<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001838503</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001520262</issuerCik>
      <issuerName>Alkermes plc.</issuerName>
      <secFileNumber>001-35299</secFileNumber>
      <issuerAddress>
        <com:street1>CONNAUGHT HOUSE</com:street1>
        <com:street2>1 BURLINGTON ROAD</com:street2>
        <com:city>DUBLIN 4</com:city>
        <com:stateOrCountry>L2</com:stateOrCountry>
        <com:zipCode>00000</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>00-353-1-772-8000</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Wright Christopher I</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>225 Liberty Street</com:street1>
          <com:street2>Floor 37</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10281</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2000</noOfUnitsSold>
      <aggregateMarketValue>90200.00</aggregateMarketValue>
      <noOfUnitsOutstanding>166675807</noOfUnitsOutstanding>
      <approxSaleDate>06/12/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>05/21/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of restricted stock unit awards</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Alkermes plc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2000</amountOfSecuritiesAcquired>
      <paymentDate>05/21/2026</paymentDate>
      <natureOfPayment>Granted as part of issuer equity compensation plan</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/12/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>03/11/2026</planAdoptionDate>
      </planAdoptionDates>
      <signature>Christopher Wright</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
