X0306 4 2023-02-17 0 0001533040 Phio Pharmaceuticals Corp. PHIO 0001313325 BRADFORD PATRICIA A C/O PHIO PHARMACEUTICALS CORP. 257 SIMARANO DRIVE, SUITE 101 MARLBOROUGH MA 01752 1 0 0 0 Common stock, $0.0001 par value 2023-02-17 4 A 0 1500 0.00 A 3167 D Represents shares underlying a restricted stock unit, which shares will vest in one installment on the first anniversary of the grant date. Includes shares of common stock underlying unvested restricted stock units. Effective as of 12:01 a.m. Eastern Time on January 26, 2023, the issuer effected a reverse split of its outstanding shares of common stock at a ratio of 1-for-12. Caitlin Kontulis, attorney-in-fact 2023-02-22