Share-based Compensation - Schedule of Stock Option Activity (Details) - Stock options	12 Months Ended
	Dec. 31, 2022 $ / shares shares
Number of Shares
Outstanding at the beginning of the period (in shares) | shares	16,747,819
Granted (in shares) | shares	3,164,468
Exercised (in shares) | shares	(1,108,772)
Expired (in shares) | shares	(660,093)
Forfeited (in shares) | shares	(546,461)
Outstanding at the end of the period (in shares) | shares	17,596,961
Exercisable at the end of the period (in shares) | shares	10,138,673
Weighted Average Exercise Price
Outstanding at the beginning of the period (in dollars per share) | $ / shares	$ 34.02
Granted (in dollars per share) | $ / shares	25.39
Exercised (in dollars per share) | $ / shares	17.70
Expired (in dollars per share) | $ / shares	48.03
Forfeited (in dollars per share) | $ / shares	22.75
Outstanding at the end of the period (in dollars per share) | $ / shares	33.32
Exercisable at the end of the period (in dollars per share) | $ / shares	$ 40.52