10. Stock-based Compensation (Details Narrative) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
Dec. 31, 2019	Dec. 31, 2018
Share-based compensation expense	$ 300	$ 282
2012 Long-Term Incentive Plan [Member]
Shares reserved for issuance	72,728
Shares available for future grants	53,864
Restricted Stock [Member] \| Dr. Cauwenbergh [Member]
Share-based compensation expense	$ 106	$ 118
Issuance of restricted stock, shares	4,419	3,697
Restricted Stock Units (RSUs) [Member]
Share-based compensation expense	$ 125	$ 52
Unrecognized compensation expense - other than options	$ 254
Unrecognized compensation expense weighted average period	3 years 3 months 22 days
Options [Member]
Weighted average grant date fair value per share of options granted	$ 16.50	$ 96.25
Share-based compensation expense	$ 69	$ 112
Unrecognized compensation expense - options	$ 116
Unrecognized compensation expense weighted average period	2 years 3 months 22 days
Options outstanding	2,649	2,576
Options [Member] \| 2012 Long-Term Incentive Plan [Member]
Options outstanding	2,649
Restricted Stock Units (RSUs) [Member]
Other than options, nonvested	14,945	2,500
Restricted Stock Units (RSUs) [Member] \| 2012 Long-Term Incentive Plan [Member]
Other than options, nonvested	14,945

Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Amount of cost to be recognized for nonvested award under share-based payment arrangement. Excludes share and unit options.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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