X0508 4 2025-05-21 0001533040 Phio Pharmaceuticals Corp. PHIO 0001304395 Bitterman Robert J C/O PHIO PHARMACEUTICALS CORP. 11 APEX DR., SUITE 300A, PMB 2006 MARLBOROUGH MA 01752 1 1 0 0 Chairman, Pres & CEO 0 Common Stock, $0.0001 par value 2025-05-21 4 P 0 3000 1.77 A 22449 D Common Stock, $0.0001 par value 2025-05-22 4 P 0 1200 1.7799 A 23649 D Includes shares of common stock underlying unvested restricted stock units. The number of reported securities has been adjusted to reflect prior reverse stock splits. /s/ Robert J. Bitterman 2025-05-23