Income Taxes - Schedule of Components of Net Deferred Tax Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Deferred tax assets:
NOL carryforwards	$ 238,128	$ 222,508
Research and development expenses	66,464
Accrued expenses and reserves	55,755	52,308
Share-based compensation	41,075	40,455
Tax credits	22,932	58,704
Other	9,993	7,758
Less: valuation allowance	(271,517)	(249,112)	$ (253,649)	$ (242,059)
Total deferred tax assets	162,830	132,621
Deferred tax liabilities:
Property, plant and equipment	(46,274)	(50,187)
Other	(1,502)	(1,150)
Total deferred tax liabilities	(47,776)	(51,337)
Net deferred tax assets	$ 115,054	$ 81,284