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Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2022

Dec. 31, 2021

Dec. 31, 2020

Pay vs Performance Disclosure [Table]

The amounts set forth below under the headings “Compensation Actually Paid to PEO” and “Average Compensation Actually Paid to Non-PEO NEOs” have been calculated in a manner consistent with Item 402(v) of Regulation S-K. Use of the term “compensation actually paid” is required by the SEC’s rules and, as a result of the calculation methodology required by the SEC, such amounts differ from compensation actually earned, realized or received by the individuals and the compensation decisions described in our Compensation Discussion and Analysis beginning on page 91 of this proxy statement.

	Summary		Compensation		Average Summary Compensation		Average Compensation Actually		Value of Initial Fixed $100 Investment Based on:⁽³⁾
Year	Compensation Table Total for PEO⁽¹⁾ ($)		Actually Paid to PEO⁽¹⁾⁽²⁾ ($)		Table Total for Non-PEO NEOs⁽¹⁾ ($)		Paid to Non-PEO NEOs⁽¹⁾⁽²⁾ ($)		TSR ($)		Peer Group TSR ($)		GAAP Net Income (Loss) ($ Millions)			Non-GAAP Net Income⁽⁴⁾ ($ Millions)
(a)	(b)		(c)		(d)		(e)		(f)		(g)		(h)			(i)
2022		10,314,172		8,321,591		4,155,421		4,206,760		128.09		113.65		(158.3	)		57.9
2021		8,846,588		11,225,263		2,942,671		2,882,217		114.02		126.45		(48.2	)		129.1
2020		8,041,702		6,883,292		2,882,616		2,656,656		97.79		126.42		(110.9	)		68.6

(1)	Richard F. Pops was our PEO for each year presented. The individuals comprising the non-PEO NEOs for each year presented are listed below.

2020	2021	2022
James M. Frates	Iain M. Brown	Iain M. Brown
David J. Gaffin	James M. Frates	David J. Gaffin
Craig C. Hopkinson, M.D.	David J. Gaffin	Craig C. Hopkinson, M.D.
Michael J. Landine	Craig C. Hopkinson, M.D.	Blair C. Jackson
	Blair C. Jackson

(2)

The amounts shown reflect the exclusion and inclusion of those certain amounts for the PEO and the non-PEO NEOs shown in the following tables. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts shown in each of the Exclusion of Stock Awards and Option Awards columns are equal to the total amounts from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table on page 119 of this proxy statement.

Year	Summary Compensation Table Total for PEO ($)		Exclusion of Stock Awards and Option Awards for PEO ($)			Inclusion of Equity Values for PEO ($)		Compensation Actually Paid to PEO ($)
2022		10,314,172		(8,009,660	)		6,017,079		8,321,591
2021		8,846,588		(6,564,945	)		8,943,620		11,225,263
2020		8,041,702		(6,040,835	)		4,882,425		6,883,292

Year	Average Summary Compensation Table Total for Non-PEO NEOs ($)		Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($)			Average Inclusion of Equity Values for Non-PEO NEOs ($)		Average Compensation Actually Paid to Non-PEO NEOs ($)
2022		4,155,421		(3,126,696	)		3,178,035		4,206,760
2021		2,942,671		(2,141,519	)		2,081,065		2,882,217
2020		2,882,616		(2,083,657	)		1,857,697		2,656,656

The amounts shown in the Inclusion of Equity Values column in each of the above tables are derived from the following amounts:

Year	Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for PEO ($)		Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for PEO ($)			Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for PEO ($)			Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for PEO ($)		Total - Inclusion of Equity Values for PEO ($)
2022		6,635,906		(948,605	)		329,778			—		6,017,079
2021		5,337,837		1,158,777			2,447,006			—		8,943,620
2020		5,747,325		(629,614	)		(235,286	)		—		4,882,425

Year	Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($)		Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($)			Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($)			Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($)			Total - Average Inclusion of Equity Values for Non-PEO NEOs ($)
2022		2,930,046		137,112			110,877			—			3,178,035
2021		2,296,714		(439,567	)		809,922			(586,004	)		2,081,065
2020		2,010,019		(91,032	)		(61,290	)		—			1,857,697

(3)

The peer group TSR shown in this table utilizes the Nasdaq Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report. The comparison assumes $100 was invested in the Company and in the Nasdaq Biotechnology Index, respectively, for the period starting December 31, 2019 through the end of the year shown. Historical share price performance is not necessarily indicative of future share price performance.

(4) We determined non-GAAP net income to be the most important financial performance measure used to link Company performance to compensation actually paid to our PEO and non-PEO NEOs in 2022. This financial performance measure may not have been the most important financial performance measure for years 2021 and 2020 and we may determine a different financial performance measure to be the most important financial performance measure in future years. See Appendix B for information regarding this non-GAAP financial measure.

Company Selected Measure Name

Non-GAAP Net Income

Named Executive Officers, Footnote [Text Block]

(1)	Richard F. Pops was our PEO for each year presented. The individuals comprising the non-PEO NEOs for each year presented are listed below.

2020	2021	2022
James M. Frates	Iain M. Brown	Iain M. Brown
David J. Gaffin	James M. Frates	David J. Gaffin
Craig C. Hopkinson, M.D.	David J. Gaffin	Craig C. Hopkinson, M.D.
Michael J. Landine	Craig C. Hopkinson, M.D.	Blair C. Jackson
	Blair C. Jackson

Peer Group Issuers, Footnote [Text Block]

(3)

PEO Total Compensation Amount

$ 10,314,172

$ 8,846,588

$ 8,041,702

PEO Actually Paid Compensation Amount

$ 8,321,591

11,225,263

6,883,292

Adjustment To PEO Compensation, Footnote [Text Block]

(2)

Year	Summary Compensation Table Total for PEO ($)		Exclusion of Stock Awards and Option Awards for PEO ($)			Inclusion of Equity Values for PEO ($)		Compensation Actually Paid to PEO ($)
2022		10,314,172		(8,009,660	)		6,017,079		8,321,591
2021		8,846,588		(6,564,945	)		8,943,620		11,225,263
2020		8,041,702		(6,040,835	)		4,882,425		6,883,292

The amounts shown in the Inclusion of Equity Values column in each of the above tables are derived from the following amounts:

Year	Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for PEO ($)		Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for PEO ($)			Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for PEO ($)			Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for PEO ($)		Total - Inclusion of Equity Values for PEO ($)
2022		6,635,906		(948,605	)		329,778			—		6,017,079
2021		5,337,837		1,158,777			2,447,006			—		8,943,620
2020		5,747,325		(629,614	)		(235,286	)		—		4,882,425

Non-PEO NEO Average Total Compensation Amount

$ 4,155,421

2,942,671

2,882,616

Non-PEO NEO Average Compensation Actually Paid Amount

$ 4,206,760

2,882,217

2,656,656

Adjustment to Non-PEO NEO Compensation Footnote [Text Block]

(2)

Year	Average Summary Compensation Table Total for Non-PEO NEOs ($)		Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($)			Average Inclusion of Equity Values for Non-PEO NEOs ($)		Average Compensation Actually Paid to Non-PEO NEOs ($)
2022		4,155,421		(3,126,696	)		3,178,035		4,206,760
2021		2,942,671		(2,141,519	)		2,081,065		2,882,217
2020		2,882,616		(2,083,657	)		1,857,697		2,656,656

The amounts shown in the Inclusion of Equity Values column in each of the above tables are derived from the following amounts:

Year	Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($)		Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($)			Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($)			Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($)			Total - Average Inclusion of Equity Values for Non-PEO NEOs ($)
2022		2,930,046		137,112			110,877			—			3,178,035
2021		2,296,714		(439,567	)		809,922			(586,004	)		2,081,065
2020		2,010,019		(91,032	)		(61,290	)		—			1,857,697

Compensation Actually Paid vs. Total Shareholder Return [Text Block]

Compensation Actually Paid vs. Net Income [Text Block]

Compensation Actually Paid vs. Company Selected Measure [Text Block]

Total Shareholder Return Vs Peer Group [Text Block]

Tabular List [Table Text Block]

The most important financial performance measures used to link compensation actually paid to our NEOs for 2022 to Company performance are set forth below. For further information regarding these performance metrics and their function in our executive compensation program, see our Compensation Discussion and Analysis beginning on page 91 of this proxy statement.

Proprietary Product Net Sales

Relative Total Shareholder Return

Non-GAAP Net Income*

Non-GAAP Net Income* as a Percentage of Total Revenue

* See Appendix B for information regarding this non-GAAP financial target.

Total Shareholder Return Amount

$ 128.09

114.02

97.79

Peer Group Total Shareholder Return Amount

113.65

126.45

126.42

Net Income (Loss)

$ (158,300,000)

$ (48,200,000)

$ (110,900,000)

Company Selected Measure Amount

57,900,000

129,100,000

68,600,000

PEO Name

Richard F. Pops

Measure [Axis]: 1

Pay vs Performance Disclosure [Table]

Measure Name

Proprietary Product Net Sales

Measure [Axis]: 2

Pay vs Performance Disclosure [Table]

Measure Name

Relative Total Shareholder Return

Measure [Axis]: 3

Pay vs Performance Disclosure [Table]

Measure Name

Non-GAAP Net Income

Non-GAAP Measure Description [Text Block]

We determined non-GAAP net income to be the most important financial performance measure used to link Company performance to compensation actually paid to our PEO and non-PEO NEOs in 2022. This financial performance measure may not have been the most important financial performance measure for years 2021 and 2020 and we may determine a different financial performance measure to be the most important financial performance measure in future years. See Appendix B for information regarding this non-GAAP financial measure.

Measure [Axis]: 4

Pay vs Performance Disclosure [Table]

Measure Name

Non-GAAP Net Income* as a Percentage of Total Revenue

PEO [Member] | Exclusion of Stock Awards and Option Awards [Member]

Pay vs Performance Disclosure [Table]

Adjustment to Compensation Amount

$ (8,009,660)

$ (6,564,945)

$ (6,040,835)

PEO [Member] | Inclusion of Equity Values [Member]

Pay vs Performance Disclosure [Table]