X0306 4 2015-05-06 0001532063 Express Scripts Holding Co. ESRX 0001235678 LAHOWCHIC NICHOLAS C/O EXPRESS SCRIPTS HOLDING COMPANY ONE EXPRESS WAY ST. LOUIS MO 63121 1 0 0 0 Common Stock 2015-03-12 5 G 0 389 0 D 25915 D Common Stock 2015-05-06 4 A 0 1189 0 A 27104 D Non-Qualified Stock Option (Right-to-Buy) 84.08 2015-05-06 4 A 0 5604 A 2025-05-06 Express Scripts Holding Company Common Stock 5604 5604 D Grant of restricted stock units pursuant to Express Scripts 2011 Long-Term Incentive Plan. Awards vest in three equal installments on May 1, 2016, May 1, 2017, and May 1, 2018. Grant of stock option pursuant to Express Scripts 2011 Long-Term Incentive Plan. Vests in three equal installments on May 1, 2016, May 1, 2017, and May 1, 2018. /s/ Martin P. Akins, as Attorney-in-Fact for Nicholas J. LaHowchic 2015-05-08