144 0001730048 XXXXXXXX LIVE 0001520262 Alkermes plc. 001-35299 CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN 4 L2 00000 00-353-1-772-8000 Hopkinson Craig C. Officer Ordinary shares Merrill Lynch

225 Liberty St Floor 37 New York NY 10281

5000 150004.95 165117509 01/08/2026 NASDAQ Ordinary shares 01/08/2025 Exercise of employee stock options Alkermes plc. N 5000 01/08/2025 Broker assisted cashless exercise N Craig Hopkinson

CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN 4 L2 00000

Ordinary shares 10/15/2025 9000 283776.70 Craig Hopkinson

CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN 4 L2 00000

Ordinary shares 11/03/2025 9000 273441.50 Craig Hopkinson

CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN 4 L2 00000

Ordinary shares 12/01/2025 4000 117200.00 Craig Hopkinson

CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN L2 00000

Ordinary shares 12/03/2025 3748 112447.26 Craig Hopkinson

CONNAUGHT HOUSE 1 BURLINGTON ROAD DUBLIN 4 L2 00000

Ordinary shares 01/02/2026 4000 112000.00 01/08/2026 03/14/2025 Craig Hopkinson