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      <amendmentNo>5</amendmentNo>
      <securitiesClassTitle>Common Stock, par value $0.01 per share (the "Shares")</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001521036</issuerCik>
        <issuerName>Lantheus Holdings, Inc.</issuerName>
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          <issuerCusipNumber>46489V104</issuerCusipNumber>
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        <issuerPrincipalExecutiveOfficeAddress>
          <common:street1>201 Burlington Road, South Building</common:street1>
          <common:city>Bedford</common:city>
          <common:stateOrCountry>MA</common:stateOrCountry>
          <common:zipCode>01730</common:zipCode>
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      </issuerInfo>
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        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
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      <reportingPersonName>Farallon Capital Partners, L.P.</reportingPersonName>
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      <reportingPersonName>Farallon Capital Institutional Partners, L.P.</reportingPersonName>
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      <reportingPersonName>Farallon Capital Institutional Partners II, L.P.</reportingPersonName>
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      <reportingPersonName>Farallon Capital Institutional Partners III, L.P.</reportingPersonName>
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      <reportingPersonName>Four Crossings Institutional Partners V, L.P.</reportingPersonName>
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      <reportingPersonName>Farallon Capital Offshore Investors II, L.P.</reportingPersonName>
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      <reportingPersonName>Farallon Capital (AM) Investors, L.P.</reportingPersonName>
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      <reportingPersonName>Farallon Capital F5 Master I, L.P.</reportingPersonName>
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      <reportingPersonName>Farallon Healthcare Partners Master, L.P.</reportingPersonName>
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      <reportingPersonName>Farallon Partners, L.L.C.</reportingPersonName>
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      <reportingPersonName>Farallon Institutional (GP) V, L.L.C.</reportingPersonName>
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      <reportingPersonName>Farallon F5 (GP), L.L.C.</reportingPersonName>
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      <reportingPersonName>Dapice Joshua J.</reportingPersonName>
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      <reportingPersonName>Dreyfuss, Philip D.</reportingPersonName>
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      <reportingPersonName>Dunn Hannah E.</reportingPersonName>
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      <reportingPersonName>Gehani, Varun N.</reportingPersonName>
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      <reportingPersonName>Giauque, Nicolas</reportingPersonName>
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      <reportingPersonName>Husen, Avner A.</reportingPersonName>
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      <reportingPersonName>Kim, David T.</reportingPersonName>
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      <reportingPersonName>Linn, Michael G.</reportingPersonName>
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      <reportingPersonName>Luo Patrick (Cheng)</reportingPersonName>
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      <reportingPersonName>Roberts, Jr., Thomas G.</reportingPersonName>
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      <reportingPersonName>Saito Edric C.</reportingPersonName>
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      <reportingPersonName>Short Daniel S.</reportingPersonName>
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      <reportingPersonName>Spokes, Andrew J. M.</reportingPersonName>
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      <reportingPersonName>Warren, John R.</reportingPersonName>
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      <reportingPersonName>Wehrly, Mark C.</reportingPersonName>
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    <items>
      <item1>
        <issuerName>Lantheus Holdings, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>201 Burlington Road, South Building, Bedford, Massachusetts 01730</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>This statement is filed by the entity and persons listed below, all of whom together are referred to herein as the "Reporting Persons."

(i) Farallon Capital Management, L.L.C., a Delaware limited liability company (the "Investment Manager"), which is the investment manager of certain investment partnerships and vehicles, including the Farallon Funds (as defined in Item 4), with respect to the Shares held by the Farallon Funds; and

(ii) The following persons, each of whom is a managing member or senior managing member, as the case may be, of the Investment Manager, with respect to the Shares held by the Farallon Funds:  Joshua J. Dapice ("Dapice"); Philip D. Dreyfuss ("Dreyfuss"); Hannah E. Dunn ("Dunn"); Varun N. Gehani ("Gehani"); Nicolas Giauque ("Giauque"); Avner A. Husen ("Husen"); David T. Kim ("Kim"); Michael G. Linn ("Linn"); Patrick (Cheng) Luo ("Luo"); Thomas G. Roberts, Jr. ("Roberts"); Edric C. Saito ("Saito"); Daniel S. Short ("Short"); Andrew J. M. Spokes ("Spokes"); John R. Warren ("Warren"); and Mark C. Wehrly ("Wehrly").

Dapice, Dreyfuss, Dunn, Gehani, Giauque, Husen, Kim, Linn, Luo, Roberts, Saito, Short, Spokes, Warren and Wehrly are together referred to herein as the "Farallon Individual Reporting Persons."</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The address of the principal business office of each of the Reporting Persons is c/o Farallon Capital Management, L.L.C., One Maritime Plaza, Suite 2100, San Francisco, California 94111.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>The jurisdiction of organization of the Investment Manager is set forth above.  Each of the Farallon Individual Reporting Persons, other than Giauque, Luo and Spokes, is a citizen of the United States.  Giauque is a citizen of France.  Luo is a citizen of China.  Spokes is a citizen of the United Kingdom.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
        <typeOfPersonFiling>HC</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>The information required by Items 4(a) - (c) and set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.

The Shares reported hereby as beneficially owned by the Reporting Persons are held directly by the following investment partnerships, of which the Investment Manager is the investment manager: (i) Farallon Capital Partners, L.P., a California limited partnership ("FCP"); (ii) Farallon Capital Institutional Partners, L.P., a California limited partnership ("FCIP"); (iii) Farallon Capital Institutional Partners II, L.P., a California limited partnership ("FCIP II"); (iv) Farallon Capital Institutional Partners III, L.P., a Delaware limited partnership ("FCIP III"); (v) Four Crossings Institutional Partners V, L.P., a Delaware limited partnership ("FCIP V"); (vi) Farallon Capital Offshore Investors II, L.P., a Cayman Islands exempted limited partnership ("FCOI II"); (vii) Farallon Capital (AM) Investors, L.P., a Delaware limited partnership ("FCAMI"); (viii) Farallon Capital F5 Master I, L.P., a Cayman Islands exempted limited partnership ("F5MI"); and (ix) Farallon Healthcare Partners Master, L.P., a Cayman Islands exempted limited partnership ("FHPM").

FCP, FCIP, FCIP II, FCIP III, FCIP V, FCOI II, FCAMI, F5MI and FHPM are together referred to herein as the "Farallon Funds."</amountBeneficiallyOwned>
        <classPercent>The information required by Items 4(a) - (c) and set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>The information required by Items 4(a) - (c) and set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>The information required by Items 4(a) - (c) and set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>The information required by Items 4(a) - (c) and set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>The information required by Items 4(a) - (c) and set forth in Rows 5 through 11 of the cover page for each Reporting Person is incorporated herein by reference for each such Reporting Person.</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>N</notApplicableFlag>
        <ownershipMoreThan5PercentOnBehalfOfAnotherPerson>The Farallon Funds have the right to receive dividends from, and the proceeds from the sale of, the securities of the Issuer beneficially owned by the Reporting Persons.</ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
      </item10>
    </items>
    <exhibitInfo>Exhibit 1. Joint Acquisition Statement Pursuant to Section 240.13d-1(k)</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>Farallon Capital Management, L.L.C.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Managing Member</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Capital Partners, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Managing Member of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Capital Institutional Partners, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Managing Member of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Capital Institutional Partners II, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Managing Member of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Capital Institutional Partners III, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Managing Member of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Four Crossings Institutional Partners V, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Manager of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Capital Offshore Investors II, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Managing Member of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Capital (AM) Investors, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Managing Member of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Capital F5 Master I, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Manager of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Healthcare Partners Master, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Manager of its General Partner</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Partners, L.L.C.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Managing Member</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Institutional (GP) V, L.L.C.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Manager</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon F5 (GP), L.L.C.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Manager</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Farallon Healthcare Partners (GP), L.L.C.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Manager</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Dapice Joshua J.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Dreyfuss, Philip D.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Dunn Hannah E.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Hannah E. Dunn</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Gehani, Varun N.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Giauque, Nicolas</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Husen, Avner A.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Kim, David T.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Linn, Michael G.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Luo Patrick (Cheng)</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Roberts, Jr., Thomas G.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Saito Edric C.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Short Daniel S.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Spokes, Andrew J. M.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Warren, John R.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Wehrly, Mark C.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Hannah E. Dunn</signature>
        <title>Attorney-In-Fact</title>
        <date>08/13/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureComments>Each of Farallon Partners, L.L.C., Farallon Institutional (GP) V, L.L.C., Farallon F5 (GP), L.L.C, and Farallon Healthcare Partners (GP), L.L.C.  has executed this statement in Mill Valley, California, on behalf of itself and each fund for which it is the general partner.</signatureComments>
  </formData>

</edgarSubmission>
