<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2019-05-09</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001524741</issuerCik>
        <issuerName>U.S. SILICA HOLDINGS, INC.</issuerName>
        <issuerTradingSymbol>SLCA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001651267</rptOwnerCik>
            <rptOwnerName>Miers Daniel Ross</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O US SILICA HOLDINGS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>24275 KATY FREEWAY SUITE 600</rptOwnerStreet2>
            <rptOwnerCity>KATY</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>77494</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>President SandBox Logistics</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>56860</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Includes (i) 35,946 shares of restricted stock granted on July 15, 2018, which will vest on July 15, 2019 and (ii) 20,914 shares of restricted stock granted on February 12, 2019, which will vest in three equal installments on the first, second and third anniversaries of the grant date.</footnote>
    </footnotes>

    <remarks>SEE EXHIBIT 24 - POWER OF ATTORNEY</remarks>

    <ownerSignature>
        <signatureName>/s/ W. Andrew Macan, attorney-in-fact for Daniel R. Miers</signatureName>
        <signatureDate>2019-05-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
