Share-based Compensation - Schedule of Stock Option Activity (Details) - Stock options	12 Months Ended
	Dec. 31, 2020 $ / shares shares
Number of Shares
Outstanding at the beginning of the period (in shares) | shares	15,235,845
Granted (in shares) | shares	3,799,952
Exercised (in shares) | shares	(682,122)
Expired (in shares) | shares	(1,266,999)
Forfeited (in shares) | shares	(974,487)
Outstanding at the end of the period (in shares) | shares	16,112,189
Exercisable at the end of the period (in shares) | shares	9,842,531
Weighted Average Exercise Price
Outstanding at the beginning of the period (in dollars per share) | $ / shares	$ 40.34
Granted (in dollars per share) | $ / shares	20.20
Exercised (in dollars per share) | $ / shares	12.27
Expired (in dollars per share) | $ / shares	49.81
Forfeited (in dollars per share) | $ / shares	36.28
Outstanding at the end of the period (in dollars per share) | $ / shares	36.27
Exercisable at the end of the period (in dollars per share) | $ / shares	$ 40.08