Fair Value of Financial Instruments - Quantitative Information and Assumptions Pertaining To The Fair Value Measurement of The Level 3 Inputs (Details) $ in Thousands	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent receivable		$ 9,300
Contingent consideration liabilities	$ 111,600	86,200
Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent receivable	0	9,300
Contingent consideration liabilities	111,600	86,200
Regulatory milestone | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent receivable	$ 0	$ 2,500
Regulatory milestone | Level 3 | Probability of success | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input	0	0.70
Regulatory milestone | Level 3 | Discount rate | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input		0.17
Royalties | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent receivable	$ 0	$ 6,800
Royalties | Level 3 | Probability of success | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input	0
Royalties | Level 3 | Probability of success | Probability adjusted discounted cash flow model | Minimum
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input		0.10
Royalties | Level 3 | Probability of success | Probability adjusted discounted cash flow model | Maximum
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input		0.60
Royalties | Level 3 | Discount rate | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input		0.17
Net sales targets - PYLARIFY (CVRs) | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent consideration liabilities	$ 99,700	$ 73,200
Net sales targets - PYLARIFY (CVRs) | Level 3 | Probability of success | Probability adjusted discounted cash flow model (as of 12/31/2022) Monte Carlo simulation (as of 12/31/2021)
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	1
Net sales targets - PYLARIFY (CVRs) | Level 3 | Discount rate | Probability adjusted discounted cash flow model (as of 12/31/2022) Monte Carlo simulation (as of 12/31/2021)
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input		0.17
1095 commercialization milestone | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent consideration liabilities	$ 1,700	$ 1,900
1095 commercialization milestone | Level 3 | Probability of success | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.40	0.40
1095 commercialization milestone | Level 3 | Discount rate | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.038	0.013
Net sales targets - AZEDRA and 1095 | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent consideration liabilities	$ 10,200	$ 11,100
Net sales targets - AZEDRA and 1095 | Level 3 | Probability of success | Probability adjusted discounted cash flow model (as of 12/31/2022) Monte Carlo simulation (as of 12/31/2021) | Minimum
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.20	0.40
Net sales targets - AZEDRA and 1095 | Level 3 | Probability of success | Probability adjusted discounted cash flow model (as of 12/31/2022) Monte Carlo simulation (as of 12/31/2021) | Maximum
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	1	1
Net sales targets - AZEDRA and 1095 | Level 3 | Discount rate | Probability adjusted discounted cash flow model (as of 12/31/2022) Monte Carlo simulation (as of 12/31/2021) | Minimum
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.16	0.16
Net sales targets - AZEDRA and 1095 | Level 3 | Discount rate | Probability adjusted discounted cash flow model (as of 12/31/2022) Monte Carlo simulation (as of 12/31/2021) | Maximum
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.17	0.17