CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (158,267)	$ (48,169)	$ (110,861)
Adjustments to reconcile net loss to cash flows from operating activities:
Depreciation and amortization	77,862	78,652	81,854
Share-based compensation expense	94,254	87,622	90,164
Deferred income taxes	(32,795)	5,081	9,985
Change in the fair value of contingent consideration	21,750	1,427	(3,945)
Other non-cash charges	5,531	2,650	2,514
Changes in assets and liabilities:
Receivables	25,250	(38,011)	(18,050)
Contract assets	4,434	6,037	(6,015)
Inventory	(31,021)	(24,769)	(22,933)
Prepaid expenses and other assets	(5,328)	11,481	4,022
Right-of-use assets	16,569	17,051	17,336
Accounts payable and accrued expenses	15,534	11,514	(14,375)
Accrued sales discounts, allowances and reserves	14,899	18,339	64,975
Contract liabilities	(7,129)	(6,080)	(4,924)
Operating lease liabilities	(33,225)	(16,777)	(16,273)
Other long-term liabilities	12,726	(4,333)	9,368
Cash flows provided by operating activities	21,044	101,715	82,842
CASH FLOWS FROM INVESTING ACTIVITIES:
Additions of property, plant and equipment	(38,255)	(28,020)	(42,219)
Proceeds from the sale of equipment		287	643
Proceeds from contingent consideration	1,273	7,937	3,886
Return of Fountain Healthcare Partners II, L.P. investment	485		2,751
Payment made for licensed Intellectual Property ("IP")		(1,000)
Purchases of investments	(309,671)	(340,418)	(229,543)
Sales and maturities of investments	281,627	295,010	253,001
Cash flows used in investing activities	(64,541)	(66,204)	(11,481)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from the issuance of ordinary shares under share-based compensation arrangements	19,630	25,319	8,373
Employee taxes paid related to net share settlement of equity awards	(18,204)	(16,571)	(7,701)
Proceeds from the issuance of long-term debt		23,567
Payment made for debt extinguishment		(993)
Principal payments of long-term debt	(3,000)	(2,250)	(2,843)
Cash flows (used in) provided by financing activities	(1,574)	29,072	(2,171)
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS	(45,071)	64,583	69,190
CASH AND CASH EQUIVALENTS—Beginning of period	337,544	272,961	203,771
CASH AND CASH EQUIVALENTS—End of period	292,473	337,544	272,961
SUPPLEMENTAL CASH FLOW DISCLOSURE:
Cash paid for interest	13,563	6,904	8,288
Cash paid for taxes	20,749	1,888	620
Non-cash investing and financing activities:
Purchased capital expenditures included in accounts payable and accrued expenses	$ 2,950	$ 6,025	$ 2,420