CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
REVENUES:
Manufacturing and royalty revenues	$ 114,072	$ 132,028	$ 355,978	$ 373,674
Product sales, net	37,903	25,802	106,212	64,476
Research and development revenue	678	2,162	3,047	5,478
Total revenues	152,653	159,992	465,237	443,628
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	33,806	47,335	104,198	129,464
Research and development	92,558	78,263	250,718	197,610
Selling, general and administrative	89,497	51,888	224,086	145,101
Amortization of acquired intangible assets	14,207	15,244	43,479	42,909
Total expenses	230,068	192,730	622,481	515,084
OPERATING LOSS	(77,415)	(32,738)	(157,244)	(71,456)
OTHER (EXPENSE) INCOME, NET:
Interest income	865	546	2,320	1,380
Interest expense	(3,325)	(3,356)	(9,928)	(10,097)
Gain on the Gainesville Transaction	26		9,937
Increase in the fair value of contingent consideration	1,200		2,700
Other income (expense), net	629	(921)	1,003	(2,253)
Gain on sale of property, plant and equipment		36		12,321
Gain on sale of investment in Acceleron Pharma Inc.				15,296
Total other (expense) income, net	(605)	(3,695)	6,032	16,647
LOSS BEFORE INCOME TAXES	(78,020)	(36,433)	(151,212)	(54,809)
PROVISION FOR INCOME TAXES	2,995	3,523	6,569	5,766
NET LOSS	$ (81,015)	$ (39,956)	$ (157,781)	$ (60,575)
LOSS PER COMMON SHARE:
Basic and diluted (in dollars per share)	$ (0.54)	$ (0.27)	$ (1.06)	$ (0.42)
WEIGHTED AVERAGE NUMBER OF COMMON SHARES OUTSTANDING:
Basic and diluted (in shares)	149,512	145,896	148,828	144,732
COMPREHENSIVE LOSS
Net loss	$ (81,015)	$ (39,956)	$ (157,781)	$ (60,575)
Unrealized gains (losses) on marketable securities, net of tax:
Holding gains (losses), net of tax of $(5), $89, $165 and $7,715, respectively	14	(154)	424	1,855
Reclassification of unrealized gains to realized gains				(15,296)
COMPREHENSIVE LOSS	$ (81,001)	$ (40,110)	$ (157,357)	$ (74,016)