CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
CURRENT ASSETS:
Cash and cash equivalents	$ 337,544	$ 272,961
Receivables, net	313,193	275,143
Investments—short-term	198,767	362,066
Inventory	150,335	125,738
Contract assets	13,363	14,401
Prepaid expenses and other current assets	48,967	60,662
Total current assets	1,062,169	1,110,971
PROPERTY, PLANT AND EQUIPMENT, NET	341,054	350,003
INVESTMENTS—LONG-TERM	229,430	24,780
RIGHT-OF-USE ASSETS	115,627	131,718
INTANGIBLE ASSETS, NET	74,043	111,191
GOODWILL	92,873	92,873
DEFERRED TAX ASSETS	81,833	86,228
CONTINGENT CONSIDERATION	16,619	24,651
OTHER ASSETS	10,836	17,315
TOTAL ASSETS	2,024,484	1,949,730
CURRENT LIABILITIES:
Accounts payable and accrued expenses	445,707	412,171
Operating lease liabilities—short-term	16,240	15,732
Contract liabilities—short-term	6,339	7,512
Current portion of long-term debt	3,000	2,843
Total current liabilities	471,286	438,258
LONG-TERM DEBT	292,804	272,118
OPERATING LEASE LIABILITIES—LONG-TERM	104,162	119,464
CONTRACT LIABILITIES—LONG-TERM	11,491	16,397
OTHER LONG-TERM LIABILITIES	32,157	36,511
Total liabilities	911,900	882,748
COMMITMENTS AND CONTINGENT LIABILITIES (Note 19)
SHAREHOLDERS’ EQUITY:
Preferred shares, par value, $0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at December 31, 2021 and 2020, respectively
Ordinary shares, par value, $0.01 per share; 450,000,000 shares authorized; 165,790,549 and 162,269,220 shares issued; 161,937,327 and 159,161,141 shares outstanding at December 31, 2021 and 2020, respectively	1,658	1,620
Treasury shares, at cost (3,853,222 and 3,108,079 shares at December 31, 2021 and 2020, respectively)	(142,658)	(126,087)
Additional paid-in capital	2,798,325	2,685,647
Accumulated other comprehensive loss	(3,723)	(1,349)
Accumulated deficit	(1,541,018)	(1,492,849)
Total shareholders’ equity	1,112,584	1,066,982
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY	$ 2,024,484	$ 1,949,730