<SEC-DOCUMENT>0000950138-16-000978-index.html : 20160309
<SEC-HEADER>0000950138-16-000978.hdr.sgml : 20160309
<ACCEPTANCE-DATETIME>20160309160125
ACCESSION NUMBER:		0000950138-16-000978
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20160307
FILED AS OF DATE:		20160309
DATE AS OF CHANGE:		20160309

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Express Scripts Holding Co.
		CENTRAL INDEX KEY:			0001532063
		STANDARD INDUSTRIAL CLASSIFICATION:	RETAIL-DRUG STORES AND PROPRIETARY STORES [5912]
		IRS NUMBER:				452884094
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE EXPRESS WAY
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63121
		BUSINESS PHONE:		314-996-0900

	MAIL ADDRESS:	
		STREET 1:		ONE EXPRESS WAY
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Aristotle Holding, Inc.
		DATE OF NAME CHANGE:	20111005

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Anderson Phyllis S.
		CENTRAL INDEX KEY:			0001655239

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35490
		FILM NUMBER:		161494540

	MAIL ADDRESS:	
		STREET 1:		ONE EXPRESS WAY
		CITY:			ST. LOUIS
		STATE:			MO
		ZIP:			63121
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
Document 1 - file: edgar.html

Document 1 - RAW XML: edgar.xml

</DOCUMENT>
</SEC-DOCUMENT>