Share-based Compensation (Tables)

12 Months Ended

Dec. 31, 2022

Schedule of Share-based Compensation Expense

The following table presents share‑based compensation expense included in the Company’s consolidated statements of operations and comprehensive loss:

	Year Ended December 31,
(In thousands)	2022		2021		2020
Cost of goods manufactured and sold	$	10,284	$	9,175	$	8,430
Research and development		27,941		24,877		26,408
Selling, general and administrative		56,029		53,570		55,326
Total share-based compensation expense	$	94,254	$	87,622	$	90,164

Schedule of Stock Option Activity

A summary of stock option activity is presented in the following table:

	Number of			Weighted Average
	Shares			Exercise Price
Outstanding, January 1, 2022		16,747,819		$	34.02
Granted		3,164,468		$	25.39
Exercised		(1,108,772	)	$	17.70
Expired		(660,093	)	$	48.03
Forfeited		(546,461	)	$	22.75
Outstanding, December 31, 2022		17,596,961		$	33.32
Exercisable, December 31, 2022		10,138,673		$	40.52

Time-based RSU Awards

Summary of RSU Activity

A summary of time-based RSU activity is presented in the following table:

				Weighted Average
	Number of Shares			Grant Date Fair Value
Unvested, January 1, 2022		6,322,685		$	23.38
Granted		3,031,864		$	25.27
Vested		(2,051,872	)	$	26.45
Forfeited		(677,255	)	$	22.96
Unvested, December 31, 2022		6,625,422		$	23.34

Performance-based RSUs Awards

Summary of RSU Activity

A summary of performance-based RSU activity is presented in the following table:

				Weighted Average
	Number of Shares			Grant Date Fair Value
Unvested, January 1, 2022		877,862		$	23.20
Granted		517,683		$	30.73
Forfeited		(45,911	)	$	24.46
Vested		—		$	—
Unvested, December 31, 2022		1,349,634		$	26.05