Share-based Compensation (Tables)

12 Months Ended

Dec. 31, 2020

Schedule of Share-based Compensation Expense

The following table presents share‑based compensation expense included in the Company’s consolidated statements of operations and comprehensive loss:

	Year Ended December 31,
(In thousands)	2020		2019		2018
Cost of goods manufactured and sold	$	8,430	$	9,948	$	9,174
Research and development		26,408		29,924		32,943
Selling, general and administrative		55,326		61,105		63,240
Total share-based compensation expense	$	90,164	$	100,977	$	105,357

Schedule of Stock Option Activity

A summary of stock option activity is presented in the following table:

	Number of			Weighted Average
	Shares			Exercise Price
Outstanding, January 1, 2020		15,235,845		$	40.34
Granted		3,799,952		$	20.20
Exercised		(682,122	)	$	12.27
Expired		(1,266,999	)	$	49.81
Forfeited		(974,487	)	$	36.28
Outstanding, December 31, 2020		16,112,189		$	36.27
Exercisable, December 31, 2020		9,842,531		$	40.08

Time-based RSU Awards

Summary of RSU Activity

A summary of time‑vested RSU activity is presented in the following table:

				Weighted Average
	Number of Shares			Grant Date Fair Value
Unvested, January 1, 2020		3,744,800		$	38.99
Granted		3,494,759		$	20.22
Vested		(1,097,210	)	$	41.84
Forfeited		(587,087	)	$	31.16
Unvested, December 31, 2020		5,555,262		$	27.45

Performance-based RSUs Awards

Summary of RSU Activity

A summary of performance-based RSU activity is presented in the following table:

				Weighted Average
	Number of Shares			Grant Date Fair Value
Unvested, January 1, 2020		543,554		$	54.75
Granted		529,578		$	23.43
Forfeited		(574,148	)	$	53.08
Vested		—		$	—
Unvested, December 31, 2020		498,984		$	23.43