CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
REVENUES:
Total revenues	$ 247,529	$ 279,872	$ 493,749	$ 502,974
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	45,053	46,223	92,264	91,584
Research and development	94,222	104,435	187,501	207,005
Selling, general and administrative	132,025	155,075	265,397	296,295
Amortization of acquired intangible assets	9,890	10,062	19,618	20,014
Total expenses	281,190	315,795	564,780	614,898
OPERATING LOSS	(33,661)	(35,923)	(71,031)	(111,924)
OTHER INCOME (EXPENSE), NET:
Interest income	1,788	3,706	4,548	7,276
Interest expense	(2,122)	(3,520)	(4,979)	(7,020)
Change in the fair value of contingent consideration	5,900	(6,500)	12,700	(29,100)
Other income, net	2,337	1,851	1,679	130
Total other income (expense), net	7,903	(4,463)	13,948	(28,714)
LOSS BEFORE INCOME TAXES	(25,758)	(40,386)	(57,083)	(140,638)
INCOME TAX PROVISION (BENEFIT)	3,673	1,604	11,002	(2,250)
NET LOSS	$ (29,431)	$ (41,990)	$ (68,085)	$ (138,388)
LOSS PER ORDINARY SHARE:
Basic and diluted (in dollars loss per ordinary share)	$ (0.19)	$ (0.27)	$ (0.43)	$ (0.88)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic and diluted (in shares)	158,895	156,991	158,495	156,665
COMPREHENSIVE LOSS:
Net loss	$ (29,431)	$ (41,990)	$ (68,085)	$ (138,388)
Unrealized gain, net of a tax provision of $409, $265, $496 and $494, respectively	1,398	896	1,715	1,666
COMPREHENSIVE LOSS	(28,033)	(41,094)	(66,370)	(136,722)
Product sales, net
REVENUES:
Total revenues	130,415	136,635	260,141	236,116
Manufacturing and royalty revenues
REVENUES:
Total revenues	116,505	127,897	232,756	236,812
Research and development revenue
REVENUES:
Total revenues	$ 609	14,340	$ 852	29,046
License revenue
REVENUES:
Total revenues		$ 1,000		$ 1,000