus Aid, Relief, and Economic Security Act. The Company followed the guidance under the FASB ASC Topic 470, “Debt,” (“ASC 470”) in assessing the accounting for the PPP loan proceeds. Per ASC 470, the Company recorded a liability on the balance sheet for the full amount of the PPP loan proceeds received and accrued interest over the term of the loan. The Company believed it used the loan proceeds for eligible purposes and applied for full loan forgiveness. In February 2021, the Small Business Administration approved the Company’s application for full loan forgiveness, and the full amount of the PPP loan was remitted to the lender for forgiveness. Upon loan forgiveness, the Company recognized a gain on the extinguishment of debt of $233,000 for the loan proceeds received and interest accrued in the consolidated statements of operations for the year ended December 31, 2021.

 
XML 27 R15.htm IDEA: XBRL DOCUMENT v3.23.1
Commitments and Contingencies
 12 Months Ended
Dec. 31, 2022
Commitments and Contingencies Disclosure [Abstract]  
Commitments and Contingencies

8. Commitments and Contingencies

 

Commitments

 

In March 2021, the Company entered into a Clinical Agreement with AgonOx to develop a T cell-based therapy using the Company’s lead product candidate, PH-762, and AgonOx’s DP TIL technology. Per the terms of the Clinical Agreement, the Company committed to make future payments of up to $4,000,000 to reimburse AgonOx for expenses incurred to support the Phase 1 clinical trial with the DP TIL technology and PH-762. Refer to Note 2 for further details on the Clinical Agreement with AgonOx.

 

The Company applies the disclosure provisions of the FASB ASC Topic 460, “Guarantor’s Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others” (“ASC 460”), to its agreements that contain guarantee or indemnification clauses. The Company provides: (i) indemnifications of varying scope and size to certain investors and other parties for certain losses suffered or incurred by the indemnified party in connection with various types of third-party claims; and (ii) indemnifications of varying scope and size to officers and directors against third-party claims arising from the services they provide to us. These indemnifications give rise only to the disclosure provisions of ASC 460. To date, the Company has not incurred costs as a result of these obligations and does not expect to incur material costs in the future. Accordingly, the Company has not accrued any liabilities in its consolidated financial statements related to these indemnifications.

 

Refer to Note 6 for more information about the Company’s obligations under its non-cancellable lease for its corporate headquarters.

 

License Commitments

 

As part of its business, the Company enters into licensing agreements with third parties that often require milestone and royalty payments based on the progress of the asset through development stages. Milestone payments may be required, for example, upon progress through clinical trials, upon approval of the product by a regulatory agency and/or upon a percentage of sales of the product pursuant to such agreements. The expenditures required under these arrangements may be material individually in relation to any product candidates covered by the intellectual property licensed under any such arrangement, and material in the aggregate in the unlikely event that milestones for multiple products covered by these arrangements were reached in the same period. Due to the contingent nature of these payments, they are not included in the table of contractual obligations shown below.

 

During the years ended December 31, 2022 and 2021, the Company did not trigger any milestone payments.

 

The Company’s contractual license obligations that will require future cash payments as of December 31, 2022, which result from payments expected in connection with annual license fees, are as follows, in thousands:

       
Year Ending December 31,
2023   $ 100  
2024     100  
2025     100  
2026     100  
2027     100  
Thereafter     200  
Total   $ 700  

 

Litigation

 

From time to time, the Company may become a party to various legal proceedings and complaints arising in the ordinary course of business. To the Company’s knowledge, it is not currently a party to any actual or threatened material legal proceedings. Accordingly, there were no contingent liabilities recorded as of the year ended December 31, 2022.

 
XML 28 R16.htm IDEA: XBRL DOCUMENT v3.23.1
Preferred Stock
 12 Months Ended
Dec. 31, 2022
Temporary Equity Disclosure [Abstract]  
Preferred Stock

9. Preferred Stock

 

The Company has authorized up to 10,000,000 shares of preferred stock, $0.0001 par value per share, for issuance. The Company’s Board of Directors is authorized under the Company’s Amended and Restated Articles of Incorporation, to designate the authorized preferred stock into one or more series and to fix and determine such rights, preferences, privileges and restrictions of any series of preferred stock, including voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences, as shall be determined by the Company’s Board of Directors upon its issuance. At December 31, 2022, the Company had designated one share of preferred stock as Series D Preferred Stock and the remaining authorized shares were undesignated.

 

On November 16, 2022, the Company issued and sold one share of the Company’s Series D Preferred Stock, par value $0.0001 per share (the “Series D Preferred Stock”) to Robert Bitterman, then its interim Executive Chairman and current Chief Executive Officer, for $1,750. The Series D Preferred Stock was entitled to 17,500,000 votes per share exclusively with respect to any proposal to amend the Company’s Amended and Restated Certificate of Incorporation (as may be amended and/or restated from time to time, the “Amended Certificate”) to effect a reverse stock split of the Company’s common stock (“Reverse Stock Split”). The terms of the Series D Preferred Stock provided that it would be voted, without action by the holder, on any such proposal in the same proportion as shares of the Company’s common stock were voted. The Series D Preferred Stock otherwise had no voting rights except as otherwise required by the General Corporation Law of the State of Delaware.

 

The Series D Preferred Stock was not convertible into, or exchangeable for, shares of any other class or series of stock or other securities of the Company. The Series D Preferred Stock had no rights with respect to any distribution of assets of the Company, including upon a liquidation, bankruptcy, reorganization, merger, acquisition, sale, dissolution or winding up of the Company, whether voluntarily or involuntarily. The holder of the Series D Preferred Stock was not entitled to receive dividends of any kind.

 

Under its terms, the outstanding share of Series D Preferred Stock was to be redeemed in whole, but not in part, at any time: (i) if such redemption was approved by the Board of Directors in its sole discretion or (ii) automatically and effective upon the approval by the Company's stockholders of a Reverse Stock Split. Upon such redemption, the holder of the Series D Preferred Stock was entitled to receive consideration of $1,750 in cash.

 

The Series D Preferred Stock has been classified outside of permanent equity (within the mezzanine section between liabilities and equity on the balance sheets) as the Company may not be able to control the actions necessary to provide for a redemption in full of the then outstanding Series D Preferred Stock.

 

The Series D Preferred Stock was redeemed in whole on January 4, 2023, upon the approval by the Company’s stockholders of a Reverse Stock Split.

 
XML 29 R17.htm IDEA: XBRL DOCUMENT v3.23.1
Stockholders’ Equity
 12 Months Ended
Dec. 31, 2022
Equity [Abstract]  
Stockholders’ Equity

10. Stockholders’ Equity

 

January 2021 Private Placement — In January 2021, the Company completed a private placement of 368,405 shares of the Company’s common stock at a purchase price per share of $36.84, pre-funded warrants to purchase an aggregate of 11,672 shares of the Company’s common stock at a purchase price per pre-funded warrant of $36.828 and warrants to purchase an aggregate of 285,061 shares of the Company’s common stock with an exercise price of $36.00 per warrant (the “Private Placement”). In connection with the Private Placement, the Company issued warrants to the placement agent, H.C. Wainwright & Co., LLC (“HCW”), to purchase a total of 28,509 shares of the Company’s common stock at an exercise price of $46.05 per warrant. Net proceeds to the Company from the Private Placement were $12,669,000 after deducting placement agent fees and offering expenses.

 

February 2021 Registered Direct Offering — In February 2021, the Company completed a registered direct offering of 187,232 shares of the Company’s common stock at a purchase price of $41.04 per share (the “Offering”). In connection with the Offering, the Company issued warrants to the placement agent, HCW, to purchase a total of 14,044 shares of the Company’s common stock at an exercise price of $51.30 per warrant. Net proceeds to the Company from the Offering were $6,908,000 after deducting placement agent fees and offering expenses.

 

Warrants

 

The Company first assesses the warrants it issues under the FASB ASC Topic 480, “Distinguishing Liabilities from Equity” (“ASC 480”) to determine whether they are within the scope of ASC 480. As there are no instances outside of the Company’s control that could require cash settlement from the warrants issued by the Company, the outstanding warrants are outside the scope of ASC 480.

 

The Company then applies and follows the applicable accounting guidance in the FASB ASC Topic 815, “Derivatives and Hedging.” Financial instruments are accounted for as either derivative liabilities or equity instruments depending on the specific terms of the agreement. The warrants issued by the Company do not meet the definition of a derivative instrument as they are indexed to the Company’s common stock and classified within stockholders’ equity. Based on this determination, the Company’s warrants are classified within stockholders’ equity.

 

The following table summarizes the Company’s outstanding equity-classified warrants at December 31, 2022:

                                                  
      Exercise    Expiration    Balance December 31,    Warrants    Warrants    Warrants   

Balance

December 31,

   
Description    Price    Date    2021    Issued    Exercised    Expired    2022   
April 2018 Warrants    $  2,079.00    5/31/2023    1,720    –     –     –     1,720   
April 2018 Placement Agent Warrants    $  2,676.00    4/9/2023    117    –     –     –     117   
October 2018 Warrants    $  125.40    10/3/2025    32,486    –     –     –     32,486   
October 2018 Underwriter Warrants    $  156.72    10/1/2023    2,438    –     –     –     2,438   
November 2019 Placement Agent Warrants    $  82.50    11/18/2024    1,138    –     –     –     1,138   
February 2020 Registered Direct Warrants    $  104.52    8/6/2025    16,425    –     –     –     16,425   
February 2020 Placement Agent Warrants    $  132.45    2/4/2025    1,233    –     –     –     1,233   
February 2020 Warrants    $  48.00    2/13/2025    110,557    –     –     –     110,557   
February 2020 Underwriter Warrants    $  60.00    2/11/2025    12,501    –     –     –     12,501   
April 2020 Warrants    $  26.52    10/2/2025    35,691    –     –     –     35,691   
April 2020 Placement Agent Warrants    $  35.0256    3/31/2025    3,481    –     –     –     3,481   
January 2021 Warrants    $  36.00    7/27/2026    285,061    –     –     –     285,061   
January 2021 Placement Agent Warrants    $  46.05    7/27/2026    28,509    –     –     –     28,509   
February 2021 Placement Agent Warrants    $  51.30    2/12/2026    14,044    –     –     –     14,044   
                     545,401    –     –     –     545,401   

 

No warrants were exercised during the year ended December 31, 2022. The Company received net proceeds of $2,146,000 from the exercise of warrants during the year ended December 31, 2021.

 
XML 30 R18.htm IDEA: XBRL DOCUMENT v3.23.1
Stock-based Compensation
 12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Stock-based Compensation

11. Stock-based Compensation

 

Stock Plans

 

The Company’s approved equity plans include the Phio Pharmaceuticals Corp. 2020 Long Term Incentive Plan (the “2020 Plan”) and the Phio Pharmaceuticals Corp. 2012 Long Term Incentive Plan (the “2012 Plan”). These plans are administered by our Board of Directors and provide for the grant of incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock awards, RSU awards, performance stock awards, and performance cash awards. Upon adoption of the 2020 Plan, shares that remained available for grant under the 2012 Plan and shares that were subject to outstanding awards under the 2012 Plan were included in the authorized shares available for grant under the 2020 Plan. Further, upon adoption of the 2020 Plan, the Company no longer grants new equity awards under the 2012 Plan.

 

As of December 31, 2022, there were an aggregate of 105,640 shares of common stock reserved under the 2020 Plan, including 141 shares subject to outstanding stock options and 47,328 shares subject to unvested RSUs and 43,807 shares available for future grants. RSUs granted by the Company to employees vest annually over 3 years after the grant date, stock options granted by the Company to employees generally vest annually over 4 years after the grant date and, in the instance of stock options, expire within ten years of issuance.

 

Restricted Stock Units

 

RSUs are issued under the 2020 Plan or as inducement grants issued outside of the 2020 Plan to new employees. RSUs are generally subject to graded vesting and the satisfaction of service requirements. Upon vesting, each outstanding RSU will be settled for one share of the Company’s common stock. Employee RSU recipients may elect to net share settle upon vesting, in which case the Company pays the employee’s income taxes due upon vesting and withholds a number of shares of equal value. The fair value of the RSUs awarded are based upon the Company’s closing stock price at the grant date and are expensed over the requisite service period.

 

The following table summarizes the activity of the Company’s RSUs for the year ended December 31, 2022:

               
    Number
of Shares		     Weighted-
Average
Grant Date Fair Value
Per Share		  
Unvested units at December 31, 2021     30,592     $ 38.52  
Granted     61,250       10.08  
Vested     (14,043 )     39.72  
Forfeited     (30,471 )      17.40  
Unvested units at December 31, 2022     47,328     $ 15.00  

 

The weighted-average fair value of RSUs granted during the years ended December 31, 2022 and 2021 was $10.08 and $35.28, respectively.

 

Stock-based compensation expense related to RSUs was $401,000 and $443,000 for the years ended December 31, 2022 and 2021, respectively.

  

The aggregate fair value of awards that vested during the years ended December 31, 2022 and 2021 was $138,000 and $9,000, which represents the market value of the Company’s common stock on the date that the RSUs vested.

 

As of December 31, 2022, the compensation expense for all unvested RSUs in the amount of approximately $458,000 will be recognized in the Company’s results of operations over a weighted average period of 1.60 years.

 

Stock Options

 

Stock options are available for issuance under the 2020 Plan or as inducement grants issued outside of the 2020 Plan to new employees. Stock options are generally subject to graded vesting and the satisfaction of service requirements. Upon the exercise of a stock option, the Company issues new shares and delivers them to the recipient. The Company does not expect to repurchase shares to satisfy stock option exercises.

 

The Company uses the Black-Scholes option-pricing model to determine the fair value of all its option grants. The risk-free interest rate used for each grant was based upon the yield on zero-coupon U.S. Treasury securities with a term similar to the expected life of the related option. The Company’s expected stock price volatility assumption is based upon the Company’s own implied volatility. As the Company has limited stock option exercise information, the expected life assumption used for option grants is based upon the simplified method provided for under ASC 718. The dividend yield assumption is based upon the fact that the Company has never paid cash dividends and presently has no intention of paying cash dividends.

 

The Company did not grant stock options during the years ended December 31, 2022 and 2021. The following table summarizes the activity of the Company’s stock option plan for the year ended December 31, 2022:

                               
    Total Number
of Shares		     Weighted-
Average
Exercise
Price
Per Share		     Weighted-
Average
Remaining
Contractual
Term		     Aggregate
Intrinsic
Value		  
Balance at December 31, 2021     208     $ 40,822.80                  
Granted     –       –                  
Exercised     –       –                  
Unvested shares cancelled     (6 )     1,181.40                  
Vested shares cancelled     (61 )     93,016.68                  
Balance at December 31, 2022     141     $ 19,761.12       5.18 years     $ –  
Exercisable at December 31, 2022     141     $ 19,761.12       5.18 years     $ –  

 

Stock-based compensation expense related to stock options for the years ended December 31, 2022 and 2021 was $13,000 and $37,000, respectively.

 

As of December 31, 2022, the compensation expense for all unvested stock options was recognized in the Company’s results of operations.

 

There is no income tax benefit as the Company is currently operating at a loss and an actual income tax benefit may not be realized.

 

Compensation Expense Related to Equity Awards

 

The following table sets forth total stock-based compensation expense for the years ended December 31, 2022 and 2021, in thousands:

        
   December 31, 
   2022   2021 
Research and development  $154   $117 
General and administrative   260    363 
Total stock-based compensation  $414   $480 

 
XML 31 R19.htm IDEA: XBRL DOCUMENT v3.23.1
Income Taxes
 12 Months Ended
Dec. 31, 2022
Income Tax Disclosure [Abstract]  
Income Taxes

12. Income Taxes

 

The provision for income taxes for the years ended December 31, 2022 and 2021 are as follows, in thousands:

               
    Years Ended December 31,  
    2022     2021  
Current                
Federal   $ –     $ –  
State     –       –  
Total current     –       –  
Deferred                
Federal     (1,733 )     (3,016 ) 
State     (553 )     (1,329 )
Total deferred     (2,286 )     (4,345 )
Valuation allowance     2,286       4,345  
Total provision for income taxes   $ –     $ –  

  

The following table presents a reconciliation of the U.S. statutory tax rate to the Company’s actual effective income tax rate:

        
   Years Ended December 31, 
   2022   2021 
Federal statutory rate   21.0%    21.0% 
State income taxes, net of federal benefit   7.4    8.5 
Non-deductible expenses    (0.8)    0.2 
Income tax credits   3.2    4.3 
Valuation allowance   (30.8)   (34.0)
Effective tax rate   0.0%    0.0% 

 

The Company recognizes deferred tax assets and liabilities to reflect the tax effects of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements in accordance with ASC 740. These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled.

 

ASC 740 requires that a valuation allowance be established when management determines that it is more likely than not that all or a portion of a deferred asset will not be realized. The Company evaluates the realizability of its net deferred income tax assets and valuation allowances as necessary, at least on an annual basis. During this evaluation, the Company reviews its forecasts of income in conjunction with other positive and negative evidence surrounding the realizability of its deferred income tax assets to determine if a valuation allowance is required. Adjustments to the valuation allowance will increase or decrease the Company’s income tax provision or benefit.

 

The significant components of the Company’s net deferred tax assets and liabilities are as follows, in thousands:

        
   Years Ending December 31, 
   2022   2021 
Deferred tax assets:          
Net operating loss carryforwards  $11,808   $10,150 
Tax credit carryforwards   1,227    946 
Stock-based compensation   435    1,363 
Capitalized research and development expenses   1,662    – 
License fees   1,680    2,018 
Lease liability   46    79 
Other timing differences   120    169 
Deferred tax assets   16,978    14,725 
Deferred tax liabilities:          
Right of use asset   (43)   (76)
Deferred tax liability   (43)   (76)
Valuation allowance   (16,935)   (14,649)
Net deferred tax asset  $–   $– 

 

The Tax Cuts and Jobs Act of 2017 included a provision that requires the capitalization and amortization of research and development costs incurred in tax years beginning after December 31, 2021. Under this provision, U.S.-based research and development expenses are amortized over a period of five years and non-U.S.-based research and development expenses are amortized over a period of 15 years. The deferred tax assets as of December 31, 2022 included capitalized research and development expenses of $1,662,000.

 

The Company evaluated the realizability of its net deferred tax assets and concluded that, in accordance with the applicable accounting standards, that it is more likely than not that the Company may not realize the benefit of all of its deferred tax assets. Accordingly, a valuation allowance against 100% of its deferred tax assets has been recorded. Significant judgment is required in the evaluation of deferred tax benefits and differences in future results from our estimates could result in material differences in the realization of these assets.

 

As of December 31, 2022, the Company had federal net operating loss (“NOL”) carryforwards of approximately $49,200,000 and state NOL carryforwards of approximately $23,200,000 to reduce future taxable income. The utilization of the federal carryforwards as an available offset to future taxable income is subject to limitations under federal income tax laws. Under current federal income tax law, the Company’s federal NOLs generated in tax years beginning after December 31, 2017, totaling approximately $48,879,000, may be carried forward indefinitely, but are limited to offset up to 80% of future taxable income. The remaining federal NOLs generated, totaling approximately $321,000, will begin to expire in 2037 and the Company’s available state NOL carryforwards will begin to expire in 2038. In addition, the Company had federal and state research and development credits of approximately $819,000 and $517,000, respectively, which will begin to expire in 2041 and 2036, respectively.

 

Ownership changes may limit the amount of NOL carryforwards or tax credit carryforwards that can be utilized to offset future taxable income or tax liability. Pursuant to Sections 382 and 383 of the Internal Revenue Code of 1986, as amended (the “Code”), NOL and tax credit carryforwards may be subject to annual limitations in the event a cumulative change in ownership of more than 50% occurs within a three-year period. Any limitation may result in expiration of a portion of the NOL carryforwards or tax credit carryforwards before utilization.

 

During 2021, the Company completed an assessment of the available NOL and tax credit carryforwards under Sections 382 and 383 of the Code and determined that the Company underwent six ownership changes during the period from 2012 to 2021. As a result, NOL and tax credit carryforwards attributable to the pre-ownership changes are subject to substantial annual limitations under Section 382 and 383 of Code due to the ownership changes. The Company adjusted its NOL and tax credit carryforwards to address the impact of the ownership changes. For the years ended prior to December 31, 2021, federal and state NOLs of $55,000,000 and $70,000,000, respectively, were reduced and federal and state tax credit carryforwards of $1,400,000 and $700,000, respectively, were also reduced.

 

The Company assesses the need to conduct an ownership change analysis to determine whether any changes occurred in ownership that would limit NOL or tax credit carryforwards on an annual basis. Due to the minimal number of share issuances during the year, the Company did not conduct an ownership change analysis in 2022. The Company may experience ownership changes in the future as a result of subsequent shifts in stock ownership, some of which may be outside of the Company’s control.

 

The recognition and measurement of benefits related to the Company’s tax positions requires significant judgment, as uncertainties often exist with respect to new laws, new interpretations of existing laws, and rulings by taxing authorities. The Company follows a more-likely-than not threshold for financial statement recognition and measurement of a tax position taken, or expected to be taken in a tax return. The guidance relates to, amongst other things, classification, accounting for interest and penalties associated with tax positions, and disclosure requirements. Any interest and penalties accrued related to uncertain tax positions are recorded as tax expense. Differences between actual results and the Company’s assumptions or changes in the Company’s assumptions in future periods are recorded in the period they become known. The Company has not recorded any uncertain tax positions as of December 31, 2022 or 2021. The Company does not believe there will be any material changes in its unrecognized tax positions over the next 12 months.

 

The Company has not incurred any interest or penalties. In the event that the Company is assessed interest or penalties at some point in the future, they will be classified in the financial statements as general and administrative expenses.

  

The Company files income tax returns in the United States, Massachusetts and New Jersey. The Company is subject to tax examinations for federal and state purposes for tax years 2014 through 2022.

 
XML 32 R20.htm IDEA: XBRL DOCUMENT v3.23.1
Net Loss per Share
 12 Months Ended
Dec. 31, 2022
Net loss per common share:  
Net Loss per Share

13. Net Loss per Share

 

The following table sets forth the potential common shares excluded from the calculation of net loss per common share because their inclusion would be anti-dilutive:

  December 31, 
   2022   2021 
Options to purchase common stock   141    208 
Unvested restricted stock units   47,328    30,592 
Warrants to purchase common stock   545,401    545,401 
Total   592,870    576,201 

 
XML 33 R21.htm IDEA: XBRL DOCUMENT v3.23.1
Organization and Significant Accounting Policies (Policies)
 12 Months Ended
Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Nature of Operations

Nature of Operations

 

Phio Pharmaceuticals Corp. (“Phio,” “we,” “our” or the “Company”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology platform is designed to make immune cells more effective in killing tumor cells. We are developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems. We are committed to discovering and developing innovative cancer treatments for patients by creating new pathways toward a cancer-free future.

 

The Company continues to respond to and monitor the ongoing coronavirus pandemic. The Company believes that the coronavirus pandemic has not had a significant impact on its financial condition and results of operations, however, the extent to which the coronavirus pandemic may materially impact our financial results and operations will depend on a number of factors, including the availability of supplies and services we rely on, the ability to enroll subjects in our clinical trials, the emergence of variant strains of the coronavirus, the development, availability, and public acceptance of effective treatments and vaccines, and the duration of the coronavirus pandemic, which remain difficult to predict and are highly uncertain.

 
Liquidity

Liquidity

 

The Company has reported recurring losses from operations since its inception and expects to continue to have negative cash flows from operations for the foreseeable future. Historically, the Company’s primary source of funding has been from sales of its securities. The Company’s ability to continue to fund its operations is dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity, or strategic opportunities, in order to maintain its operations. This is dependent on a number of factors, including the market demand or liquidity of the Company’s common stock, which may be adversely impacted by the coronavirus pandemic, rates of inflation and the ongoing conflict between Russia and Ukraine. There is no guarantee that debt, additional equity or other funding will be available to us on acceptable terms, or at all. If we fail to obtain additional funding when needed, we would be forced to scale back or terminate our operations or seek to merge with or to be acquired by another company.

 

The Company has limited cash resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through an equity offering, debt offering or strategic opportunity to fund its operations. There can be no assurance that the Company will be successful in accomplishing these plans in order to continue as a going concern. These financial statements do not include any adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.

 
Basis of Presentation

Basis of Presentation

 

The accompanying financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”).

 
Principles of Consolidation

Principles of Consolidation

 

The consolidated financial statements include the accounts of Phio and its wholly-owned subsidiary, MirImmune, LLC. All material intercompany accounts have been eliminated in consolidation.

 
Reverse Stock Split

Reverse Stock Split

 

Effective January 26, 2023, the Company completed a 1-for-12 reverse stock split of the Company’s outstanding common stock. All share and per share amounts in the financial statements have been retroactively adjusted for all periods presented to give effect to the reverse stock split, including reclassifying an amount equal to the reduction in par value to additional paid-in capital. Unless otherwise noted, shares of common stock issued and outstanding, shares underlying warrants and stock awards, shares reserved, conversion price of convertible securities, exercise prices of warrants and stock awards and loss per share have been proportionately adjusted to reflect the reverse stock split. The reverse stock split did not reduce the number of authorized shares of the Company’s common stock or preferred stock.

 
Uses of Estimates in Preparation of Financial Statements

Uses of Estimates in Preparation of Financial Statements

 

The preparation of financial statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. The areas subject to significant estimates and judgement include, among others, those related to the fair value of equity awards, accruals for research and development expenses, useful lives of property and equipment, income taxes, and the valuation allowance on our deferred tax assets. On an ongoing basis we evaluate our estimates and base our estimates on historical experience and other relevant assumptions that we believe are reasonable under the circumstances. Actual results could differ materially from these estimates.

 
Restricted Cash

Restricted Cash

 

Restricted cash consists of certificates of deposit held by financial institutions as collateral for the Company’s corporate credit cards.

 
Concentrations of Credit Risk

Concentrations of Credit Risk

 

Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash. The Company maintains cash balances in several accounts with a financial institution that management believes is creditworthy, which at times are in excess of federally insured limits. These accounts are insured by the Federal Deposit Insurance Corporation for up to $250,000 per institution.

 
Property and Equipment

Property and Equipment

 

Property and equipment are stated at cost and depreciated using the straight-line method based on the estimated useful lives of the related assets. The Company provides for depreciation over the assets’ estimated useful lives as follows:

 
Computer equipment 3 years
Machinery & equipment 5 years
Furniture & fixtures 5 years
Leasehold improvements Lesser of remaining lease term or 5 years

 
Impairment of Long-Lived Assets

Impairment of Long-Lived Assets

 

The Company reviews long-lived assets for impairment annually or whenever an event or change in circumstance occurs in which the related carrying amounts may not be recoverable. An impairment loss would be recognized based on the difference between the carrying value of the asset and its estimated fair value, which would be determined based on either discounted future cash flows or other appropriate fair value methods. As of December 31, 2022 and 2021, the Company believes no impairment existed.

  
Leases

Leases

 

At the inception of a contract, the Company determines whether the contract is or contains a lease based on all relevant facts and circumstances. For contracts that contain a lease, the Company identifies the lease and non-lease components, determines the consideration in the contract and recognizes the classification of the lease as operating or financing. For leases with a term greater than one year, the Company recognizes a liability to make lease payments and an asset representing the right to use the underlying asset during the lease term at the commencement date of the lease.

 

Lease liabilities and the corresponding right of use assets are recorded based on the present value of lease payments to be made over the lease term. The discount rate used to calculate the present value is the rate implicit in the lease, or if not readily determinable, the Company’s incremental borrowing rate. The Company’s incremental borrowing rate is the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. Certain adjustments to the right of use asset may be required for items such as initial direct costs or incentives received. Lease payments on operating leases, including scheduled increases, are recognized on a straight-line basis over the expected term of the lease. Lease payments on financing leases are recognized using the effective interest method.

 
Derivative Financial Instruments

Derivative Financial Instruments

 

Financial instruments that meet the definition of a derivative are classified as an asset or liability and measured at fair value on the issuance date and are revalued on each subsequent balance sheet date. The changes in fair value are recognized as current period income or loss. Financial instruments that do not meet the definition of a derivative are classified as equity and measured at fair value and recorded as additional paid-in capital in stockholders’ equity at the date of issuance. No further adjustments to their valuation are made.

 
Research and Development Expenses

Research and Development Expenses

 

Research and development expenses relate to compensation and benefits for research and development personnel, facility-related expenses, supplies, external services, costs to acquire technology licenses, research activities under our research collaborations, expenses associated with preclinical and clinical development activities and other operating costs. Research and development expenses are charged to expense as incurred. Payments made by the Company in advance for research and development services not yet provided and/or for materials not yet received are recorded as prepaid expenses and expensed when the service has been performed or when the goods have been received.

 

Accrued liabilities are recorded related to those expenses for which vendors have not yet billed the Company with respect to services provided and/or materials that it has received. Accrued liabilities for the services provided by contract research organizations are recorded during the period incurred based on such estimates and assumptions as expected cost, passage of time, the achievement of milestones and other information available to us and are assessed on a quarterly basis. Actual results may differ from these estimates and could have a material impact on the Company’s reported results. The Company’s historical accrual estimates have not been materially different from its actual costs.

 
Collaborative Arrangements

Collaborative Arrangements

 

The Company follows the provisions of the Financial Accounting Standards Board (the “FASB”) Accounting Standards Codification (“ASC”) Topic 808, “Collaborative Arrangements,” (“Topic 808”) when collaboration agreements involve joint operating activities in which both parties are active participants and that are also both exposed to significant risks and rewards. The Company also considers the guidance in the FASB ASC Topic 606, “Revenue from Contracts with Customers,” (“Topic 606”) in determining the appropriate treatment for activities between the Company and its collaborative partners that are more reflective of a vendor-customer relationship and therefore, within the scope of Topic 606. Under Topic 808, the Company determines an appropriate recognition method, either by analogy to appropriate accounting literature or by applying a reasonable accounting policy election. Generally, the classification of transactions under the collaborative arrangements is determined based on the nature and contractual terms of the arrangement along with the nature of the operations of the participants. The Company recognizes its share of costs arising from research and development activities performed by collaborators in the period its collaborators incur such expense. Payments or reimbursements that are the result of a collaborative relationship instead of a customer relationship, such as co-development activities, are evaluated on a quarterly basis and recorded as an offset to research and development expense incurred.

 
Patents and Patent Application Costs

Patents and Patent Application Costs

 

Although the Company believes that its patents and underlying technology have continuing value, the amount of future benefits to be derived from the patents is uncertain. Patent costs are, therefore, expensed as general and administrative costs as incurred.

 
Stock-based Compensation

Stock-based Compensation

 

The Company follows the provisions of the FASB ASC Topic 718, “Compensation — Stock Compensation” (“ASC 718”), which requires the measurement and recognition of compensation expense for all stock-based payment awards. The fair value of restricted stock units (“RSUs”) is based upon the Company’s closing stock price at the grant date. The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options at the grant date. The Black-Scholes valuation model requires the input of valuation assumptions to calculate the value of stock options, including expected volatility, expected term, risk-free interest rate and expected dividends. Stock-based compensation expense is recognized on a straight-line basis over the requisite service period, which generally represents the vesting period, and commences at the date of grant based on the fair value of the award.

 

Stock-based compensation expense recognized in the financial statements is based on awards that are ultimately expected to vest. Accordingly, we are also required to estimate forfeitures at the time of grant and to revise those estimates in subsequent periods if actual forfeitures differ from estimates. We use historical data to estimate pre-vesting award forfeitures and record stock-based compensation expense only for those awards that are expected to vest. Our forfeiture rate estimates are based on an analysis of our actual forfeiture experience, employee turnover behavior, and other factors. The impact of any adjustments to our forfeiture rates or to the extent that actual forfeitures differ from our estimates, is recorded as a cumulative adjustment in the period the estimates are revised.

 
Income Taxes

Income Taxes

 

The Company recognizes assets or liabilities for the deferred tax consequences of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements in accordance with the FASB ASC Topic 740, “Accounting for Income Taxes” (“ASC 740”). These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled. Those temporary differences referred to as deferred tax assets and liabilities are determined at the end of each period using the tax rate expected to be in effect when taxes are actually paid or recovered. Valuation allowances are established if, based on the weight of available evidence, it is more likely than not that all or a portion of a deferred tax asset will not be realized. The provision for income taxes, if any, represents the tax payable for the period and the change in deferred income tax assets and liabilities during the period.

 
Comprehensive Loss

Comprehensive Loss

 

The Company’s comprehensive loss is equal to its net loss for all periods presented.

 
Net Loss per Share

Net Loss per Share

 

Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding. Diluted net loss per share is computed by dividing the Company’s net loss by the weighted average number of common shares outstanding and the impact of all dilutive potential common shares outstanding, except where such dilutive potential common shares would be anti-dilutive. Dilutive potential common shares primarily consist of warrants, RSUs and stock options.

 
Recent Accounting Pronouncements

Recent Accounting Pronouncements

 

In May 2021, the FASB issued Accounting Standards Update 2021-04, “Earnings per Share (Topic 260), Debt – Modifications and Extinguishments (Subtopic 470-50), Compensation – Stock Compensation (Topic 718), and Derivatives and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40)” (“ASU 2021-04”). The amendments in the updates are intended to clarify and reduce diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options that remain equity classified after modification or exchange. The amendments in ASU 2021-04 are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. An entity should apply the amendments prospectively to modifications or exchanges occurring on or after the effective date of the amendments. The Company adopted ASU 2021-04 on January 1, 2022. The adoption of this standard had no impact on the Company’s consolidated financial statements.

 
XML 34 R22.htm IDEA: XBRL DOCUMENT v3.23.1
Organization and Significant Accounting Policies (Tables)
 12 Months Ended
Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Schedule of estimated useful lives
 
Computer equipment 3 years
Machinery & equipment 5 years
Furniture & fixtures 5 years
Leasehold improvements Lesser of remaining lease term or 5 years
XML 35 R23.htm IDEA: XBRL DOCUMENT v3.23.1
Property and Equipment (Tables)
 12 Months Ended
Dec. 31, 2022
Property, Plant and Equipment [Abstract]  
Schedule of property and equipment
        
   December 31, 
   2022   2021 
Computer equipment  $116   $108 
Machinery & equipment   1,077    1,035 
Furniture & fixtures   119    49 
Leasehold improvements   46    46 
Total gross fixed assets   1,358    1,238 
Less: accumulated depreciation and amortization   (1,175)   (1,105)
Property and equipment, net  $183   $133 
XML 36 R24.htm IDEA: XBRL DOCUMENT v3.23.1
Accrued Expenses (Tables)
 12 Months Ended
Dec. 31, 2022
Payables and Accruals [Abstract]  
Schedule of accrued expenses and other current liabilities
               
    December 31,  
    2022     2021  
Compensation and benefits   $ 408     $ 572  
Professional fees     97       102  
Research and development costs     501       1,986  
Other     19       –  
Total accrued expenses   $ 1,025     $ 2,660  
XML 37 R25.htm IDEA: XBRL DOCUMENT v3.23.1
Leases (Tables)
 12 Months Ended
Dec. 31, 2022
Leases [Abstract]  
Schedule of lease amounts recorded in balance sheet
        
   December 31, 
   2022   2021 
Assets        
Right of use asset  $161   $283 
Liabilities          
Lease liability, current   135    125 
Lease liability, non-current   35    170 
Total lease liability  $170   $295 
Lease Term and Discount Rate          
Weighted average remaining lease term   1.25    2.25 
Weighted average discount rate   4.70%    4.70% 
Aggregate future minimum lease payments
    
2023  $140 
2024   35 
Total lease payments   175 
Less: Imputed interest   (5)
Total operating lease liabilities (includes current portion)  $170 
XML 38 R26.htm IDEA: XBRL DOCUMENT v3.23.1
Commitments and Contingencies (Tables)
 12 Months Ended
Dec. 31, 2022
Commitments and Contingencies Disclosure [Abstract]  
Schedule of future cash payments for contractual license obligations
       
Year Ending December 31,
2023   $ 100  
2024     100  
2025     100  
2026     100  
2027     100  
Thereafter     200  
Total   $ 700  
XML 39 R27.htm IDEA: XBRL DOCUMENT v3.23.1
Stockholders’ Equity (Tables)
 12 Months Ended
Dec. 31, 2022
Equity [Abstract]  
Summary of outstanding warrants
                                                  
      Exercise    Expiration    Balance December 31,    Warrants    Warrants    Warrants   

Balance

December 31,

   
Description    Price    Date    2021    Issued    Exercised    Expired    2022   
April 2018 Warrants    $  2,079.00    5/31/2023    1,720    –     –     –     1,720   
April 2018 Placement Agent Warrants    $  2,676.00    4/9/2023    117    –     –     –     117   
October 2018 Warrants    $  125.40    10/3/2025    32,486    –     –     –     32,486   
October 2018 Underwriter Warrants    $  156.72    10/1/2023    2,438    –     –     –     2,438   
November 2019 Placement Agent Warrants    $  82.50    11/18/2024    1,138    –     –     –     1,138   
February 2020 Registered Direct Warrants    $  104.52    8/6/2025    16,425    –     –     –     16,425   
February 2020 Placement Agent Warrants    $  132.45    2/4/2025    1,233    –     –     –     1,233   
February 2020 Warrants    $  48.00    2/13/2025    110,557    –     –     –     110,557   
February 2020 Underwriter Warrants    $  60.00    2/11/2025    12,501    –     –     –     12,501   
April 2020 Warrants    $  26.52    10/2/2025    35,691    –     –     –     35,691   
April 2020 Placement Agent Warrants    $  35.0256    3/31/2025    3,481    –     –     –     3,481   
January 2021 Warrants    $  36.00    7/27/2026    285,061    –     –     –     285,061   
January 2021 Placement Agent Warrants    $  46.05    7/27/2026    28,509    –     –     –     28,509   
February 2021 Placement Agent Warrants    $  51.30    2/12/2026    14,044    –     –     –     14,044   
                     545,401    –     –     –     545,401   
XML 40 R28.htm IDEA: XBRL DOCUMENT v3.23.1
Stock-based Compensation (Tables)
 12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Summary of RSU activity
               
    Number
of Shares		     Weighted-
Average
Grant Date Fair Value
Per Share		  
Unvested units at December 31, 2021     30,592     $ 38.52  
Granted     61,250       10.08  
Vested     (14,043 )     39.72  
Forfeited     (30,471 )      17.40  
Unvested units at December 31, 2022     47,328     $ 15.00  
Summary of Stock Option Activity
                               
    Total Number
of Shares		     Weighted-
Average
Exercise
Price
Per Share		     Weighted-
Average
Remaining
Contractual
Term		     Aggregate
Intrinsic
Value		  
Balance at December 31, 2021     208     $ 40,822.80                  
Granted     –       –                  
Exercised     –       –                  
Unvested shares cancelled     (6 )     1,181.40                  
Vested shares cancelled     (61 )     93,016.68                  
Balance at December 31, 2022     141     $ 19,761.12       5.18 years     $ –  
Exercisable at December 31, 2022     141     $ 19,761.12       5.18 years     $ –  
Details of Stock-based Compensation Expense
        
   December 31, 
   2022   2021 
Research and development  $154   $117 
General and administrative   260    363 
Total stock-based compensation  $414   $480 
XML 41 R29.htm IDEA: XBRL DOCUMENT v3.23.1
Income Taxes (Tables)
 12 Months Ended
Dec. 31, 2022
Income Tax Disclosure [Abstract]  
Components of Federal and State Income Tax Expense
               
    Years Ended December 31,  
    2022     2021  
Current                
Federal   $ –     $ –  
State     –       –  
Total current     –       –  
Deferred                
Federal     (1,733 )     (3,016 ) 
State     (553 )     (1,329 )
Total deferred     (2,286 )     (4,345 )
Valuation allowance     2,286       4,345  
Total provision for income taxes   $ –     $ –  
Schedule of effective income tax reconciliation
        
   Years Ended December 31, 
   2022   2021 
Federal statutory rate   21.0%    21.0% 
State income taxes, net of federal benefit   7.4    8.5 
Non-deductible expenses    (0.8)    0.2 
Income tax credits   3.2    4.3 
Valuation allowance   (30.8)   (34.0)
Effective tax rate   0.0%    0.0% 
Schedule of deferred tax assets
        
   Years Ending December 31, 
   2022   2021 
Deferred tax assets:          
Net operating loss carryforwards  $11,808   $10,150 
Tax credit carryforwards   1,227    946 
Stock-based compensation   435    1,363 
Capitalized research and development expenses   1,662    – 
License fees   1,680    2,018 
Lease liability   46    79 
Other timing differences   120    169 
Deferred tax assets   16,978    14,725 
Deferred tax liabilities:          
Right of use asset   (43)   (76)
Deferred tax liability   (43)   (76)
Valuation allowance   (16,935)   (14,649)
Net deferred tax asset  $–   $– 
XML 42 R30.htm IDEA: XBRL DOCUMENT v3.23.1
Net Loss per Share (Tables)
 12 Months Ended
Dec. 31, 2022
Net loss per common share:  
Schedule of antidilutive stock
  December 31, 
   2022   2021 
Options to purchase common stock   141    208 
Unvested restricted stock units   47,328    30,592 
Warrants to purchase common stock   545,401    545,401 
Total   592,870    576,201 
XML 43 R31.htm IDEA: XBRL DOCUMENT v3.23.1
Summary of Significant Accounting Policies (Details - Property useful lives)
 12 Months Ended
Dec. 31, 2022
Computer Equipment [Member]  
Property, Plant and Equipment [Line Items]  
Property, Plant and Equipment, Estimated Useful Lives 3 years
Machinery and Equipment [Member]  
Property, Plant and Equipment [Line Items]  
Property, Plant and Equipment, Estimated Useful Lives 5 years
Furniture and Fixtures [Member]  
Property, Plant and Equipment [Line Items]  
Property, Plant and Equipment, Estimated Useful Lives 5 years
Leasehold Improvements [Member]  
Property, Plant and Equipment [Line Items]  
Property, Plant and Equipment, Estimated Useful Lives Lesser of remaining lease term or 5 years
XML 44 R32.htm IDEA: XBRL DOCUMENT v3.23.1
Organization and Significant Accounting Policies (Details Narrative) - USD ($)
 12 Months Ended
Jan. 26, 2023
Dec. 31, 2022
Dec. 31, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]      
Stockholders' Equity, Reverse Stock Split 1-for-12 reverse stock split    
Cash, FDIC Insured Amount   $ 250,000  
Impairment of Long-Lived Assets   $ 0 $ 0
XML 45 R33.htm IDEA: XBRL DOCUMENT v3.23.1
Collaboration and License Agreements (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Advirna [Member]    
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Annual contractural obligation $ 100,000  
Percentage of issuance of common shares from contractual obligations 5.00%  
Agon Ox Clinical Agreement [Member]    
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Total future payments from contractual obligations $ 4,000,000  
Research and development expense 130,000 $ 0
Prepayments from contractual obligations $ 120,000  
XML 46 R34.htm IDEA: XBRL DOCUMENT v3.23.1
Fair Value of Financial Instruments (Details Narrative) - USD ($)
Dec. 31, 2022
Dec. 31, 2021
Fair Value, Inputs, Level 2 [Member]    
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]    
Cash and cash equivalents $ 50,000 $ 50,000
XML 47 R35.htm IDEA: XBRL DOCUMENT v3.23.1
Property and Equipment (Details - Schedule of Property and Equipment) - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Property, Plant and Equipment [Abstract]    
Computer equipment $ 116 $ 108
Machinery & equipment 1,077 1,035
Furniture & fixtures 119 49
Leasehold improvements 46 46
Total gross fixed assets 1,358 1,238
Less: accumulated depreciation and amortization (1,175) (1,105)
Property and equipment, net $ 183 $ 133
XML 48 R36.htm IDEA: XBRL DOCUMENT v3.23.1
Property and Equipment (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Property, Plant and Equipment [Abstract]    
Depreciation $ 71,000 $ 75,000
XML 49 R37.htm IDEA: XBRL DOCUMENT v3.23.1
Accrued Expenses (Details - Schedule of Accrued Expenses) - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Payables and Accruals [Abstract]    
Compensation and benefits $ 408 $ 572
Professional fees 97 102
Research and development costs 501 1,986
Other 19 0
Total accrued expenses $ 1,025 $ 2,660
XML 50 R38.htm IDEA: XBRL DOCUMENT v3.23.1
Leases (Details - Balance sheet lease items) - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Leases [Abstract]    
Right of use asset $ 161 $ 283
Lease liability, current 135 125
Lease liability, non-current 35 170
Total lease liability $ 170 $ 295
Weighted average remaining lease term 1 year 3 months 2 years 3 months
Operating Lease, Weighted Average Discount Rate, Percent 4.70% 4.70%
XML 51 R39.htm IDEA: XBRL DOCUMENT v3.23.1
Leases (Details - Future lease payments) - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Leases [Abstract]    
2023 $ 140  
2024 35  
Total lease payments 175  
Less: Imputed interest (5)  
Total operating lease liabilities (includes current portion) $ 170 $ 295
XML 52 R40.htm IDEA: XBRL DOCUMENT v3.23.1
Leases (Details Narrative)
 12 Months Ended
Dec. 31, 2022
USD ($)
ft²
Dec. 31, 2021
USD ($)
Operating Lease, Cost $ 132,000 $ 132,000
Operating lease payments $ 135,000 $ 132,000
Property Subject to Operating Lease [Member]    
Operating lease footage | ft² 7,581  
Lease expiration date Mar. 31, 2024  
XML 53 R41.htm IDEA: XBRL DOCUMENT v3.23.1
Debt (Details Narrative) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Debt Instrument [Line Items]    
Gain on loan extinguishment $ (0) $ 233
PPP Loan [Member]    
Debt Instrument [Line Items]    
Gain on loan extinguishment   $ 233
XML 54 R42.htm IDEA: XBRL DOCUMENT v3.23.1
Commitments and Contingencies - (Details - Future Cash Payments)
$ in Thousands
Dec. 31, 2022
USD ($)
Commitments and Contingencies Disclosure [Abstract]  
2023 $ 100
2024 100
2025 100
2026 100
2027 100
Thereafter 200
Total $ 700
XML 55 R43.htm IDEA: XBRL DOCUMENT v3.23.1
Commitments and Contingencies (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Milestone payments $ 0 $ 0
Contingent liabilities 0  
AgonOx [Member]    
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Total future payments from contractual obligations $ 4,000,000  
XML 56 R44.htm IDEA: XBRL DOCUMENT v3.23.1
Preferred Stock (Details Narrative) - USD ($)
 1 Months Ended 12 Months Ended
Nov. 16, 2022
Nov. 16, 2022
Dec. 31, 2022
Dec. 31, 2021
Temporary Equity [Line Items]        
Preferred stock, shares authorized     10,000,000  
Preferred stock, par value     $ 0.0001  
Sale of preferred stock, value      
Series D Preferred Stock [Member]        
Temporary Equity [Line Items]        
Temporary Equity, Shares Authorized     1 0
Temporary Equity Stock Issued During Period Shares New Issues 1      
Temporary Equity, Par or Stated Value Per Share $ 0.0001 $ 0.0001 $ 0.0001  
Series D Preferred Stock voting rights $ 17,500,000 $ 17,500,000    
Temporary Equity, Aggregate Amount of Redemption Requirement     $ 1,750  
Series D Preferred Stock [Member] | Robert Bitterman [Member]        
Temporary Equity [Line Items]        
Sale of preferred stock, value   $ 1,750    
XML 57 R45.htm IDEA: XBRL DOCUMENT v3.23.1
Stockholders' Equity (Details - Warrants outstanding) - $ / shares
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Class of Warrant or Right [Line Items]    
Warrants exercised 0  
Warrant [Member]    
Class of Warrant or Right [Line Items]    
Warrants outstanding 545,401 545,401
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | April 2018 Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 2,079.00  
Warrant expiration date May 31, 2023  
Warrants outstanding 1,720 1,720
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | April 2018 Placement Agent Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 2,676.00  
Warrant expiration date Apr. 09, 2023  
Warrants outstanding 117 117
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | October 2018 Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 125.40  
Warrant expiration date Oct. 03, 2025  
Warrants outstanding 32,486 32,486
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | Option to purchase shares of common stock, shares    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 156.72  
Warrant expiration date Oct. 01, 2023  
Warrants outstanding 2,438 2,438
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | Nov 2019 Placement Agent Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 82.50  
Warrant expiration date Nov. 18, 2024  
Warrants outstanding 1,138 1,138
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | PPP Loan [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 104.52  
Warrant expiration date Aug. 06, 2025  
Warrants outstanding 16,425 16,425
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | Feb 2020 Placement Agent Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 132.45  
Warrant expiration date Feb. 04, 2025  
Warrants outstanding 1,233 1,233
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | Feb 2020 Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 48.00  
Warrant expiration date Feb. 13, 2025  
Warrants outstanding 110,557 110,557
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | Feb 2020 Underwriter Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 60.00  
Warrant expiration date Feb. 11, 2025  
Warrants outstanding 12,501 12,501
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | April 2020 Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 26.52  
Warrant expiration date Oct. 02, 2025  
Warrants outstanding 35,691 35,691
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | Income Tax Disclosure [Line Items]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 35.0256  
Warrant expiration date Mar. 31, 2025  
Warrants outstanding 3,481 3,481
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | January 2021 Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 36.00  
Warrant expiration date Jul. 27, 2026  
Warrants outstanding 285,061 285,061
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | January 2021 Placement Agent Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 46.05  
Warrant expiration date Jul. 27, 2026  
Warrants outstanding 28,509 28,509
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
Warrant [Member] | February 2021 Placement Agent Warrants [Member]    
Class of Warrant or Right [Line Items]    
Warrant exercise price $ 51.30  
Warrant expiration date Feb. 12, 2026  
Warrants outstanding 14,044 14,044
Warrants issued 0  
Warrants exercised 0  
Warrants expired 0  
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Stockholders’ Equity (Details Narrative) - USD ($)
 1 Months Ended 12 Months Ended
Feb. 28, 2021
Jan. 31, 2021
Dec. 31, 2022
Dec. 31, 2021
Class of Stock [Line Items]        
Warrants exercised shares     0  
Proceeds from Warrant Exercises     $ 0 $ 2,146,000
Jan 2021 Private Placement [Member]        
Class of Stock [Line Items]        
Stock Issued During Period, Shares, New Issues   368,405    
Shares Issued, Price Per Share   $ 36.84    
Proceeds from Issuance or Sale of Equity   $ 12,669,000    
Jan 2021 Private Placement [Member] | Jan 2021 Pre Funded Warrants [Member]        
Class of Stock [Line Items]        
Shares Issued, Price Per Share   $ 36.828    
Warrants issued   11,672    
Jan 2021 Private Placement [Member] | Jan 2021 Warrants [Member]        
Class of Stock [Line Items]        
Warrants issued   285,061    
Class of Warrant or Right, Exercise Price of Warrants or Rights   $ 36.00    
Jan 2021 Private Placement [Member] | Jan 2021 Placement Agent Warrants [Member]        
Class of Stock [Line Items]        
Warrants issued   28,509    
Class of Warrant or Right, Exercise Price of Warrants or Rights   $ 46.05    
Feb 2021 Registered Direct Offering [Member]        
Class of Stock [Line Items]        
Stock Issued During Period, Shares, New Issues 187,232      
Shares Issued, Price Per Share $ 41.04      
Proceeds from Issuance or Sale of Equity $ 6,908,000      
Feb 2021 Registered Direct Offering [Member] | Feb 2021 Placement Agent Warrants [Member]        
Class of Stock [Line Items]        
Warrants issued 14,044      
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 51.30      
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Stock-based Compensation (Details - RSU activity) - Restricted Stock Units (RSUs) [Member] - $ / shares
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
RSU's unvested units, beginning balance 30,592  
RSU beginning balance, price per share $ 38.52  
RSU's granted 61,250  
RSU's granted, price per share $ 10.08 $ 35.28
RSU's vested (14,043)  
RSU's vested, price per share $ 39.72  
RSU's forfeited (30,471)  
RSU's forfeited, price per share $ 17.40  
RSU's unvested units, ending balance 47,328 30,592
RSU ending balance, price per share $ 15.00 $ 38.52
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Stock-based Compensation (Details - Option activity)
$ / shares in Units, $ in Thousands
 12 Months Ended
Dec. 31, 2022
USD ($)
$ / shares
shares
Equity Option [Member]  
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]  
Options outstanding | shares 208
Weighted-Average Exercise Price Per Share, Beginning Balance | $ / shares $ 40,822.80
Options granted | shares 0
Weighted-Average Exercise Price per Share, Granted | $ / shares $ 0
Options exercised | shares 0
Weighted-Average Exercise Price per Share, Options Unvested, Shares Cancelled | $ / shares $ 1,181.40
Weighted-Average Exercise Price per Share, Options Vested, Shares Cancelled | $ / shares $ 93,016.68
Options outstanding | shares 141
Weighted-Average Exercise Price Per Share, Ending Balance | $ / shares $ 19,761.12
Weighted-Average Contractual Term, Outstanding 5 years 2 months 4 days
Aggregate Intrinsic Value, Ending Balance | $ $ 0
Options exercisable | shares 141
Weighted-Average Exercise Price Per Share, Exercisable | $ / shares $ 19,761.12
Weighted-Average Contractual Term, Exercisable 5 years 2 months 4 days
Aggregate Intrinsic Value, Exercisable | $ $ 0
Equity Option [Member] | Unvested Shares [Member]  
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]  
Options cancelled | shares (6)
Equity Option [Member] | Vested Shares [Member]  
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]  
Options cancelled | shares (61)
Stock Options [Member]  
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]  
Weighted-Average Exercise Price Per Share, Exercised | $ / shares $ 0
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Stock-based Compensation (Details - Share-based compensation) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Total stock-based compensation $ 414 $ 480
Research and Development Expense [Member]    
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Total stock-based compensation 154 117
General and Administrative Expense [Member]    
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]    
Total stock-based compensation $ 260 $ 363
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Stock-based Compensation (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Share-based compensation expense $ 414,000 $ 480,000
Restricted Stock Units (RSUs) [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number 47,328 30,592
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value $ 10.08 $ 35.28
Share-based compensation expense $ 401,000 $ 443,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value 138,000 $ 9,000
Unrecognized share-based compensation expense $ 458,000  
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition 1 year 7 months 6 days  
Equity Option [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number 141 208
Share-based compensation expense $ 13,000 $ 37,000
Plan 2020 [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized 105,640  
Plan 2020 [Member] | Stock Options [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number 141  
Plan 2020 [Member] | Unvested RSU's [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number 47,328  
Plan 2020 [Member] | Shares Available For Future Grants [Member]    
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]    
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant 43,807  
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Income Taxes - (Details - Components of Federal and State Income Tax Expense) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Current    
Federal $ 0 $ 0
State 0 0
Total current 0 0
Deferred    
Federal 1,733 3,016
State 553 1,329
Total deferred 2,286 4,345
Valuation allowance (2,286) (4,345)
Total provision for income taxes $ 0 $ 0
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Income Taxes - (Details - Effect Income Tax Rate Reconciliation)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Income Tax Disclosure [Abstract]    
Federal statutory rate 21.00% 21.00%
State income taxes, net of federal benefit 7.40% 8.50%
Non-deductible expenses (0.80%) 0.20%
Income tax credits 3.20% 4.30%
Valuation allowance 30.80% 34.00%
Effective tax rate 0.00% 0.00%
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Income Taxes - (Details - Components of Net Deferred Tax Assets) - USD ($)
Dec. 31, 2022
Dec. 31, 2021
Deferred tax assets:    
Net operating loss carryforwards $ 11,808,000 $ 10,150,000
Tax credit carryforwards 1,227,000 946,000
Stock-based compensation 435,000 1,363,000
Capitalized research and development expenses 1,662,000 0
License fees 1,680,000 2,018,000
Lease liability 46,000 79,000
Other timing differences 120,000 169,000
Deferred tax assets 16,978,000 14,725,000
Deferred tax liabilities:    
Right of use asset (43,000) (76,000)
Deferred tax liability (43,000) (76,000)
Valuation allowance (16,935,000) (14,649,000)
Net deferred tax asset $ 0 $ 0
XML 66 R54.htm IDEA: XBRL DOCUMENT v3.23.1
Income Taxes (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Operating Loss Carryforwards [Line Items]    
Deferred tax asset, research and development cost $ 1,662,000 $ 0
Federal [Member]    
Operating Loss Carryforwards [Line Items]    
Net operating loss carryforwards 49,200,000  
Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration 48,879,000  
Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration 321,000  
Tax Credit Carryforward, Amount $ 819,000  
Tax Credit Carryforward, Expiration Date Dec. 31, 2041  
Reduction in operating loss carryforwards   55,000,000
Reduction in tax credit carryforward deferred tax asset   1,400,000
Federal [Member] | Net Operating Loss Carryforward [Member]    
Operating Loss Carryforwards [Line Items]    
Operating Loss Carryforwards, Expiration Date Dec. 31, 2037  
State [Member]    
Operating Loss Carryforwards [Line Items]    
Net operating loss carryforwards $ 23,200,000  
Tax Credit Carryforward, Amount $ 517,000  
Tax Credit Carryforward, Expiration Date Dec. 31, 2036  
Reduction in operating loss carryforwards   70,000,000
Reduction in tax credit carryforward deferred tax asset   $ 700,000
State [Member] | Net Operating Loss Carryforward [Member]    
Operating Loss Carryforwards [Line Items]    
Operating Loss Carryforwards, Expiration Date Dec. 31, 2038  
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Net Loss per Share (Details - Antidilutive shares) - shares
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount 592,870 576,201
Options [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount 141 208
Restricted Stock Units (RSUs) [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount 47,328 30,592
Warrants [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount 545,401 545,401
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us-gaap:RestrictedStockUnitsRSUMember 2022-01-01 2022-12-31 0001533040 us-gaap:RestrictedStockUnitsRSUMember 2021-01-01 2021-12-31 0001533040 phio:WarrantsMember 2022-01-01 2022-12-31 0001533040 phio:WarrantsMember 2021-01-01 2021-12-31 iso4217:USD shares iso4217:USD shares pure utr:sqft 0001533040 false 2022 FY 1 1 2037-12-31 2038-12-31 2041-12-31 2036-12-31 10-K true 2022-12-31 --12-31 false 001-36304 PHIO PHARMACEUTICALS CORP. DE 45-3215903 257 Simarano Drive Suite 101 Marlborough MA 01752 508 767-3861 Common Stock, par value, $0.0001 per share PHIO NASDAQ No No Yes Yes Non-accelerated Filer true false false false 9500000 1150582 None 243 BDO USA, LLP Boston, Massachusetts 11781000 24057000 50000 50000 615000 620000 12446000 24727000 161000 283000 183000 133000 24000 27000 12814000 25170000 779000 283000 1025000 2660000 135000 125000 1939000 3068000 35000 170000 1974000 3238000 0.0001 1 1 1 0 0 0 2000 0 0.0001 0.0001 100000000 100000000 1139024 1139024 1127917 1127917 0 0 139218000 138832000 -128380000 -116900000 10838000 21932000 12814000 25170000 7012000 8886000 4450000 4625000 11462000 13511000 -11462000 -13511000 -18000 224000 -11480000 -13287000 0 0 -11480000 -13287000 -10.10 -12.43 -10.10 -12.43 1136566 1069234 1136566 1069234 481749 116630000 -103613000 13017000 368405 12669000 12669000 187232 6908000 6908000 90276 2146000 2146000 279 24 1000 1000 480000 480000 -13287000 -13287000 1127917 138832000 -116900000 21932000 14043 2936 28000 28000 1 2000 414000 414000 -11480000 -11480000 1 2000 1139024 139218000 -128380000 10838000 -11480000 -13287000 71000 75000 122000 117000 414000 480000 -0 233000 -8000 -241000 496000 -445000 -1635000 1310000 -125000 -116000 -12129000 -11858000 121000 51000 -121000 -51000 0 19577000 0 2146000 28000 1000 2000 0 -26000 21722000 -12276000 9813000 24107000 14294000 11831000 24107000 11781000 24057000 50000 50000 11831000 24107000 <p id="xdx_802_eus-gaap--OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock_zmfwDD8K2oM9" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>1. <span id="xdx_82B_zC3VzgaO3MVe">Organization and Significant Accounting Policies</span> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_84B_eus-gaap--NatureOfOperations_zqZOtW3TDga9" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_864_z3qzzUGtC505">Nature of Operations</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Phio Pharmaceuticals Corp. (“<b>Phio</b>,” “<b>we</b>,” “<b>our</b>” or the “<b>Company</b>”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology platform is designed to make immune cells more effective in killing tumor cells. We are developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems. We are committed to discovering and developing innovative cancer treatments for patients by creating new pathways toward a cancer-free future.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company continues to respond to and monitor the ongoing coronavirus pandemic. The Company believes that the coronavirus pandemic has not had a significant impact on its financial condition and results of operations, however, the extent to which the coronavirus pandemic may materially impact our financial results and operations will depend on a number of factors, including the availability of supplies and services we rely on, the ability to enroll subjects in our clinical trials, the emergence of variant strains of the coronavirus, the development, availability, and public acceptance of effective treatments and vaccines, and the duration of the coronavirus pandemic, which remain difficult to predict and are highly uncertain.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_846_ecustom--LiquidityPolicyTextBlock_zPmz8u8fSv98" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><i><span id="xdx_86C_zdj9w1Z3ZFM6">Liquidity</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">The Company has reported recurring losses from operations since its inception and expects to continue to have negative cash flows from operations for the foreseeable future. Historically, the Company’s primary source of funding has been from sales of its securities. The Company’s ability to continue to fund its operations is dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity, or strategic opportunities, in order to maintain its operations. This is dependent on a number of factors, including the market demand or liquidity of the Company’s common stock, which may be adversely impacted by the coronavirus pandemic, rates of inflation and the ongoing conflict between Russia and Ukraine. There is no guarantee that debt, additional equity or other funding will be available to us on acceptable terms, or at all. If we fail to obtain additional funding when needed, we would be forced to scale back or terminate our operations or seek to merge with or to be acquired by another company.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">The Company has limited cash resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through an equity offering, debt offering or strategic opportunity to fund its operations. There can be no assurance that the Company will be successful in accomplishing these plans in order to continue as a going concern. These financial statements do not include any adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_845_eus-gaap--BasisOfAccountingPolicyPolicyTextBlock_zWNRhMrTWsh5" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_86D_zIdUYEMflnsj">Basis of Presentation</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The accompanying financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“<b>GAAP</b>”).</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_848_eus-gaap--ConsolidationPolicyTextBlock_z5NNe6aQJaO2" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_868_zLpqhUVBQVe6">Principles of Consolidation</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The consolidated financial statements include the accounts of Phio and its wholly-owned subsidiary, MirImmune, LLC. All material intercompany accounts have been eliminated in consolidation.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_84F_eus-gaap--StockholdersEquityPolicyTextBlock_zPinmFch5ymc" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_86C_zJMuy8Iv7z06">Reverse Stock Split</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Effective January 26, 2023, the Company completed a <span id="xdx_903_eus-gaap--StockholdersEquityReverseStockSplit_c20230125__20230126_zpK95ySfR0Il">1-for-12 reverse stock split</span> of the Company’s outstanding common stock. All share and per share amounts in the financial statements have been retroactively adjusted for all periods presented to give effect to the reverse stock split, including reclassifying an amount equal to the reduction in par value to additional paid-in capital. Unless otherwise noted, shares of common stock issued and outstanding, shares underlying warrants and stock awards, shares reserved, conversion price of convertible securities, exercise prices of warrants and stock awards and loss per share have been proportionately adjusted to reflect the reverse stock split. The reverse stock split did not reduce the number of authorized shares of the Company’s common stock or preferred stock.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_846_eus-gaap--UseOfEstimates_zVOijOKDTId7" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_861_z5PgkMqSU5mk">Uses of Estimates in Preparation of Financial Statements</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 27pt"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The preparation of financial statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. The areas subject to significant estimates and judgement include, among others, those related to the fair value of equity awards, accruals for research and development expenses, useful lives of property and equipment, income taxes, and the valuation allowance on our deferred tax assets. On an ongoing basis we evaluate our estimates and base our estimates on historical experience and other relevant assumptions that we believe are reasonable under the circumstances. Actual results could differ materially from these estimates.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_849_eus-gaap--CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_zwFD1IzDEcN1" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_86B_zjCyY5Wj7NVf">Restricted Cash</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Restricted cash consists of certificates of deposit held by financial institutions as collateral for the Company’s corporate credit cards.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"> </p> <p id="xdx_840_eus-gaap--ConcentrationRiskCreditRisk_zyB3Rskx9Xqg" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_865_zJFpgU2X2Isg">Concentrations of Credit Risk</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash. The Company maintains cash balances in several accounts with a financial institution that management believes is creditworthy, which at times are in excess of federally insured limits. These accounts are insured by the Federal Deposit Insurance Corporation for up to $<span id="xdx_900_eus-gaap--CashFDICInsuredAmount_iI_c20221231_zAIbJZqZ7wH4">250,000</span> per institution.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_840_eus-gaap--PropertyPlantAndEquipmentPolicyTextBlock_z4KKLppAy1Td" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_869_zYCB1AOm9OR8">Property and Equipment</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Property and equipment are stated at cost and depreciated using the straight-line method based on the estimated useful lives of the related assets. The Company provides for depreciation over the assets’ estimated useful lives as follows:</p> <table cellpadding="0" cellspacing="0" id="xdx_883_ecustom--ScheduleOfUsefulLivesOfPropertyAndEquipmentTableTextBlock_z8PMMD8Oqzoi" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; width: 75%; border-collapse: collapse; margin-right: auto" summary="xdx: Disclosure - Summary of Significant Accounting Policies (Details - Property useful lives)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B6_zjlvmmzhsDh" style="display: none">Schedule of estimated useful lives</span></td> <td style="white-space: nowrap"> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 77%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Computer equipment</span></td> <td id="xdx_985_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--ComputerEquipmentMember_zsEvCC3nERqh" style="white-space: nowrap; width: 23%" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">3 years</span></td></tr> <tr style="vertical-align: bottom"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Machinery &amp; equipment</span></td> <td id="xdx_981_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--MachineryAndEquipmentMember_zTVGKx3gpna3" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">5 years</span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Furniture &amp; fixtures</span></td> <td id="xdx_989_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--FurnitureAndFixturesMember_zOuRDfxEHNgj" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">5 years</span></td></tr> <tr style="vertical-align: bottom"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Leasehold improvements</span></td> <td id="xdx_988_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--LeaseholdImprovementsMember_zoc2C2OsGFQc" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Lesser of remaining lease term or 5 years</span></td></tr> </table> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_844_eus-gaap--ImpairmentOrDisposalOfLongLivedAssetsIncludingIntangibleAssetsPolicyPolicyTextBlock_zw9I0dch24Hk" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_866_zhUo2SPorS0h">Impairment of Long-Lived Assets</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company reviews long-lived assets for impairment annually or whenever an event or change in circumstance occurs in which the related carrying amounts may not be recoverable. An impairment loss would be recognized based on the difference between the carrying value of the asset and its estimated fair value, which would be determined based on either discounted future cash flows or other appropriate fair value methods. As of December 31, 2022 and 2021, the Company believes <span id="xdx_90B_eus-gaap--ImpairmentOfLongLivedAssetsHeldForUse_pn3n3_do_c20220101__20221231_zSBLypv2lSJ8" title="Impairment of Long-Lived Assets"><span id="xdx_904_eus-gaap--ImpairmentOfLongLivedAssetsHeldForUse_pn3n3_do_c20210101__20211231_zreRS5b4qR9g" title="Impairment of Long-Lived Assets">no</span></span> impairment existed.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">  </p> <p id="xdx_847_eus-gaap--LesseeLeasesPolicyTextBlock_zkLdjWId9Pza" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_865_zX0Np5lYVmA1">Leases</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">At the inception of a contract, the Company determines whether the contract is or contains a lease based on all relevant facts and circumstances. For contracts that contain a lease, the Company identifies the lease and non-lease components, determines the consideration in the contract and recognizes the classification of the lease as operating or financing. For leases with a term greater than one year, the Company recognizes a liability to make lease payments and an asset representing the right to use the underlying asset during the lease term at the commencement date of the lease.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Lease liabilities and the corresponding right of use assets are recorded based on the present value of lease payments to be made over the lease term. The discount rate used to calculate the present value is the rate implicit in the lease, or if not readily determinable, the Company’s incremental borrowing rate. The Company’s incremental borrowing rate is the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. Certain adjustments to the right of use asset may be required for items such as initial direct costs or incentives received. Lease payments on operating leases, including scheduled increases, are recognized on a straight-line basis over the expected term of the lease. Lease payments on financing leases are recognized using the effective interest method.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p id="xdx_843_eus-gaap--DerivativesPolicyTextBlock_zPrJ2U49Dmwb" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_86E_z7HlP5WzQC3">Derivative Financial Instruments</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Financial instruments that meet the definition of a derivative are classified as an asset or liability and measured at fair value on the issuance date and are revalued on each subsequent balance sheet date. The changes in fair value are recognized as current period income or loss. Financial instruments that do not meet the definition of a derivative are classified as equity and measured at fair value and recorded as additional paid-in capital in stockholders’ equity at the date of issuance. No further adjustments to their valuation are made.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_849_eus-gaap--ResearchAndDevelopmentExpensePolicy_zsoXNmA50DJg" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_861_zW7KYNfOfjT5">Research and Development Expenses</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Research and development expenses relate to compensation and benefits for research and development personnel, facility-related expenses, supplies, external services, costs to acquire technology licenses, research activities under our research collaborations, expenses associated with preclinical and clinical development activities and other operating costs. Research and development expenses are charged to expense as incurred. Payments made by the Company in advance for research and development services not yet provided and/or for materials not yet received are recorded as prepaid expenses and expensed when the service has been performed or when the goods have been received.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Accrued liabilities are recorded related to those expenses for which vendors have not yet billed the Company with respect to services provided and/or materials that it has received. Accrued liabilities for the services provided by contract research organizations are recorded during the period incurred based on such estimates and assumptions as expected cost, passage of time, the achievement of milestones and other information available to us and are assessed on a quarterly basis. Actual results may differ from these estimates and could have a material impact on the Company’s reported results. The Company’s historical accrual estimates have not been materially different from its actual costs.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_84D_eus-gaap--CollaborativeArrangementAccountingPolicy_z5qk8fWgwJH7" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_866_zLXdwPRDZerh">Collaborative Arrangements</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company follows the provisions of the Financial Accounting Standards Board (the “<b>FASB</b>”) Accounting Standards Codification (“<b>ASC</b>”) Topic 808, “<i>Collaborative Arrangements</i>,” (“<b>Topic 808</b>”) when collaboration agreements involve joint operating activities in which both parties are active participants and that are also both exposed to significant risks and rewards. The Company also considers the guidance in the FASB ASC Topic 606, “<i>Revenue from Contracts with Customers</i>,” (“<b>Topic 606</b>”) in determining the appropriate treatment for activities between the Company and its collaborative partners that are more reflective of a vendor-customer relationship and therefore, within the scope of Topic 606. Under Topic 808, the Company determines an appropriate recognition method, either by analogy to appropriate accounting literature or by applying a reasonable accounting policy election. Generally, the classification of transactions under the collaborative arrangements is determined based on the nature and contractual terms of the arrangement along with the nature of the operations of the participants. The Company recognizes its share of costs arising from research and development activities performed by collaborators in the period its collaborators incur such expense. Payments or reimbursements that are the result of a collaborative relationship instead of a customer relationship, such as co-development activities, are evaluated on a quarterly basis and recorded as an offset to research and development expense incurred.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_84E_ecustom--PatentsAndPatentApplicationCostsPolicy_zC6lj5BkMGG4" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_867_zo3DjFxceLV2">Patents and Patent Application Costs</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Although the Company believes that its patents and underlying technology have continuing value, the amount of future benefits to be derived from the patents is uncertain. Patent costs are, therefore, expensed as general and administrative costs as incurred.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_845_eus-gaap--ShareBasedCompensationOptionAndIncentivePlansPolicy_zL2GxIOuWkid" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_869_zzjb1GY3EOde">Stock-based Compensation</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">The Company follows the provisions of the FASB ASC Topic 718, “<i>Compensation — Stock Compensation</i>” (“<b>ASC 718</b>”), which requires the measurement and recognition of compensation expense for all stock-based payment awards. The fair value of restricted stock units (“<b>RSUs</b>”) is based upon the Company’s closing stock price at the grant date. The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options at the grant date. The Black-Scholes valuation model requires the input of valuation assumptions to calculate the value of stock options, including expected volatility, expected term, risk-free interest rate and expected dividends. Stock-based compensation expense is recognized on a straight-line basis over the requisite service period, which generally represents the vesting period, and commences at the date of grant based on the fair value of the award.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Stock-based compensation expense recognized in the financial statements is based on awards that are ultimately expected to vest. Accordingly, we are also required to estimate forfeitures at the time of grant and to revise those estimates in subsequent periods if actual forfeitures differ from estimates. We use historical data to estimate pre-vesting award forfeitures and record stock-based compensation expense only for those awards that are expected to vest. Our forfeiture rate estimates are based on an analysis of our actual forfeiture experience, employee turnover behavior, and other factors. The impact of any adjustments to our forfeiture rates or to the extent that actual forfeitures differ from our estimates, is recorded as a cumulative adjustment in the period the estimates are revised.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_844_eus-gaap--IncomeTaxPolicyTextBlock_zSs2dKUvyrM7" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_864_zprpWW9Cnvle">Income Taxes</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company recognizes assets or liabilities for the deferred tax consequences of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements in accordance with the FASB ASC Topic 740, <i>“Accounting for Income Taxes”</i> (“<b>ASC 740</b>”)<i>.</i> These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled. Those temporary differences referred to as deferred tax assets and liabilities are determined at the end of each period using the tax rate expected to be in effect when taxes are actually paid or recovered. Valuation allowances are established if, based on the weight of available evidence, it is more likely than not that all or a portion of a deferred tax asset will not be realized. The provision for income taxes, if any, represents the tax payable for the period and the change in deferred income tax assets and liabilities during the period.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_845_eus-gaap--ComprehensiveIncomePolicyPolicyTextBlock_zyA8XnklK211" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_860_z7jt7rqN9Mce">Comprehensive Loss</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company’s comprehensive loss is equal to its net loss for all periods presented.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_843_eus-gaap--EarningsPerSharePolicyTextBlock_z7IjHDZcvS5c" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_865_z7ZUp9H3Aa1c">Net Loss per Share</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding. Diluted net loss per share is computed by dividing the Company’s net loss by the weighted average number of common shares outstanding and the impact of all dilutive potential common shares outstanding, except where such dilutive potential common shares would be anti-dilutive. Dilutive potential common shares primarily consist of warrants, RSUs and stock options.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p id="xdx_84E_eus-gaap--NewAccountingPronouncementsPolicyPolicyTextBlock_zXpNDcRjaKWh" style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin-top: 0pt; margin-bottom: 0pt"><i>Recent Accounting Pronouncements</i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In May 2021, the FASB issued Accounting Standards Update 2021-04, “<i>Earnings per Share (Topic 260), Debt – Modifications and Extinguishments (Subtopic 470-50), Compensation – Stock Compensation (Topic 718), and Derivatives and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40)</i>” (“<b>ASU 2021-04</b>”). The amendments in the updates are intended to clarify and reduce diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options that remain equity classified after modification or exchange. The amendments in ASU 2021-04 are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. An entity should apply the amendments prospectively to modifications or exchanges occurring on or after the effective date of the amendments. The Company adopted ASU 2021-04 on January 1, 2022. The adoption of this standard had no impact on the Company’s consolidated financial statements.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_84B_eus-gaap--NatureOfOperations_zqZOtW3TDga9" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_864_z3qzzUGtC505">Nature of Operations</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Phio Pharmaceuticals Corp. (“<b>Phio</b>,” “<b>we</b>,” “<b>our</b>” or the “<b>Company</b>”) is a clinical stage biotechnology company whose proprietary INTASYL™ self-delivering RNAi technology platform is designed to make immune cells more effective in killing tumor cells. We are developing therapeutics that are designed to leverage INTASYL to precisely target specific proteins that reduce the body’s ability to fight cancer, without the need for specialized formulations or drug delivery systems. We are committed to discovering and developing innovative cancer treatments for patients by creating new pathways toward a cancer-free future.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company continues to respond to and monitor the ongoing coronavirus pandemic. The Company believes that the coronavirus pandemic has not had a significant impact on its financial condition and results of operations, however, the extent to which the coronavirus pandemic may materially impact our financial results and operations will depend on a number of factors, including the availability of supplies and services we rely on, the ability to enroll subjects in our clinical trials, the emergence of variant strains of the coronavirus, the development, availability, and public acceptance of effective treatments and vaccines, and the duration of the coronavirus pandemic, which remain difficult to predict and are highly uncertain.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_846_ecustom--LiquidityPolicyTextBlock_zPmz8u8fSv98" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><i><span id="xdx_86C_zdj9w1Z3ZFM6">Liquidity</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">The Company has reported recurring losses from operations since its inception and expects to continue to have negative cash flows from operations for the foreseeable future. Historically, the Company’s primary source of funding has been from sales of its securities. The Company’s ability to continue to fund its operations is dependent on obtaining funding from third parties, such as proceeds from the issuance of debt, sale of equity, or strategic opportunities, in order to maintain its operations. This is dependent on a number of factors, including the market demand or liquidity of the Company’s common stock, which may be adversely impacted by the coronavirus pandemic, rates of inflation and the ongoing conflict between Russia and Ukraine. There is no guarantee that debt, additional equity or other funding will be available to us on acceptable terms, or at all. If we fail to obtain additional funding when needed, we would be forced to scale back or terminate our operations or seek to merge with or to be acquired by another company.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">The Company has limited cash resources, has reported recurring losses from operations since inception and has not yet received product revenues. These factors raise substantial doubt regarding the Company’s ability to continue as a going concern, and the Company’s current cash resources may not provide sufficient capital to fund operations for at least the next 12 months from the date of the release of these financial statements. The continuation of the Company as a going concern depends upon the Company’s ability to raise additional capital through an equity offering, debt offering or strategic opportunity to fund its operations. There can be no assurance that the Company will be successful in accomplishing these plans in order to continue as a going concern. These financial statements do not include any adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_845_eus-gaap--BasisOfAccountingPolicyPolicyTextBlock_zWNRhMrTWsh5" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_86D_zIdUYEMflnsj">Basis of Presentation</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The accompanying financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“<b>GAAP</b>”).</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_848_eus-gaap--ConsolidationPolicyTextBlock_z5NNe6aQJaO2" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_868_zLpqhUVBQVe6">Principles of Consolidation</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The consolidated financial statements include the accounts of Phio and its wholly-owned subsidiary, MirImmune, LLC. All material intercompany accounts have been eliminated in consolidation.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p id="xdx_84F_eus-gaap--StockholdersEquityPolicyTextBlock_zPinmFch5ymc" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_86C_zJMuy8Iv7z06">Reverse Stock Split</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Effective January 26, 2023, the Company completed a <span id="xdx_903_eus-gaap--StockholdersEquityReverseStockSplit_c20230125__20230126_zpK95ySfR0Il">1-for-12 reverse stock split</span> of the Company’s outstanding common stock. All share and per share amounts in the financial statements have been retroactively adjusted for all periods presented to give effect to the reverse stock split, including reclassifying an amount equal to the reduction in par value to additional paid-in capital. Unless otherwise noted, shares of common stock issued and outstanding, shares underlying warrants and stock awards, shares reserved, conversion price of convertible securities, exercise prices of warrants and stock awards and loss per share have been proportionately adjusted to reflect the reverse stock split. The reverse stock split did not reduce the number of authorized shares of the Company’s common stock or preferred stock.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> 1-for-12 reverse stock split <p id="xdx_846_eus-gaap--UseOfEstimates_zVOijOKDTId7" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_861_z5PgkMqSU5mk">Uses of Estimates in Preparation of Financial Statements</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 27pt"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The preparation of financial statements in accordance with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities as of the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. The areas subject to significant estimates and judgement include, among others, those related to the fair value of equity awards, accruals for research and development expenses, useful lives of property and equipment, income taxes, and the valuation allowance on our deferred tax assets. On an ongoing basis we evaluate our estimates and base our estimates on historical experience and other relevant assumptions that we believe are reasonable under the circumstances. Actual results could differ materially from these estimates.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_849_eus-gaap--CashAndCashEquivalentsRestrictedCashAndCashEquivalentsPolicy_zwFD1IzDEcN1" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_86B_zjCyY5Wj7NVf">Restricted Cash</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Restricted cash consists of certificates of deposit held by financial institutions as collateral for the Company’s corporate credit cards.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"> </p> <p id="xdx_840_eus-gaap--ConcentrationRiskCreditRisk_zyB3Rskx9Xqg" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_865_zJFpgU2X2Isg">Concentrations of Credit Risk</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash. The Company maintains cash balances in several accounts with a financial institution that management believes is creditworthy, which at times are in excess of federally insured limits. These accounts are insured by the Federal Deposit Insurance Corporation for up to $<span id="xdx_900_eus-gaap--CashFDICInsuredAmount_iI_c20221231_zAIbJZqZ7wH4">250,000</span> per institution.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p> 250000 <p id="xdx_840_eus-gaap--PropertyPlantAndEquipmentPolicyTextBlock_z4KKLppAy1Td" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_869_zYCB1AOm9OR8">Property and Equipment</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Property and equipment are stated at cost and depreciated using the straight-line method based on the estimated useful lives of the related assets. The Company provides for depreciation over the assets’ estimated useful lives as follows:</p> <table cellpadding="0" cellspacing="0" id="xdx_883_ecustom--ScheduleOfUsefulLivesOfPropertyAndEquipmentTableTextBlock_z8PMMD8Oqzoi" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; width: 75%; border-collapse: collapse; margin-right: auto" summary="xdx: Disclosure - Summary of Significant Accounting Policies (Details - Property useful lives)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B6_zjlvmmzhsDh" style="display: none">Schedule of estimated useful lives</span></td> <td style="white-space: nowrap"> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 77%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Computer equipment</span></td> <td id="xdx_985_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--ComputerEquipmentMember_zsEvCC3nERqh" style="white-space: nowrap; width: 23%" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">3 years</span></td></tr> <tr style="vertical-align: bottom"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Machinery &amp; equipment</span></td> <td id="xdx_981_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--MachineryAndEquipmentMember_zTVGKx3gpna3" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">5 years</span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Furniture &amp; fixtures</span></td> <td id="xdx_989_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--FurnitureAndFixturesMember_zOuRDfxEHNgj" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">5 years</span></td></tr> <tr style="vertical-align: bottom"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Leasehold improvements</span></td> <td id="xdx_988_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--LeaseholdImprovementsMember_zoc2C2OsGFQc" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Lesser of remaining lease term or 5 years</span></td></tr> </table> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <table cellpadding="0" cellspacing="0" id="xdx_883_ecustom--ScheduleOfUsefulLivesOfPropertyAndEquipmentTableTextBlock_z8PMMD8Oqzoi" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; width: 75%; border-collapse: collapse; margin-right: auto" summary="xdx: Disclosure - Summary of Significant Accounting Policies (Details - Property useful lives)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B6_zjlvmmzhsDh" style="display: none">Schedule of estimated useful lives</span></td> <td style="white-space: nowrap"> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 77%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Computer equipment</span></td> <td id="xdx_985_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--ComputerEquipmentMember_zsEvCC3nERqh" style="white-space: nowrap; width: 23%" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">3 years</span></td></tr> <tr style="vertical-align: bottom"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Machinery &amp; equipment</span></td> <td id="xdx_981_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--MachineryAndEquipmentMember_zTVGKx3gpna3" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">5 years</span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Furniture &amp; fixtures</span></td> <td id="xdx_989_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--FurnitureAndFixturesMember_zOuRDfxEHNgj" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">5 years</span></td></tr> <tr style="vertical-align: bottom"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Leasehold improvements</span></td> <td id="xdx_988_ecustom--PropertyPlantAndEquipmentEstimatedUsefulLives1_c20220101__20221231__us-gaap--PropertyPlantAndEquipmentByTypeAxis__us-gaap--LeaseholdImprovementsMember_zoc2C2OsGFQc" style="white-space: nowrap" title="Property, Plant and Equipment, Estimated Useful Lives"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Lesser of remaining lease term or 5 years</span></td></tr> </table> 3 years 5 years 5 years Lesser of remaining lease term or 5 years <p id="xdx_844_eus-gaap--ImpairmentOrDisposalOfLongLivedAssetsIncludingIntangibleAssetsPolicyPolicyTextBlock_zw9I0dch24Hk" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_866_zhUo2SPorS0h">Impairment of Long-Lived Assets</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company reviews long-lived assets for impairment annually or whenever an event or change in circumstance occurs in which the related carrying amounts may not be recoverable. An impairment loss would be recognized based on the difference between the carrying value of the asset and its estimated fair value, which would be determined based on either discounted future cash flows or other appropriate fair value methods. As of December 31, 2022 and 2021, the Company believes <span id="xdx_90B_eus-gaap--ImpairmentOfLongLivedAssetsHeldForUse_pn3n3_do_c20220101__20221231_zSBLypv2lSJ8" title="Impairment of Long-Lived Assets"><span id="xdx_904_eus-gaap--ImpairmentOfLongLivedAssetsHeldForUse_pn3n3_do_c20210101__20211231_zreRS5b4qR9g" title="Impairment of Long-Lived Assets">no</span></span> impairment existed.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">  </p> 0 0 <p id="xdx_847_eus-gaap--LesseeLeasesPolicyTextBlock_zkLdjWId9Pza" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_865_zX0Np5lYVmA1">Leases</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">At the inception of a contract, the Company determines whether the contract is or contains a lease based on all relevant facts and circumstances. For contracts that contain a lease, the Company identifies the lease and non-lease components, determines the consideration in the contract and recognizes the classification of the lease as operating or financing. For leases with a term greater than one year, the Company recognizes a liability to make lease payments and an asset representing the right to use the underlying asset during the lease term at the commencement date of the lease.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Lease liabilities and the corresponding right of use assets are recorded based on the present value of lease payments to be made over the lease term. The discount rate used to calculate the present value is the rate implicit in the lease, or if not readily determinable, the Company’s incremental borrowing rate. The Company’s incremental borrowing rate is the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. Certain adjustments to the right of use asset may be required for items such as initial direct costs or incentives received. Lease payments on operating leases, including scheduled increases, are recognized on a straight-line basis over the expected term of the lease. Lease payments on financing leases are recognized using the effective interest method.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p id="xdx_843_eus-gaap--DerivativesPolicyTextBlock_zPrJ2U49Dmwb" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_86E_z7HlP5WzQC3">Derivative Financial Instruments</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Financial instruments that meet the definition of a derivative are classified as an asset or liability and measured at fair value on the issuance date and are revalued on each subsequent balance sheet date. The changes in fair value are recognized as current period income or loss. Financial instruments that do not meet the definition of a derivative are classified as equity and measured at fair value and recorded as additional paid-in capital in stockholders’ equity at the date of issuance. No further adjustments to their valuation are made.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_849_eus-gaap--ResearchAndDevelopmentExpensePolicy_zsoXNmA50DJg" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_861_zW7KYNfOfjT5">Research and Development Expenses</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Research and development expenses relate to compensation and benefits for research and development personnel, facility-related expenses, supplies, external services, costs to acquire technology licenses, research activities under our research collaborations, expenses associated with preclinical and clinical development activities and other operating costs. Research and development expenses are charged to expense as incurred. Payments made by the Company in advance for research and development services not yet provided and/or for materials not yet received are recorded as prepaid expenses and expensed when the service has been performed or when the goods have been received.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Accrued liabilities are recorded related to those expenses for which vendors have not yet billed the Company with respect to services provided and/or materials that it has received. Accrued liabilities for the services provided by contract research organizations are recorded during the period incurred based on such estimates and assumptions as expected cost, passage of time, the achievement of milestones and other information available to us and are assessed on a quarterly basis. Actual results may differ from these estimates and could have a material impact on the Company’s reported results. The Company’s historical accrual estimates have not been materially different from its actual costs.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_84D_eus-gaap--CollaborativeArrangementAccountingPolicy_z5qk8fWgwJH7" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_866_zLXdwPRDZerh">Collaborative Arrangements</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company follows the provisions of the Financial Accounting Standards Board (the “<b>FASB</b>”) Accounting Standards Codification (“<b>ASC</b>”) Topic 808, “<i>Collaborative Arrangements</i>,” (“<b>Topic 808</b>”) when collaboration agreements involve joint operating activities in which both parties are active participants and that are also both exposed to significant risks and rewards. The Company also considers the guidance in the FASB ASC Topic 606, “<i>Revenue from Contracts with Customers</i>,” (“<b>Topic 606</b>”) in determining the appropriate treatment for activities between the Company and its collaborative partners that are more reflective of a vendor-customer relationship and therefore, within the scope of Topic 606. Under Topic 808, the Company determines an appropriate recognition method, either by analogy to appropriate accounting literature or by applying a reasonable accounting policy election. Generally, the classification of transactions under the collaborative arrangements is determined based on the nature and contractual terms of the arrangement along with the nature of the operations of the participants. The Company recognizes its share of costs arising from research and development activities performed by collaborators in the period its collaborators incur such expense. Payments or reimbursements that are the result of a collaborative relationship instead of a customer relationship, such as co-development activities, are evaluated on a quarterly basis and recorded as an offset to research and development expense incurred.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_84E_ecustom--PatentsAndPatentApplicationCostsPolicy_zC6lj5BkMGG4" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_867_zo3DjFxceLV2">Patents and Patent Application Costs</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Although the Company believes that its patents and underlying technology have continuing value, the amount of future benefits to be derived from the patents is uncertain. Patent costs are, therefore, expensed as general and administrative costs as incurred.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_845_eus-gaap--ShareBasedCompensationOptionAndIncentivePlansPolicy_zL2GxIOuWkid" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_869_zzjb1GY3EOde">Stock-based Compensation</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">The Company follows the provisions of the FASB ASC Topic 718, “<i>Compensation — Stock Compensation</i>” (“<b>ASC 718</b>”), which requires the measurement and recognition of compensation expense for all stock-based payment awards. The fair value of restricted stock units (“<b>RSUs</b>”) is based upon the Company’s closing stock price at the grant date. The Company uses the Black-Scholes option-pricing model to estimate the fair value of stock options at the grant date. The Black-Scholes valuation model requires the input of valuation assumptions to calculate the value of stock options, including expected volatility, expected term, risk-free interest rate and expected dividends. Stock-based compensation expense is recognized on a straight-line basis over the requisite service period, which generally represents the vesting period, and commences at the date of grant based on the fair value of the award.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Stock-based compensation expense recognized in the financial statements is based on awards that are ultimately expected to vest. Accordingly, we are also required to estimate forfeitures at the time of grant and to revise those estimates in subsequent periods if actual forfeitures differ from estimates. We use historical data to estimate pre-vesting award forfeitures and record stock-based compensation expense only for those awards that are expected to vest. Our forfeiture rate estimates are based on an analysis of our actual forfeiture experience, employee turnover behavior, and other factors. The impact of any adjustments to our forfeiture rates or to the extent that actual forfeitures differ from our estimates, is recorded as a cumulative adjustment in the period the estimates are revised.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_844_eus-gaap--IncomeTaxPolicyTextBlock_zSs2dKUvyrM7" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_864_zprpWW9Cnvle">Income Taxes</span></i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company recognizes assets or liabilities for the deferred tax consequences of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements in accordance with the FASB ASC Topic 740, <i>“Accounting for Income Taxes”</i> (“<b>ASC 740</b>”)<i>.</i> These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled. Those temporary differences referred to as deferred tax assets and liabilities are determined at the end of each period using the tax rate expected to be in effect when taxes are actually paid or recovered. Valuation allowances are established if, based on the weight of available evidence, it is more likely than not that all or a portion of a deferred tax asset will not be realized. The provision for income taxes, if any, represents the tax payable for the period and the change in deferred income tax assets and liabilities during the period.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_845_eus-gaap--ComprehensiveIncomePolicyPolicyTextBlock_zyA8XnklK211" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_860_z7jt7rqN9Mce">Comprehensive Loss</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company’s comprehensive loss is equal to its net loss for all periods presented.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_843_eus-gaap--EarningsPerSharePolicyTextBlock_z7IjHDZcvS5c" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i><span id="xdx_865_z7ZUp9H3Aa1c">Net Loss per Share</span> </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Basic net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding. Diluted net loss per share is computed by dividing the Company’s net loss by the weighted average number of common shares outstanding and the impact of all dilutive potential common shares outstanding, except where such dilutive potential common shares would be anti-dilutive. Dilutive potential common shares primarily consist of warrants, RSUs and stock options.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p id="xdx_84E_eus-gaap--NewAccountingPronouncementsPolicyPolicyTextBlock_zXpNDcRjaKWh" style="font: 10pt Times New Roman, Times, Serif; text-align: left; margin-top: 0pt; margin-bottom: 0pt"><i>Recent Accounting Pronouncements</i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In May 2021, the FASB issued Accounting Standards Update 2021-04, “<i>Earnings per Share (Topic 260), Debt – Modifications and Extinguishments (Subtopic 470-50), Compensation – Stock Compensation (Topic 718), and Derivatives and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40)</i>” (“<b>ASU 2021-04</b>”). The amendments in the updates are intended to clarify and reduce diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options that remain equity classified after modification or exchange. The amendments in ASU 2021-04 are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. An entity should apply the amendments prospectively to modifications or exchanges occurring on or after the effective date of the amendments. The Company adopted ASU 2021-04 on January 1, 2022. The adoption of this standard had no impact on the Company’s consolidated financial statements.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p id="xdx_806_eus-gaap--CollaborativeArrangementDisclosureTextBlock_zHe1P27kv009" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>2. <span id="xdx_828_zhVsf6bldi9c">Collaboration and License Agreements</span></b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>AgonOx, Inc. (“<b>AgonOx</b>”)</i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">In March 2021, the Company entered into a clinical co-development collaboration agreement (the “<b>Clinical Agreement</b>”) with AgonOx, a private company developing a pipeline of novel immunotherapy drugs targeting key regulators of the immune response to cancer. Under the Clinical Agreement, Phio and AgonOx are working to develop a T cell-based therapy using the Company’s lead product candidate, PH-762, and AgonOx’s “double positive” TIL (“<b>DP TIL</b>”) technology. Per the terms of the Clinical Agreement, the Company committed to make future payments of up to $<span id="xdx_90A_ecustom--TotalFuturePaymentsFromContractualObligations_iI_c20221231__us-gaap--TransactionTypeAxis__custom--AgonOxClinicalAgreementMember_zLR3rGUhalO4">4,000,000</span> to reimburse AgonOx for expenses incurred to support the Phase 1 clinical trial with the DP TIL technology and PH-762.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">The Company will recognize its share of costs arising from research and development activities performed by AgonOx in the Company’s financial statements in the period AgonOx incurs such expense. Phio will be entitled to certain future development milestones and low single-digit sales-based royalty payments from AgonOx’s licensing of its DP TIL technology. The Company recognized approximately $<span id="xdx_907_ecustom--ExpenseFromContractualObligations_c20220101__20221231__us-gaap--TransactionTypeAxis__custom--AgonOxClinicalAgreementMember_z2rcv2TcqdSb" title="Research and development expense">130,000</span> of expense in connection with these efforts during the year ended December 31, 2022. <span id="xdx_90A_ecustom--ExpenseFromContractualObligations_do_c20210101__20211231__us-gaap--TransactionTypeAxis__custom--AgonOxClinicalAgreementMember_za2s3N9bzOPe" title="Research and development expense">No</span> expense under the Clinical Agreement was recognized during the year ended December 31, 2021. <span style="background-color: white">There was approximately $<span id="xdx_90E_eus-gaap--PrepaidExpenseAndOtherAssets_iI_c20221231__us-gaap--TransactionTypeAxis__custom--AgonOxClinicalAgreementMember_zWOreuytdDJj" title="Prepayments from contractual obligations">120,000</span> recorded as prepaid expenses and other current assets as of December 31, 2022.</span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><span style="background-color: white"><i>Advanced RNA Technologies, LLC (“<b>Advirna</b>”)</i></span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"> </p><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">In September 2011, the Company entered into an agreement with Advirna, pursuant to which Advirna assigned to us its existing patent and technology rights related to the INTASYL technology in exchange for an annual maintenance fee of $<span id="xdx_906_ecustom--AnnualContractualObligation_iI_c20221231__srt--CounterpartyNameAxis__custom--AdvirnaMember_z5Bn6Ba4JIs">100,000</span>, a one-time milestone payment upon the future issuance of the first patent with valid claims covering the assigned patent and technology rights and the issuance of shares of common stock of the Company equal to <span id="xdx_90B_ecustom--PercentageOfIssuanceofCommonSharesFromContractualObligations_iI_dp_c20221231__srt--CounterpartyNameAxis__custom--AdvirnaMember_znaPSVzBlxo8">5</span>% of the Company’s fully-diluted shares outstanding at the time of issuance. The one-time milestone payment and the issuance of shares of common stock in the Company were completed in 2014 and 2012, respectively. Additionally, the Company is required to pay low single-digit royalties to Advirna on any licensing revenue received by the Company with respect to future licensing of the assigned Advirna patent and technology rights. To date, any royalties owed to Advirna under the agreement have been minimal.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Phio’s rights under the Advirna agreement will expire upon the later of: (i) the expiration of the last-to-expire of the “patent rights” (as defined therein) included in the agreement; or (ii) the abandonment of the last-to-be abandoned of such patents, unless earlier terminated in accordance with the provisions of the agreement. Further, the Company also granted back to Advirna a license under the assigned patent and technology rights for fields of use outside human therapeutics.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"/> 4000000 130000 0 120000 100000 0.05 <p id="xdx_807_eus-gaap--FairValueDisclosuresTextBlock_zCCwLdkqjPFf" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><span style="background-color: white"><b>3. <span id="xdx_82F_zO1JtRSDXzj1">Fair Value of Financial Instruments</span></b></span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in"><span style="background-color: white">The Company follows the provisions of the FASB ASC Topic 820, “<i>Fair Value Measurement</i>,” for the Company’s financial assets and liabilities that are re-measured and reported at fair value each reporting period and are re-measured and reported at fair value at least annually using a fair value hierarchy that is broken down into three levels. Level inputs are defined as follows:</span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><span style="background-color: white">Level 1 – quoted prices in active markets for identical assets or liabilities.</span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: left"><span style="background-color: white">Level 2 – other significant observable inputs for the assets or liabilities through corroboration with market data at the measurement date.</span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: left"><span style="background-color: white">Level 3 – significant unobservable inputs that reflect management’s best estimate of what market participants would use to price the assets or liabilities at the measurement date.</span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in"><span style="background-color: white">At December 31, 2022 and 2021, the Company categorized its restricted cash of $<span id="xdx_90B_eus-gaap--CashAndCashEquivalentsFairValueDisclosure_iI_c20221231__us-gaap--FairValueByFairValueHierarchyLevelAxis__us-gaap--FairValueInputsLevel2Member_zpwyXlItKt08" title="Cash and cash equivalents"><span id="xdx_901_eus-gaap--CashAndCashEquivalentsFairValueDisclosure_iI_c20211231__us-gaap--FairValueByFairValueHierarchyLevelAxis__us-gaap--FairValueInputsLevel2Member_zbs9DiumxIR5" title="Cash and cash equivalents">50,000</span></span> as Level 2 hierarchy. The assets classified as Level 2 have initially been valued at the applicable transaction price and subsequently valued, at the end of each reporting period, using other market observable data. Observable market data points include quoted prices, interest rates, reportable trades and other industry and economic events.</span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">The carrying amounts of cash, accounts payable and accrued expenses of the Company approximate their fair values due to their short-term nature.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> 50000 50000 <p id="xdx_803_eus-gaap--PropertyPlantAndEquipmentDisclosureTextBlock_z3MAlMjJfbld" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>4. <span id="xdx_82D_zAiYEqy5ZXsl">Property and Equipment</span></b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table summarizes the Company’s major classes of property and equipment, in thousands:</p> <table cellpadding="0" cellspacing="0" id="xdx_88C_eus-gaap--PropertyPlantAndEquipmentTextBlock_pn3n3_ziUalDynVCi8" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Property and Equipment (Details - Schedule of Property and Equipment)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8BA_zaTCmlst5hCi" style="display: none">Schedule of property and equipment</span></td><td> </td> <td colspan="2" id="xdx_49F_20221231_z0IumiXUNPIi" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" id="xdx_495_20211231_z253fm7hxywi" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr id="xdx_40B_eus-gaap--PropertyPlantAndEquipmentOther_iI_pn3n3_maPPAEGzsX6_z7SfFkc4UaT1" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 62%; text-align: left">Computer equipment</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 16%; text-align: right">116</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 16%; text-align: right">108</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_402_eus-gaap--MachineryAndEquipmentGross_iI_pn3n3_maPPAEGzsX6_zsFzbCz9hji1" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Machinery &amp; equipment</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,077</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,035</td><td style="text-align: left"> </td></tr> <tr id="xdx_403_eus-gaap--FurnitureAndFixturesGross_iI_pn3n3_maPPAEGzsX6_z99bGzSZV6m4" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Furniture &amp; fixtures</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">119</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">49</td><td style="text-align: left"> </td></tr> <tr id="xdx_40C_eus-gaap--LeaseholdImprovementsGross_iI_pn3n3_maPPAEGzsX6_zXNSNlA2jI4c" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Leasehold improvements</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">46</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">46</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_409_eus-gaap--PropertyPlantAndEquipmentGross_iTI_pn3n3_mtPPAEGzsX6_maPPAENz7bd_zpq52XWpuFyb" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Total gross fixed assets</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,358</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,238</td><td style="text-align: left"> </td></tr> <tr id="xdx_401_eus-gaap--AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_iNI_pn3n3_di_msPPAENz7bd_zLCFuGqvAQf8" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Less: accumulated depreciation and amortization</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(1,175</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(1,105</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_401_eus-gaap--PropertyPlantAndEquipmentNet_iTI_pn3n3_mtPPAENz7bd_zOOyniufbCue" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 2.5pt; text-indent: 0.25in">Property and equipment, net</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">183</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">133</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Depreciation and amortization expense for the years ended December 31, 2022 and 2021 was $<span id="xdx_905_eus-gaap--Depreciation_c20220101__20221231_z69utCfpMxok">71,000</span> and $<span id="xdx_905_eus-gaap--Depreciation_c20210101__20211231_zm0KlGWD5R32">75,000</span>, respectively.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <table cellpadding="0" cellspacing="0" id="xdx_88C_eus-gaap--PropertyPlantAndEquipmentTextBlock_pn3n3_ziUalDynVCi8" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Property and Equipment (Details - Schedule of Property and Equipment)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8BA_zaTCmlst5hCi" style="display: none">Schedule of property and equipment</span></td><td> </td> <td colspan="2" id="xdx_49F_20221231_z0IumiXUNPIi" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" id="xdx_495_20211231_z253fm7hxywi" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr id="xdx_40B_eus-gaap--PropertyPlantAndEquipmentOther_iI_pn3n3_maPPAEGzsX6_z7SfFkc4UaT1" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 62%; text-align: left">Computer equipment</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 16%; text-align: right">116</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 16%; text-align: right">108</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_402_eus-gaap--MachineryAndEquipmentGross_iI_pn3n3_maPPAEGzsX6_zsFzbCz9hji1" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Machinery &amp; equipment</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,077</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,035</td><td style="text-align: left"> </td></tr> <tr id="xdx_403_eus-gaap--FurnitureAndFixturesGross_iI_pn3n3_maPPAEGzsX6_z99bGzSZV6m4" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Furniture &amp; fixtures</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">119</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">49</td><td style="text-align: left"> </td></tr> <tr id="xdx_40C_eus-gaap--LeaseholdImprovementsGross_iI_pn3n3_maPPAEGzsX6_zXNSNlA2jI4c" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Leasehold improvements</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">46</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">46</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_409_eus-gaap--PropertyPlantAndEquipmentGross_iTI_pn3n3_mtPPAEGzsX6_maPPAENz7bd_zpq52XWpuFyb" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Total gross fixed assets</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,358</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,238</td><td style="text-align: left"> </td></tr> <tr id="xdx_401_eus-gaap--AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_iNI_pn3n3_di_msPPAENz7bd_zLCFuGqvAQf8" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Less: accumulated depreciation and amortization</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(1,175</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(1,105</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_401_eus-gaap--PropertyPlantAndEquipmentNet_iTI_pn3n3_mtPPAENz7bd_zOOyniufbCue" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 2.5pt; text-indent: 0.25in">Property and equipment, net</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">183</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">133</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> 116000 108000 1077000 1035000 119000 49000 46000 46000 1358000 1238000 1175000 1105000 183000 133000 71000 75000 <p id="xdx_801_eus-gaap--AccountsPayableAndAccruedLiabilitiesDisclosureTextBlock_zsdJG7jDsgol" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>5. <span id="xdx_82C_zA7v7DK3ZOV9">Accrued Expenses</span> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Accrued expenses consist of the following, in thousands:</p> <table cellpadding="0" cellspacing="0" id="xdx_889_eus-gaap--ScheduleOfAccruedLiabilitiesTableTextBlock_pn3n3_zHSA1PxWytZi" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Accrued Expenses (Details - Schedule of Accrued Expenses)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8B7_zRU6WTKI1m6h" style="display: none">Schedule of accrued expenses and other current liabilities</span></td> <td> </td> <td> </td> <td id="xdx_498_20221231_zWJDFgmIqulj" style="text-align: center"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_49B_20211231_zcUhj2daLHd8" style="text-align: center"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="6" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>December 31,</b></span></td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2022</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2021</b></span></td> <td> </td></tr> <tr id="xdx_40E_eus-gaap--EmployeeRelatedLiabilitiesCurrent_iI_pn3n3_maALCzQOj_zv2vNByLRKpe" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 62%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Compensation and benefits</span></td> <td style="width: 1%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="width: 16%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">408</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="width: 16%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">572</span></td> <td style="width: 1%"> </td></tr> <tr id="xdx_40C_eus-gaap--AccruedProfessionalFeesCurrent_iI_pn3n3_maALCzQOj_zCcxbZkgpIV" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Professional fees</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">97</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">102</span></td> <td> </td></tr> <tr id="xdx_40E_ecustom--AccruedResearchAndDevelopmentExpenses_iI_pn3n3_maALCzQOj_zWirLMoR9jub" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Research and development costs</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">501</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1,986</span></td> <td> </td></tr> <tr id="xdx_40C_eus-gaap--OtherAccruedLiabilitiesCurrent_iI_pn3n3_d0_maALCzQOj_zUQw23kHM47l" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Other</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">19</span></td> <td> </td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr id="xdx_408_eus-gaap--AccruedLiabilitiesCurrent_iTI_pn3n3_mtALCzQOj_zMnwjB9dWev1" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total accrued expenses </span></td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1,025</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2,660</span></td> <td> </td></tr> </table> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <table cellpadding="0" cellspacing="0" id="xdx_889_eus-gaap--ScheduleOfAccruedLiabilitiesTableTextBlock_pn3n3_zHSA1PxWytZi" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Accrued Expenses (Details - Schedule of Accrued Expenses)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8B7_zRU6WTKI1m6h" style="display: none">Schedule of accrued expenses and other current liabilities</span></td> <td> </td> <td> </td> <td id="xdx_498_20221231_zWJDFgmIqulj" style="text-align: center"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_49B_20211231_zcUhj2daLHd8" style="text-align: center"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="6" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>December 31,</b></span></td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2022</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2021</b></span></td> <td> </td></tr> <tr id="xdx_40E_eus-gaap--EmployeeRelatedLiabilitiesCurrent_iI_pn3n3_maALCzQOj_zv2vNByLRKpe" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 62%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Compensation and benefits</span></td> <td style="width: 1%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="width: 16%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">408</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="width: 16%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">572</span></td> <td style="width: 1%"> </td></tr> <tr id="xdx_40C_eus-gaap--AccruedProfessionalFeesCurrent_iI_pn3n3_maALCzQOj_zCcxbZkgpIV" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Professional fees</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">97</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">102</span></td> <td> </td></tr> <tr id="xdx_40E_ecustom--AccruedResearchAndDevelopmentExpenses_iI_pn3n3_maALCzQOj_zWirLMoR9jub" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Research and development costs</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">501</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1,986</span></td> <td> </td></tr> <tr id="xdx_40C_eus-gaap--OtherAccruedLiabilitiesCurrent_iI_pn3n3_d0_maALCzQOj_zUQw23kHM47l" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Other</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">19</span></td> <td> </td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr id="xdx_408_eus-gaap--AccruedLiabilitiesCurrent_iTI_pn3n3_mtALCzQOj_zMnwjB9dWev1" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="text-indent: 0.25in"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total accrued expenses </span></td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">1,025</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2,660</span></td> <td> </td></tr> </table> 408000 572000 97000 102000 501000 1986000 19000 0 1025000 2660000 <p id="xdx_80F_eus-gaap--LesseeOperatingLeasesTextBlock_zdpIEs4BswZ" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>6. <span id="xdx_829_zkIu9qKCu3Z7">Leases</span></b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">In January 2019, the Company amended the lease for its corporate headquarters and primary research facility in Marlborough, Massachusetts. The lease is for a total of <span id="xdx_90B_eus-gaap--AreaOfRealEstateProperty_iI_pip0_uArea_c20221231__us-gaap--PropertySubjectToOrAvailableForOperatingLeaseAxis__us-gaap--PropertySubjectToOperatingLeaseMember_zHCO6nilmO5" title="Operating lease footage">7,581</span> square feet of office and laboratory space and will expire on <span id="xdx_90F_eus-gaap--LeaseExpirationDate1_dd_c20220101__20221231__us-gaap--PropertySubjectToOrAvailableForOperatingLeaseAxis__us-gaap--PropertySubjectToOperatingLeaseMember_ziYopvGDtCx2" title="Lease expiration date">March 31, 2024</span>. The lease contains an option to terminate after two or three years by providing advance written notice of termination pursuant to the terms of the agreement. The exercise of this option was not determined to be reasonably certain and thus was not included in the lease liability on the Company’s balance sheet. The Company did not exercise its option to terminate in either the second or third year of the lease, and the option to terminate has expired. Additionally, the lease agreement did not contain information to determine the borrowing rate implicit in the lease. As such, the Company calculated its incremental borrowing rate based on what the Company would have to pay to borrow on a collateralized basis over the lease term for an amount equal to the remaining lease payments, taking into consideration such assumptions as, but not limited to, the U.S. treasury yield rate and borrowing rates from a creditworthy financial institution using the above lease factors.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The lease for our corporate headquarters represents all of our significant lease obligations. The amounts reported in the consolidated balance sheets for operating leases in which the Company is the lessee and other supplemental balance sheet information is set forth as follows, in thousands, except the lease term (number of years) and discount rate:</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <table cellpadding="0" cellspacing="0" id="xdx_89B_ecustom--SupplementalBalanceSheetInformationRelatedToOperatingLeasesTableTextBlock_pn3n3_z67Dhnce2mHc" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Leases (Details - Balance sheet lease items)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B3_zgHw3zisvCo1" style="display: none">Schedule of lease amounts recorded in balance sheet</span></td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="font-weight: bold">Assets</td><td> </td> <td colspan="2" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 62%; text-align: left; padding-bottom: 2.5pt">Right of use asset</td><td style="width: 1%; padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; width: 1%; text-align: left">$</td><td id="xdx_98A_eus-gaap--OperatingLeaseRightOfUseAsset_iI_pn3n3_c20221231_zB7zGGFqbHke" style="border-bottom: Black 2.5pt double; width: 16%; text-align: right" title="Right of use asset">161</td><td style="width: 1%; padding-bottom: 2.5pt; text-align: left"> </td><td style="width: 1%; padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; width: 1%; text-align: left">$</td><td id="xdx_983_eus-gaap--OperatingLeaseRightOfUseAsset_c20211231_pn3n3" style="border-bottom: Black 2.5pt double; width: 16%; text-align: right" title="Right of use asset">283</td><td style="width: 1%; padding-bottom: 2.5pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="font-weight: bold">Liabilities</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Lease liability, current</td><td> </td> <td style="text-align: left"> </td><td id="xdx_98F_eus-gaap--OperatingLeaseLiabilityCurrent_iI_pn3n3_c20221231_zrbwsWT3ldZf" style="text-align: right" title="Lease liability, current">135</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td id="xdx_98F_eus-gaap--OperatingLeaseLiabilityCurrent_c20211231_pn3n3" style="text-align: right" title="Lease liability, current">125</td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Lease liability, non-current</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_986_eus-gaap--OperatingLeaseLiabilityNoncurrent_iI_pn3n3_c20221231_zmddAsMNYKki" style="border-bottom: Black 1pt solid; text-align: right" title="Lease liability, non-current">35</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_98B_eus-gaap--OperatingLeaseLiabilityNoncurrent_c20211231_pn3n3" style="border-bottom: Black 1pt solid; text-align: right" title="Lease liability, non-current">170</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total lease liability</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98F_eus-gaap--OperatingLeaseLiability_iI_pn3n3_c20221231_zhr3obAqQTof" style="border-bottom: Black 2.5pt double; text-align: right" title="Total lease liability">170</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_986_eus-gaap--OperatingLeaseLiability_c20211231_pn3n3" style="border-bottom: Black 2.5pt double; text-align: right" title="Total lease liability">295</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="font-weight: bold; text-align: left">Lease Term and Discount Rate</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td>Weighted average remaining lease term</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_903_eus-gaap--OperatingLeaseWeightedAverageRemainingLeaseTerm1_iI_dtY_c20221231_zzJRIrlBskYb" title="Weighted average remaining lease term">1.25</span></td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_908_eus-gaap--OperatingLeaseWeightedAverageRemainingLeaseTerm1_iI_dtY_c20211231_zomLVtM3wkS4" title="Weighted average remaining lease term">2.25</span></td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td>Weighted average discount rate</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_904_eus-gaap--OperatingLeaseWeightedAverageDiscountRatePercent_iI_pip0_dp_c20221231_zAJ2xTjvSwg2" title="Operating Lease, Weighted Average Discount Rate, Percent">4.70</span>%</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_900_eus-gaap--OperatingLeaseWeightedAverageDiscountRatePercent_iI_pip0_dp_c20211231_zS64CqbfnDof" title="Operating Lease, Weighted Average Discount Rate, Percent">4.70</span>%</td><td style="text-align: left"> </td></tr> </table> <p id="xdx_8AE_zsYSn6YxhhP8" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Operating lease costs included in operating expense were $<span id="xdx_904_eus-gaap--OperatingLeaseCost_c20220101__20221231_z8unyRCeqjN6"><span id="xdx_904_eus-gaap--OperatingLeaseCost_c20210101__20211231_zEvrCSObGSK4">132,000</span></span> for the years ended December 31, 2022 and 2021, respectively.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">  </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Cash paid for the amounts included in the measurement of the operating lease liability on the Company’s consolidated balance sheets and included within changes in the lease liability in the operating activities of our consolidated statements of cash flows was $<span id="xdx_907_eus-gaap--OperatingLeasePayments_c20220101__20221231_zQjr5LNgwIX5" title="Operating lease payments">135,000</span> and $<span id="xdx_90A_eus-gaap--OperatingLeasePayments_c20210101__20211231_zmo4nhyXcOJ1" title="Operating lease payments">132,000</span> for the years ended December 31, 2022 and 2021, respectively.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Future lease payments for our non-cancellable operating leases and a reconciliation to the carrying amount of the operating lease liability presented in the consolidated balance sheet as of December 31, 2022 is as follows, in thousands:</p> <table cellpadding="0" cellspacing="0" id="xdx_897_eus-gaap--LesseeOperatingLeaseLiabilityMaturityTableTextBlock_pn3n3_zu6dCC0KlXu1" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 65%; margin-right: auto" summary="xdx: Disclosure - Leases (Details - Future lease payments)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B0_zkYgGX6KDcrj" style="display: none">Aggregate future minimum lease payments</span></td><td> </td> <td colspan="2" id="xdx_496_20221231_zRzliToVrILc" style="text-align: center"> </td><td> </td></tr> <tr id="xdx_406_eus-gaap--LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_iI_pn3n3_maLOLLPzFxX_zzFs2UzvrBgb" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 79%; text-align: left">2023</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 18%; text-align: right">140</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_404_eus-gaap--LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_iI_pn3n3_maLOLLPzFxX_zALOfCbMXFra" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">2024</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">35</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_401_eus-gaap--LesseeOperatingLeaseLiabilityPaymentsDue_iTI_pn3n3_mtLOLLPzFxX_zUkZOdr5IL04" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Total lease payments</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">175</td><td style="text-align: left"> </td></tr> <tr id="xdx_402_eus-gaap--LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_iNI_pn3n3_di_zQ2o4iXMSwK5" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Less: Imputed interest</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(5</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_401_eus-gaap--OperatingLeaseLiability_iI_pn3n3" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 2.5pt">Total operating lease liabilities (includes current portion)</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">170</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <p id="xdx_8A2_zshdhhgenNL6" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> 7581 2024-03-31 <table cellpadding="0" cellspacing="0" id="xdx_89B_ecustom--SupplementalBalanceSheetInformationRelatedToOperatingLeasesTableTextBlock_pn3n3_z67Dhnce2mHc" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Leases (Details - Balance sheet lease items)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B3_zgHw3zisvCo1" style="display: none">Schedule of lease amounts recorded in balance sheet</span></td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="font-weight: bold">Assets</td><td> </td> <td colspan="2" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="width: 62%; text-align: left; padding-bottom: 2.5pt">Right of use asset</td><td style="width: 1%; padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; width: 1%; text-align: left">$</td><td id="xdx_98A_eus-gaap--OperatingLeaseRightOfUseAsset_iI_pn3n3_c20221231_zB7zGGFqbHke" style="border-bottom: Black 2.5pt double; width: 16%; text-align: right" title="Right of use asset">161</td><td style="width: 1%; padding-bottom: 2.5pt; text-align: left"> </td><td style="width: 1%; padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; width: 1%; text-align: left">$</td><td id="xdx_983_eus-gaap--OperatingLeaseRightOfUseAsset_c20211231_pn3n3" style="border-bottom: Black 2.5pt double; width: 16%; text-align: right" title="Right of use asset">283</td><td style="width: 1%; padding-bottom: 2.5pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="font-weight: bold">Liabilities</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Lease liability, current</td><td> </td> <td style="text-align: left"> </td><td id="xdx_98F_eus-gaap--OperatingLeaseLiabilityCurrent_iI_pn3n3_c20221231_zrbwsWT3ldZf" style="text-align: right" title="Lease liability, current">135</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td id="xdx_98F_eus-gaap--OperatingLeaseLiabilityCurrent_c20211231_pn3n3" style="text-align: right" title="Lease liability, current">125</td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Lease liability, non-current</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_986_eus-gaap--OperatingLeaseLiabilityNoncurrent_iI_pn3n3_c20221231_zmddAsMNYKki" style="border-bottom: Black 1pt solid; text-align: right" title="Lease liability, non-current">35</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_98B_eus-gaap--OperatingLeaseLiabilityNoncurrent_c20211231_pn3n3" style="border-bottom: Black 1pt solid; text-align: right" title="Lease liability, non-current">170</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Total lease liability</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98F_eus-gaap--OperatingLeaseLiability_iI_pn3n3_c20221231_zhr3obAqQTof" style="border-bottom: Black 2.5pt double; text-align: right" title="Total lease liability">170</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_986_eus-gaap--OperatingLeaseLiability_c20211231_pn3n3" style="border-bottom: Black 2.5pt double; text-align: right" title="Total lease liability">295</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="font-weight: bold; text-align: left">Lease Term and Discount Rate</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td>Weighted average remaining lease term</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_903_eus-gaap--OperatingLeaseWeightedAverageRemainingLeaseTerm1_iI_dtY_c20221231_zzJRIrlBskYb" title="Weighted average remaining lease term">1.25</span></td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_908_eus-gaap--OperatingLeaseWeightedAverageRemainingLeaseTerm1_iI_dtY_c20211231_zomLVtM3wkS4" title="Weighted average remaining lease term">2.25</span></td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td>Weighted average discount rate</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_904_eus-gaap--OperatingLeaseWeightedAverageDiscountRatePercent_iI_pip0_dp_c20221231_zAJ2xTjvSwg2" title="Operating Lease, Weighted Average Discount Rate, Percent">4.70</span>%</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_900_eus-gaap--OperatingLeaseWeightedAverageDiscountRatePercent_iI_pip0_dp_c20211231_zS64CqbfnDof" title="Operating Lease, Weighted Average Discount Rate, Percent">4.70</span>%</td><td style="text-align: left"> </td></tr> </table> 161000 283000 135000 125000 35000 170000 170000 295000 P1Y3M P2Y3M 0.0470 0.0470 132000 132000 135000 132000 <table cellpadding="0" cellspacing="0" id="xdx_897_eus-gaap--LesseeOperatingLeaseLiabilityMaturityTableTextBlock_pn3n3_zu6dCC0KlXu1" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 65%; margin-right: auto" summary="xdx: Disclosure - Leases (Details - Future lease payments)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B0_zkYgGX6KDcrj" style="display: none">Aggregate future minimum lease payments</span></td><td> </td> <td colspan="2" id="xdx_496_20221231_zRzliToVrILc" style="text-align: center"> </td><td> </td></tr> <tr id="xdx_406_eus-gaap--LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_iI_pn3n3_maLOLLPzFxX_zzFs2UzvrBgb" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 79%; text-align: left">2023</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 18%; text-align: right">140</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_404_eus-gaap--LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_iI_pn3n3_maLOLLPzFxX_zALOfCbMXFra" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">2024</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">35</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_401_eus-gaap--LesseeOperatingLeaseLiabilityPaymentsDue_iTI_pn3n3_mtLOLLPzFxX_zUkZOdr5IL04" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Total lease payments</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">175</td><td style="text-align: left"> </td></tr> <tr id="xdx_402_eus-gaap--LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_iNI_pn3n3_di_zQ2o4iXMSwK5" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">Less: Imputed interest</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(5</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_401_eus-gaap--OperatingLeaseLiability_iI_pn3n3" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 2.5pt">Total operating lease liabilities (includes current portion)</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">170</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> 140000 35000 175000 5000 170000 <p id="xdx_80A_eus-gaap--DebtDisclosureTextBlock_zbwnUNPPqnBc" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>7. <span id="xdx_820_zJqxZ9CpJjdk">Debt</span></b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white">In May 2020, the Company received loan proceeds pursuant to the Paycheck Protection Program (the “<b>PPP</b>”) under the Coronavirus Aid, Relief, and Economic Security Act. The Company followed the guidance under the FASB ASC Topic 470, “<i>Debt</i>,” (“<b>ASC 470</b>”) in assessing the accounting for the PPP loan proceeds. Per ASC 470, the Company recorded a liability on the balance sheet for the full amount of the PPP loan proceeds received and accrued interest over the term of the loan. The Company believed it used the loan proceeds for eligible purposes and applied for full loan forgiveness. In February 2021, the Small Business Administration approved the Company’s application for full loan forgiveness, and the full amount of the PPP loan was remitted to the lender for forgiveness. Upon loan forgiveness, the Company recognized a gain on the extinguishment of debt of $<span id="xdx_907_eus-gaap--GainsLossesOnExtinguishmentOfDebt_pn3n3_c20210101__20211231__us-gaap--LongtermDebtTypeAxis__custom--PppLoanMember_z9xu48dB4Ou3" title="Gain on loan extinguishment">233</span>,000 for the loan proceeds received and interest accrued in the consolidated statements of operations for the year ended December 31, 2021.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; background-color: white"> </p> 233000 <p id="xdx_80E_eus-gaap--CommitmentsAndContingenciesDisclosureTextBlock_zvZj8FrBAUx9" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>8. <span id="xdx_820_zIHriogDFWx4">Commitments and Contingencies</span> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Commitments </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">In March 2021, the Company entered into a Clinical Agreement with AgonOx to develop a T cell-based therapy using the Company’s lead product candidate, PH-762, and AgonOx’s DP TIL technology. Per the terms of the Clinical Agreement, the Company committed to make future payments of up to $<span id="xdx_904_ecustom--TotalFuturePaymentsFromContractualObligations_iI_c20221231__srt--CounterpartyNameAxis__custom--AgonOxMember_z5HoR9TGEhNk" title="Total future payments from contractual obligations">4,000,000</span> to reimburse AgonOx for expenses incurred to support the Phase 1 clinical trial with the DP TIL technology and PH-762. Refer to Note 2 for further details on the Clinical Agreement with AgonOx.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company applies the disclosure provisions of the FASB ASC Topic 460, “<i>Guarantor’s Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others</i>” (“<b>ASC 460</b>”), to its agreements that contain guarantee or indemnification clauses. The Company provides: (i) indemnifications of varying scope and size to certain investors and other parties for certain losses suffered or incurred by the indemnified party in connection with various types of third-party claims; and (ii) indemnifications of varying scope and size to officers and directors against third-party claims arising from the services they provide to us. These indemnifications give rise only to the disclosure provisions of ASC 460. To date, the Company has not incurred costs as a result of these obligations and does not expect to incur material costs in the future. Accordingly, the Company has not accrued any liabilities in its consolidated financial statements related to these indemnifications.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Refer to Note 6 for more information about the Company’s obligations under its non-cancellable lease for its corporate headquarters.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>License Commitments </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As part of its business, the Company enters into licensing agreements with third parties that often require milestone and royalty payments based on the progress of the asset through development stages. Milestone payments may be required, for example, upon progress through clinical trials, upon approval of the product by a regulatory agency and/or upon a percentage of sales of the product pursuant to such agreements. The expenditures required under these arrangements may be material individually in relation to any product candidates covered by the intellectual property licensed under any such arrangement, and material in the aggregate in the unlikely event that milestones for multiple products covered by these arrangements were reached in the same period. Due to the contingent nature of these payments, they are not included in the table of contractual obligations shown below.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">During the years ended December 31, 2022 and 2021, the Company did <span id="xdx_908_ecustom--MilestonePayments_do_c20220101__20221231_zWTAKO2iowG7"><span id="xdx_909_ecustom--MilestonePayments_do_c20210101__20211231_zOHfusTgNGI5">no</span></span>t trigger any milestone payments.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left; text-indent: 0.5in">The Company’s contractual license obligations that will require future cash payments as of December 31, 2022, which result from payments expected in connection with annual license fees, are as follows, in thousands:</p> <table cellpadding="0" cellspacing="0" id="xdx_882_esrt--ContractualObligationFiscalYearMaturityScheduleTableTextBlock_pn3n3_zRJBSz1Xk3Bh" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 65%; margin-right: auto" summary="xdx: Disclosure - Commitments and Contingencies - (Details - Future Cash Payments)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8BE_z7RqjL3kA8d7" style="display: none">Schedule of future cash payments for contractual license obligations</span></td> <td> </td> <td> </td> <td id="xdx_495_20221231_zUJ0RQpeEKQg" style="text-align: center"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td colspan="5"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Year Ending December 31,</span></td></tr> <tr id="xdx_40E_eus-gaap--ContractualObligationDueInNextTwelveMonths_iI_pn3n3_maCOzIQW_z8bFyC4knwLl" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 79%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2023</span></td> <td style="width: 1%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="width: 18%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td style="width: 1%"> </td></tr> <tr id="xdx_40D_eus-gaap--ContractualObligationDueInSecondYear_iI_pn3n3_maCOzIQW_zAL8ouPxbRKi" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2024</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td> </td></tr> <tr id="xdx_40F_eus-gaap--ContractualObligationDueInThirdYear_iI_pn3n3_maCOzIQW_zZzizfuqrof6" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2025</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td> </td></tr> <tr id="xdx_40A_eus-gaap--ContractualObligationDueInFourthYear_iI_pn3n3_maCOzIQW_zb1WJb77Zp93" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2026</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td> </td></tr> <tr id="xdx_40E_eus-gaap--ContractualObligationDueInFifthYear_iI_pn3n3_maCOzIQW_zJEH13r4CxBh" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2027</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td> </td></tr> <tr id="xdx_40A_eus-gaap--ContractualObligationDueAfterFifthYear_iI_pn3n3_maCOzIQW_zH3bP3IChQik" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Thereafter</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">200</span></td> <td> </td></tr> <tr id="xdx_406_eus-gaap--ContractualObligation_iTI_pn3n3_mtCOzIQW_zxW4YRHlDXaj" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">700</span></td> <td> </td></tr> </table> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Litigation</i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">From time to time, the Company may become a party to various legal proceedings and complaints arising in the ordinary course of business. To the Company’s knowledge, it is not currently a party to any actual or threatened material legal proceedings. Accordingly, there were <span id="xdx_909_eus-gaap--LossContingencyLossInPeriod_do_c20220101__20221231_zUN0B7dNL7h7" title="Contingent liabilities">no</span> contingent liabilities recorded as of the year ended December 31, 2022.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> 4000000 0 0 <table cellpadding="0" cellspacing="0" id="xdx_882_esrt--ContractualObligationFiscalYearMaturityScheduleTableTextBlock_pn3n3_zRJBSz1Xk3Bh" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 65%; margin-right: auto" summary="xdx: Disclosure - Commitments and Contingencies - (Details - Future Cash Payments)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8BE_z7RqjL3kA8d7" style="display: none">Schedule of future cash payments for contractual license obligations</span></td> <td> </td> <td> </td> <td id="xdx_495_20221231_zUJ0RQpeEKQg" style="text-align: center"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td colspan="5"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Year Ending December 31,</span></td></tr> <tr id="xdx_40E_eus-gaap--ContractualObligationDueInNextTwelveMonths_iI_pn3n3_maCOzIQW_z8bFyC4knwLl" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 79%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2023</span></td> <td style="width: 1%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="width: 18%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td style="width: 1%"> </td></tr> <tr id="xdx_40D_eus-gaap--ContractualObligationDueInSecondYear_iI_pn3n3_maCOzIQW_zAL8ouPxbRKi" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2024</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td> </td></tr> <tr id="xdx_40F_eus-gaap--ContractualObligationDueInThirdYear_iI_pn3n3_maCOzIQW_zZzizfuqrof6" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2025</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td> </td></tr> <tr id="xdx_40A_eus-gaap--ContractualObligationDueInFourthYear_iI_pn3n3_maCOzIQW_zb1WJb77Zp93" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2026</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td> </td></tr> <tr id="xdx_40E_eus-gaap--ContractualObligationDueInFifthYear_iI_pn3n3_maCOzIQW_zJEH13r4CxBh" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2027</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">100</span></td> <td> </td></tr> <tr id="xdx_40A_eus-gaap--ContractualObligationDueAfterFifthYear_iI_pn3n3_maCOzIQW_zH3bP3IChQik" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Thereafter</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">200</span></td> <td> </td></tr> <tr id="xdx_406_eus-gaap--ContractualObligation_iTI_pn3n3_mtCOzIQW_zxW4YRHlDXaj" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">700</span></td> <td> </td></tr> </table> 100000 100000 100000 100000 100000 200000 700000 0 <p id="xdx_805_eus-gaap--TemporaryEquityTableTextBlock_z1lWAh7tmG3a" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>9. <span id="xdx_823_zSP5elPVPTH">Preferred Stock</span></b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company has authorized up to <span id="xdx_901_eus-gaap--PreferredStockSharesAuthorized_iI_pip0_c20221231_zhxDCsIhHbEk" title="Preferred stock, shares authorized">10,000,000</span> shares of preferred stock, $<span id="xdx_90F_eus-gaap--PreferredStockParOrStatedValuePerShare_iI_pip0_c20221231_zRRhCw2RFrah" title="Preferred stock, par value">0.0001</span> par value per share, for issuance. The Company’s Board of Directors is authorized under the Company’s Amended and Restated Articles of Incorporation, to designate the authorized preferred stock into one or more series and to fix and determine such rights, preferences, privileges and restrictions of any series of preferred stock, including voting rights, dividend rights, conversion rights, redemption privileges and liquidation preferences, as shall be determined by the Company’s Board of Directors upon its issuance. At December 31, 2022, the Company had designated <span id="xdx_90A_eus-gaap--TemporaryEquitySharesAuthorized_iI_dxL_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--SeriesDPreferredStockMember_z1qfnVyUO398" title="::XDX::1"><span style="-sec-ix-hidden: xdx2ixbrl0641">one</span></span> share of preferred stock as Series D Preferred Stock and the remaining authorized shares were undesignated.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">On November 16, 2022, the Company issued and sold <span id="xdx_907_ecustom--TemporaryEquityStockIssuedDuringPeriodSharesNewIssues_dxL_c20221115__20221116__us-gaap--StatementClassOfStockAxis__us-gaap--SeriesDPreferredStockMember_zHn3mPvrPz8b" title="::XDX::1"><span style="-sec-ix-hidden: xdx2ixbrl0642">one</span></span> share of the Company’s Series D Preferred Stock, par value $<span id="xdx_905_eus-gaap--TemporaryEquityParOrStatedValuePerShare_iI_c20221116__us-gaap--StatementClassOfStockAxis__us-gaap--SeriesDPreferredStockMember_zctbcV61119j">0.0001</span> per share (the “<b>Series D Preferred Stock</b>”) to Robert Bitterman, then its interim Executive Chairman and current Chief Executive Officer, for $<span id="xdx_903_eus-gaap--TemporaryEquityStockIssuedDuringPeriodValueNewIssues_c20221101__20221116__us-gaap--StatementClassOfStockAxis__us-gaap--SeriesDPreferredStockMember__srt--CounterpartyNameAxis__custom--RobertBittermanMember_ziLoZ7E7AX9b" title="Sale of preferred stock, value">1,750</span>. The Series D Preferred Stock was entitled to <span id="xdx_906_ecustom--TemporaryEquityVotingRights_iI_c20221116__us-gaap--StatementClassOfStockAxis__us-gaap--SeriesDPreferredStockMember_zMRIeOvk0Vu8" title="Series D Preferred Stock voting rights">17,500,000</span> votes per share exclusively with respect to any proposal to amend the Company’s Amended and Restated Certificate of Incorporation (as may be amended and/or restated from time to time, the “<b>Amended Certificate</b>”) to effect a reverse stock split of the Company’s common stock (“<b>Reverse Stock Split</b>”). The terms of the Series D Preferred Stock provided that it would be voted, without action by the holder, on any such proposal in the same proportion as shares of the Company’s common stock were voted. The Series D Preferred Stock otherwise had no voting rights except as otherwise required by the General Corporation Law of the State of Delaware.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">The Series D Preferred Stock was not convertible into, or exchangeable for, shares of any other class or series of stock or other securities of the Company. The Series D Preferred Stock had no rights with respect to any distribution of assets of the Company, including upon a liquidation, bankruptcy, reorganization, merger, acquisition, sale, dissolution or winding up of the Company, whether voluntarily or involuntarily. The holder of the Series D Preferred Stock was not entitled to receive dividends of any kind.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">Under its terms, the outstanding share of Series D Preferred Stock was to be redeemed in whole, but not in part, at any time: (i) if such redemption was approved by the Board of Directors in its sole discretion or (ii) automatically and effective upon the approval by the Company's stockholders of a Reverse Stock Split. Upon such redemption, the holder of the Series D Preferred Stock was entitled to receive consideration of $<span id="xdx_90C_eus-gaap--TemporaryEquityAggregateAmountOfRedemptionRequirement_iI_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--SeriesDPreferredStockMember_zOwb2YDi57Be">1,750</span> in cash.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Series D Preferred Stock has been classified outside of permanent equity (within the mezzanine section between liabilities and equity on the balance sheets) as the Company may not be able to control the actions necessary to provide for a redemption in full of the then outstanding Series D Preferred Stock.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Series D Preferred Stock was redeemed in whole on January 4, 2023, upon the approval by the Company’s stockholders of a Reverse Stock Split.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b> </b></p> 10000000 0.0001 0.0001 1750 17500000 1750 <p id="xdx_80E_eus-gaap--StockholdersEquityNoteDisclosureTextBlock_zTGjenacZbx4" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>10. <span id="xdx_822_zrIcgWYsXS96">Stockholders’ Equity</span> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><i>January 2021 Private Placement</i> <i>—</i> In January 2021, the Company completed a private placement of <span id="xdx_907_eus-gaap--StockIssuedDuringPeriodSharesNewIssues_pip0_c20210101__20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember_zpjMaz7d2pQc">368,405</span> shares of the Company’s common stock at a purchase price per share of $<span id="xdx_900_eus-gaap--SharesIssuedPricePerShare_iI_pip0_c20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember_z5j0aCfcGl14">36.84</span>, pre-funded warrants to purchase an aggregate of <span id="xdx_903_ecustom--WarrantsIssuedNewShares_iI_pip0_c20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember__us-gaap--StatementClassOfStockAxis__custom--Jan2021PreFundedWarrantsMember_zwBizUT4ual3">11,672</span> shares of the Company’s common stock at a purchase price per pre-funded warrant of $<span id="xdx_909_eus-gaap--SharesIssuedPricePerShare_iI_pip0_c20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember__us-gaap--StatementClassOfStockAxis__custom--Jan2021PreFundedWarrantsMember_z2imxZ5pbXJ3">36.828</span> and warrants to purchase an aggregate of <span id="xdx_90D_ecustom--WarrantsIssuedNewShares_iI_pip0_c20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember__us-gaap--StatementClassOfStockAxis__custom--Jan2021WarrantsMember_zV6s1hiJZb59">285,061</span> shares of the Company’s common stock with an exercise price of $<span id="xdx_90D_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember__us-gaap--StatementClassOfStockAxis__custom--Jan2021WarrantsMember_zonDZofMbRw6">36.00</span> per warrant (the “<b>Private Placement</b>”). In connection with the Private Placement, the Company issued warrants to the placement agent, H.C. Wainwright &amp; Co., LLC (“<b>HCW</b>”), to purchase a total of <span id="xdx_90A_ecustom--WarrantsIssuedNewShares_iI_pip0_c20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember__us-gaap--StatementClassOfStockAxis__custom--Jan2021PlacementAgentWarrantsMember_zz1ElqbIR2s8">28,509</span> shares of the Company’s common stock at an exercise price of $<span id="xdx_90A_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember__us-gaap--StatementClassOfStockAxis__custom--Jan2021PlacementAgentWarrantsMember_zHazWVcID1kl">46.05</span> per warrant. Net proceeds to the Company from the Private Placement were $<span id="xdx_905_eus-gaap--ProceedsFromIssuanceOrSaleOfEquity_c20210101__20210131__us-gaap--SecuritiesFinancingTransactionAxis__custom--Jan2021PrivatePlacementMember_zzIIPyOM612l">12,669,000</span> after deducting placement agent fees and offering expenses.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><i>February 2021 Registered Direct Offering —</i> In February 2021, the Company completed a registered direct offering of <span id="xdx_900_eus-gaap--StockIssuedDuringPeriodSharesNewIssues_pip0_c20210201__20210228__us-gaap--SecuritiesFinancingTransactionAxis__custom--Feb2021RegisteredDirectOfferingMember_zYfss4N7NfK5" title="Stock Issued During Period, Shares, New Issues">187,232</span> shares of the Company’s common stock at a purchase price of $<span id="xdx_901_eus-gaap--SharesIssuedPricePerShare_iI_pip0_c20210228__us-gaap--SecuritiesFinancingTransactionAxis__custom--Feb2021RegisteredDirectOfferingMember_zHBS1ZpVhBk1">41.04</span> per share (the “<b>Offering</b>”). In connection with the Offering, the Company issued warrants to the placement agent, HCW, to purchase a total of <span id="xdx_909_ecustom--WarrantsIssuedNewShares_iI_c20210228__us-gaap--SecuritiesFinancingTransactionAxis__custom--Feb2021RegisteredDirectOfferingMember__us-gaap--StatementClassOfStockAxis__custom--Feb2021PlacementAgentWarrantsMember_zATk0Dy8fxU9">14,044</span> shares of the Company’s common stock at an exercise price of $<span id="xdx_901_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20210228__us-gaap--SecuritiesFinancingTransactionAxis__custom--Feb2021RegisteredDirectOfferingMember__us-gaap--StatementClassOfStockAxis__custom--Feb2021PlacementAgentWarrantsMember_zvhA49AYJlnl">51.30</span> per warrant. Net proceeds to the Company from the Offering were $<span id="xdx_904_eus-gaap--ProceedsFromIssuanceOrSaleOfEquity_c20210201__20210228__us-gaap--SecuritiesFinancingTransactionAxis__custom--Feb2021RegisteredDirectOfferingMember_zH19ZsZOam2b">6,908,000</span> after deducting placement agent fees and offering expenses.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Warrants</i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company first assesses the warrants it issues under the FASB ASC Topic 480, “<i>Distinguishing Liabilities from Equity</i>” (“<b>ASC 480</b>”) to determine whether they are within the scope of ASC 480. As there are no instances outside of the Company’s control that could require cash settlement from the warrants issued by the Company, the outstanding warrants are outside the scope of ASC 480.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company then applies and follows the applicable accounting guidance in the FASB ASC Topic 815, “<i>Derivatives and Hedging.</i>” Financial instruments are accounted for as either derivative liabilities or equity instruments depending on the specific terms of the agreement. The warrants issued by the Company do not meet the definition of a derivative instrument as they are indexed to the Company’s common stock and classified within stockholders’ equity. Based on this determination, the Company’s warrants are classified within stockholders’ equity.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table summarizes the Company’s outstanding equity-classified warrants at December 31, 2022:</p> <table cellpadding="0" cellspacing="0" id="xdx_881_eus-gaap--ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_zam9jGG05rI4" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Stockholders' Equity (Details - Warrants outstanding)"> <tr style="vertical-align: bottom"> <td style="width: 28%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  <span id="xdx_8B1_zLsMAIN8YMnc" style="display: none">Summary of outstanding warrants</span></span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td colspan="2" style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Exercise</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Expiration</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Balance December 31,</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Warrants</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Warrants</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Warrants</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><span style="font-size: 9pt"><b>Balance</b></span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><span style="font-size: 9pt"><b>December 31,</b></span></p></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Description</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Price</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Date</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>2021</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Issued</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Exercised</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Expired</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>2022</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">April 2018 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98E_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zaick93VXW3f" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">2,079.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90B_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zrBpZ4qYSxyc" title="Warrant expiration date">5/31/2023</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zJJYHS4q98n7" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,720</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zNC5Qdl7PlJ6" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98E_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zwU3VCm7E7Dh" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zxIPWcKwCypd" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_z7ctKe1P8dOl" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,720</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">April 2018 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_985_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zdN6QOTZSur6" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">2,676.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_904_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_z5B09wIlg1ma" title="Warrant expiration date">4/9/2023</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zVrEWe5mu31k" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">117</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_985_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zdcXpOpSiE15" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98C_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zvVFE8rhT561" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98E_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_z1eZfFMlE5X1" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zzv2jEEvTLza" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">117</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">October 2018 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zxfDj59Xu3Xe" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">125.40</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90D_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zt1ZF5wBxptg" title="Warrant expiration date">10/3/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_985_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zZcRUaazRwSi" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">32,486</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zKhQOZQuPFOh" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zxsXy3j1ZSsa" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zykyuOH53uL3" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zBaMQTPCGp54" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">32,486</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">October 2018 Underwriter Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98A_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zcuJzziUu7Z3" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">156.72</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_903_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_znB927mOnZmc" title="Warrant expiration date">10/1/2023</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zCmXgg93s7p" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">2,438</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zvFDnHB6RPm3" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zlMyIyXlnAEb" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zdsvwJIBpJW4" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_z6Ergtc7wudl" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">2,438</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">November 2019 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98F_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zVStpOOE7qBb" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">82.50</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90B_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zLlROYODxzx1" title="Warrant expiration date">11/18/2024</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zDjeBUaCgE" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,138</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zJbzV4QxCmzc" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zlYSnzuSSZfa" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zfwKeXkLmgw3" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zgRkgxKxjM58" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,138</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2020 Registered Direct Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_986_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zJV96V5Ocrs8" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">104.52</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_903_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zSGZRYiBoAYk" title="Warrant expiration date">8/6/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zi8STT7lSrk" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">16,425</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_984_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zGcdOAi5vW9c" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98E_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zoA0UV8q7wz2" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zGDipjVKDDFj" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zjA8J819hHG5" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">16,425</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2020 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98E_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zmhgU3PgTd5c" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">132.45</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90E_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zOE7SerJdw27" title="Warrant expiration date">2/4/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_986_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zRuW3QsFu0xi" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,233</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98A_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zEKsQPXlCwG3" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_985_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zGTN9bSqs2d8" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zhbzdscPCIu5" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zUd5SODBoNXl" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,233</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2020 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_989_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_zkDt0Hn6NSud" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">48.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_907_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_zvaeZpNQ7Xhk" title="Warrant expiration date">2/13/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_z6WIZFJ7Bv6" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">110,557</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_zgOXGDwyzhx9" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_z2du4CxGxeHh" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_zscUmlkPOiQ5" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_z8OJLyXGB0Kf" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">110,557</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2020 Underwriter Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zS6csbHomWZ4" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">60.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_905_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_z3HJf9VSAJB2" title="Warrant expiration date">2/11/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zeLOpukLyf61" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">12,501</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zkaoxEq0lDLh" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zDoBv4gR3Zk9" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zEEVlujekIJl" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zgigec8v0tc5" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">12,501</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">April 2020 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_989_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zcDTYsZuOj04" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">26.52</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_902_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zvy6oU9qLIgg" title="Warrant expiration date">10/2/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zUTCOt0YbSP1" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">35,691</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zhieCyMPQ1Oe" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zn9fhlVNFEXa" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zmdBdDo1suzi" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zfje31tv1Ge2" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">35,691</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">April 2020 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_983_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zuvy7ZjYRtSf" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">35.0256</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_903_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zlEE7pkAI5ej" title="Warrant expiration date">3/31/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_znP3QTqNUAL2" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">3,481</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zKaP5dcKrrK" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_ztnSwrA0S5gk" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_985_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zEJzziEV5S86" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zddF8k7jCrok" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">3,481</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">January 2021 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98C_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zrrixBeuIvwk" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">36.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_905_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zAVTD8o2KlEg" title="Warrant expiration date">7/27/2026</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zmXeotMGkA66" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">285,061</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zgijRn7fFaWd" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_986_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zOGQ9MWlFpU7" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zm4bpsgXJZa9" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zerYKm4xQGC1" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">285,061</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">January 2021 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zjkSbBiQ8OOf" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">46.05</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90F_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zWrYC0YU5bL5" title="Warrant expiration date">7/27/2026</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_z8NsORU9m863" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">28,509</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zMI84cHKfR99" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98E_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zWTFeTYIzsp2" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zfeXTsXWe0P7" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zyGwPMWjNkz2" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">28,509</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2021 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zJLRRcEpBu9j" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">51.30</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_906_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zUTMzjhnHaO5" title="Warrant expiration date">2/12/2026</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zabGfkeoaiYi" style="border-bottom: black 1pt solid; text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">14,044</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zGwi6PeYuKgk" style="border-bottom: black 1pt solid; text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zKw08DAidjBa" style="border-bottom: black 1pt solid; text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98C_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_z33H9fMJNn53" style="border-bottom: black 1pt solid; text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98C_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_z6yjnQlT5lw1" style="border-bottom: black 1pt solid; text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">14,044</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_zEAJStTANBIb" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">545,401</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_zjqJL4m3HNo9" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98C_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_z62Fri31tWeb" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_zwQlWGfPZj26" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_zL8to2GzD52j" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">545,401</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> </table> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"><span id="xdx_90D_ecustom--WarrantsExercisedShares_do_c20220101__20221231_ztV2FJ3zQhE1" title="Warrants exercised shares">No</span> warrants were exercised during the year ended December 31, 2022. The Company received net proceeds of $<span id="xdx_903_eus-gaap--ProceedsFromWarrantExercises_pn3n3_c20210101__20211231_zDJKJqO3ZbBg" title="Proceeds from Warrant Exercises">2,146</span>,000 from the exercise of warrants during the year ended December 31, 2021.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b> </b></p> 368405 36.84 11672 36.828 285061 36.00 28509 46.05 12669000 187232 41.04 14044 51.30 6908000 <table cellpadding="0" cellspacing="0" id="xdx_881_eus-gaap--ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_zam9jGG05rI4" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Stockholders' Equity (Details - Warrants outstanding)"> <tr style="vertical-align: bottom"> <td style="width: 28%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  <span id="xdx_8B1_zLsMAIN8YMnc" style="display: none">Summary of outstanding warrants</span></span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 9%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td colspan="2" style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Exercise</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Expiration</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Balance December 31,</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Warrants</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Warrants</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Warrants</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><span style="font-size: 9pt"><b>Balance</b></span></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><span style="font-size: 9pt"><b>December 31,</b></span></p></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Description</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Price</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Date</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>2021</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Issued</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Exercised</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>Expired</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><b>2022</b></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">April 2018 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98E_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zaick93VXW3f" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">2,079.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90B_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zrBpZ4qYSxyc" title="Warrant expiration date">5/31/2023</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zJJYHS4q98n7" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,720</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zNC5Qdl7PlJ6" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98E_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zwU3VCm7E7Dh" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_zxIPWcKwCypd" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018WarrantsMember_z7ctKe1P8dOl" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,720</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">April 2018 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_985_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zdN6QOTZSur6" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">2,676.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_904_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_z5B09wIlg1ma" title="Warrant expiration date">4/9/2023</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zVrEWe5mu31k" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">117</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_985_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zdcXpOpSiE15" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98C_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zvVFE8rhT561" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98E_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_z1eZfFMlE5X1" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2018PlacementAgentWarrantsMember_zzv2jEEvTLza" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">117</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">October 2018 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zxfDj59Xu3Xe" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">125.40</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90D_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zt1ZF5wBxptg" title="Warrant expiration date">10/3/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_985_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zZcRUaazRwSi" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">32,486</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zKhQOZQuPFOh" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zxsXy3j1ZSsa" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zykyuOH53uL3" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018WarrantsMember_zBaMQTPCGp54" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">32,486</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">October 2018 Underwriter Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98A_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zcuJzziUu7Z3" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">156.72</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_903_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_znB927mOnZmc" title="Warrant expiration date">10/1/2023</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zCmXgg93s7p" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">2,438</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zvFDnHB6RPm3" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zlMyIyXlnAEb" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_zdsvwJIBpJW4" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--October2018UnderwriterWarrantsMember_z6Ergtc7wudl" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">2,438</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">November 2019 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98F_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zVStpOOE7qBb" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">82.50</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90B_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zLlROYODxzx1" title="Warrant expiration date">11/18/2024</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zDjeBUaCgE" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,138</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zJbzV4QxCmzc" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zlYSnzuSSZfa" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zfwKeXkLmgw3" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Nov2019PlacementAgentWarrantsMember_zgRkgxKxjM58" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,138</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2020 Registered Direct Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_986_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zJV96V5Ocrs8" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">104.52</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_903_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zSGZRYiBoAYk" title="Warrant expiration date">8/6/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zi8STT7lSrk" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">16,425</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_984_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zGcdOAi5vW9c" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98E_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zoA0UV8q7wz2" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zGDipjVKDDFj" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020RegisteredDirectWarrantsMember_zjA8J819hHG5" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">16,425</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2020 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98E_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zmhgU3PgTd5c" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">132.45</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90E_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zOE7SerJdw27" title="Warrant expiration date">2/4/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_986_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zRuW3QsFu0xi" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,233</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98A_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zEKsQPXlCwG3" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_985_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zGTN9bSqs2d8" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zhbzdscPCIu5" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020PlacementAgentWarrantsMember_zUd5SODBoNXl" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">1,233</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2020 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_989_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_zkDt0Hn6NSud" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">48.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_907_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_zvaeZpNQ7Xhk" title="Warrant expiration date">2/13/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_z6WIZFJ7Bv6" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">110,557</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_zgOXGDwyzhx9" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_z2du4CxGxeHh" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_zscUmlkPOiQ5" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020WarrantsMember_z8OJLyXGB0Kf" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">110,557</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2020 Underwriter Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zS6csbHomWZ4" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">60.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_905_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_z3HJf9VSAJB2" title="Warrant expiration date">2/11/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zeLOpukLyf61" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">12,501</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zkaoxEq0lDLh" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zDoBv4gR3Zk9" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_987_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zEEVlujekIJl" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--Feb2020UnderwriterWarrantsMember_zgigec8v0tc5" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">12,501</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">April 2020 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_989_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zcDTYsZuOj04" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">26.52</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_902_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zvy6oU9qLIgg" title="Warrant expiration date">10/2/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zUTCOt0YbSP1" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">35,691</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zhieCyMPQ1Oe" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zn9fhlVNFEXa" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zmdBdDo1suzi" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020WarrantsMember_zfje31tv1Ge2" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">35,691</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">April 2020 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_983_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zuvy7ZjYRtSf" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">35.0256</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_903_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zlEE7pkAI5ej" title="Warrant expiration date">3/31/2025</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_znP3QTqNUAL2" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">3,481</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zKaP5dcKrrK" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_989_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_ztnSwrA0S5gk" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_985_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zEJzziEV5S86" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--April2020PlacementAgentWarrantsMember_zddF8k7jCrok" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">3,481</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">January 2021 Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98C_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zrrixBeuIvwk" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">36.00</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_905_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zAVTD8o2KlEg" title="Warrant expiration date">7/27/2026</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zmXeotMGkA66" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">285,061</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zgijRn7fFaWd" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_986_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zOGQ9MWlFpU7" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zm4bpsgXJZa9" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021WarrantsMember_zerYKm4xQGC1" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">285,061</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">January 2021 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zjkSbBiQ8OOf" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">46.05</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_90F_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zWrYC0YU5bL5" title="Warrant expiration date">7/27/2026</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_z8NsORU9m863" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">28,509</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zMI84cHKfR99" style="text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98E_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zWTFeTYIzsp2" style="text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zfeXTsXWe0P7" style="text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_982_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--January2021PlacementAgentWarrantsMember_zyGwPMWjNkz2" style="text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">28,509</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">February 2021 Placement Agent Warrants</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">$ </span></td> <td id="xdx_980_eus-gaap--ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zJLRRcEpBu9j" style="text-align: right" title="Warrant exercise price"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">51.30</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt"><span id="xdx_906_ecustom--ClassOfWarrantOrRightsDateFromWhichWarrantsOrRightsExpire_dd_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zUTMzjhnHaO5" title="Warrant expiration date">2/12/2026</span></span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zabGfkeoaiYi" style="border-bottom: black 1pt solid; text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">14,044</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_988_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zGwi6PeYuKgk" style="border-bottom: black 1pt solid; text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_981_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_zKw08DAidjBa" style="border-bottom: black 1pt solid; text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98C_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_z33H9fMJNn53" style="border-bottom: black 1pt solid; text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98C_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember__us-gaap--AwardTypeAxis__custom--February2021PlacementAgentWarrantsMember_z6yjnQlT5lw1" style="border-bottom: black 1pt solid; text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">14,044</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98D_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20211231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_zEAJStTANBIb" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">545,401</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98F_ecustom--WarrantsIssuedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_zjqJL4m3HNo9" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants issued"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98C_ecustom--WarrantsExercisedShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_z62Fri31tWeb" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_983_ecustom--WarrantsExpiredShares_d0_c20220101__20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_zwQlWGfPZj26" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants expired"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">– </span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td> <td id="xdx_98B_eus-gaap--ClassOfWarrantOrRightOutstanding_iI_pip0_c20221231__us-gaap--StatementClassOfStockAxis__us-gaap--WarrantMember_zL8to2GzD52j" style="border-bottom: black 2.25pt double; text-align: right" title="Warrants outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">545,401</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 9pt">  </span></td></tr> </table> 2079.00 2023-05-31 1720 0 0 0 1720 2676.00 2023-04-09 117 0 0 0 117 125.40 2025-10-03 32486 0 0 0 32486 156.72 2023-10-01 2438 0 0 0 2438 82.50 2024-11-18 1138 0 0 0 1138 104.52 2025-08-06 16425 0 0 0 16425 132.45 2025-02-04 1233 0 0 0 1233 48.00 2025-02-13 110557 0 0 0 110557 60.00 2025-02-11 12501 0 0 0 12501 26.52 2025-10-02 35691 0 0 0 35691 35.0256 2025-03-31 3481 0 0 0 3481 36.00 2026-07-27 285061 0 0 0 285061 46.05 2026-07-27 28509 0 0 0 28509 51.30 2026-02-12 14044 0 0 0 14044 545401 0 0 0 545401 0 2146000 <p id="xdx_804_eus-gaap--DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_zfxNakX1o5yl" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>11. <span id="xdx_828_zZvZ4PokZXud">Stock-based Compensation</span> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Stock Plans </i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">The Company’s approved equity plans include the Phio Pharmaceuticals Corp. 2020 Long Term Incentive Plan (the “<b>2020 Plan</b>”) and the Phio Pharmaceuticals Corp. 2012 Long Term Incentive Plan (the “<b>2012 Plan</b>”). These plans are administered by our Board of Directors and provide for the grant of incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock awards, RSU awards, performance stock awards, and performance cash awards. Upon adoption of the 2020 Plan, shares that remained available for grant under the 2012 Plan and shares that were subject to outstanding awards under the 2012 Plan were included in the authorized shares available for grant under the 2020 Plan. Further, upon adoption of the 2020 Plan, the Company no longer grants new equity awards under the 2012 Plan.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As of December 31, 2022, there were an aggregate of <span id="xdx_905_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_iI_pip0_c20221231__us-gaap--PlanNameAxis__custom--Plan2020Member_zzCLnCT4Ywdc">105,640 </span>shares of common stock reserved under the 2020 Plan, including <span id="xdx_902_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iI_pip0_c20221231__us-gaap--PlanNameAxis__custom--Plan2020Member__us-gaap--AwardTypeAxis__custom--StockOptionsMember_zrqfgk6Nk6Nh">141 </span>shares subject to outstanding stock options and <span id="xdx_903_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_iI_pip0_c20221231__us-gaap--PlanNameAxis__custom--Plan2020Member__us-gaap--AwardTypeAxis__custom--UnvestedRSUMember_zIi0YdBAm3zf">47,328 </span>shares subject to unvested RSUs and <span id="xdx_906_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_iI_pip0_c20221231__us-gaap--PlanNameAxis__custom--Plan2020Member__us-gaap--AwardTypeAxis__custom--SharesAvailableForFutureGrantsMember_zDGew79OnX8h">43,807 </span>shares available for future grants. RSUs granted by the Company to employees vest annually over 3 years after the grant date, stock options granted by the Company to employees generally vest annually over 4 years after the grant date and, in the instance of stock options, expire within ten years of issuance.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Restricted Stock Units</i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">RSUs are issued under the 2020 Plan or as inducement grants issued outside of the 2020 Plan to new employees. RSUs are generally subject to graded vesting and the satisfaction of service requirements. Upon vesting, each outstanding RSU will be settled for one share of the Company’s common stock. Employee RSU recipients may elect to net share settle upon vesting, in which case the Company pays the employee’s income taxes due upon vesting and withholds a number of shares of equal value. The fair value of the RSUs awarded are based upon the Company’s closing stock price at the grant date and are expensed over the requisite service period.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table summarizes the activity of the Company’s RSUs for the year ended December 31, 2022:</p> <table cellpadding="0" cellspacing="0" id="xdx_89E_eus-gaap--ScheduleOfShareBasedCompensationRestrictedStockUnitsAwardActivityTableTextBlock_z16A8CocPJQ" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; width: 80%; border-collapse: collapse; margin-right: auto" summary="xdx: Disclosure - Stock-based Compensation (Details - RSU activity)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8B9_z9Se2qNzSvwf" style="display: none">Summary of RSU activity</span></td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Number<br/> of Shares</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Weighted-<br/> Average<br/> Grant Date Fair Value<br/> Per Share</b></span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 60%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Unvested units at December 31, 2021</span></td> <td style="width: 2%"> </td> <td style="width: 1%"> </td> <td id="xdx_98C_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_iS_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zjtePJVf5U08" style="width: 16%; text-align: right" title="RSU's unvested units, beginning balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">30,592</span></td> <td style="width: 1%"> </td> <td style="width: 2%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_98F_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_iS_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zc4s8HQNntDj" style="width: 16%; text-align: right" title="RSU beginning balance, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">38.52</span></td> <td style="width: 1%"> </td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Granted</span></td> <td> </td> <td> </td> <td id="xdx_985_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zGzPGgq87Ccj" style="text-align: right" title="RSU's granted"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">61,250</span></td> <td> </td> <td> </td> <td> </td> <td id="xdx_980_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_z94CbW22DGLc" style="text-align: right" title="RSU's granted, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">10.08</span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Vested</span></td> <td> </td> <td> </td> <td id="xdx_98E_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_iN_pip0_di_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zltIEa2dGWJe" style="text-align: right" title="RSU's vested"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(14,043</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td> </td> <td> </td> <td id="xdx_984_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_z6fr7LowSkid" style="text-align: right" title="RSU's vested, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">39.72</span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Forfeited</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td id="xdx_98F_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_iN_pip0_di_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zNNedoWhrEx9" style="border-bottom: black 1pt solid; text-align: right" title="RSU's forfeited"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(30,471</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">) </span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td id="xdx_988_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_ztznRXCOsOZc" style="border-bottom: black 1pt solid; text-align: right" title="RSU's forfeited, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">17.40</span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Unvested units at December 31, 2022</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"> </td> <td id="xdx_989_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_iE_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zG5dh0jSyuA8" style="border-bottom: black 2.25pt double; text-align: right" title="RSU's unvested units, ending balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">47,328</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_983_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_iE_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zBvouTIvaDrj" style="border-bottom: black 2.25pt double; text-align: right" title="RSU ending balance, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">15.00</span></td> <td> </td></tr> </table> <p id="xdx_8AF_zk8Ud367JNw7" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">The weighted-average fair value of RSUs granted during the years ended December 31, 2022 and 2021 was $<span id="xdx_903_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zihtVAffgyh9">10.08</span> and $<span id="xdx_905_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_c20210101__20211231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zmkuSPt4Dgga">35.28</span>, respectively.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Stock-based compensation expense related to RSUs was $<span id="xdx_90C_eus-gaap--ShareBasedCompensation_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zo3ktoRpG87d" title="Share-based compensation expense">401,000</span> and $<span id="xdx_901_eus-gaap--ShareBasedCompensation_c20210101__20211231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zbNomGEsxAG7" title="Share-based compensation expense">443,000</span> for the years ended December 31, 2022 and 2021, respectively.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">  </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The aggregate fair value of awards that vested during the years ended December 31, 2022 and 2021 was $<span id="xdx_904_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_z5AMmxTbS8lk">138,000</span> and $<span id="xdx_903_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_c20210101__20211231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zMwnNeh5WjX1">9,000</span>, which represents the market value of the Company’s common stock on the date that the RSUs vested.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As of December 31, 2022, the compensation expense for all unvested RSUs in the amount of approximately $<span id="xdx_900_eus-gaap--EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_iI_c20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zLTk22xJbnw6" title="Unrecognized share-based compensation expense">458,000</span> will be recognized in the Company’s results of operations over a weighted average period of <span id="xdx_90E_eus-gaap--EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_dtY_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zPt9SYiGWuWb">1.60</span> years.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Stock Options</i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i> </i></p><p style="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">Stock options are available for issuance under the 2020 Plan or as inducement grants issued outside of the 2020 Plan to new employees. Stock options are generally subject to graded vesting and the satisfaction of service requirements. Upon the exercise of a stock option, the Company issues new shares and delivers them to the recipient. The Company does not expect to repurchase shares to satisfy stock option exercises.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company uses the Black-Scholes option-pricing model to determine the fair value of all its option grants. The risk-free interest rate used for each grant was based upon the yield on zero-coupon U.S. Treasury securities with a term similar to the expected life of the related option. The Company’s expected stock price volatility assumption is based upon the Company’s own implied volatility. As the Company has limited stock option exercise information, the expected life assumption used for option grants is based upon the simplified method provided for under ASC 718. The dividend yield assumption is based upon the fact that the Company has never paid cash dividends and presently has no intention of paying cash dividends.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company did not grant stock options during the years ended December 31, 2022 and 2021. The following table summarizes the activity of the Company’s stock option plan for the year ended December 31, 2022:</p> <table cellpadding="0" cellspacing="0" id="xdx_89C_eus-gaap--ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_pn3n3_zVRts6DLq2wa" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Stock-based Compensation (Details - Option activity)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8B8_zXQQnnaSFIQl" style="display: none">Summary of Stock Option Activity</span></td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Total Number<br/> of Shares</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Weighted-<br/> Average<br/> Exercise<br/> Price<br/> Per Share</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Weighted-<br/> Average<br/> Remaining<br/> Contractual<br/> Term</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Aggregate<br/> Intrinsic<br/> Value</b></span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 36%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Balance at December 31, 2021</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td id="xdx_987_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iS_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zbAi4DOqzN1j" style="width: 13%; text-align: right" title="Options outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">208</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_98A_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_iS_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_z7JZ0siBpPh5" style="width: 13%; text-align: right" title="Weighted-Average Exercise Price Per Share, Beginning Balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">40,822.80</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 13%; text-align: right"> </td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 13%; text-align: right"> </td> <td style="width: 1%"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Granted</span></td> <td> </td> <td> </td> <td id="xdx_987_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_pip0_d0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zt5q27JaDXcj" style="text-align: right" title="Options granted"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td id="xdx_98F_eus-gaap--ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_pip0_d0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zKqiSNOmX5Tb" style="text-align: right" title="Weighted-Average Exercise Price per Share, Granted"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Exercised</span></td> <td> </td> <td> </td> <td id="xdx_98A_eus-gaap--StockIssuedDuringPeriodSharesStockOptionsExercised_pip0_d0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_znm5R1iitoF6" style="text-align: right" title="Options exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td id="xdx_987_eus-gaap--ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_pip0_d0_c20220101__20221231__us-gaap--AwardTypeAxis__custom--StockOptionsMember_zYmgvS03tNJd" style="text-align: right" title="Weighted-Average Exercise Price Per Share, Exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td>Unvested shares cancelled</td> <td> </td> <td> </td> <td id="xdx_981_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_iN_pip0_di_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember__us-gaap--VestingAxis__custom--UnvestedSharesMember_zhcaMTKiQEB6" style="text-align: right" title="Options cancelled">(6</td> <td>)</td> <td> </td> <td> </td> <td id="xdx_980_eus-gaap--ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zkXA6L0cHHr3" style="text-align: right" title="Weighted-Average Exercise Price per Share, Options Unvested, Shares Cancelled">1,181.40</td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Vested shares cancelled</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td id="xdx_980_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_iN_pip0_di_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember__us-gaap--VestingAxis__custom--VestedSharesMember_zJJKCz5SmRd6" style="border-bottom: black 1pt solid; text-align: right" title="Options cancelled"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(61</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td id="xdx_983_eus-gaap--ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zIqNPulxz2r8" style="border-bottom: black 1pt solid; text-align: right" title="Weighted-Average Exercise Price per Share, Options Vested, Shares Cancelled"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">93,016.68</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Balance at December 31, 2022</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"> </td> <td id="xdx_98E_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iE_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zh6lwrDUy87d" style="border-bottom: black 2.25pt double; text-align: right" title="Options outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">141</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_987_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_iE_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_z8pJRRMX5SF3" style="border-bottom: black 2.25pt double; text-align: right" title="Weighted-Average Exercise Price Per Share, Ending Balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">19,761.12</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><span id="xdx_90C_eus-gaap--SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_dtY_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zzyEVyvFynu9" title="Weighted-Average Contractual Term, Outstanding">5.18</span> years</span></td> <td> </td> <td> </td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_985_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_iI_pn3n3_d0_c20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zTjJPjqrWVP5" style="text-align: right" title="Aggregate Intrinsic Value, Ending Balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Exercisable at December 31, 2022</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"> </td> <td id="xdx_98A_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_iI_pip0_c20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zIGxvihWLwcd" style="border-bottom: black 2.25pt double; text-align: right" title="Options exercisable"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">141</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_98F_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_iI_pip0_c20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zfbDxvKnwVx" style="border-bottom: black 2.25pt double; text-align: right" title="Weighted-Average Exercise Price Per Share, Exercisable"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">19,761.12</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><span id="xdx_90E_eus-gaap--SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_dtY_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zjRmhobbczU5" title="Weighted-Average Contractual Term, Exercisable">5.18</span> years</span></td> <td> </td> <td> </td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_986_eus-gaap--SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_iI_pn3n3_d0_c20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zuFVtxsVRB3f" style="text-align: right" title="Aggregate Intrinsic Value, Exercisable"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> </table> <p id="xdx_8A6_zRmFPUgL7HM1" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Stock-based compensation expense related to stock options for the years ended December 31, 2022 and 2021 was $<span id="xdx_909_eus-gaap--ShareBasedCompensation_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zGQYFv0FaPQh" title="Share-based compensation expense">13,000</span> and $<span id="xdx_902_eus-gaap--ShareBasedCompensation_c20210101__20211231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_z1JxAh2qRwRa" title="Share-based compensation expense">37,000</span>, respectively.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As of December 31, 2022, the compensation expense for all unvested stock options was recognized in the Company’s results of operations.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">There is no income tax benefit as the Company is currently operating at a loss and an actual income tax benefit may not be realized.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><i>Compensation Expense Related to Equity Awards</i></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table sets forth total stock-based compensation expense for the years ended December 31, 2022 and 2021, in thousands:</p> <table cellpadding="0" cellspacing="0" id="xdx_89D_eus-gaap--ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_pn3n3_zXWGVVoZmq1j" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Stock-based Compensation (Details - Share-based compensation)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B8_zOloQRiysNna" style="display: none">Details of Stock-based Compensation Expense</span></td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 62%; text-align: left">Research and development</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98D_eus-gaap--ShareBasedCompensation_pn3n3_c20220101__20221231__us-gaap--IncomeStatementLocationAxis__us-gaap--ResearchAndDevelopmentExpenseMember_zrHgHvIfYOf1" style="width: 16%; text-align: right" title="Total stock-based compensation">154</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_987_eus-gaap--ShareBasedCompensation_c20210101__20211231__us-gaap--IncomeStatementLocationAxis__us-gaap--ResearchAndDevelopmentExpenseMember_pn3n3" style="width: 16%; text-align: right" title="Total stock-based compensation">117</td><td style="width: 1%; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">General and administrative</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_985_eus-gaap--ShareBasedCompensation_pn3n3_c20220101__20221231__us-gaap--IncomeStatementLocationAxis__us-gaap--GeneralAndAdministrativeExpenseMember_zBKGl59gG5Xh" style="border-bottom: Black 1pt solid; text-align: right" title="Total stock-based compensation">260</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_987_eus-gaap--ShareBasedCompensation_c20210101__20211231__us-gaap--IncomeStatementLocationAxis__us-gaap--GeneralAndAdministrativeExpenseMember_pn3n3" style="border-bottom: Black 1pt solid; text-align: right" title="Total stock-based compensation">363</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left; padding-bottom: 2.5pt">Total stock-based compensation</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_985_eus-gaap--ShareBasedCompensation_pn3n3_c20220101__20221231_zfvId6IpIAZ2" style="border-bottom: Black 2.5pt double; text-align: right" title="Total stock-based compensation">414</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98D_eus-gaap--ShareBasedCompensation_c20210101__20211231_pn3n3" style="border-bottom: Black 2.5pt double; text-align: right" title="Total stock-based compensation">480</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <p id="xdx_8AE_zqYqWLwumOSi" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> 105640 141 47328 43807 <table cellpadding="0" cellspacing="0" id="xdx_89E_eus-gaap--ScheduleOfShareBasedCompensationRestrictedStockUnitsAwardActivityTableTextBlock_z16A8CocPJQ" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; width: 80%; border-collapse: collapse; margin-right: auto" summary="xdx: Disclosure - Stock-based Compensation (Details - RSU activity)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8B9_z9Se2qNzSvwf" style="display: none">Summary of RSU activity</span></td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Number<br/> of Shares</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Weighted-<br/> Average<br/> Grant Date Fair Value<br/> Per Share</b></span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td style="width: 60%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Unvested units at December 31, 2021</span></td> <td style="width: 2%"> </td> <td style="width: 1%"> </td> <td id="xdx_98C_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_iS_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zjtePJVf5U08" style="width: 16%; text-align: right" title="RSU's unvested units, beginning balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">30,592</span></td> <td style="width: 1%"> </td> <td style="width: 2%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_98F_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_iS_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zc4s8HQNntDj" style="width: 16%; text-align: right" title="RSU beginning balance, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">38.52</span></td> <td style="width: 1%"> </td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Granted</span></td> <td> </td> <td> </td> <td id="xdx_985_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zGzPGgq87Ccj" style="text-align: right" title="RSU's granted"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">61,250</span></td> <td> </td> <td> </td> <td> </td> <td id="xdx_980_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_z94CbW22DGLc" style="text-align: right" title="RSU's granted, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">10.08</span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Vested</span></td> <td> </td> <td> </td> <td id="xdx_98E_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_iN_pip0_di_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zltIEa2dGWJe" style="text-align: right" title="RSU's vested"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(14,043</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td> </td> <td> </td> <td id="xdx_984_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_z6fr7LowSkid" style="text-align: right" title="RSU's vested, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">39.72</span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Forfeited</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td id="xdx_98F_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_iN_pip0_di_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zNNedoWhrEx9" style="border-bottom: black 1pt solid; text-align: right" title="RSU's forfeited"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(30,471</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">) </span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td id="xdx_988_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_ztznRXCOsOZc" style="border-bottom: black 1pt solid; text-align: right" title="RSU's forfeited, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">17.40</span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Unvested units at December 31, 2022</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"> </td> <td id="xdx_989_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_iE_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zG5dh0jSyuA8" style="border-bottom: black 2.25pt double; text-align: right" title="RSU's unvested units, ending balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">47,328</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_983_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_iE_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--RestrictedStockUnitsRSUMember_zBvouTIvaDrj" style="border-bottom: black 2.25pt double; text-align: right" title="RSU ending balance, price per share"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">15.00</span></td> <td> </td></tr> </table> 30592 38.52 61250 10.08 14043 39.72 30471 17.40 47328 15.00 10.08 35.28 401000 443000 138000 9000 458000 P1Y7M6D <table cellpadding="0" cellspacing="0" id="xdx_89C_eus-gaap--ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_pn3n3_zVRts6DLq2wa" style="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse" summary="xdx: Disclosure - Stock-based Compensation (Details - Option activity)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8B8_zXQQnnaSFIQl" style="display: none">Summary of Stock Option Activity</span></td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Total Number<br/> of Shares</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Weighted-<br/> Average<br/> Exercise<br/> Price<br/> Per Share</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Weighted-<br/> Average<br/> Remaining<br/> Contractual<br/> Term</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Aggregate<br/> Intrinsic<br/> Value</b></span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 36%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Balance at December 31, 2021</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td id="xdx_987_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iS_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zbAi4DOqzN1j" style="width: 13%; text-align: right" title="Options outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">208</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_98A_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_iS_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_z7JZ0siBpPh5" style="width: 13%; text-align: right" title="Weighted-Average Exercise Price Per Share, Beginning Balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">40,822.80</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 13%; text-align: right"> </td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 13%; text-align: right"> </td> <td style="width: 1%"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Granted</span></td> <td> </td> <td> </td> <td id="xdx_987_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_pip0_d0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zt5q27JaDXcj" style="text-align: right" title="Options granted"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td id="xdx_98F_eus-gaap--ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_pip0_d0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zKqiSNOmX5Tb" style="text-align: right" title="Weighted-Average Exercise Price per Share, Granted"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Exercised</span></td> <td> </td> <td> </td> <td id="xdx_98A_eus-gaap--StockIssuedDuringPeriodSharesStockOptionsExercised_pip0_d0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_znm5R1iitoF6" style="text-align: right" title="Options exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td id="xdx_987_eus-gaap--ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_pip0_d0_c20220101__20221231__us-gaap--AwardTypeAxis__custom--StockOptionsMember_zYmgvS03tNJd" style="text-align: right" title="Weighted-Average Exercise Price Per Share, Exercised"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td>Unvested shares cancelled</td> <td> </td> <td> </td> <td id="xdx_981_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_iN_pip0_di_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember__us-gaap--VestingAxis__custom--UnvestedSharesMember_zhcaMTKiQEB6" style="text-align: right" title="Options cancelled">(6</td> <td>)</td> <td> </td> <td> </td> <td id="xdx_980_eus-gaap--ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zkXA6L0cHHr3" style="text-align: right" title="Weighted-Average Exercise Price per Share, Options Unvested, Shares Cancelled">1,181.40</td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Vested shares cancelled</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td id="xdx_980_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod_iN_pip0_di_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember__us-gaap--VestingAxis__custom--VestedSharesMember_zJJKCz5SmRd6" style="border-bottom: black 1pt solid; text-align: right" title="Options cancelled"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(61</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td id="xdx_983_eus-gaap--ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zIqNPulxz2r8" style="border-bottom: black 1pt solid; text-align: right" title="Weighted-Average Exercise Price per Share, Options Vested, Shares Cancelled"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">93,016.68</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Balance at December 31, 2022</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"> </td> <td id="xdx_98E_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_iE_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zh6lwrDUy87d" style="border-bottom: black 2.25pt double; text-align: right" title="Options outstanding"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">141</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_987_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_iE_pip0_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_z8pJRRMX5SF3" style="border-bottom: black 2.25pt double; text-align: right" title="Weighted-Average Exercise Price Per Share, Ending Balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">19,761.12</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><span id="xdx_90C_eus-gaap--SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_dtY_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zzyEVyvFynu9" title="Weighted-Average Contractual Term, Outstanding">5.18</span> years</span></td> <td> </td> <td> </td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_985_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_iI_pn3n3_d0_c20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zTjJPjqrWVP5" style="text-align: right" title="Aggregate Intrinsic Value, Ending Balance"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Exercisable at December 31, 2022</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"> </td> <td id="xdx_98A_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_iI_pip0_c20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zIGxvihWLwcd" style="border-bottom: black 2.25pt double; text-align: right" title="Options exercisable"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">141</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_98F_eus-gaap--ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_iI_pip0_c20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zfbDxvKnwVx" style="border-bottom: black 2.25pt double; text-align: right" title="Weighted-Average Exercise Price Per Share, Exercisable"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">19,761.12</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><span id="xdx_90E_eus-gaap--SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_dtY_c20220101__20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zjRmhobbczU5" title="Weighted-Average Contractual Term, Exercisable">5.18</span> years</span></td> <td> </td> <td> </td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td id="xdx_986_eus-gaap--SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_iI_pn3n3_d0_c20221231__us-gaap--AwardTypeAxis__us-gaap--StockOptionMember_zuFVtxsVRB3f" style="text-align: right" title="Aggregate Intrinsic Value, Exercisable"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> </table> 208 40822.80 0 0 0 0 6 1181.40 61 93016.68 141 19761.12 P5Y2M4D 0 141 19761.12 P5Y2M4D 0 13000 37000 <table cellpadding="0" cellspacing="0" id="xdx_89D_eus-gaap--ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_pn3n3_zXWGVVoZmq1j" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Stock-based Compensation (Details - Share-based compensation)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B8_zOloQRiysNna" style="display: none">Details of Stock-based Compensation Expense</span></td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 62%; text-align: left">Research and development</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_98D_eus-gaap--ShareBasedCompensation_pn3n3_c20220101__20221231__us-gaap--IncomeStatementLocationAxis__us-gaap--ResearchAndDevelopmentExpenseMember_zrHgHvIfYOf1" style="width: 16%; text-align: right" title="Total stock-based compensation">154</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td id="xdx_987_eus-gaap--ShareBasedCompensation_c20210101__20211231__us-gaap--IncomeStatementLocationAxis__us-gaap--ResearchAndDevelopmentExpenseMember_pn3n3" style="width: 16%; text-align: right" title="Total stock-based compensation">117</td><td style="width: 1%; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 1pt">General and administrative</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_985_eus-gaap--ShareBasedCompensation_pn3n3_c20220101__20221231__us-gaap--IncomeStatementLocationAxis__us-gaap--GeneralAndAdministrativeExpenseMember_zBKGl59gG5Xh" style="border-bottom: Black 1pt solid; text-align: right" title="Total stock-based compensation">260</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_987_eus-gaap--ShareBasedCompensation_c20210101__20211231__us-gaap--IncomeStatementLocationAxis__us-gaap--GeneralAndAdministrativeExpenseMember_pn3n3" style="border-bottom: Black 1pt solid; text-align: right" title="Total stock-based compensation">363</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left; padding-bottom: 2.5pt">Total stock-based compensation</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_985_eus-gaap--ShareBasedCompensation_pn3n3_c20220101__20221231_zfvId6IpIAZ2" style="border-bottom: Black 2.5pt double; text-align: right" title="Total stock-based compensation">414</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td id="xdx_98D_eus-gaap--ShareBasedCompensation_c20210101__20211231_pn3n3" style="border-bottom: Black 2.5pt double; text-align: right" title="Total stock-based compensation">480</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> 154000 117000 260000 363000 414000 480000 <p id="xdx_80A_eus-gaap--IncomeTaxDisclosureTextBlock_zvxpfGVoDXt2" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>12. <span id="xdx_826_ziMZA1zmrFDl">Income Taxes</span> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The provision for income taxes for the years ended December 31, 2022 and 2021 are as follows, in thousands:</p> <table cellpadding="0" cellspacing="0" id="xdx_89B_eus-gaap--ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_pn3n3_z5J5PmCnwIQa" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Income Taxes - (Details - Components of Federal and State Income Tax Expense)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8B2_zN6WarzOggV1" style="display: none">Components of Federal and State Income Tax Expense</span></td> <td> </td> <td> </td> <td id="xdx_499_20220101__20221231_z0hFJqaIRAb2" style="text-align: center"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_497_20210101__20211231_z4BbVc3n5uad" style="text-align: center"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="6" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Years Ended December 31,</b></span></td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2022</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2021</b></span></td> <td> </td></tr> <tr id="xdx_400_eus-gaap--CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_iB" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Current</span></td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr id="xdx_407_eus-gaap--CurrentFederalTaxExpenseBenefit_i01_pn3n3_d0_zY6MNCzlEpPc" style="vertical-align: bottom; background-color: white"> <td style="padding-left: 10pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Federal</span></td> <td> </td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr id="xdx_407_eus-gaap--CurrentStateAndLocalTaxExpenseBenefit_i01_pn3n3_d0_zlOe25cboAF6" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="padding-left: 10pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">State</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr id="xdx_408_eus-gaap--CurrentIncomeTaxExpenseBenefit_i01_pn3n3_d0_zNwKP6hqlssb" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total current</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr id="xdx_400_eus-gaap--DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_iB" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Deferred</span></td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr id="xdx_40E_eus-gaap--DeferredFederalIncomeTaxExpenseBenefit_i01N_pn3n3" style="vertical-align: bottom; background-color: white"> <td style="padding-left: 10pt; width: 62%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Federal</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 16%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(1,733</span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 16%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(3,016</span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">) </span></td></tr> <tr id="xdx_40E_eus-gaap--DeferredStateAndLocalIncomeTaxExpenseBenefit_i01N_pn3n3" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="padding-left: 10pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">State</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(553</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(1,329</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td></tr> <tr id="xdx_403_eus-gaap--DeferredFederalStateAndLocalTaxExpenseBenefit_i01N_pn3n3" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total deferred</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(2,286</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(4,345</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td></tr> <tr id="xdx_403_eus-gaap--ValuationAllowanceDeferredTaxAssetChangeInAmount_i01N_pn3n3" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Valuation allowance</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2,286</span></td> <td> </td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">4,345</span></td> <td> </td></tr> <tr id="xdx_40E_eus-gaap--IncomeTaxExpenseBenefit_i01_pn3n3_d0_zcVmF5x00HL3" style="vertical-align: bottom; background-color: white"> <td style="padding-left: 10pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total provision for income taxes</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> </table> <p id="xdx_8A7_zIiVO5VRWpTa" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">  </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table presents a reconciliation of the U.S. statutory tax rate to the Company’s actual effective income tax rate:</p> <table cellpadding="0" cellspacing="0" id="xdx_89A_eus-gaap--ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_pn3n3_zBY6ye1g7e75" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Income Taxes - (Details - Effect Income Tax Rate Reconciliation)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8BA_zNs86OUKpsb5" style="display: none">Schedule of effective income tax reconciliation</span></td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Years Ended December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 62%; text-align: left">Federal statutory rate</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left"> </td><td style="width: 16%; text-align: right"><span id="xdx_90C_eus-gaap--EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_pip0_dp_c20220101__20221231_z1ZLGyxcyqfd" title="Federal statutory rate">21.0</span>%</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left"> </td><td style="width: 16%; text-align: right"><span id="xdx_90F_eus-gaap--EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_pip0_dp_c20210101__20211231_zQw6KiHbgAoc" title="Federal statutory rate">21.0</span>%</td><td style="width: 1%; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">State income taxes, net of federal benefit</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_905_eus-gaap--EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_pip0_dp_c20220101__20221231_zGxi92ovXtzb" title="State income taxes, net of federal benefit">7.4</span></td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_90E_eus-gaap--EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_pip0_dp_c20210101__20211231_zEgDt9SxCr6l" title="State income taxes, net of federal benefit">8.5</span></td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Non-deductible expenses</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"> <span id="xdx_905_eus-gaap--EffectiveIncomeTaxRateReconciliationNondeductibleExpense_pip0_dp_c20220101__20221231_zeLg4ZbPePz8" title="Non-deductible expenses">(0.8)</span></span></td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_90D_eus-gaap--EffectiveIncomeTaxRateReconciliationNondeductibleExpense_pip0_dp_c20210101__20211231_zO6GcHESmf5g" title="Non-deductible expenses">0.2</span></td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Income tax credits</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_906_eus-gaap--EffectiveIncomeTaxRateReconciliationTaxCredits_pip0_dp_c20220101__20221231_zya9Y5ozmer2" title="Income tax credits">3.2</span></td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_901_eus-gaap--EffectiveIncomeTaxRateReconciliationTaxCredits_pip0_dp_c20210101__20211231_zgp5G6poDqub" title="Income tax credits">4.3</span></td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Valuation allowance</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(<span id="xdx_90F_eus-gaap--EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_pip0_dp_c20220101__20221231_zVzVofTp65J1" title="Valuation allowance">30.8</span></td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(<span id="xdx_90F_eus-gaap--EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_pip0_dp_c20210101__20211231_zfjUXitwYAa5" title="Valuation allowance">34.0</span></td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Effective tax rate</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left"> </td><td style="border-bottom: Black 2.5pt double; text-align: right"><span id="xdx_907_eus-gaap--EffectiveIncomeTaxRateContinuingOperations_pip0_dp_c20220101__20221231_zrkZzkVBdm6g" title="Effective tax rate">0.0</span>%</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left"> </td><td style="border-bottom: Black 2.5pt double; text-align: right"><span id="xdx_909_eus-gaap--EffectiveIncomeTaxRateContinuingOperations_pip0_dp_c20210101__20211231_zQi22uqtYhBc" title="Effective tax rate">0.0</span>%</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <p id="xdx_8A3_zThkhqALbkR3" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company recognizes deferred tax assets and liabilities to reflect the tax effects of temporary differences between the tax basis of assets or liabilities and their reported amounts in the financial statements in accordance with ASC 740. These temporary differences will result in taxable or deductible amounts in future years when the reported amounts of the assets or liabilities are recovered or settled.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">ASC 740 requires that a valuation allowance be established when management determines that it is more likely than not that all or a portion of a deferred asset will not be realized. The Company evaluates the realizability of its net deferred income tax assets and valuation allowances as necessary, at least on an annual basis. During this evaluation, the Company reviews its forecasts of income in conjunction with other positive and negative evidence surrounding the realizability of its deferred income tax assets to determine if a valuation allowance is required. Adjustments to the valuation allowance will increase or decrease the Company’s income tax provision or benefit.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The significant components of the Company’s net deferred tax assets and liabilities are as follows, in thousands:</p> <table cellpadding="0" cellspacing="0" id="xdx_896_eus-gaap--ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_pn3n3_zFNgYiCE2Zj4" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Income Taxes - (Details - Components of Net Deferred Tax Assets)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B7_zTZm8k4hVKJ7" style="display: none">Schedule of deferred tax assets</span></td><td> </td> <td colspan="2" id="xdx_494_20221231_zH63MkSCKj04" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" id="xdx_49E_20211231_zx2UTReXC8L2" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Years Ending December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr id="xdx_40A_eus-gaap--DeferredTaxAssetsGrossAbstract_iB" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Deferred tax assets:</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr id="xdx_407_eus-gaap--DeferredTaxAssetsOperatingLossCarryforwards_i01I_pn3n3" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; width: 62%; text-align: left">Net operating loss carryforwards</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 16%; text-align: right">11,808</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 16%; text-align: right">10,150</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_407_eus-gaap--DeferredTaxAssetsTaxCreditCarryforwards_i01I_pn3n3" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left">Tax credit carryforwards</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,227</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">946</td><td style="text-align: left"> </td></tr> <tr id="xdx_400_eus-gaap--DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_i01I_pn3n3_zzukt0ejbiHb" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; text-align: left">Stock-based compensation</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">435</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,363</td><td style="text-align: left"> </td></tr> <tr id="xdx_401_ecustom--DeferredTaxAssetResearchAndDevelopmentCost_i01I_pn3n3_d0_zOXQbLoA6nL6" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left">Capitalized research and development expenses</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,662</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">–</td><td style="text-align: left"> </td></tr> <tr id="xdx_40A_eus-gaap--DeferredTaxAssetsGoodwillAndIntangibleAssets_i01I_pn3n3_zo3zWQVc20wc" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; text-align: left">License fees</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,680</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">2,018</td><td style="text-align: left"> </td></tr> <tr id="xdx_40C_ecustom--DeferredTaxAssetsOperatingLeaseLiability_i01I_pn3n3" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left">Lease liability</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">46</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">79</td><td style="text-align: left"> </td></tr> <tr id="xdx_40E_eus-gaap--DeferredTaxAssetsOther_i01I_pn3n3" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; text-align: left; padding-bottom: 1pt">Other timing differences</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">120</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">169</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_40B_eus-gaap--DeferredTaxAssetsGross_i01I_pn3n3" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left">Deferred tax assets</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">16,978</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">14,725</td><td style="text-align: left"> </td></tr> <tr id="xdx_40F_eus-gaap--DeferredTaxLiabilitiesAbstract_iB" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Deferred tax liabilities:</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr id="xdx_40B_eus-gaap--DeferredTaxLiabilitiesLeasingArrangements_i01NI_pn3n3_di_zZgF0iFQgdE7" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left; padding-bottom: 1pt">Right of use asset</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(43</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(76</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_404_eus-gaap--DeferredIncomeTaxLiabilities_i01NI_pn3n3_di_zV27WbqcTWvg" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; text-align: left">Deferred tax liability</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(43</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(76</td><td style="text-align: left">)</td></tr> <tr id="xdx_404_eus-gaap--DeferredTaxAssetsValuationAllowance_i01NI_pn3n3_di_zowBPgj8K1Sf" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Valuation allowance</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(16,935</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(14,649</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_40A_eus-gaap--DeferredTaxAssetsLiabilitiesNet_i01I_pn3n3_d0_zkHoI5lYEhBd" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Net deferred tax asset</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">–</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">–</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <p id="xdx_8A4_zoLHHP5m4K72" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 24.5pt"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Tax Cuts and Jobs Act of 2017 included a provision that requires the capitalization and amortization of research and development costs incurred in tax years beginning after December 31, 2021. Under this provision, U.S.-based research and development expenses are amortized over a period of five years and non-U.S.-based research and development expenses are amortized over a period of 15 years. The deferred tax assets as of December 31, 2022 included capitalized research and development expenses of $<span id="xdx_902_ecustom--DeferredTaxAssetResearchAndDevelopmentCost_iI_c20221231_zJsD3f55q7qc">1,662,000</span>.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company evaluated the realizability of its net deferred tax assets and concluded that, in accordance with the applicable accounting standards, that it is more likely than not that the Company may not realize the benefit of all of its deferred tax assets. Accordingly, a valuation allowance against 100% of its deferred tax assets has been recorded. Significant judgment is required in the evaluation of deferred tax benefits and differences in future results from our estimates could result in material differences in the realization of these assets.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">As of December 31, 2022, the Company had federal net operating loss (“<b>NOL</b>”) carryforwards of approximately $<span id="xdx_901_eus-gaap--OperatingLossCarryforwards_iI_c20221231__us-gaap--IncomeTaxAuthorityAxis__custom--FederalMember_zVqbFA627l54" title="Net operating loss carryforwards">49,200,000</span> and state NOL carryforwards of approximately $<span id="xdx_900_eus-gaap--OperatingLossCarryforwards_iI_c20221231__us-gaap--IncomeTaxAuthorityAxis__custom--StateMember_zpw2RC9dDwn6" title="Net operating loss carryforwards">23,200,000</span> to reduce future taxable income. The utilization of the federal carryforwards as an available offset to future taxable income is subject to limitations under federal income tax laws. Under current federal income tax law, the Company’s federal NOLs generated in tax years beginning after December 31, 2017, totaling approximately $<span id="xdx_905_eus-gaap--DeferredTaxAssetsOperatingLossCarryforwardsNotSubjectToExpiration_iI_c20221231__us-gaap--IncomeTaxAuthorityAxis__custom--FederalMember_zW5WccghE9i1">48,879,000</span>, may be carried forward indefinitely, but are limited to offset up to 80% of future taxable income. The remaining federal NOLs generated, totaling approximately $<span id="xdx_908_eus-gaap--DeferredTaxAssetsOperatingLossCarryforwardsSubjectToExpiration_iI_c20221231__us-gaap--IncomeTaxAuthorityAxis__custom--FederalMember_zLI8sjFRIEga">321,000</span>, will begin to expire in <span id="xdx_90F_eus-gaap--OperatingLossCarryforwardsExpirationDate_ddxL_c20220101__20221231__us-gaap--IncomeTaxAuthorityAxis__custom--FederalMember__us-gaap--TaxCreditCarryforwardAxis__custom--NetOperatingLossCarryforwardMember_zHdNFuN0kFCj" title="::XDX::2037-12-31"><span style="-sec-ix-hidden: xdx2ixbrl1108">2037</span></span> and the Company’s available state NOL carryforwards will begin to expire in <span id="xdx_90E_eus-gaap--OperatingLossCarryforwardsExpirationDate_ddxL_c20220101__20221231__us-gaap--IncomeTaxAuthorityAxis__custom--StateMember__us-gaap--TaxCreditCarryforwardAxis__custom--NetOperatingLossCarryforwardMember_zvPmajJUNZjj" title="::XDX::2038-12-31"><span style="-sec-ix-hidden: xdx2ixbrl1109">2038</span></span>. In addition, the Company had federal and state research and development credits of approximately $<span id="xdx_906_eus-gaap--TaxCreditCarryforwardAmount_iI_c20221231__us-gaap--IncomeTaxAuthorityAxis__custom--FederalMember_zhjQFUcrAvN3">819,000</span> and $<span id="xdx_905_eus-gaap--TaxCreditCarryforwardAmount_iI_c20221231__us-gaap--IncomeTaxAuthorityAxis__custom--StateMember_z60BYdXiACUi">517,000</span>, respectively, which will begin to expire in <span id="xdx_902_eus-gaap--TaxCreditCarryforwardExpirationDate_ddxL_c20220101__20221231__us-gaap--IncomeTaxAuthorityAxis__custom--FederalMember_zwjwhSJaCzMc" title="::XDX::2041-12-31"><span style="-sec-ix-hidden: xdx2ixbrl1112">2041</span></span> and <span id="xdx_90D_eus-gaap--TaxCreditCarryforwardExpirationDate_ddxL_c20220101__20221231__us-gaap--IncomeTaxAuthorityAxis__custom--StateMember_zRmRea7E6f7l" title="::XDX::2036-12-31"><span style="-sec-ix-hidden: xdx2ixbrl1113">2036</span></span>, respectively.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">Ownership changes may limit the amount of NOL carryforwards or tax credit carryforwards that can be utilized to offset future taxable income or tax liability. Pursuant to Sections 382 and 383 of the Internal Revenue Code of 1986, as amended (the “<b>Code</b>”), NOL and tax credit carryforwards may be subject to annual limitations in the event a cumulative change in ownership of more than 50% occurs within a three-year period. Any limitation may result in expiration of a portion of the NOL carryforwards or tax credit carryforwards before utilization.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">During 2021, the Company completed an assessment of the available NOL and tax credit carryforwards under Sections 382 and 383 of the Code and determined that the Company underwent six ownership changes during the period from 2012 to 2021. As a result, NOL and tax credit carryforwards attributable to the pre-ownership changes are subject to substantial annual limitations under Section 382 and 383 of Code due to the ownership changes. The Company adjusted its NOL and tax credit carryforwards to address the impact of the ownership changes. For the years ended prior to December 31, 2021, federal and state NOLs of $<span id="xdx_904_ecustom--ReductionInOperatingLossCarryforwards_c20210101__20211231__us-gaap--IncomeTaxAuthorityAxis__custom--FederalMember_z4Z7oPEYN9Pd">55,000,000</span> and $<span id="xdx_905_ecustom--ReductionInOperatingLossCarryforwards_c20210101__20211231__us-gaap--IncomeTaxAuthorityAxis__custom--StateMember_z0LMBCc0PK81">70,000,000</span>, respectively, were reduced and federal and state tax credit carryforwards of $<span id="xdx_904_ecustom--ReductionInTaxCreditCarryforwardDeferredTaxAsset_c20210101__20211231__us-gaap--IncomeTaxAuthorityAxis__custom--FederalMember_zPQ63RT09FT8">1,400,000</span> and $<span id="xdx_904_ecustom--ReductionInTaxCreditCarryforwardDeferredTaxAsset_c20210101__20211231__us-gaap--IncomeTaxAuthorityAxis__custom--StateMember_zyuVIUnMvy24">700,000</span>, respectively, were also reduced.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p><p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company assesses the need to conduct an ownership change analysis to determine whether any changes occurred in ownership that would limit NOL or tax credit carryforwards on an annual basis. Due to the minimal number of share issuances during the year, the Company did not conduct an ownership change analysis in 2022. The Company may experience ownership changes in the future as a result of subsequent shifts in stock ownership, some of which may be outside of the Company’s control.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The recognition and measurement of benefits related to the Company’s tax positions requires significant judgment, as uncertainties often exist with respect to new laws, new interpretations of existing laws, and rulings by taxing authorities. The Company follows a more-likely-than not threshold for financial statement recognition and measurement of a tax position taken, or expected to be taken in a tax return. The guidance relates to, amongst other things, classification, accounting for interest and penalties associated with tax positions, and disclosure requirements. Any interest and penalties accrued related to uncertain tax positions are recorded as tax expense. Differences between actual results and the Company’s assumptions or changes in the Company’s assumptions in future periods are recorded in the period they become known. The Company has not recorded any uncertain tax positions as of December 31, 2022 or 2021. The Company does not believe there will be any material changes in its unrecognized tax positions over the next 12 months.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The Company has not incurred any interest or penalties. In the event that the Company is assessed interest or penalties at some point in the future, they will be classified in the financial statements as general and administrative expenses.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">  </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">The Company files income tax returns in the United States, Massachusetts and New Jersey. The Company is subject to tax examinations for federal and state purposes for tax years 2014 through 2022.</p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in"/> <table cellpadding="0" cellspacing="0" id="xdx_89B_eus-gaap--ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_pn3n3_z5J5PmCnwIQa" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Income Taxes - (Details - Components of Federal and State Income Tax Expense)"> <tr style="vertical-align: bottom; background-color: white"> <td><span id="xdx_8B2_zN6WarzOggV1" style="display: none">Components of Federal and State Income Tax Expense</span></td> <td> </td> <td> </td> <td id="xdx_499_20220101__20221231_z0hFJqaIRAb2" style="text-align: center"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_497_20210101__20211231_z4BbVc3n5uad" style="text-align: center"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="6" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>Years Ended December 31,</b></span></td> <td> </td></tr> <tr style="vertical-align: bottom"> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2022</b></span></td> <td> </td> <td> </td> <td colspan="2" style="border-bottom: black 1pt solid; text-align: center"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"><b>2021</b></span></td> <td> </td></tr> <tr id="xdx_400_eus-gaap--CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_iB" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Current</span></td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr id="xdx_407_eus-gaap--CurrentFederalTaxExpenseBenefit_i01_pn3n3_d0_zY6MNCzlEpPc" style="vertical-align: bottom; background-color: white"> <td style="padding-left: 10pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Federal</span></td> <td> </td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr id="xdx_407_eus-gaap--CurrentStateAndLocalTaxExpenseBenefit_i01_pn3n3_d0_zlOe25cboAF6" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="padding-left: 10pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">State</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr id="xdx_408_eus-gaap--CurrentIncomeTaxExpenseBenefit_i01_pn3n3_d0_zNwKP6hqlssb" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total current</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> <tr id="xdx_400_eus-gaap--DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_iB" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Deferred</span></td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td> <td> </td> <td> </td> <td style="text-align: right"> </td> <td> </td></tr> <tr id="xdx_40E_eus-gaap--DeferredFederalIncomeTaxExpenseBenefit_i01N_pn3n3" style="vertical-align: bottom; background-color: white"> <td style="padding-left: 10pt; width: 62%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Federal</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 16%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(1,733</span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td style="width: 1%"> </td> <td style="width: 1%"> </td> <td style="width: 16%; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(3,016</span></td> <td style="width: 1%"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">) </span></td></tr> <tr id="xdx_40E_eus-gaap--DeferredStateAndLocalIncomeTaxExpenseBenefit_i01N_pn3n3" style="vertical-align: bottom; background-color: #EEEEEE"> <td style="padding-left: 10pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">State</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(553</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(1,329</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td></tr> <tr id="xdx_403_eus-gaap--DeferredFederalStateAndLocalTaxExpenseBenefit_i01N_pn3n3" style="vertical-align: bottom; background-color: white"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total deferred</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(2,286</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td> <td> </td> <td> </td> <td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">(4,345</span></td> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">)</span></td></tr> <tr id="xdx_403_eus-gaap--ValuationAllowanceDeferredTaxAssetChangeInAmount_i01N_pn3n3" style="vertical-align: bottom; background-color: #EEEEEE"> <td><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Valuation allowance</span></td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">2,286</span></td> <td> </td> <td> </td> <td style="border-bottom: black 1pt solid"> </td> <td style="border-bottom: black 1pt solid; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">4,345</span></td> <td> </td></tr> <tr id="xdx_40E_eus-gaap--IncomeTaxExpenseBenefit_i01_pn3n3_d0_zcVmF5x00HL3" style="vertical-align: bottom; background-color: white"> <td style="padding-left: 10pt"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">Total provision for income taxes</span></td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td> <td> </td> <td style="border-bottom: black 2.25pt double"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">$</span></td> <td style="border-bottom: black 2.25pt double; text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt">–</span></td> <td> </td></tr> </table> 0 0 0 0 0 0 -1733000 -3016000 -553000 -1329000 -2286000 -4345000 2286000 4345000 0 0 <table cellpadding="0" cellspacing="0" id="xdx_89A_eus-gaap--ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_pn3n3_zBY6ye1g7e75" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Income Taxes - (Details - Effect Income Tax Rate Reconciliation)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8BA_zNs86OUKpsb5" style="display: none">Schedule of effective income tax reconciliation</span></td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Years Ended December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 62%; text-align: left">Federal statutory rate</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left"> </td><td style="width: 16%; text-align: right"><span id="xdx_90C_eus-gaap--EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_pip0_dp_c20220101__20221231_z1ZLGyxcyqfd" title="Federal statutory rate">21.0</span>%</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left"> </td><td style="width: 16%; text-align: right"><span id="xdx_90F_eus-gaap--EffectiveIncomeTaxRateReconciliationAtFederalStatutoryIncomeTaxRate_pip0_dp_c20210101__20211231_zQw6KiHbgAoc" title="Federal statutory rate">21.0</span>%</td><td style="width: 1%; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">State income taxes, net of federal benefit</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_905_eus-gaap--EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_pip0_dp_c20220101__20221231_zGxi92ovXtzb" title="State income taxes, net of federal benefit">7.4</span></td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_90E_eus-gaap--EffectiveIncomeTaxRateReconciliationStateAndLocalIncomeTaxes_pip0_dp_c20210101__20211231_zEgDt9SxCr6l" title="State income taxes, net of federal benefit">8.5</span></td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Non-deductible expenses</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span style="font-family: Times New Roman, Times, Serif; font-size: 10pt"> <span id="xdx_905_eus-gaap--EffectiveIncomeTaxRateReconciliationNondeductibleExpense_pip0_dp_c20220101__20221231_zeLg4ZbPePz8" title="Non-deductible expenses">(0.8)</span></span></td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_90D_eus-gaap--EffectiveIncomeTaxRateReconciliationNondeductibleExpense_pip0_dp_c20210101__20211231_zO6GcHESmf5g" title="Non-deductible expenses">0.2</span></td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Income tax credits</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_906_eus-gaap--EffectiveIncomeTaxRateReconciliationTaxCredits_pip0_dp_c20220101__20221231_zya9Y5ozmer2" title="Income tax credits">3.2</span></td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"><span id="xdx_901_eus-gaap--EffectiveIncomeTaxRateReconciliationTaxCredits_pip0_dp_c20210101__20211231_zgp5G6poDqub" title="Income tax credits">4.3</span></td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Valuation allowance</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(<span id="xdx_90F_eus-gaap--EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_pip0_dp_c20220101__20221231_zVzVofTp65J1" title="Valuation allowance">30.8</span></td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(<span id="xdx_90F_eus-gaap--EffectiveIncomeTaxRateReconciliationChangeInDeferredTaxAssetsValuationAllowance_pip0_dp_c20210101__20211231_zfjUXitwYAa5" title="Valuation allowance">34.0</span></td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Effective tax rate</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left"> </td><td style="border-bottom: Black 2.5pt double; text-align: right"><span id="xdx_907_eus-gaap--EffectiveIncomeTaxRateContinuingOperations_pip0_dp_c20220101__20221231_zrkZzkVBdm6g" title="Effective tax rate">0.0</span>%</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left"> </td><td style="border-bottom: Black 2.5pt double; text-align: right"><span id="xdx_909_eus-gaap--EffectiveIncomeTaxRateContinuingOperations_pip0_dp_c20210101__20211231_zQi22uqtYhBc" title="Effective tax rate">0.0</span>%</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> 0.210 0.210 0.074 0.085 -0.008 0.002 0.032 0.043 0.308 0.340 0.000 0.000 <table cellpadding="0" cellspacing="0" id="xdx_896_eus-gaap--ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_pn3n3_zFNgYiCE2Zj4" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Income Taxes - (Details - Components of Net Deferred Tax Assets)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B7_zTZm8k4hVKJ7" style="display: none">Schedule of deferred tax assets</span></td><td> </td> <td colspan="2" id="xdx_494_20221231_zH63MkSCKj04" style="text-align: center"> </td><td> </td><td> </td> <td colspan="2" id="xdx_49E_20211231_zx2UTReXC8L2" style="text-align: center"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">Years Ending December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr id="xdx_40A_eus-gaap--DeferredTaxAssetsGrossAbstract_iB" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left">Deferred tax assets:</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr id="xdx_407_eus-gaap--DeferredTaxAssetsOperatingLossCarryforwards_i01I_pn3n3" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; width: 62%; text-align: left">Net operating loss carryforwards</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 16%; text-align: right">11,808</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left">$</td><td style="width: 16%; text-align: right">10,150</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_407_eus-gaap--DeferredTaxAssetsTaxCreditCarryforwards_i01I_pn3n3" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left">Tax credit carryforwards</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,227</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">946</td><td style="text-align: left"> </td></tr> <tr id="xdx_400_eus-gaap--DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost_i01I_pn3n3_zzukt0ejbiHb" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; text-align: left">Stock-based compensation</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">435</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,363</td><td style="text-align: left"> </td></tr> <tr id="xdx_401_ecustom--DeferredTaxAssetResearchAndDevelopmentCost_i01I_pn3n3_d0_zOXQbLoA6nL6" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left">Capitalized research and development expenses</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,662</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">–</td><td style="text-align: left"> </td></tr> <tr id="xdx_40A_eus-gaap--DeferredTaxAssetsGoodwillAndIntangibleAssets_i01I_pn3n3_zo3zWQVc20wc" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; text-align: left">License fees</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">1,680</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">2,018</td><td style="text-align: left"> </td></tr> <tr id="xdx_40C_ecustom--DeferredTaxAssetsOperatingLeaseLiability_i01I_pn3n3" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left">Lease liability</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">46</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">79</td><td style="text-align: left"> </td></tr> <tr id="xdx_40E_eus-gaap--DeferredTaxAssetsOther_i01I_pn3n3" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; text-align: left; padding-bottom: 1pt">Other timing differences</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">120</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">169</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr id="xdx_40B_eus-gaap--DeferredTaxAssetsGross_i01I_pn3n3" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left">Deferred tax assets</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">16,978</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">14,725</td><td style="text-align: left"> </td></tr> <tr id="xdx_40F_eus-gaap--DeferredTaxLiabilitiesAbstract_iB" style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Deferred tax liabilities:</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td style="text-align: right"> </td><td style="text-align: left"> </td></tr> <tr id="xdx_40B_eus-gaap--DeferredTaxLiabilitiesLeasingArrangements_i01NI_pn3n3_di_zZgF0iFQgdE7" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="padding-left: 10pt; text-align: left; padding-bottom: 1pt">Right of use asset</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(43</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(76</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_404_eus-gaap--DeferredIncomeTaxLiabilities_i01NI_pn3n3_di_zV27WbqcTWvg" style="vertical-align: bottom; background-color: White"> <td style="padding-left: 10pt; text-align: left">Deferred tax liability</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(43</td><td style="text-align: left">)</td><td> </td> <td style="text-align: left"> </td><td style="text-align: right">(76</td><td style="text-align: left">)</td></tr> <tr id="xdx_404_eus-gaap--DeferredTaxAssetsValuationAllowance_i01NI_pn3n3_di_zowBPgj8K1Sf" style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Valuation allowance</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(16,935</td><td style="padding-bottom: 1pt; text-align: left">)</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td style="border-bottom: Black 1pt solid; text-align: right">(14,649</td><td style="padding-bottom: 1pt; text-align: left">)</td></tr> <tr id="xdx_40A_eus-gaap--DeferredTaxAssetsLiabilitiesNet_i01I_pn3n3_d0_zkHoI5lYEhBd" style="vertical-align: bottom; background-color: White"> <td style="text-align: left; padding-bottom: 2.5pt">Net deferred tax asset</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">–</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left">$</td><td style="border-bottom: Black 2.5pt double; text-align: right">–</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> 11808000 10150000 1227000 946000 435000 1363000 1662000 0 1680000 2018000 46000 79000 120000 169000 16978000 14725000 43000 76000 43000 76000 16935000 14649000 0 0 1662000 49200000 23200000 48879000 321000 819000 517000 55000000 70000000 1400000 700000 <p id="xdx_80D_eus-gaap--EarningsPerShareTextBlock_zZLVm04Hot1k" style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b>13. <span id="xdx_822_zKKuzKN5ZXF">Net Loss per Share</span> </b></p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"> </p> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">The following table sets forth the potential common shares excluded from the calculation of net loss per common share because their inclusion would be anti-dilutive:</p> <table cellpadding="0" cellspacing="0" id="xdx_880_eus-gaap--ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_pn3n3_zrCviHpCVMlk" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Net Loss per Share (Details - Antidilutive shares)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B1_zqkfty4zv1Ta" style="display: none">Schedule of antidilutive stock</span></td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 62%; text-align: left">Options to purchase common stock</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left"> </td><td id="xdx_98F_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20220101__20221231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__custom--OptionsMember_zh8jRCeZIOr6" style="width: 16%; text-align: right">141</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left"> </td><td id="xdx_981_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20210101__20211231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__custom--OptionsMember_zCEa2eNwun64" style="width: 16%; text-align: right">208</td><td style="width: 1%; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Unvested restricted stock units</td><td> </td> <td style="text-align: left"> </td><td id="xdx_98C_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20220101__20221231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__us-gaap--RestrictedStockUnitsRSUMember_ziNv8YtZUx98" style="text-align: right">47,328</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td id="xdx_984_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20210101__20211231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__us-gaap--RestrictedStockUnitsRSUMember_z2Y2JhjdfBsl" style="text-align: right">30,592</td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Warrants to purchase common stock</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_98F_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20220101__20221231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__custom--WarrantsMember_z3j5y86KmBef" style="border-bottom: Black 1pt solid; text-align: right">545,401</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_98B_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20210101__20211231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__custom--WarrantsMember_z5Iu0MaGBWT1" style="border-bottom: Black 1pt solid; text-align: right">545,401</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 2.5pt">Total</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left"> </td><td id="xdx_98E_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20220101__20221231_zMltLj3YXcd" style="border-bottom: Black 2.5pt double; text-align: right">592,870</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left"> </td><td id="xdx_981_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20210101__20211231_zbUnmqEJJaqc" style="border-bottom: Black 2.5pt double; text-align: right">576,201</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> <p style="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><b> </b></p> <table cellpadding="0" cellspacing="0" id="xdx_880_eus-gaap--ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_pn3n3_zrCviHpCVMlk" style="font: 10pt Times New Roman, Times, Serif; margin-left: auto; border-collapse: collapse; width: 80%; margin-right: auto" summary="xdx: Disclosure - Net Loss per Share (Details - Antidilutive shares)"> <tr style="vertical-align: bottom"> <td><span id="xdx_8B1_zqkfty4zv1Ta" style="display: none">Schedule of antidilutive stock</span></td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="6" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">December 31,</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom"> <td> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2022</td><td style="padding-bottom: 1pt; font-weight: bold"> </td><td style="font-weight: bold; padding-bottom: 1pt"> </td> <td colspan="2" style="border-bottom: Black 1pt solid; font-weight: bold; text-align: center">2021</td><td style="padding-bottom: 1pt; font-weight: bold"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="width: 62%; text-align: left">Options to purchase common stock</td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left"> </td><td id="xdx_98F_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20220101__20221231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__custom--OptionsMember_zh8jRCeZIOr6" style="width: 16%; text-align: right">141</td><td style="width: 1%; text-align: left"> </td><td style="width: 1%"> </td> <td style="width: 1%; text-align: left"> </td><td id="xdx_981_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20210101__20211231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__custom--OptionsMember_zCEa2eNwun64" style="width: 16%; text-align: right">208</td><td style="width: 1%; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="text-align: left">Unvested restricted stock units</td><td> </td> <td style="text-align: left"> </td><td id="xdx_98C_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20220101__20221231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__us-gaap--RestrictedStockUnitsRSUMember_ziNv8YtZUx98" style="text-align: right">47,328</td><td style="text-align: left"> </td><td> </td> <td style="text-align: left"> </td><td id="xdx_984_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20210101__20211231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__us-gaap--RestrictedStockUnitsRSUMember_z2Y2JhjdfBsl" style="text-align: right">30,592</td><td style="text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: rgb(238,238,238)"> <td style="text-align: left; padding-bottom: 1pt">Warrants to purchase common stock</td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_98F_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20220101__20221231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__custom--WarrantsMember_z3j5y86KmBef" style="border-bottom: Black 1pt solid; text-align: right">545,401</td><td style="padding-bottom: 1pt; text-align: left"> </td><td style="padding-bottom: 1pt"> </td> <td style="border-bottom: Black 1pt solid; text-align: left"> </td><td id="xdx_98B_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20210101__20211231__us-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis__custom--WarrantsMember_z5Iu0MaGBWT1" style="border-bottom: Black 1pt solid; text-align: right">545,401</td><td style="padding-bottom: 1pt; text-align: left"> </td></tr> <tr style="vertical-align: bottom; background-color: White"> <td style="padding-bottom: 2.5pt">Total</td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left"> </td><td id="xdx_98E_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20220101__20221231_zMltLj3YXcd" style="border-bottom: Black 2.5pt double; text-align: right">592,870</td><td style="padding-bottom: 2.5pt; text-align: left"> </td><td style="padding-bottom: 2.5pt"> </td> <td style="border-bottom: Black 2.5pt double; text-align: left"> </td><td id="xdx_981_eus-gaap--AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_pip0_c20210101__20211231_zbUnmqEJJaqc" style="border-bottom: Black 2.5pt double; text-align: right">576,201</td><td style="padding-bottom: 2.5pt; text-align: left"> </td></tr> </table> 141 208 47328 30592 545401 545401 592870 576201 EXCEL 69 Financial_Report.xlsx IDEA: XBRL DOCUMENT begin 644 Financial_Report.xlsx M4$L#!!0 ( Z(=E8'04UB@0 +$ 0 9&]C4')O<',O87!P+GAM M;$V./0L",1!$_\IQO;=!P4)B0-!2L+(/>QLOD&1#LD)^OCG!CVX>;QA&WPIG M*N*I#BV&5(_C(I(/ !47BK9.7:=N')=HI6-Y #OGDK7A.YNJQ<&4GPZ4A!0W_J=0U[R;UEA_6\#MI7E!+ P04 M " .B'96*#"/+.T K @ $0 &1O8U!R;W!S+V-O&ULS9+! 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