Fair Value of Financial Instruments - Quantitative Information and Assumptions Pertaining To The Fair Value Measurement of The Level 3 Inputs (Details) $ in Thousands	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent receivable	$ 9,300	$ 11,300
Contingent consideration liabilities	86,200	15,800
Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent receivable	9,300	11,300
Contingent consideration liabilities	86,200	15,800
Regulatory milestone | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent receivable	$ 2,500	$ 3,200
Regulatory milestone | Level 3 | Probability of success | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input	0.70	0.90
Regulatory milestone | Level 3 | Discount rate | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input	0.17	0.24
Royalties | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent receivable	$ 6,800	$ 8,100
Royalties | Level 3 | Probability of success | Probability adjusted discounted cash flow model | Minimum
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input	0.10	0.13
Royalties | Level 3 | Probability of success | Probability adjusted discounted cash flow model | Maximum
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input	0.60	0.77
Royalties | Level 3 | Discount rate | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Asset measurement input	0.17	0.24
Net sales targets - PYLARIFY (CVRs) | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent consideration liabilities	$ 73,200	$ 4,200
Net sales targets - PYLARIFY (CVRs) | Level 3 | Discount rate | Monte Carlo simulation
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.17	0.24
1095 commercialization milestone | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent consideration liabilities	$ 1,900	$ 2,200
1095 commercialization milestone | Level 3 | Probability of success | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.40	0.45
1095 commercialization milestone | Level 3 | Discount rate | Probability adjusted discounted cash flow model
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.013	0.005
Net sales targets - AZEDRA and 1095 | Level 3
Fair Value, Option, Quantitative Disclosures [Line Items]
Contingent consideration liabilities	$ 11,100	$ 9,400
Net sales targets - AZEDRA and 1095 | Level 3 | Probability of success | Monte Carlo simulation | Minimum
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.40	0.40
Net sales targets - AZEDRA and 1095 | Level 3 | Probability of success | Monte Carlo simulation | Maximum
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	1	1
Net sales targets - AZEDRA and 1095 | Level 3 | Discount rate | Monte Carlo simulation | Minimum
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.16	0.23
Net sales targets - AZEDRA and 1095 | Level 3 | Discount rate | Monte Carlo simulation | Maximum
Fair Value, Option, Quantitative Disclosures [Line Items]
Liability measurement input	0.17	0.24