CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
REVENUES:
Total revenues	$ 223,102	$ 225,150
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	45,361	44,476
Research and development	102,570	108,346
Selling, general and administrative	141,220	118,147
Amortization of acquired intangible assets	9,952	16,069
Total expenses	299,103	287,038
OPERATING LOSS	(76,001)	(61,888)
OTHER EXPENSE, NET:
Interest income	3,570	1,485
Interest expense	(3,500)	(5,487)
Change in the fair value of contingent consideration	(22,600)	(1,900)
Other (expense) income, net	(1,721)	792
Total other expense, net	(24,251)	(5,110)
LOSS BEFORE INCOME TAXES	(100,252)	(66,998)
INCOME TAX BENEFIT	(3,854)	(4,493)
NET LOSS	$ (96,398)	$ (62,505)
LOSS PER ORDINARY SHARE:
Basic and diluted (in dollars loss per ordinary share)	$ (0.62)	$ (0.40)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic and diluted (in shares)	156,336	154,424
COMPREHENSIVE LOSS:
Net loss	$ (96,398)	$ (62,505)
Holding gain (loss), net of a tax provision (benefit) of $229 and $(100), respectively	770	(336)
COMPREHENSIVE LOSS	(95,628)	(62,841)
Manufacturing and royalty revenues
REVENUES:
Total revenues	108,915	114,601
Product sales, net
REVENUES:
Total revenues	99,481	91,842
Research and development revenue
REVENUES:
Total revenues	$ 14,706	$ 18,707