CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
REVENUES:
Total revenues	$ 1,173,751	$ 1,038,756	$ 1,170,947
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	197,387	178,316	180,385
Research and development	406,526	394,588	512,833
Selling, general and administrative	560,977	538,827	599,449
Amortization of acquired intangible assets	38,148	39,452	40,358
Restructuring expense			13,401
Total expenses	1,203,038	1,151,183	1,346,426
OPERATING LOSS	(29,287)	(112,427)	(175,479)
OTHER (EXPENSE) INCOME, NET:
Interest income	2,408	6,960	13,976
Interest expense	(11,219)	(8,659)	(13,601)
Change in the fair value of contingent consideration	(1,427)	3,945	(22,800)
Other income, net	219	13,644	848
Total other (expense) income, net	(10,019)	15,890	(21,577)
LOSS BEFORE INCOME TAXES	(39,306)	(96,537)	(197,056)
INCOME TAX PROVISION (BENEFIT)	8,863	14,324	(436)
NET LOSS	$ (48,169)	$ (110,861)	$ (196,620)
LOSS PER ORDINARY SHARE:
Basic and diluted (in dollars loss per ordinary share)	$ (0.30)	$ (0.70)	$ (1.25)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic and diluted (in shares)	160,942	158,803	157,051
COMPREHENSIVE LOSS:
Net loss	$ (48,169)	$ (110,861)	$ (196,620)
Holding (loss) gain, net of a tax (benefit) provision of $(706), $130 and $426, respectively	(2,374)	467	1,464
COMPREHENSIVE LOSS	(50,543)	(110,394)	(195,156)
Manufacturing and royalty revenues
REVENUES:
Total revenues	541,807	484,000	447,882
Product sales, net
REVENUES:
Total revenues	627,424	551,760	524,499
Research and development revenue
REVENUES:
Total revenues	1,020	1,946	52,816
License revenue
REVENUES:
Total revenues	$ 3,500	$ 1,050	$ 145,750