CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
REVENUES:
Total revenues	$ 1,038,756	$ 1,170,947	$ 1,094,274
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	178,316	180,385	176,420
Research and development	394,588	512,833	425,406
Selling, general and administrative	538,827	599,449	526,408
Amortization of acquired intangible assets	39,452	40,358	65,168
Restructuring expense		13,401
Total expenses	1,151,183	1,346,426	1,193,402
OPERATING LOSS	(112,427)	(175,479)	(99,128)
OTHER INCOME (EXPENSE), NET:
Interest income	6,960	13,976	9,238
Interest expense	(8,659)	(13,601)	(15,437)
Change in the fair value of contingent consideration	3,945	(22,800)	(19,600)
Other income (expense), net	13,644	848	(2,040)
Total other income (expense), net	15,890	(21,577)	(27,839)
LOSS BEFORE INCOME TAXES	(96,537)	(197,056)	(126,967)
INCOME TAX PROVISION (BENEFIT)	14,324	(436)	12,344
NET LOSS	$ (110,861)	$ (196,620)	$ (139,311)
LOSS PER ORDINARY SHARE:
Basic and diluted (in dollars loss per ordinary share)	$ (0.70)	$ (1.25)	$ (0.90)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic and diluted (in shares)	158,803	157,051	155,112
COMPREHENSIVE LOSS:
Net loss	$ (110,861)	$ (196,620)	$ (139,311)
Holding gain, net of a tax provision of $130, $426, $159, respectively	467	1,464	512
COMPREHENSIVE LOSS	(110,394)	(195,156)	(138,799)
Manufacturing and royalty revenues
REVENUES:
Total revenues	484,000	447,882	526,675
Product sales, net
REVENUES:
Total revenues	551,760	524,499	450,334
Research and development revenue
REVENUES:
Total revenues	1,946	52,816	68,895
License revenue
REVENUES:
Total revenues	$ 1,050	$ 145,750	$ 48,370