<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2022-12-12</periodOfReport>

    <issuer>
        <issuerCik>0001527469</issuerCik>
        <issuerName>Athene Holding Ltd</issuerName>
        <issuerTradingSymbol>ATH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001518052</rptOwnerCik>
            <rptOwnerName>Klein Martin P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ATHENE HOLDING LTD.</rptOwnerStreet1>
            <rptOwnerStreet2>WASHINGTON HOUSE, 16 CHURCH STREET</rptOwnerStreet2>
            <rptOwnerCity>HAMILTON</rptOwnerCity>
            <rptOwnerState>D0</rptOwnerState>
            <rptOwnerZipCode>HM 11</rptOwnerZipCode>
            <rptOwnerStateDescription>BERMUDA</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>true</isOfficer>
            <officerTitle>Executive VP and CFO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Depositary Shares of Series E Preference Shares</value>
                <footnoteId id="F1"/>
            </securityTitle>
            <transactionDate>
                <value>2022-12-12</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>20000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>25</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>20000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Complete Title of Security: Depositary Shares Each Representing a 1/1,000th Interest in a Share of 7.750% Fixed-Rate Reset Perpetual Non-Cumulative Preference Shares, Series E. Neither the Depositary Shares nor the underlying Series E Preference Shares are convertible into, or exchangeable for, shares of any other class or series of stock or other securities of the Issuer or its subsidiaries and, except in very limited circumstances, neither the Depositary Shares nor the underlying Series E Preference Shares have voting rights. Neither the Depositary Shares nor the underlying Series E Preference Shares will be obligations of, or guaranteed by, Apollo Global Management, Inc., the beneficial owner of 100% of Class A common shares of the Issuer, or any entity other than the Issuer.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Ira Rosenblatt, attorney-in-fact</signatureName>
        <signatureDate>2022-12-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
