<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2019-05-09</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001524741</issuerCik>
        <issuerName>U.S. SILICA HOLDINGS, INC.</issuerName>
        <issuerTradingSymbol>SLCA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001776798</rptOwnerCik>
            <rptOwnerName>Carusona Zach</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O US SILICA HOLDINGS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>24275 KATY FREEWAY SUITE 600</rptOwnerStreet2>
            <rptOwnerCity>KATY</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President Specialty Minerals</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>28471</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>22.09</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2017-06-03</value>
            </exerciseDate>
            <expirationDate>
                <value>2023-06-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>12500</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>32.41</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2018-03-02</value>
            </exerciseDate>
            <expirationDate>
                <value>2025-03-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>388</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>30.85</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2018-06-01</value>
            </exerciseDate>
            <expirationDate>
                <value>2025-06-01</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>356</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Includes (i) 208 shares of restricted stock granted on April 1, 2017 which vest on April 1, 2020, (ii) 4,373 shares of restricted stock granted on April 1, 2018, which will vest in two equal installments on April 1, 2020 and April 1, 2021 and (iii) 17,428 shares of restricted stock granted on February 12, 2019, which will vest in three equal installments on the first, second and third anniversaries of the grant date.</footnote>
    </footnotes>

    <remarks>SEE EXHIBIT 24 - POWER OF ATTORNEY</remarks>

    <ownerSignature>
        <signatureName>/s/ W. Andrew Macan, attorney-in-fact for Zach Carusona</signatureName>
        <signatureDate>2019-05-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
