Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Share-based compensation Expense
Total share-based compensation expense	$ 94,254	$ 87,622	$ 90,164
Cost of goods manufactured and sold
Share-based compensation Expense
Total share-based compensation expense	10,284	9,175	8,430
Research and development
Share-based compensation Expense
Total share-based compensation expense	27,941	24,877	26,408
Selling, general and administrative
Share-based compensation Expense
Total share-based compensation expense	$ 56,029	$ 53,570	$ 55,326