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Income Taxes - Additional Information (Details)
$ in Thousands, € in Millions
1 Months Ended 12 Months Ended
Nov. 30, 2022
EUR (€)
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Income Taxes [Line Items]          
Cumulative unremitted earnings of overseas subsidiaries   $ 812,800      
Valuation allowance   271,517 $ 249,112 $ 253,649 $ 242,059
Federal research and development credits   5,700      
State tax credits   29,000      
LTA 2017          
Income Taxes [Line Items]          
Notice of Assessment | € € 2.2        
LTA 2018          
Income Taxes [Line Items]          
Notice of Assessment   $ 0      
Minimum          
Income Taxes [Line Items]          
Period after loss carryforwards utilized that tax returns remain open to examination   3 years      
Maximum          
Income Taxes [Line Items]          
Period after loss carryforwards utilized that tax returns remain open to examination   4 years      
U.S. state          
Income Taxes [Line Items]          
Valuation allowance   $ 25,700      
Operating loss carryforwards   43,200      
U.S. state | Rodin Therapeutics Incorporation          
Income Taxes [Line Items]          
Operating loss carryforwards   6,800      
U.S. federal          
Income Taxes [Line Items]          
Operating loss carryforwards   15,100      
U.S. federal | Rodin Therapeutics Incorporation          
Income Taxes [Line Items]          
Operating loss carryforwards   15,100      
Federal research and development credits   500      
Ireland          
Income Taxes [Line Items]          
Income taxes payable on repatriation of unremitted earnings   55,000      
Valuation allowance   245,800      
Operating loss carryforwards   $ 1,700,000