Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Share-based compensation Expense
Total share-based compensation expense	$ 100,977	$ 105,357	$ 83,917
Cost of goods manufactured and sold
Share-based compensation Expense
Total share-based compensation expense	9,948	9,174	7,596
Research and development
Share-based compensation Expense
Total share-based compensation expense	29,924	32,943	22,635
Selling, general and administrative
Share-based compensation Expense
Total share-based compensation expense	$ 61,105	$ 63,240	$ 53,686