Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Share-based compensation Expense
Total share-based compensation expense	$ 90,164	$ 100,977	$ 105,357
Cost of goods manufactured and sold
Share-based compensation Expense
Total share-based compensation expense	8,430	9,948	9,174
Research and development
Share-based compensation Expense
Total share-based compensation expense	26,408	29,924	32,943
Selling, general and administrative
Share-based compensation Expense
Total share-based compensation expense	$ 55,326	$ 61,105	$ 63,240