CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
REVENUES:
Manufacturing and royalty revenues	$ 106,159	$ 128,744
Product sales, net	49,374	31,137
Research and development revenue	1,241	1,333
Total revenues	156,774	161,214
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	27,711	39,974
Research and development	101,072	70,278
Selling, general and administrative	89,719	63,050
Amortization of acquired intangible assets	15,156	15,220
Total expenses	233,658	188,522
OPERATING LOSS	(76,884)	(27,308)
OTHER EXPENSE, NET:
Interest income	1,011	660
Interest expense	(3,295)	(3,288)
Increase in the fair value of contingent consideration	1,900
Other income (expense), net	249	(211)
Total other expense, net	(135)	(2,839)
LOSS BEFORE INCOME TAXES	(77,019)	(30,147)
PROVISION FOR INCOME TAXES	404	510
NET LOSS	$ (77,423)	$ (30,657)
LOSS PER COMMON SHARE:
Basic and diluted (in dollars per share)	$ (0.51)	$ (0.21)
WEIGHTED AVERAGE NUMBER OF COMMON SHARES OUTSTANDING:
Basic and Diluted (in shares)	150,825	148,089
COMPREHENSIVE LOSS
Net loss	$ (77,423)	$ (30,657)
Holding gains, net of a tax provision of $425 and $209, respectively	935	489
COMPREHENSIVE LOSS	$ (76,488)	$ (30,168)