X0306 4 2013-04-30 0 0001532063 Express Scripts Holding Co. ESRX 0001317254 McNamee Patrick C/O EXPRESS SCRIPTS HOLDING COMPANY ONE EXPRESS WAY ST. LOUIS MO 63121 0 1 0 0 EVP & Chief Operating Officer Common Stock 2013-04-30 4 M 0 106454 22.87 A 222069 D Common Stock 2013-04-30 4 S 0 106454 59.5518 D 115615 D Common Stock 2013-04-30 4 M 0 77518 31.92 A 193133 D Common Stock 2013-04-30 4 S 0 77518 59.5518 D 115615 D Common Stock 2013-04-30 4 S 0 62839 59.8534 D 52776 D Common Stock 2013-04-30 4 S 0 25161 59.8534 D 35645 I By Spouse Trust Non-Qualified Stock Option (Right-to-Buy) 22.87 2013-04-30 4 M 0 106454 D 2016-03-02 Express Scripts Holding Company Common Stock 106454 0 D Non-Qualified Stock Option (Right-to-Buy) 31.92 2013-04-30 4 M 0 77518 D 2015-02-26 Express Scripts Holding Company Common Stock 77518 0 D The transactions reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by Reporting Person on December 3, 2012. Options vested in three equal installments on March 2, 2010, March 2, 2011, and March 2, 2012. Options vested in three equal installments on February 26, 2009, February 26, 2010, and February 26, 2011. Employee Stock Option granted pursuant to Express Scripts, Inc. 2000 Long-Term Incentive Plan. Patrick McNamee 2013-05-02