CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
REVENUES:
Total revenues	$ 617,397	$ 276,219	$ 904,992	$ 554,764
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	63,260	58,360	121,435	113,519
Research and development	100,788	92,873	194,425	188,826
Selling, general and administrative	205,258	150,377	379,735	295,429
Amortization of acquired intangible assets	8,898	9,066	17,698	18,032
Total expenses	378,204	310,676	713,293	615,806
OPERATING INCOME (LOSS)	239,193	(34,457)	191,699	(61,042)
OTHER INCOME (EXPENSE), NET:
Interest income	6,769	896	11,735	1,469
Interest expense	(5,684)	(2,369)	(10,972)	(4,719)
Change in the fair value of contingent consideration		870		(18,197)
Other (expense) income, net	(525)	1,810	(564)	4,241
Total other income (expense), net	560	1,207	199	(17,206)
INCOME (LOSS) BEFORE INCOME TAXES	239,753	(33,250)	191,898	(78,248)
INCOME TAX PROVISION (BENEFIT)	2,688	(3,114)	(3,322)	(12,209)
NET INCOME (LOSS)	$ 237,065	$ (30,136)	$ 195,220	$ (66,039)
EARNINGS (LOSS) PER ORDINARY SHARE:
Basic	$ 1.43	$ (0.18)	$ 1.18	$ (0.4)
Diluted	$ 1.38	$ (0.18)	$ 1.14	$ (0.4)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic	166,279	163,839	165,686	163,165
Diluted	171,553	163,839	170,747	163,165
COMPREHENSIVE INCOME (LOSS):
Net income (loss)	$ 237,065	$ (30,136)	$ 195,220	$ (66,039)
Holding gain (loss), net of a tax provision (benefit) of $99, $326, $587 and $(1,055), respectively	692	(2,254)	3,452	(6,765)
COMPREHENSIVE INCOME (LOSS)	237,757	(32,390)	198,672	(72,804)
Product sales, net
REVENUES:
Total revenues	231,477	190,787	446,204	362,055
Manufacturing and royalty revenues
REVENUES:
Total revenues	385,913	85,326	458,775	190,496
License revenue
REVENUES:
Total revenues				2,000
Research and development revenue
REVENUES:
Total revenues	$ 7	$ 106	$ 13	$ 213