CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
REVENUES:
Total revenues	$ 278,545	$ 251,430
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	55,159	41,020
Research and development	95,953	92,268
Selling, general and administrative	145,052	125,168
Amortization of acquired intangible assets	8,966	9,406
Total expenses	305,130	267,862
OPERATING LOSS	(26,585)	(16,432)
OTHER EXPENSE, NET:
Interest income	573	864
Interest expense	(2,350)	(3,970)
Change in the fair value of contingent consideration	(19,067)	1,278
Other income (expense), net	2,431	(393)
Total other expense, net	(18,413)	(2,221)
LOSS BEFORE INCOME TAXES	(44,998)	(18,653)
INCOME TAX (BENEFIT) PROVISION	(9,095)	3,765
NET LOSS	$ (35,903)	$ (22,418)
LOSS PER ORDINARY SHARE:
Basic and diluted	$ (0.22)	$ (0.14)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic and diluted	162,483	159,634
COMPREHENSIVE LOSS:
Net loss	$ (35,903)	$ (22,418)
Holding loss, net of a tax benefit of $(1,382) and $(174), respectively	(4,511)	(601)
COMPREHENSIVE LOSS	(40,414)	(23,019)
Product sales, net
REVENUES:
Total revenues	171,268	129,963
Manufacturing and royalty revenues
REVENUES:
Total revenues	105,170	119,847
License revenue
REVENUES:
Total revenues	2,000	1,500
Research and development revenue
REVENUES:
Total revenues	$ 107	$ 120