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Net loss per share (Details) - shares
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Net loss per share        
Potentially anti-dilutive securities excluded from calculation of diluted net loss per share (in shares) 7,573,155 6,833,916 7,573,155 6,833,916
Outstanding stock options        
Net loss per share        
Potentially anti-dilutive securities excluded from calculation of diluted net loss per share (in shares) 7,573,155 6,691,059 7,573,155 6,691,059
Outstanding warrants        
Net loss per share        
Potentially anti-dilutive securities excluded from calculation of diluted net loss per share (in shares)   142,857   142,857